價格 | 詢價 |
包裝 | 1mg |
最小起訂量 | 1mg |
發(fā)貨地 | 湖北 |
更新日期 | 2025-04-22 |
中文名稱:5-(4-氯苯基)-1-(4-甲氧基苯基)-3-(三氟甲基)-1H-吡唑; SC-560 | 英文名稱:5-(4-chlorophenyl)-1 |
產(chǎn)品類別: 生化試劑 |
中文名稱
5-(4-氯苯基)-1-(4-甲氧基苯基)-3-(三氟甲基)-1H-吡唑; SC-560
英文名字
5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole; SC-560
供應(yīng)商
開曼生物
產(chǎn)品貨號
70340-1
產(chǎn)品報價
¥231/1mg
產(chǎn)品說明書
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購買方式
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產(chǎn)品新聞
背景資料
SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors which includes celecoxib (Celebrex?) and rofecoxib (Vioxx?). However, unlike these selective COX-2 inhibitors, SC-560 is a selective inhibitor of COX-1. Using human recombinant enzymes, the IC50 value for SC-560 with respect to COX-1 is 9 nM, while the corresponding IC50 value for COX-2 is 6.3 uM. Thus, SC-560 shows 700-fold selectivity for the COX-1 enzyme. SC-560 is orally active in the rat, where 10 mg/kg completely abolishes the ionophore-induced production of thromboxane B2 in whole blood. However, SC-560 is ineffective in the treatment of inflammation in models such as the LPS-induced rat air-pouch model, in which the COX-2 generated prostaglandins play a significant role in the inflammatory process. In whole cells, however, SC-560 appears to act as a non-selective COX inhibitor. The mechanism of the selective versus non-selective effects of SC-560 in a cell-free environment compared whole cells has not been elucidated.
產(chǎn)品描述
SC-560 is a member of the diaryl heterocycle class of COX inhibitors which includes celecoxib (Celebrex?) and rofecoxib (Vioxx?). However, unlike these selective COX-2 inhibitors, SC-560 is a selective inhibitor of COX-1. Using human recombinant enzymes, the IC50 value for SC-560 with respect to COX-1 is 9 nM, while the corresponding IC50 value for COX-2 is 6.3 uM.{7675} Thus, SC-560 shows 700-fold selectivity for the COX-1 enzyme. SC-560 is orally active in the rat, where 10 mg/kg completely abolishes the ionophore-induced production of TXB2 in whole blood. However, SC-560 is ineffective in the treatment of inflammation in models such as the LPS-induced rat air-pouch model, in which the COX-2 generated prostaglandins play a significant role in the inflammatory process.{1282} In whole cells, however, SC-560 appears to act as a non-selective COX inhibitor.{14472} The mechanism of the selective versus non-selective effects of SC-560 in a cell-free environment compared whole cells has not been elucidated.
保存建議
建議您在收到開曼生物品牌的SC-560 (1 mg)產(chǎn)品后置于-20度保存,產(chǎn)品有效期為730天.
其他
開曼生物向全球科學(xué)工作者提供多研究領(lǐng)域的生化、免疫試劑和分析試劑盒,其產(chǎn)品被廣泛應(yīng)用于腫瘤、氧化氮、神經(jīng)學(xué)、凋亡、氧化性損傷、內(nèi)分泌學(xué)等不同研究領(lǐng)域.開曼生物可提供用于檢測的特色試劑盒,如:類花生酸類物質(zhì)、游離的生物標(biāo)志、環(huán)核苷、激素及氧化氮等;也提供多種高質(zhì)量試劑,包括:類花生酸類物質(zhì)、氧化氮試劑及許多相關(guān)脂質(zhì)、脂肪酸、酶和抗體.作為開曼生物在中國的區(qū)域總代理,艾美捷科技有限公司將為中國客戶提供最全面的開曼生物產(chǎn)品以及客戶訂制化服務(wù).
成立日期 | 2009-01-09 (17年) | 注冊資本 | 有限責(zé)任公司(自然人投資或控股) |
員工人數(shù) | 100-500人 | 年營業(yè)額 | ¥ 1000萬-5000萬 |
主營行業(yè) | 生化試劑,抗體,細(xì)胞培養(yǎng),蛋白組學(xué) | 經(jīng)營模式 | 服務(wù) |
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