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Afatinib Dimaleate

別名: BIBW2992 Dimaleate 中文名稱：馬來酸阿法替尼

Afatinib Dimaleate不可逆地抑制 EGFR/HER2，包括 EGFR(wt)，EGFR(L858R)，EGFR(L858R/T790M) 和 HER2，IC50 分別為0.5 nM，0.4 nM，10 nM 和 14 nM；活性比對Gefitinib抵抗型L858R-T790M EGFR突變體高100倍。Afatinib (BIBW2992) Dimaleate 可誘導(dǎo)自噬。

Afatinib Dimaleate Chemical Structure

Afatinib Dimaleate Chemical Structure

CAS: 850140-73-7

規(guī)格 價格 庫存 購買數(shù)量
10mM (1mL in DMSO) 970 現(xiàn)貨
10mg 812.49 現(xiàn)貨
50mg 1043.87 現(xiàn)貨
200mg 2101.53 現(xiàn)貨
1g 6470.1 現(xiàn)貨
更大包裝 有超大折扣

400-668-6834

info@selleck.cn
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Afatinib Dimaleate相關(guān)產(chǎn)品

相關(guān)信號通路圖

EGFR Signaling Pathways

EGFR信號通路圖

細胞實驗數(shù)據(jù)示例

細胞系 實驗類型 給藥濃度 孵育時間 活性描述 文獻信息
NCI-H1975 Proliferation assay 72 h Antiproliferative activity against human NCI-H1975 cells expressing EGFR T790M mutant after 72 hrs by SRB assay, IC50=0.148 μM 24183742
A431 Proliferation assay 72 h Antiproliferative activity against human A431 cells after 72 hrs by SRB assay, IC50=0.023 nM 24183742
MDA-MB-231 Proliferation assay 72 h Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay, EC50=1 nM 20180906
NCI-H1975 Cytotoxicity assay 48 h Cytotoxicity against human NCI-H1975 cells after 48 hrs by MTT assay, IC50=0.392 μM 20150404
NIH/3T3 Cytotoxicity assay 48 h Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by MTT assay, IC50=3.605 μM 20150404
A549 Cytotoxicity assay 72 h Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50=0.05 μM 20180905
PC3 Cytotoxicity assay 72 h Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, IC50=4.1 μM 20180905
HeLa Cytotoxicity assay 72 h Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50=6.81 μM 20180905
MCF7 Cytotoxicity assay 72 h Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50=5.83 μM 20180905
NSCLC Cytotoxicity assay 72 h Cytotoxicity against human NSCLC cells, IC50=0.5 nM 20180905
HCC827 cell Proliferation assay Antiproliferative activity against human HCC827 cells after 96 hrs by MTS assay, IC50=8 nM 20550212
NCI-H1563 Growth inhibition assay Inhibition of human NCI-H1563 cell growth in a cell viability assay. IC50=9.76031 μM SANGER
NCI-H1573 Growth inhibition assay Inhibition of human NCI-H1573 cell growth in a cell viability assay. IC50=0.7363 μM SANGER
NCI-H1581 Growth inhibition assay Inhibition of human NCI-H1581 cell growth in a cell viability assay. IC50=29.3145 μM SANGER
NCI-H1648 Growth inhibition assay Inhibition of human NCI-H1648 cell growth in a cell viability assay. IC50=0.44182 μM SANGER
NCI-H1793 Growth inhibition assay Inhibition of human NCI-H1793 cell growth in a cell viability assay. IC50=14.2087 μM SANGER
NCI-H1838 Growth inhibition assay Inhibition of human NCI-H1838 cell growth in a cell viability assay. IC50=0.60299 μM SANGER
NCI-H1770 Growth inhibition assay Inhibition of human NCI-H1770 cell growth in a cell viability assay. IC50=0.1028 μM SANGER
NCI-H1651 Growth inhibition assay Inhibition of human NCI-H1651 cell growth in a cell viability assay. IC50=25.597 μM SANGER
NCI-H1975 Growth inhibition assay Inhibition of human NCI-H1975 cell growth in a cell viability assay. IC50=0.61728 μM SANGER
NCI-H1666 Growth inhibition assay Inhibition of human NCI-H1666 cell growth in a cell viability assay. IC50=1.80948 μM SANGER
NCI-H2009 Growth inhibition assay Inhibition of human NCI-H2009 cell growth in a cell viability assay. IC50=3.61216 μM SANGER
NCI-H2126 Growth inhibition assay Inhibition of human NCI-H2126 cell growth in a cell viability assay. IC50=0.51926 μM SANGER
NCI-H1693 Growth inhibition assay Inhibition of human NCI-H1693 cell growth in a cell viability assay. IC50=3.84181 μM SANGER
NCI-H2087 Growth inhibition assay Inhibition of human NCI-H2087 cell growth in a cell viability assay. IC50=49.9682 μM SANGER
NCI-H2029 Growth inhibition assay Inhibition of human NCI-H2029 cell growth in a cell viability assay. IC50=43.5581 μM SANGER
NCI-H2170 Growth inhibition assay Inhibition of human NCI-H2170 cell growth in a cell viability assay. IC50=0.03728 μM SANGER
NCI-H226 Growth inhibition assay Inhibition of human NCI-H226 cell growth in a cell viability assay. IC50=49.7785 μM SANGER
NCI-H2030 Growth inhibition assay Inhibition of human NCI-H2030 cell growth in a cell viability assay. IC50=14.6448 μM SANGER
NCI-H2052 Growth inhibition assay Inhibition of human NCI-H2052 cell growth in a cell viability assay. IC50=21.8963 μM SANGER
NCI-H292 Growth inhibition assay Inhibition of human NCI-H292 cell growth in a cell viability assay. IC50=0.0609 μM SANGER
NCI-H441 Growth inhibition assay Inhibition of human NCI-H441 cell growth in a cell viability assay. IC50=3.59841 μM SANGER
NCI-H2291 Growth inhibition assay Inhibition of human NCI-H2291 cell growth in a cell viability assay. IC50=5.98943 μM SANGER
NCI-H358 Growth inhibition assay Inhibition of human NCI-H358 cell growth in a cell viability assay. IC50=0.5321 μM SANGER
NCI-H460 Growth inhibition assay Inhibition of human NCI-H460 cell growth in a cell viability assay. IC50=46.523 μM SANGER
NCI-H661 Growth inhibition assay Inhibition of human NCI-H661 cell growth in a cell viability assay. IC50=16.9694 μM SANGER
NCI-H23 Growth inhibition assay Inhibition of human NCI-H23 cell growth in a cell viability assay. IC50=37.4196 μM SANGER
NCI-H630 Growth inhibition assay Inhibition of human NCI-H630 cell growth in a cell viability assay. IC50=1.45582 μM SANGER
NCI-H2342 Growth inhibition assay Inhibition of human NCI-H2342 cell growth in a cell viability assay. IC50=17.557 μM SANGER
