中文名稱

LLME;?L-亮氨酰-L-亮氨酸甲酯，一鹽酸鹽

英文名字

LLME; L-leucyl-L-leucine methyl ester, monohydrochloride

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開曼生物

產(chǎn)品貨號

16008-1

產(chǎn)品報價

￥1/1g

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背景資料

L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes without affecting helper T cells and B cells.{26052,26051} It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid tumor cells.{26051} Upon entry into cells via receptor-mediated endocytosis, LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. This condensation leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T cells and natural killer cells.{26051}

產(chǎn)品描述

A lysosomal condensation product that selectively eliminates dipeptidyl peptidase I-expressing immune cells, including cytotoxic T cells and natural killer cells

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