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Isoliquiritigenin

中文名稱(chēng)：異甘草素

Isoliquiritigenin 是Glycyrrhiza glabra根系分泌的一種類(lèi)黃酮，能抑制醛糖還原酶，IC50為320 nM。具有抗腫瘤活性。

Isoliquiritigenin Chemical Structure

Isoliquiritigenin Chemical Structure

CAS: 961-29-5

規(guī)格 價(jià)格 庫(kù)存 購(gòu)買(mǎi)數(shù)量
10mM (1mL in DMSO) 1812.47 現(xiàn)貨
10mg 1415.93 現(xiàn)貨
50mg 4677.85 現(xiàn)貨
1g 22686.3 現(xiàn)貨
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Isoliquiritigenin相關(guān)產(chǎn)品

細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

細(xì)胞系 實(shí)驗(yàn)類(lèi)型 給藥濃度 孵育時(shí)間 活性描述 文獻(xiàn)信息
MCF7 cells Cytotoxicity assay 25-150 μM 72 h Cytotoxicity against human MCF7 cells at 25 to 150 uM after 72 hrs by MTT assay 18603336
U937 cells Function assay 5 ug/ml 24 h Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced CCL5 secretion at 5 ug/ml after 24 hrs by ELISA relative to control 21866899
dog MDCK cells Function assay 20 ug/mL 1 h Antiviral activity against Influenza virus A/Puerto Rico/8/34 H1N1 infected in dog MDCK cells assessed as inhibition of viral replication at 20 ug/mL incubated at 1 hr post-infection measured after 24 hrs by hemagglutininating unit assay relative to control 22743086
U937 cells Function assay 5 ug/ml Inhibition of LPS-induced AP-1 activation in human U937 cells at 5 ug/ml after 1 hr relative to control 21866899
J774.1 cells Function assay 24 h Inhibition of LPS-induced NO production in mouse J774.1 cells after 24 hrs by Griess reagent assay, IC50=29.3 μM 15974608
colon 26-L5 cells Cytotoxicity assay 72 h Cytotoxicity against mouse colon 26-L5 cells after 72 hrs by MTT assay, IC50=21.8 μM 18440233
human T47D cells Function assay 96 h Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay 19928832
MCF7 cells Function assay 96 h Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay 19928832
mouse NIH3T3 cells Function assay 8 h Inhibition of cobalt chloride-induced HIF-1 activation expressed in mouse NIH3T3 cells after 8 hrs by luciferase reporter gene assay, IC50=4.8 μM 21112783
OE21 cells Cytotoxicity assay 72 h Cytotoxicity against human OE21 cells after 72 hrs by MTT assay, IC50=48 μM 21696954
dog MDCK cells Function assay 8 h Inhibition of PKC/p38MAPK-mediated nuclear-cytoplasmic viral ribonucleoprotein export in dog MDCK cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 8 hrs post-infection by inmmunofluorescence 22743086
HUVEC Cytotoxicity assay 48 h Toxicity against HUVEC incubated for 48 hrs by MTT assay, IC50=41.17 μM 25590864
K562 cells Cytotoxicity assay 48 h Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay, IC50=29.27 μM 25590864
KB cells Growth inhibition assay Compound concentration required to reduce the exponential growth of KB cells by 50%, CC50=12 μM 9767632
MT-4 cells Growth inhibition assay Compound concentration required to reduce the exponential growth of MT-4 cells by 50%, CC50=7.4 μM 9767632
Hepa lclc7 cells Cytotoxicity assay Cytotoxicity against mouse Hepa lclc7 cells, IC50=39 μM 18076142
CHO cells Cytotoxicity assay Cytotoxicity against CHO cells by MTT assay, IC50=45.9 μM 19572738
MCF7 cells Function assay Estrogenic activity in luciferase transfected human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by luciferase reporter gene assay 19928832
NCI-H292 cells Function assay Inhibition of PKC-mediated PKD phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis 22743086
NCI-H292 cells Function assay Inhibition of PKC-mediated p38MAPK phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis 22743086
NCI-H292 cells Function assay Inhibition of PKC-mediated JNK phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis 22743086
dog MDCK cells Function assay Restoration of GSH level in dog MDCK cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 24 hrs post-infection by DTNB-based colometric assay 22743086
RBL-1 cells Function assay In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined, IC50=35 μM 8254620
PC3 cells Cytotoxicity assay Cytotoxicity against human PC3 cells, IC50=46.4 μM 16441066
Hepa-1c1c7 cells Function assay Induction of quinone reductase activity in mouse Hepa-1c1c7 cells assessed as drug level required to double enzyme activity 12762787
Hepa lclc7 cells Function assay Induction of mouse quinone reductase in mouse Hepa lclc7 cells assessed as concentration required to double enzyme activity 18076142
點(diǎn)擊查看更多細(xì)胞系數(shù)據(jù)

生物活性

產(chǎn)品描述 Isoliquiritigenin 是Glycyrrhiza glabra根系分泌的一種類(lèi)黃酮，能抑制醛糖還原酶，IC50為320 nM。具有抗腫瘤活性。
靶點(diǎn)
Aldose reductase [1]
(Cell-free assay)
320 nM
體外研究(In Vitro)
體外研究活性 Isoliquiritigenin通過(guò)抑制大鼠晶狀體醛糖還原酶可能能夠有效預(yù)防糖尿病并發(fā)癥，IC50為320 nM，并且能夠預(yù)防山梨糖醇在人類(lèi)紅細(xì)胞中的積累，IC50為2.0 μM。[1] Isoliquiritigenin通過(guò)抑制單酚酪氨酸酶和二酚酪氨酸酶的活性可以用作美白劑，IC50為8.1 μM。[2] 在DU145和LNCaP 細(xì)胞系中，Isoliquiritigenin誘導(dǎo)細(xì)胞周期停滯并抑制細(xì)胞生長(zhǎng)。[3]在人類(lèi)胃癌MGC-803細(xì)胞中， Isoliquiritigenin通過(guò)增加細(xì)胞內(nèi)游離鈣離子濃度，并降低線(xiàn)粒體膜電位(Deltapsi(m))而誘導(dǎo)細(xì)胞凋亡。[4]
體內(nèi)研究(In Vivo)
體內(nèi)研究活性 LD50: 小鼠>6克/千克(灌胃) [5]

化學(xué)信息&溶解度

分子量 256.25 分子式

C15H12O4
CAS號(hào) 961-29-5 SDF Download Isoliquiritigenin SDF
Smiles C1=CC(=CC=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O
儲(chǔ)存條件(自收到貨起)

體外溶解度
批次：

Ethanol : 26 mg/mL (101.46 mM)

DMSO : 12 mg/mL ( (46.82 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開(kāi)封DMSO)

Water : Insoluble

摩爾濃度計(jì)算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請(qǐng)按從左到右的順序依次添加，澄清后再加入下一溶劑

 動(dòng)物體內(nèi)配方計(jì)算器

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量 濃度 體積 分子量

動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請(qǐng)輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過(guò)程中的損耗，建議多配一只動(dòng)物的藥量）

mg/kg g μL 只

第二步：請(qǐng)輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請(qǐng)聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過(guò)該批次藥物DMSO溶解度，請(qǐng)先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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