NCI-H69 Growth inhibition assay Inhibition of human NCI-H69 cell growth in a cell viability assay. IC50=0.21451 μM SANGER
NCI-H650 Growth inhibition assay Inhibition of human NCI-H650 cell growth in a cell viability assay. IC50=11.2418 μM SANGER
NCI-H747 Growth inhibition assay Inhibition of human NCI-H747 cell growth in a cell viability assay. IC50=5.42472 μM SANGER
NCI-H2405 Growth inhibition assay Inhibition of human NCI-H2405 cell growth in a cell viability assay. IC50=17.1974 μM SANGER
NCI-H520 Growth inhibition assay Inhibition of human NCI-H520 cell growth in a cell viability assay. IC50=24.8861 μM SANGER
NCI-H810 Growth inhibition assay Inhibition of human NCI-H810 cell growth in a cell viability assay. IC50=34.7278 μM SANGER
NCI-H720 Growth inhibition assay Inhibition of human NCI-H720 cell growth in a cell viability assay. IC50=0.05325 μM SANGER
NCI-SNU-1 Growth inhibition assay Inhibition of human NCI-SNU-1 cell growth in a cell viability assay. IC50=3.69735 μM SANGER
NH-12 Growth inhibition assay Inhibition of human NH-12 cell growth in a cell viability assay. IC50=7.72808 μM SANGER
NCI-SNU-5 Growth inhibition assay Inhibition of human NCI-SNU-5 cell growth in a cell viability assay. IC50=1.239 μM SANGER
NKM-1 Growth inhibition assay Inhibition of human NKM-1 cell growth in a cell viability assay. IC50=3.18744 μM SANGER
NCI-H526 Growth inhibition assay Inhibition of human NCI-H526 cell growth in a cell viability assay. IC50=0.07823 μM SANGER
NTERA-S-cl-D1 Growth inhibition assay Inhibition of human NTERA-S-cl-D1 cell growth in a cell viability assay. IC50=5.54537 μM SANGER
NMC-G1 Growth inhibition assay Inhibition of human NMC-G1 cell growth in a cell viability assay. IC50=12.9234 μM SANGER
NCI-H82 Growth inhibition assay Inhibition of human NCI-H82 cell growth in a cell viability assay. IC50=1.54006 μM SANGER
NCI-H1623 Growth inhibition assay Inhibition of human NCI-H1623 cell growth in a cell viability assay. IC50=0.08025 μM SANGER
NOMO-1 Growth inhibition assay Inhibition of human NOMO-1 cell growth in a cell viability assay. IC50=34.5703 μM SANGER
NCI-N87 Growth inhibition assay Inhibition of human NCI-N87 cell growth in a cell viability assay. IC50=0.02773 μM SANGER
NCI-H1650 Growth inhibition assay Inhibition of human NCI-H1650 cell growth in a cell viability assay. IC50=9.60946 μM SANGER
NCI-H1703 Growth inhibition assay Inhibition of human NCI-H1703 cell growth in a cell viability assay. IC50=9.34375 μM SANGER
NCI-H1755 Growth inhibition assay Inhibition of human NCI-H1755 cell growth in a cell viability assay. IC50=41.8725 μM SANGER
NCI-H1993 Growth inhibition assay Inhibition of human NCI-H1993 cell growth in a cell viability assay. IC50=8.33631 μM SANGER
NCI-H209 Growth inhibition assay Inhibition of human NCI-H209 cell growth in a cell viability assay. IC50=0.2046 μM SANGER
NCI-H2122 Growth inhibition assay Inhibition of human NCI-H2122 cell growth in a cell viability assay. IC50=34.3471 μM SANGER
NY Growth inhibition assay Inhibition of human NY cell growth in a cell viability assay. IC50=3.53655 μM SANGER
OAW-42 Growth inhibition assay Inhibition of human OAW-42 cell growth in a cell viability assay. IC50=3.50026 μM SANGER
OC-314 Growth inhibition assay Inhibition of human OC-314 cell growth in a cell viability assay. IC50=15.4714 μM SANGER
NCI-H2228 Growth inhibition assay Inhibition of human NCI-H2228 cell growth in a cell viability assay. IC50=32.6602 μM SANGER
OCI-AML2 Growth inhibition assay Inhibition of human OCI-AML2 cell growth in a cell viability assay. IC50=8.95481 μM SANGER
OCUB-M Growth inhibition assay Inhibition of human OCUB-M cell growth in a cell viability assay. IC50=3.76187 μM SANGER
OE33 Growth inhibition assay Inhibition of human OE33 cell growth in a cell viability assay. IC50=13.786 μM SANGER
NCI-H28 Growth inhibition assay Inhibition of human NCI-H28 cell growth in a cell viability assay. IC50=7.16405 μM SANGER
OS-RC-2 Growth inhibition assay Inhibition of human OS-RC-2 cell growth in a cell viability assay. IC50=9.0219 μM SANGER
ONS-76 Growth inhibition assay Inhibition of human ONS-76 cell growth in a cell viability assay. IC50=41.4709 μM SANGER
OVCAR-3 Growth inhibition assay Inhibition of human OVCAR-3 cell growth in a cell viability assay. IC50=2.67167 μM SANGER
OVCAR-4 Growth inhibition assay Inhibition of human OVCAR-4 cell growth in a cell viability assay. IC50=10.8835 μM SANGER
OVCAR-5 Growth inhibition assay Inhibition of human OVCAR-5 cell growth in a cell viability assay. IC50=13.1593 μM SANGER
P12-ICHIKAWA Growth inhibition assay Inhibition of human P12-ICHIKAWA cell growth in a cell viability assay. IC50=25.4785 μM SANGER
NCI-H446 Growth inhibition assay Inhibition of human NCI-H446 cell growth in a cell viability assay. IC50=37.4862 μM SANGER
NCI-H510A Growth inhibition assay Inhibition of human NCI-H510A cell growth in a cell viability assay. IC50=31.4006 μM SANGER
NCI-H596 Growth inhibition assay Inhibition of human NCI-H596 cell growth in a cell viability assay. IC50=12.0369 μM SANGER
PA-1 Growth inhibition assay Inhibition of human PA-1 cell growth in a cell viability assay. IC50=49.8335 μM SANGER
PC-14 Growth inhibition assay Inhibition of human PC-14 cell growth in a cell viability assay. IC50=0.05668 μM SANGER
PANC-03-27 Growth inhibition assay Inhibition of human PANC-03-27 cell growth in a cell viability assay. IC50=2.16631 μM SANGER
PANC-08-13 Growth inhibition assay Inhibition of human PANC-08-13 cell growth in a cell viability assay. IC50=1.16416 μM SANGER
