7.2 重組蛋白相關(guān)產(chǎn)品
重組蛋白是指利用DNA重組技術(shù)生產(chǎn)的蛋白質(zhì)。重組蛋白可彌補(bǔ)體內(nèi)功能蛋白缺陷，或者增加體內(nèi)蛋白功能，達(dá)到治療疾病目的，藥物是重組蛋白發(fā)展的重要方向，在部分疾病治療領(lǐng)域具有不可替代的重要作用。用于重組蛋白生產(chǎn)的宿主細(xì)胞可以來(lái)自細(xì)菌、哺乳動(dòng)物細(xì)胞、昆蟲(chóng)和酵母。匯智泰康致力于為客戶提供各種高純度、低成本活性重組蛋白，包括細(xì)胞因子、生長(zhǎng)因子、CD分子、免疫檢查點(diǎn)等等。
產(chǎn)品應(yīng)用：
? 免疫檢查點(diǎn) | ? 抗體藥物靶點(diǎn) |
? CAR-T細(xì)胞治療靶點(diǎn) | ? Fc受體 |
? 疫苗研發(fā) | ? 細(xì)胞因子 |
產(chǎn)品優(yōu)勢(shì)：
? 高活性、高純度 | ? 低成本 |
? 不同的大小，種類(lèi)和標(biāo)簽 | ? 貨期短 |
產(chǎn)品類(lèi)別：
7.2.1. 細(xì)胞因子(cytokine，CK)
是由多種組織細(xì)胞(主要為免疫細(xì)胞)所合成和分泌的小分子多肽或糖蛋白。細(xì)胞因子能介導(dǎo)細(xì)胞間的相互作用，具有多種生物學(xué)功能，如調(diào)節(jié)細(xì)胞生長(zhǎng)、分化成熟、功能維持、調(diào)節(jié)免疫應(yīng)答、參與炎癥反應(yīng)、創(chuàng)傷愈合和腫瘤消長(zhǎng)等。
貨號(hào) | 名稱 | 標(biāo)簽 | 規(guī)格 |
071A011 | Recombinant human IL-2 | His Tag | 100μg |
071A012 | Recombinant human IL-3 | His Tag | 25μg |
071A021 | Recombinant human IL-4 | His Tag | 100μg |
071A022 | Recombinant human IL-4 | His Tag | 25μg |
071A023 | Recombinant human IL-4 | human Fc | 100μg |
071A024 | Recombinant human IL-4 | human Fc | 25μg |
071A025 | Recombinant human IL-4 | mouse Fc | 100μg |
071A026 | Recombinant human IL-4 | mouse Fc | 25μg |
071A031 | Recombinant human IL-6 | His Tag | 100μg |
071A032 | Recombinant human IL-6 | His Tag | 25μg |
071A033 | Recombinant human IL-6 | human Fc | 100μg |
071A034 | Recombinant human IL-6 | human Fc | 25μg |
071A041 | Recombinant human IL-13 | His Tag | 100μg |
071A042 | Recombinant human IL-13 | His Tag | 25μg |
071A051 | Recombinant human IL-17A | His Tag | 100μg |
071A052 | Recombinant human IL-17A | His Tag | 25μg |
071A053 | Recombinant human IL-17A | human Fc | 100μg |
071A054 | Recombinant human IL-17A | human Fc | 25μg |
071A055 | Recombinant human IL-17A | mouse Fc | 100μg |
071A056 | Recombinant human IL-17A | mouse Fc | 25μg |
071A061 | Recombinant human TSLP | His Tag | 100μg |
071A062 | Recombinant human TSLP | His Tag | 25μg |
071A063 | Recombinant human TSLP | human Fc | 100μg |
071A064 | Recombinant human TSLP | human Fc | 25μg |
071A065 | Recombinant human TSLP | mouse Fc | 100μg |
071A066 | Recombinant human TSLP | mouse Fc | 25μg |
071A071 | Recombinant human IL-6R | His Tag | 100μg |
071A072 | Recombinant human IL-6R | His Tag | 25μg |
071A073 | Recombinant human IL-6R | human Fc | 100μg |
071A074 | Recombinant human IL-6R | human Fc | 25μg |
071A075 | Recombinant human IL-6R | mouse Fc | 100μg |
071A076 | Recombinant human IL-6R | mouse Fc | 25μg |
071A081 | Recombinant human IL-4R | His Tag | 100μg |
071A082 | Recombinant human IL-4R | His Tag | 25μg |
071A083 | Recombinant human IL-4R | human Fc | 100μg |
071A084 | Recombinant human IL-4R | human Fc | 25μg |
071A085 | Recombinant human IL-4R | mouse Fc | 100μg |
071A086 | Recombinant human IL-4R | mouse Fc | 25μg |
071A091 | Recombinant human IL7R | His Tag | 100μg |
071A092 | Recombinant human IL7R | His Tag | 25μg |
071A093 | Recombinant human IL7R | human Fc | 100μg |
071A094 | Recombinant human IL7R | human Fc | 25μg |
