中文名稱(chēng)

RQ-00015986; 4-[（1S）-1-[[5-氯-2-（4-氟苯氧基）苯甲?；鵠氨基]乙基]-苯甲酸

英文名字

RQ-00015986; 4-[(1S)-1-[[5-chloro-2-(4-fluorophenoxy)benzoyl]amino]ethyl]-benzoic acid

供應(yīng)商

開(kāi)曼生物

產(chǎn)品貨號(hào)

10010428-10

產(chǎn)品報(bào)價(jià)

￥677.6/10mg

產(chǎn)品說(shuō)明書(shū)

點(diǎn)擊查看

購(gòu)買(mǎi)方式

銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868

產(chǎn)品新聞

背景資料

Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis.{16772,16773,16619} CJ-42794 is a selective antagonist of EP4 (Ki = 3.16 nM) that less potently binds EP2 (Ki = 631 nM) and has no affinity for EP1 or EP3.{14996,26030} It has minimal effect on numerous other receptors, enzymes, or channels.{26030} Unlike general inhibitors of PGE2 synthesis, CJ-42794 does not cause damage to rat gastrointestinal mucosa.{14996} Instead, it delays the healing of gastric ulcers in mice and rats, suppressing the upregulation of VEGF expression and angiogenesis.{26032} CJ-42794 blocks pain and inflammation in rat models of arthritis as well as gastric tumorigenesis in mice.{25895,26031}

產(chǎn)品描述

A selective antagonist of EP4 (Ki = 3.2 nM) that less potently binds EP2 (Ki = 630 nM) and has no affinity for EP1 or EP3; delays the healing of gastric ulcers, suppressing the upregulation of VEGF expression and angiogenesis; blocks pain and inflammation in rat models of arthritis and gastric tumorigenesis in mice

保存建議

建議您在收到開(kāi)曼生物品牌的CJ-42794 (10 mg)產(chǎn)品后置于-20度保存，產(chǎn)品有效期為730天.

其他

開(kāi)曼生物向全球科學(xué)工作者提供多研究領(lǐng)域的生化、免疫試劑和分析試劑盒，其產(chǎn)品被廣泛應(yīng)用于腫瘤、氧化氮、神經(jīng)學(xué)、凋亡、氧化性損傷、內(nèi)分泌學(xué)等不同研究領(lǐng)域.開(kāi)曼生物可提供用于檢測(cè)的特色試劑盒，如：類(lèi)花生酸類(lèi)物質(zhì)、游離的生物標(biāo)志、環(huán)核苷、激素及氧化氮等；也提供多種高質(zhì)量試劑，包括：類(lèi)花生酸類(lèi)物質(zhì)、氧化氮試劑及許多相關(guān)脂質(zhì)、脂肪酸、酶和抗體.作為開(kāi)曼生物在中國(guó)的區(qū)域總代理，艾美捷科技有限公司將為中國(guó)客戶提供最全面的開(kāi)曼生物產(chǎn)品以及客戶訂制化服務(wù).