NCI-H727 Growth inhibition assay Inhibition of human NCI-H727 cell growth in a cell viability assay. IC50=8.1042 μM SANGER
RD Growth inhibition assay Inhibition of human RD cell growth in a cell viability assay. IC50=29.5233 μM SANGER
QIMR-WIL Growth inhibition assay Inhibition of human QIMR-WIL cell growth in a cell viability assay. IC50=16.7105 μM SANGER
RERF-LC-MS Growth inhibition assay Inhibition of human RERF-LC-MS cell growth in a cell viability assay. IC50=17.5508 μM SANGER
RCC10RGB Growth inhibition assay Inhibition of human RCC10RGB cell growth in a cell viability assay. IC50=18.0559 μM SANGER
RH-18 Growth inhibition assay Inhibition of human RH-18 cell growth in a cell viability assay. IC50=18.0035 μM SANGER
RO82-W-1 Growth inhibition assay Inhibition of human RO82-W-1 cell growth in a cell viability assay. IC50=32.1604 μM SANGER
RKO Growth inhibition assay Inhibition of human RKO cell growth in a cell viability assay. IC50=14.5075 μM SANGER
RPMI-7951 Growth inhibition assay Inhibition of human RPMI-7951 cell growth in a cell viability assay. IC50=3.0759 μM SANGER
NEC8 Growth inhibition assay Inhibition of human NEC8 cell growth in a cell viability assay. IC50=14.5472 μM SANGER
RPMI-8226 Growth inhibition assay Inhibition of human RPMI-8226 cell growth in a cell viability assay. IC50=4.11631 μM SANGER
RS4-11 Growth inhibition assay Inhibition of human RS4-11 cell growth in a cell viability assay. IC50=12.1725 μM SANGER
RXF393 Growth inhibition assay Inhibition of human RXF393 cell growth in a cell viability assay. IC50=36.3785 μM SANGER
NOS-1 Growth inhibition assay Inhibition of human NOS-1 cell growth in a cell viability assay. IC50=11.711 μM SANGER
Ramos-2G6-4C10 Growth inhibition assay Inhibition of human Ramos-2G6-4C10 cell growth in a cell viability assay. IC50=14.0202 μM SANGER
S-117 Growth inhibition assay Inhibition of human S-117 cell growth in a cell viability assay. IC50=36.3008 μM SANGER
SCC-25 Growth inhibition assay Inhibition of human SCC-25 cell growth in a cell viability assay. IC50=0.84171 μM SANGER
SBC-1 Growth inhibition assay Inhibition of human SBC-1 cell growth in a cell viability assay. IC50=0.18959 μM SANGER
SCC-15 Growth inhibition assay Inhibition of human SCC-15 cell growth in a cell viability assay. IC50=1.39451 μM SANGER
SCC-4 Growth inhibition assay Inhibition of human SCC-4 cell growth in a cell viability assay. IC50=8.44059 μM SANGER
NUGC-3 Growth inhibition assay Inhibition of human NUGC-3 cell growth in a cell viability assay. IC50=0.38373 μM SANGER
SCC-9 Growth inhibition assay Inhibition of human SCC-9 cell growth in a cell viability assay. IC50=37.7838 μM SANGER
SCH Growth inhibition assay Inhibition of human SCH cell growth in a cell viability assay. IC50=18.6456 μM SANGER
OAW-28 Growth inhibition assay Inhibition of human OAW-28 cell growth in a cell viability assay. IC50=7.94578 μM SANGER
SF126 Growth inhibition assay Inhibition of human SF126 cell growth in a cell viability assay. IC50=23.6924 μM SANGER
SF295 Growth inhibition assay Inhibition of human SF295 cell growth in a cell viability assay. IC50=26.0425 μM SANGER
OE19 Growth inhibition assay Inhibition of human OE19 cell growth in a cell viability assay. IC50=1.71512 μM SANGER
SF539 Growth inhibition assay Inhibition of human SF539 cell growth in a cell viability assay. IC50=9.23562 μM SANGER
SH-4 Growth inhibition assay Inhibition of human SH-4 cell growth in a cell viability assay. IC50=32.1858 μM SANGER
SHP-77 Growth inhibition assay Inhibition of human SHP-77 cell growth in a cell viability assay. IC50=29.6182 μM SANGER
OMC-1 Growth inhibition assay Inhibition of human OMC-1 cell growth in a cell viability assay. IC50=2.08169 μM SANGER
SK-HEP-1 Growth inhibition assay Inhibition of human SK-HEP-1 cell growth in a cell viability assay. IC50=30.6326 μM SANGER
SJSA-1 Growth inhibition assay Inhibition of human SJSA-1 cell growth in a cell viability assay. IC50=27.0176 μM SANGER
OVCAR-8 Growth inhibition assay Inhibition of human OVCAR-8 cell growth in a cell viability assay. IC50=15.8861 μM SANGER
SK-LU-1 Growth inhibition assay Inhibition of human SK-LU-1 cell growth in a cell viability assay. IC50=40.6568 μM SANGER
SK-MEL-1 Growth inhibition assay Inhibition of human SK-MEL-1 cell growth in a cell viability assay. IC50=13.7135 μM SANGER
SK-MEL-24 Growth inhibition assay Inhibition of human SK-MEL-24 cell growth in a cell viability assay. IC50=11.2366 μM SANGER
P30-OHK Growth inhibition assay Inhibition of human P30-OHK cell growth in a cell viability assay. IC50=35.8752 μM SANGER
PANC-10-05 Growth inhibition assay Inhibition of human PANC-10-05 cell growth in a cell viability assay. IC50=14.6247 μM SANGER
SK-MEL-3 Growth inhibition assay Inhibition of human SK-MEL-3 cell growth in a cell viability assay. IC50=16.4787 μM SANGER
SK-MES-1 Growth inhibition assay Inhibition of human SK-MES-1 cell growth in a cell viability assay. IC50=1.11487 μM SANGER
PC-3 Growth inhibition assay Inhibition of human PC-3 cell growth in a cell viability assay. IC50=19.9604 μM SANGER
SK-NEP-1 Growth inhibition assay Inhibition of human SK-NEP-1 cell growth in a cell viability assay. IC50=1.17513 μM SANGER
SK-N-DZ Growth inhibition assay Inhibition of human SK-N-DZ cell growth in a cell viability assay. IC50=28.6885 μM SANGER
SK-OV-3 Growth inhibition assay Inhibition of human SK-OV-3 cell growth in a cell viability assay. IC50=8.71329 μM SANGER