071A095 | Recombinant human IL7R | mouse Fc | 100μg |
071A096 | Recombinant human IL7R | mouse Fc | 25μg |
071A101 | Recombinant human IL-17RA | His Tag | 100μg |
071A102 | Recombinant human IL-17RA | His Tag | 25μg |
071A111 | Recombinant human TSLPR | His Tag | 100μg |
071A112 | Recombinant human TSLPR | His Tag | 25μg |
7.2.2. 生長(zhǎng)因子（growth factor）
是 一類(lèi)通過(guò)與特異的、高親和的細(xì)胞膜受體結(jié)合，調(diào)節(jié)細(xì)胞生長(zhǎng)與其他細(xì)胞功能等多效應(yīng)的多肽類(lèi)物質(zhì)。其是由多種細(xì)胞分泌，作用于特定的靶細(xì)胞，調(diào)節(jié)細(xì)胞分裂、基質(zhì)合成與組織分化的細(xì)胞因子。有胰島素、表皮生長(zhǎng)因子（EGF）、成纖細(xì)胞生長(zhǎng)因子（fibroblast growth factor，FGF）、血小板來(lái)源增殖因子（platelet－derived growth factor，PDGF）以及生長(zhǎng)激素釋放抑制因子（somatostatin=SRIH）等。
貨號(hào) | 名稱 | 標(biāo)簽 | 規(guī)格 |
072A011 | Recombinant human VEGF | His Tag | 100μg |
072A012 | Recombinant human VEGF | His Tag | 25μg |
072A013 | Recombinant human VEGF | human Fc | 100μg |
072A014 | Recombinant human VEGF | human Fc | 25μg |
072A015 | Recombinant human VEGF | mouse Fc | 100μg |
072A016 | Recombinant human VEGF | mouse Fc | 25μg |
072A021 | Recombinant human VEGFR | His Tag | 100μg |
072A022 | Recombinant human VEGFR | His Tag | 25μg |
072A023 | Recombinant human VEGFR | human Fc | 100μg |
072A024 | Recombinant human VEGFR | human Fc | 25μg |
072A025 | Recombinant human VEGFR | mouse Fc | 100μg |
072A026 | Recombinant human VEGFR | mouse Fc | 25μg |
7.2.3. CD分子
是不同譜系的白細(xì)胞在正常分化成熟的不同階段及活化過(guò)程中，出現(xiàn)或消失的細(xì)胞表面標(biāo)記。它們是細(xì)胞膜上的一類(lèi)蛋白質(zhì)或糖蛋白。在生理學(xué)上，CD分子有許多用途，通常用作細(xì)胞的重要受體或配體。 不僅可作為表面標(biāo)志用于細(xì)胞的鑒定和分離，還廣泛參與細(xì)胞的生長(zhǎng)、成熟、分化、發(fā)育、遷移、激活。
貨號(hào) | 名稱 | 標(biāo)簽 | 規(guī)格 |
073A011 | Recombinant human CD3 | His Tag | 100μg |
073A012 | Recombinant human CD3 | His Tag | 25μg |
073A021 | Recombinant human CD4 | His Tag | 100μg |
073A022 | Recombinant human CD4 | His Tag | 25μg |
073A031 | Recombinant human CD8 | His Tag | 100μg |
073A032 | Recombinant human CD8 | His Tag | 25μg |
073A041 | Recombinant human CD11 | His Tag | 100μg |
073A042 | Recombinant human CD11 | His Tag | 25μg |
073A051 | Recombinant human CD19 | His Tag | 100μg |
073A052 | Recombinant human CD19 | His Tag | 25μg |
073A061 | Recombinant human CD34 | His Tag | 100μg |
073A062 | Recombinant human CD34 | His Tag | 25μg |
073A071 | Recombinant human CD45 | His Tag | 100μg |
073A072 | Recombinant human CD45 | His Tag | 25μg |
073A081 | Recombinant human CD56 | His Tag | 100μg |
073A082 | Recombinant human CD56 | His Tag | 25μg |
073A091 | Recombinant human CD138 | His Tag | 100μg |
073A092 | Recombinant human CD138 | His Tag | 25μg |
073A101 | Recombinant human CD271 | His Tag | 100μg |
073A102 | Recombinant human CD271 | His Tag | 25μg |
073B111 | Recombinant mouse CD3 | His Tag | 100μg |
073B112 | Recombinant mouse CD3 | His Tag | 25μg |
073B121 | Recombinant mouse CD4 | His Tag | 100μg |
073B122 | Recombinant mouse CD4 | His Tag | 25μg |
073B131 | Recombinant mouse CD8 | His Tag | 100μg |
073B132 | Recombinant mouse CD8 | His Tag | 25μg |
