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JENNIO-LAB(GUANGDONG) LIFE SCIENCE TECHNOLOGY CENTER??? ?? ??? ?????.
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Metabolic system
Screening model of gastrointestinal motility inhibitors
Myocardial injury protective agent screening model
Screening model of renal protective agents
Reproductive toxicity and reproductive ability evaluation; Gonadal growth evaluation; Histological sections of gonads;
Gastrointestinal peristalsis function (autonomic nerve).
inflammatory reaction
Intestinal morphology; Intestinal peristalsis requires motor function.
Carry out appropriate toxicity tests with experimental animals
Genetically modified animal model
Apoptosis inhibitor screening model
Fat metabolism model
Erythrocyte thrombosis model
Mouse bradycardia model
Incidence of developmental toxicity and teratogenicity (brain, jaw, eye, kidney, intestine, trunk / tail / spinal cord / somite, body coloring, circulatory system, body edema, bleeding)
Behavior (touch response, movement influence, light and dark influence);
Behavior
Anaphylactic reaction
Animal model of depression
Preclinical drug experiment preclinical research (outsourcing entrusted experiment)
Efficacy evaluation model of drug efficacy evaluation system
Mitochondrial function
Protective model of vascular endothelial injury
Promoting tissue regeneration / wound healing
Embryotoxicity (OECD standard)
Degree of liver degeneration; Yolk sac size.
Osteotoxicity
Phenotypic observation
Induction model of high sugar and high fat diet
Screening model of antialcoholic agents
Screening model of angiogenesis promoters
Cytochrome P450 analysis
Cartilage injury model
apoptotic cell
The incidence of renal capsule edema;.
Ocular toxicity
Mortality; Evaluation of median lethal concentration (LC50).
Screening model of P-glycoprotein inhibitors
Screening model of energy metabolism regulator
Induced qi stagnation and blood stasis thrombosis model
Liver kidney model
Cardiovascular toxicity heart rate; Heart rhythm; The incidence of pericardial edema; Incidence of bleeding; Incidence of changes in blood flow velocity; Incidence of thrombosis
Fluorescence signal intensity of apoptotic cells in central nervous system;
Carcinogenicity (mice)
Tryptase expression level (OD value); Anaphylactic reaction test.
Animal experiment of depression
Screening model of bone development promoters
The incidence of egg coagulation; No heart rate; Hatching rate; The incidence of no somite formation; Incidence of tail non separation;
Nephrotoxicity
Bone mineral density (fluorescence signal intensity); Number of vertebrae.
Median lethal concentration
Should we experiment with animals
Skin irritation; Muscle texture; Quantification of skin apoptotic cells; Skin pigment changes.
Fluorescence signal intensity of apoptotic cells (AO staining, TUNEL staining)
Audiotoxicity
Eye size; Ocular apoptotic cells; Ocular vascular area; Ocular histopathology.
Genotoxicity
mycoalert mycoplasma detection kit
Preclinical spinal cord injury experiment
Angiogenesis inhibitor screening
Hypolipidemic model
Platelet aggregation thrombosis model
Oxygen free radical (ROS) scavenger screening model
Incidence of acute toxicity (brain, jaw, eye, kidney, intestine, trunk / tail / spinal cord / somite, body coloring, circulatory system, body edema, bleeding)
Vitellogenin (VTG) content detection; The expression of genes related to hypothalamic pituitary gonadal axis was detected.
Behavioral toxicity
Number of neutrophils; Expression level of inflammatory factors.
Factors affecting animal models
Comet experiment; Genotoxicity evaluation.
Skin toxicity
Fluorescence signal intensity of hair cells
Hepatotoxicity (juvenile fish)
Drug safety evaluation model index
Analgesic drug screening
Intestinal mucus secretion function
Spleen yang deficiency model
Preclinical evaluation of reproductive toxicity
Drug evaluation and testing items (outsourcing entrusted experiment)
Genetic engineering animal model
Why do experiments with animals
Gastrointestinal toxicity
Macrophage function
Peripheral motor nerve length; Incidence of brain degeneration;
Number of hematotoxic neutrophils; Number of macrophages; Number of red blood cells (signal intensity); Blood flow.
Screening model of hepatoprotective drugs
Drug screening model for the treatment of heart failure
Pharmacodynamic evaluation model of slimming drugs
Induction model of caspase activity
neurotoxicity
Screening model of therapeutic agents for osteoporosis
Skeletal muscle
Intestinal digestive function
Uric acid model
Preclinical evaluation of antiviral research and development
Safety evaluation
PM2. 5. Screening model of drainage promoters
Cardio cerebrovascular
Anti angiogenesis model
Preclinical evaluation of cardiac drugs
Immunotoxicity
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