PFSK-1 Growth inhibition assay Inhibition of human PFSK-1 cell growth in a cell viability assay. IC50=13.06 μM SANGER
SK-PN-DW Growth inhibition assay Inhibition of human SK-PN-DW cell growth in a cell viability assay. IC50=35.4369 μM SANGER
SK-UT-1 Growth inhibition assay Inhibition of human SK-UT-1 cell growth in a cell viability assay. IC50=13.1083 μM SANGER
RCM-1 Growth inhibition assay Inhibition of human RCM-1 cell growth in a cell viability assay. IC50=2.52938 μM SANGER
SKG-IIIa Growth inhibition assay Inhibition of human SKG-IIIa cell growth in a cell viability assay. IC50=3.52237 μM SANGER
SNU-387 Growth inhibition assay Inhibition of human SNU-387 cell growth in a cell viability assay. IC50=40.4553 μM SANGER
SNU-449 Growth inhibition assay Inhibition of human SNU-449 cell growth in a cell viability assay. IC50=3.65826 μM SANGER
RMG-I Growth inhibition assay Inhibition of human RMG-I cell growth in a cell viability assay. IC50=7.39296 μM SANGER
SNU-C2B Growth inhibition assay Inhibition of human SNU-C2B cell growth in a cell viability assay. IC50=2.68616 μM SANGER
RPMI-2650 Growth inhibition assay Inhibition of human RPMI-2650 cell growth in a cell viability assay. IC50=11.5885 μM SANGER
SW1116 Growth inhibition assay Inhibition of human SW1116 cell growth in a cell viability assay. IC50=1.01287 μM SANGER
SW13 Growth inhibition assay Inhibition of human SW13 cell growth in a cell viability assay. IC50=0.16216 μM SANGER
SW1463 Growth inhibition assay Inhibition of human SW1463 cell growth in a cell viability assay. IC50=15.0485 μM SANGER
RPMI-8866 Growth inhibition assay Inhibition of human RPMI-8866 cell growth in a cell viability assay. IC50=27.7562 μM SANGER
RT-112 Growth inhibition assay Inhibition of human RT-112 cell growth in a cell viability assay. IC50=22.8616 μM SANGER
SW1710 Growth inhibition assay Inhibition of human SW1710 cell growth in a cell viability assay. IC50=8.18515 μM SANGER
RVH-421 Growth inhibition assay Inhibition of human RVH-421 cell growth in a cell viability assay. IC50=35.7645 μM SANGER
SW626 Growth inhibition assay Inhibition of human SW626 cell growth in a cell viability assay. IC50=11.5755 μM SANGER
SW1990 Growth inhibition assay Inhibition of human SW1990 cell growth in a cell viability assay. IC50=16.1755 μM SANGER
SW756 Growth inhibition assay Inhibition of human SW756 cell growth in a cell viability assay. IC50=6.91176 μM SANGER
SW48 Growth inhibition assay Inhibition of human SW48 cell growth in a cell viability assay. IC50=1.25432 μM SANGER
SW620 Growth inhibition assay Inhibition of human SW620 cell growth in a cell viability assay. IC50=5.24964 μM SANGER
SAS Growth inhibition assay Inhibition of human SAS cell growth in a cell viability assay. IC50=0.48398 μM SANGER
SW837 Growth inhibition assay Inhibition of human SW837 cell growth in a cell viability assay. IC50=12.9028 μM SANGER
SW872 Growth inhibition assay Inhibition of human SW872 cell growth in a cell viability assay. IC50=42.6331 μM SANGER
SW900 Growth inhibition assay Inhibition of human SW900 cell growth in a cell viability assay. IC50=7.82121 μM SANGER
SW948 Growth inhibition assay Inhibition of human SW948 cell growth in a cell viability assay. IC50=46.4462 μM SANGER
SiHa Growth inhibition assay Inhibition of human SiHa cell growth in a cell viability assay. IC50=23.9327 μM SANGER
SW962 Growth inhibition assay Inhibition of human SW962 cell growth in a cell viability assay. IC50=5.62032 μM SANGER
T-24 Growth inhibition assay Inhibition of human T-24 cell growth in a cell viability assay. IC50=34.0205 μM SANGER
Saos-2 Growth inhibition assay Inhibition of human Saos-2 cell growth in a cell viability assay. IC50=19.1162 μM SANGER
T47D Growth inhibition assay Inhibition of human T47D cell growth in a cell viability assay. IC50=3.62217 μM SANGER
T98G Growth inhibition assay Inhibition of human T98G cell growth in a cell viability assay. IC50=27.5846 μM SANGER
T84 Growth inhibition assay Inhibition of human T84 cell growth in a cell viability assay. IC50=11.3907 μM SANGER
SF268 Growth inhibition assay Inhibition of human SF268 cell growth in a cell viability assay. IC50=29.5932 μM SANGER
22RV1 Growth inhibition assay Inhibition of human 22RV1 cell growth in a cell viability assay. IC50=34.1754 μM SANGER
TE-1 Growth inhibition assay Inhibition of human TE-1 cell growth in a cell viability assay. IC50=1.81475 μM SANGER
23132-87 Growth inhibition assay Inhibition of human 23132-87 cell growth in a cell viability assay. IC50=0.31923 μM SANGER
SJRH30 Growth inhibition assay Inhibition of human SJRH30 cell growth in a cell viability assay. IC50=30.2108 μM SANGER
5637 Growth inhibition assay Inhibition of human 5637 cell growth in a cell viability assay. IC50=1.0151 μM SANGER
647-V Growth inhibition assay Inhibition of human 647-V cell growth in a cell viability assay. IC50=3.98452 μM SANGER
639-V Growth inhibition assay Inhibition of human 639-V cell growth in a cell viability assay. IC50=31.5243 μM SANGER
769-P Growth inhibition assay Inhibition of human 769-P cell growth in a cell viability assay. IC50=2.29037 μM SANGER
8-MG-BA Growth inhibition assay Inhibition of human 8-MG-BA cell growth in a cell viability assay. IC50=36.9483 μM SANGER
8305C Growth inhibition assay Inhibition of human 8305C cell growth in a cell viability assay. IC50=3.75911 μM SANGER
SK-MEL-2 Growth inhibition assay Inhibition of human SK-MEL-2 cell growth in a cell viability assay. IC50=32.6527 μM SANGER
8505C Growth inhibition assay Inhibition of human 8505C cell growth in a cell viability assay. IC50=13.2067 μM SANGER