073B141 | Recombinant mouse CD11B | His Tag | 100μg |
073B142 | Recombinant mouse CD11B | His Tag | 25μg |
073B151 | Recombinant mouse CD11C | His Tag | 100μg |
073B152 | Recombinant mouse CD11C | His Tag | 25μg |
073B161 | Recombinant mouse CD19 | His Tag | 100μg |
073B162 | Recombinant mouse CD19 | His Tag | 25μg |
073B171 | Recombinant mouse CD25 | His Tag | 100μg |
073B172 | Recombinant mouse CD25 | His Tag | 25μg |
073B181 | Recombinant mouse CD45 | His Tag | 100μg |
073B182 | Recombinant mouse CD45 | His Tag | 25μg |
073B191 | Recombinant mouse CD117 | His Tag | 100μg |
073B192 | Recombinant mouse CD117 | His Tag | 25μg |
7.2.4. 免疫檢查點(diǎn)
一些存在人體免疫系統(tǒng)的共刺激和共抑制分子、蛋白，它們會(huì)傳遞信號(hào)；共刺激分子受體會(huì)提高機(jī)體的免疫反應(yīng)用來(lái)對(duì)抗病原體，抑制性分子受體能夠負(fù)向調(diào)節(jié)T細(xì)胞活力，用來(lái)保護(hù)過(guò)度的炎癥反應(yīng)。它們是癌癥治療中很值得關(guān)注的靶點(diǎn)，比如PD-1、PD-L1、B7、CD28、TIM、CD226家族。
重組蛋白表達(dá)系統(tǒng)分為原核表達(dá)和真核表達(dá)系統(tǒng)。原核表達(dá)主要是大腸桿菌表達(dá)系統(tǒng)，真核生物表達(dá)系統(tǒng)主要有酵母菌、哺乳動(dòng)物細(xì)胞、昆蟲(chóng)細(xì)胞等表達(dá)系統(tǒng)。
貨號(hào) | 名稱 | 標(biāo)簽 | 規(guī)格 |
074A011 | Recombinant human PD-1 | His Tag | 100μg |
074A012 | Recombinant human PD-1 | His Tag | 25μg |
074A013 | Recombinant human PD-1 | human Fc | 100μg |
074A014 | Recombinant human PD-1 | human Fc | 25μg |
074A015 | Recombinant human PD-1 | mouse Fc | 100μg |
074A016 | Recombinant human PD-1 | mouse Fc | 25μg |
074A021 | Recombinant human PD-L1 | His Tag | 100μg |
074A022 | Recombinant human PD-L1 | His Tag | 25μg |
074A023 | Recombinant human PD-L1 | human Fc | 100μg |
074A024 | Recombinant human PD-L1 | human Fc | 25μg |
074A025 | Recombinant human PD-L1 | mouse Fc | 100μg |
074A026 | Recombinant human PD-L1 | mouse Fc | 25μg |
074A031 | Recombinant human B7H3 | His Tag | 100μg |
074A032 | Recombinant human B7H3 | His Tag | 25μg |
074A033 | Recombinant human B7H3 | human Fc | 100μg |
074A034 | Recombinant human B7H3 | human Fc | 25μg |
074A035 | Recombinant human B7H3 | mouse Fc | 100μg |
074A036 | Recombinant human B7H3 | mouse Fc | 25μg |
7.2.5. SARS-cov2 相關(guān)蛋白
新型冠狀病毒由雙層脂質(zhì)的囊膜組成，包含刺突蛋白（Spike protein，S）、包膜蛋白（Envelope protein，E）、膜蛋白（Membrane protein，M）以及核衣殼蛋白（Nucleoc-apsid protein，N）。其中S蛋白和N蛋白是其中最重要的用于檢測(cè)的靶點(diǎn)蛋白。N蛋白一般種屬特異性較高，通常作為檢測(cè)的靶點(diǎn)，而表面的S蛋白特異性會(huì)低一些。S蛋白含有兩個(gè)亞基，S1和S2，其中S1主要包含有受體結(jié)合區(qū)（receptor binding domain，RBD），負(fù)責(zé)識(shí)別細(xì)胞的受體，S2含有膜融合過(guò)程所需的基本元件。新型冠狀病毒是通過(guò)識(shí)別ACE2蛋白進(jìn)入人體細(xì)胞的。ACE2就像是“門(mén)把手”，病毒抓住它，從而打開(kāi)了進(jìn)入人體細(xì)胞的大門(mén)。
貨號(hào) | 名稱 | 標(biāo)簽 | 規(guī)格 |
075A011 | S1 | His Tag | 100μg |
075A012 | S1 | His Tag | 25μg |
075A021 | ACE2 | His Tag | 100μg |
075A022 | ACE2 | His Tag | 25μg |
075A031 | RBD | His Tag | 100μg |
075A032 | RBD | His Tag | 25μg |
關(guān)鍵字： 細(xì)胞因子;生長(zhǎng)因子;CD分子;免疫檢查點(diǎn);SARS-cov2 相關(guān)蛋;
匯智泰康是一家位于中美兩地的生物醫(yī)藥合同研發(fā)機(jī)構(gòu)，整合中美兩地的藥物研發(fā)技術(shù)服務(wù)平臺(tái)，基于AAALAC、GLP、ISO/IEC 17025實(shí)驗(yàn)室認(rèn)證，面向全球企業(yè)及研發(fā)機(jī)構(gòu)提供分析化學(xué)、DMPK、藥理藥效、生物學(xué)、以及毒理安全性評(píng)價(jià)產(chǎn)品與服務(wù)。