A204 Growth inhibition assay Inhibition of human A204 cell growth in a cell viability assay. IC50=32.5069 μM SANGER
A101D Growth inhibition assay Inhibition of human A101D cell growth in a cell viability assay. IC50=49.9425 μM SANGER
SK-MEL-28 Growth inhibition assay Inhibition of human SK-MEL-28 cell growth in a cell viability assay. IC50=19.3363 μM SANGER
SK-N-AS Growth inhibition assay Inhibition of human SK-N-AS cell growth in a cell viability assay. IC50=21.8275 μM SANGER
A2780 Growth inhibition assay Inhibition of human A2780 cell growth in a cell viability assay. IC50=2.06294 μM SANGER
A3-KAW Growth inhibition assay Inhibition of human A3-KAW cell growth in a cell viability assay. IC50=23.1003 μM SANGER
A4-Fuk Growth inhibition assay Inhibition of human A4-Fuk cell growth in a cell viability assay. IC50=22.1419 μM SANGER
A431 Growth inhibition assay Inhibition of human A431 cell growth in a cell viability assay. IC50=0.48233 μM SANGER
A388 Growth inhibition assay Inhibition of human A388 cell growth in a cell viability assay. IC50=0.36857 μM SANGER
SK-N-FI Growth inhibition assay Inhibition of human SK-N-FI cell growth in a cell viability assay. IC50=28.433 μM SANGER
A549 Growth inhibition assay Inhibition of human A549 cell growth in a cell viability assay. IC50=6.12553 μM SANGER
A673 Growth inhibition assay Inhibition of human A673 cell growth in a cell viability assay. IC50=41.5157 μM SANGER
ACN Growth inhibition assay Inhibition of human ACN cell growth in a cell viability assay. IC50=0.55094 μM SANGER
A704 Growth inhibition assay Inhibition of human A704 cell growth in a cell viability assay. IC50=18.4753 μM SANGER
SN12C Growth inhibition assay Inhibition of human SN12C cell growth in a cell viability assay. IC50=2.91964 μM SANGER
ALL-PO Growth inhibition assay Inhibition of human ALL-PO cell growth in a cell viability assay. IC50=11.2512 μM SANGER
ABC-1 Growth inhibition assay Inhibition of human ABC-1 cell growth in a cell viability assay. IC50=34.3693 μM SANGER
ACHN Growth inhibition assay Inhibition of human ACHN cell growth in a cell viability assay. IC50=0.31994 μM SANGER
AN3-CA Growth inhibition assay Inhibition of human AN3-CA cell growth in a cell viability assay. IC50=28.4395 μM SANGER
ATN-1 Growth inhibition assay Inhibition of human ATN-1 cell growth in a cell viability assay. IC50=33.1416 μM SANGER
AU565 Growth inhibition assay Inhibition of human AU565 cell growth in a cell viability assay. IC50=0.08504 μM SANGER
BALL-1 Growth inhibition assay Inhibition of human BALL-1 cell growth in a cell viability assay. IC50=9.21907 μM SANGER
BB65-RCC Growth inhibition assay Inhibition of human BB65-RCC cell growth in a cell viability assay. IC50=0.34593 μM SANGER
BB49-HNC Growth inhibition assay Inhibition of human BB49-HNC cell growth in a cell viability assay. IC50=43.2356 μM SANGER
SW1417 Growth inhibition assay Inhibition of human SW1417 cell growth in a cell viability assay. IC50=4.12147 μM SANGER
BHY Growth inhibition assay Inhibition of human BHY cell growth in a cell viability assay. IC50=0.28655 μM SANGER
BCPAP Growth inhibition assay Inhibition of human BCPAP cell growth in a cell viability assay. IC50=27.137 μM SANGER
BFTC-905 Growth inhibition assay Inhibition of human BFTC-905 cell growth in a cell viability assay. IC50=29.2706 μM SANGER
BE-13 Growth inhibition assay Inhibition of human BE-13 cell growth in a cell viability assay. IC50=7.98112 μM SANGER
BHT-101 Growth inhibition assay Inhibition of human BHT-101 cell growth in a cell viability assay. IC50=14.241 μM SANGER
SW1573 Growth inhibition assay Inhibition of human SW1573 cell growth in a cell viability assay. IC50=11.7294 μM SANGER
SW684 Growth inhibition assay Inhibition of human SW684 cell growth in a cell viability assay. IC50=19.1326 μM SANGER
BPH-1 Growth inhibition assay Inhibition of human BPH-1 cell growth in a cell viability assay. IC50=0.05988 μM SANGER
SW780 Growth inhibition assay Inhibition of human SW780 cell growth in a cell viability assay. IC50=25.3264 μM SANGER
BT-474 Growth inhibition assay Inhibition of human BT-474 cell growth in a cell viability assay. IC50=0.04986 μM SANGER
SW954 Growth inhibition assay Inhibition of human SW954 cell growth in a cell viability assay. IC50=1.20214 μM SANGER
C2BBe1 Growth inhibition assay Inhibition of human C2BBe1 cell growth in a cell viability assay. IC50=14.764 μM SANGER
BV-173 Growth inhibition assay Inhibition of human BV-173 cell growth in a cell viability assay. IC50=0.17596 μM SANGER
SW982 Growth inhibition assay Inhibition of human SW982 cell growth in a cell viability assay. IC50=18.2671 μM SANGER
Becker Growth inhibition assay Inhibition of human Becker cell growth in a cell viability assay. IC50=20.7201 μM SANGER
BxPC-3 Growth inhibition assay Inhibition of human BxPC-3 cell growth in a cell viability assay. IC50=10.0973 μM SANGER
C8166 Growth inhibition assay Inhibition of human C8166 cell growth in a cell viability assay. IC50=33.8854 μM SANGER
C-33-A Growth inhibition assay Inhibition of human C-33-A cell growth in a cell viability assay. IC50=0.81297 μM SANGER
C3A Growth inhibition assay Inhibition of human C3A cell growth in a cell viability assay. IC50=30.2927 μM SANGER
CAKI-1 Growth inhibition assay Inhibition of human CAKI-1 cell growth in a cell viability assay. IC50=1.78211 μM SANGER
TCCSUP Growth inhibition assay Inhibition of human TCCSUP cell growth in a cell viability assay. IC50=28.6418 μM SANGER
CAL-120 Growth inhibition assay Inhibition of human CAL-120 cell growth in a cell viability assay. IC50=15.1447 μM SANGER
CAL-12T Growth inhibition assay Inhibition of human CAL-12T cell growth in a cell viability assay. IC50=1.88945 μM SANGER
CAL-27 Growth inhibition assay Inhibition of human CAL-27 cell growth in a cell viability assay. IC50=0.17636 μM SANGER
CAL-51 Growth inhibition assay Inhibition of human CAL-51 cell growth in a cell viability assay. IC50=31.5667 μM SANGER
CAL-39 Growth inhibition assay Inhibition of human CAL-39 cell growth in a cell viability assay. IC50=0.11792 μM SANGER
CAL-54 Growth inhibition assay Inhibition of human CAL-54 cell growth in a cell viability assay. IC50=0.61621 μM SANGER
697 Growth inhibition assay Inhibition of human 697 cell growth in a cell viability assay. IC50=28.6331 μM SANGER
CAL-85-1 Growth inhibition assay Inhibition of human CAL-85-1 cell growth in a cell viability assay. IC50=9.87383 μM SANGER
CAL-62 Growth inhibition assay Inhibition of human CAL-62 cell growth in a cell viability assay. IC50=43.4028 μM SANGER
CAL-72 Growth inhibition assay Inhibition of human CAL-72 cell growth in a cell viability assay. IC50=10.9391 μM SANGER
786-0 Growth inhibition assay Inhibition of human 786-0 cell growth in a cell viability assay. IC50=3.06408 μM SANGER
TE-11 Growth inhibition assay Inhibition of human TE-11 cell growth in a cell viability assay. IC50=26.7752 μM SANGER
A172 Growth inhibition assay Inhibition of human A172 cell growth in a cell viability assay. IC50=12.0798 μM SANGER
TE-5 Growth inhibition assay Inhibition of human TE-5 cell growth in a cell viability assay. IC50=5.4085 μM SANGER
TE-6 Growth inhibition assay Inhibition of human TE-6 cell growth in a cell viability assay. IC50=0.40246 μM SANGER
TE-9 Growth inhibition assay Inhibition of human TE-9 cell growth in a cell viability assay. IC50=3.84382 μM SANGER
TGBC24TKB Growth inhibition assay Inhibition of human TGBC24TKB cell growth in a cell viability assay. IC50=1.6823 μM SANGER
A2058 Growth inhibition assay Inhibition of human A2058 cell growth in a cell viability assay. IC50=15.0409 μM SANGER
TI-73 Growth inhibition assay Inhibition of human TI-73 cell growth in a cell viability assay. IC50=0.14715 μM SANGER
A427 Growth inhibition assay Inhibition of human A427 cell growth in a cell viability assay. IC50=37.9107 μM SANGER
TK10 Growth inhibition assay Inhibition of human TK10 cell growth in a cell viability assay. IC50=0.26738 μM SANGER
TGBC1TKB Growth inhibition assay Inhibition of human TGBC1TKB cell growth in a cell viability assay. IC50=30.1238 μM SANGER
A498 Growth inhibition assay Inhibition of human A498 cell growth in a cell viability assay. IC50=0.40674 μM SANGER
AGS Growth inhibition assay Inhibition of human AGS cell growth in a cell viability assay. IC50=0.83648 μM SANGER
U-2-OS Growth inhibition assay Inhibition of human U-2-OS cell growth in a cell viability assay. IC50=17.5307 μM SANGER
U-118-MG Growth inhibition assay Inhibition of human U-118-MG cell growth in a cell viability assay. IC50=36.8847 μM SANGER
U-266 Growth inhibition assay Inhibition of human U-266 cell growth in a cell viability assay. IC50=16.2299 μM SANGER
U031 Growth inhibition assay Inhibition of human U031 cell growth in a cell viability assay. IC50=5.25424 μM SANGER
UACC-257 Growth inhibition assay Inhibition of human UACC-257 cell growth in a cell viability assay. IC50=41.7369 μM SANGER
U-87-MG Growth inhibition assay Inhibition of human U-87-MG cell growth in a cell viability assay. IC50=4.10481 μM SANGER
AsPC-1 Growth inhibition assay Inhibition of human AsPC-1 cell growth in a cell viability assay. IC50=19.6471 μM SANGER
UACC-893 Growth inhibition assay Inhibition of human UACC-893 cell growth in a cell viability assay. IC50=0.11885 μM SANGER
BB30-HNC Growth inhibition assay Inhibition of human BB30-HNC cell growth in a cell viability assay. IC50=0.16576 μM SANGER
UM-UC-3 Growth inhibition assay Inhibition of human UM-UC-3 cell growth in a cell viability assay. IC50=9.9503 μM SANGER
VM-CUB-1 Growth inhibition assay Inhibition of human VM-CUB-1 cell growth in a cell viability assay. IC50=4.86819 μM SANGER
UMC-11 Growth inhibition assay Inhibition of human UMC-11 cell growth in a cell viability assay. IC50=26.4514 μM SANGER
BEN Growth inhibition assay Inhibition of human BEN cell growth in a cell viability assay. IC50=27.8517 μM SANGER
WM-115 Growth inhibition assay Inhibition of human WM-115 cell growth in a cell viability assay. IC50=11.7588 μM SANGER
BFTC-909 Growth inhibition assay Inhibition of human BFTC-909 cell growth in a cell viability assay. IC50=9.06799 μM SANGER
YAPC Growth inhibition assay Inhibition of human YAPC cell growth in a cell viability assay. IC50=11.9259 μM SANGER
BT-20 Growth inhibition assay Inhibition of human BT-20 cell growth in a cell viability assay. IC50=3.69795 μM SANGER
YKG-1 Growth inhibition assay Inhibition of human YKG-1 cell growth in a cell viability assay. IC50=1.05419 μM SANGER
CAPAN-1 Growth inhibition assay Inhibition of human CAPAN-1 cell growth in a cell viability assay. IC50=30.5181 μM SANGER
no-10 Growth inhibition assay Inhibition of human no-10 cell growth in a cell viability assay. IC50=16.6343 μM SANGER
CAMA-1 Growth inhibition assay Inhibition of human CAMA-1 cell growth in a cell viability assay. IC50=9.28128 μM SANGER
CAS-1 Growth inhibition assay Inhibition of human CAS-1 cell growth in a cell viability assay. IC50=46.7701 μM SANGER
BT-549 Growth inhibition assay Inhibition of human BT-549 cell growth in a cell viability assay. IC50=6.66889 μM SANGER
CCRF-CEM Growth inhibition assay Inhibition of human CCRF-CEM cell growth in a cell viability assay. IC50=25.967 μM SANGER
CGTH-W-1 Growth inhibition assay Inhibition of human CGTH-W-1 cell growth in a cell viability assay. IC50=42.4955 μM SANGER
CHP-212 Growth inhibition assay Inhibition of human CHP-212 cell growth in a cell viability assay. IC50=22.3222 μM SANGER
C32 Growth inhibition assay Inhibition of human C32 cell growth in a cell viability assay. IC50=9.33064 μM SANGER
COLO-320-HSR Growth inhibition assay Inhibition of human COLO-320-HSR cell growth in a cell viability assay. IC50=18.746 μM SANGER
CAL-33 Growth inhibition assay Inhibition of human CAL-33 cell growth in a cell viability assay. IC50=0.20184 μM SANGER
COLO-678 Growth inhibition assay Inhibition of human COLO-678 cell growth in a cell viability assay. IC50=0.80834 μM SANGER
COLO-680N Growth inhibition assay Inhibition of human COLO-680N cell growth in a cell viability assay. IC50=44.339 μM SANGER
COLO-684 Growth inhibition assay Inhibition of human COLO-684 cell growth in a cell viability assay. IC50=16.9477 μM SANGER
TE-10 Growth inhibition assay Inhibition of human TE-10 cell growth in a cell viability assay. IC50=2.68078 μM SANGER
COLO-741 Growth inhibition assay Inhibition of human COLO-741 cell growth in a cell viability assay. IC50=20.66 μM SANGER
COLO-792 Growth inhibition assay Inhibition of human COLO-792 cell growth in a cell viability assay. IC50=25.2732 μM SANGER
TE-12 Growth inhibition assay Inhibition of human TE-12 cell growth in a cell viability assay. IC50=1.80414 μM SANGER
COR-L23 Growth inhibition assay Inhibition of human COR-L23 cell growth in a cell viability assay. IC50=24.1767 μM SANGER
COLO-824 Growth inhibition assay Inhibition of human COLO-824 cell growth in a cell viability assay. IC50=15.1579 μM SANGER
COR-L105 Growth inhibition assay Inhibition of human COR-L105 cell growth in a cell viability assay. IC50=0.21084 μM SANGER
COR-L88 Growth inhibition assay Inhibition of human COR-L88 cell growth in a cell viability assay. IC50=0.64113 μM SANGER
TE-8 Growth inhibition assay Inhibition of human TE-8 cell growth in a cell viability assay. IC50=1.91377 μM SANGER
TGBC11TKB Growth inhibition assay Inhibition of human TGBC11TKB cell growth in a cell viability assay. IC50=47.1777 μM SANGER
CP50-MEL-B Growth inhibition assay Inhibition of human CP50-MEL-B cell growth in a cell viability assay. IC50=17.0343 μM SANGER
CP66-MEL Growth inhibition assay Inhibition of human CP66-MEL cell growth in a cell viability assay. IC50=15.4688 μM SANGER
CTB-1 Growth inhibition assay Inhibition of human CTB-1 cell growth in a cell viability assay. IC50=4.8488 μM SANGER
CaR-1 Growth inhibition assay Inhibition of human CaR-1 cell growth in a cell viability assay. IC50=2.28281 μM SANGER
CTV-1 Growth inhibition assay Inhibition of human CTV-1 cell growth in a cell viability assay. IC50=0.64392 μM SANGER
CW-2 Growth inhibition assay Inhibition of human CW-2 cell growth in a cell viability assay. IC50=0.46914 μM SANGER
Ca-Ski Growth inhibition assay Inhibition of human Ca-Ski cell growth in a cell viability assay. IC50=7.64259 μM SANGER
U251 Growth inhibition assay Inhibition of human U251 cell growth in a cell viability assay. IC50=40.4054 μM SANGER
Ca9-22 Growth inhibition assay Inhibition of human Ca9-22 cell growth in a cell viability assay. IC50=0.08353 μM SANGER
Calu-3 Growth inhibition assay Inhibition of human Calu-3 cell growth in a cell viability assay. IC50=0.81434 μM SANGER
Capan-2 Growth inhibition assay Inhibition of human Capan-2 cell growth in a cell viability assay. IC50=3.46875 μM SANGER
UACC-62 Growth inhibition assay Inhibition of human UACC-62 cell growth in a cell viability assay. IC50=11.2368 μM SANGER
ChaGo-K-1 Growth inhibition assay Inhibition of human ChaGo-K-1 cell growth in a cell viability assay. IC50=32.007 μM SANGER
VA-ES-BJ Growth inhibition assay Inhibition of human VA-ES-BJ cell growth in a cell viability assay. IC50=35.4648 μM SANGER
D-263MG Growth inhibition assay Inhibition of human D-263MG cell growth in a cell viability assay. IC50=33.8378 μM SANGER
VMRC-RCZ Growth inhibition assay Inhibition of human VMRC-RCZ cell growth in a cell viability assay. IC50=8.01697 μM SANGER
D-336MG Growth inhibition assay Inhibition of human D-336MG cell growth in a cell viability assay. IC50=30.2892 μM SANGER
D-392MG Growth inhibition assay Inhibition of human D-392MG cell growth in a cell viability assay. IC50=35.0565 μM SANGER
D-566MG Growth inhibition assay Inhibition of human D-566MG cell growth in a cell viability assay. IC50=29.9393 μM SANGER
D-423MG Growth inhibition assay Inhibition of human D-423MG cell growth in a cell viability assay. IC50=5.61705 μM SANGER
DBTRG-05MG Growth inhibition assay Inhibition of human DBTRG-05MG cell growth in a cell viability assay. IC50=13.0633 μM SANGER
D-502MG Growth inhibition assay Inhibition of human D-502MG cell growth in a cell viability assay. IC50=8.29282 μM SANGER
ZR-75-30 Growth inhibition assay Inhibition of human ZR-75-30 cell growth in a cell viability assay. IC50=0.09545 μM SANGER
D-542MG Growth inhibition assay Inhibition of human D-542MG cell growth in a cell viability assay. IC50=1.01064 μM SANGER
DMS-273 Growth inhibition assay Inhibition of human DMS-273 cell growth in a cell viability assay. IC50=32.5322 μM SANGER
DJM-1 Growth inhibition assay Inhibition of human DJM-1 cell growth in a cell viability assay. IC50=6.92012 μM SANGER
DK-MG Growth inhibition assay Inhibition of human DK-MG cell growth in a cell viability assay. IC50=30.5456 μM SANGER
no-11 Growth inhibition assay Inhibition of human no-11 cell growth in a cell viability assay. IC50=3.53564 μM SANGER
DMS-114 Growth inhibition assay Inhibition of human DMS-114 cell growth in a cell viability assay. IC50=40.8374 μM SANGER
DMS-79 Growth inhibition assay Inhibition of human DMS-79 cell growth in a cell viability assay. IC50=40.5889 μM SANGER
DOK Growth inhibition assay Inhibition of human DOK cell growth in a cell viability assay. IC50=0.03194 μM SANGER
CFPAC-1 Growth inhibition assay Inhibition of human CFPAC-1 cell growth in a cell viability assay. IC50=1.42493 μM SANGER
DSH1 Growth inhibition assay Inhibition of human DSH1 cell growth in a cell viability assay. IC50=0.03314 μM SANGER
DU-145 Growth inhibition assay Inhibition of human DU-145 cell growth in a cell viability assay. IC50=0.44833 μM SANGER
CHL-1 Growth inhibition assay Inhibition of human CHL-1 cell growth in a cell viability assay. IC50=0.01839 μM SANGER
DU-4475 Growth inhibition assay Inhibition of human DU-4475 cell growth in a cell viability assay. IC50=1.40121 μM SANGER
DoTc2-4510 Growth inhibition assay Inhibition of human DoTc2-4510 cell growth in a cell viability assay. IC50=0.32219 μM SANGER
Daoy Growth inhibition assay Inhibition of human Daoy cell growth in a cell viability assay. IC50=24.126 μM SANGER
Detroit562 Growth inhibition assay Inhibition of human Detroit562 cell growth in a cell viability assay. IC50=1.70152 μM SANGER
ECC10 Growth inhibition assay Inhibition of human ECC10 cell growth in a cell viability assay. IC50=1.55369 μM SANGER
EC-GI-10 Growth inhibition assay Inhibition of human EC-GI-10 cell growth in a cell viability assay. IC50=0.05912 μM SANGER
EFM-19 Growth inhibition assay Inhibition of human EFM-19 cell growth in a cell viability assay. IC50=37.7967 μM SANGER
COLO-679 Growth inhibition assay Inhibition of human COLO-679 cell growth in a cell viability assay. IC50=35.388 μM SANGER
EFO-21 Growth inhibition assay Inhibition of human EFO-21 cell growth in a cell viability assay. IC50=11.1045 μM SANGER
EFO-27 Growth inhibition assay Inhibition of human EFO-27 cell growth in a cell viability assay. IC50=0.05182 μM SANGER
EKVX Growth inhibition assay Inhibition of human EKVX cell growth in a cell viability assay. IC50=1.01064 μM SANGER
EGI-1 Growth inhibition assay Inhibition of human EGI-1 cell growth in a cell viability assay. IC50=28.5928 μM SANGER
EPLC-272H Growth inhibition assay Inhibition of human EPLC-272H cell growth in a cell viability assay. IC50=4.41533 μM SANGER
COLO-800 Growth inhibition assay Inhibition of human COLO-800 cell growth in a cell viability assay. IC50=7.41446 μM SANGER
COLO-829 Growth inhibition assay Inhibition of human COLO-829 cell growth in a cell viability assay. IC50=8.80976 μM SANGER
ES3 Growth inhibition assay Inhibition of human ES3 cell growth in a cell viability assay. IC50=16.9134 μM SANGER
ES8 Growth inhibition assay Inhibition of human ES8 cell growth in a cell viability assay. IC50=17.6087 μM SANGER
ES4 Growth inhibition assay Inhibition of human ES4 cell growth in a cell viability assay. IC50=0.97836 μM SANGER
ETK-1 Growth inhibition assay Inhibition of human ETK-1 cell growth in a cell viability assay. IC50=1.37456 μM SANGER
EW-1 Growth inhibition assay Inhibition of human EW-1 cell growth in a cell viability assay. IC50=45.9689 μM SANGER
ES5 Growth inhibition assay Inhibition of human ES5 cell growth in a cell viability assay. IC50=4.83723 μM SANGER
EW-11 Growth inhibition assay Inhibition of human EW-11 cell growth in a cell viability assay. IC50=9.17653 μM SANGER
EW-13 Growth inhibition assay Inhibition of human EW-13 cell growth in a cell viability assay. IC50=14.0352 μM SANGER
EW-18 Growth inhibition assay Inhibition of human EW-18 cell growth in a cell viability assay. IC50=0.68698 μM SANGER
EW-3 Growth inhibition assay Inhibition of human EW-3 cell growth in a cell viability assay. IC50=1.07883 μM SANGER
EW-24 Growth inhibition assay Inhibition of human EW-24 cell growth in a cell viability assay. IC50=21.3945 μM SANGER
Calu-6 Growth inhibition assay Inhibition of human Calu-6 cell growth in a cell viability assay. IC50=30.2963 μM SANGER
FTC-133 Growth inhibition assay Inhibition of human FTC-133 cell growth in a cell viability assay. IC50=11.1407 μM SANGER
EoL-1-cell Growth inhibition assay Inhibition of human EoL-1-cell cell growth in a cell viability assay. IC50=0.26892 μM SANGER
FADU Growth inhibition assay Inhibition of human FADU cell growth in a cell viability assay. IC50=0.54404 μM SANGER
G-401 Growth inhibition assay Inhibition of human G-401 cell growth in a cell viability assay. IC50=1.67413 μM SANGER
GAK Growth inhibition assay Inhibition of human GAK cell growth in a cell viability assay. IC50=25.2963 μM SANGER
GAMG Growth inhibition assay Inhibition of human GAMG cell growth in a cell viability assay. IC50=3.91314 μM SANGER
GMS-10 Growth inhibition assay Inhibition of human GMS-10 cell growth in a cell viability assay. IC50=2.03517 μM SANGER
GB-1 Growth inhibition assay Inhibition of human GB-1 cell growth in a cell viability assay. IC50=25.4068 μM SANGER
GI-ME-N Growth inhibition assay Inhibition of human GI-ME-N cell growth in a cell viability assay. IC50=31.0571 μM SANGER
GOTO Growth inhibition assay Inhibition of human GOTO cell growth in a cell viability assay. IC50=31.8506 μM SANGER
GCIY Growth inhibition assay Inhibition of human GCIY cell growth in a cell viability assay. IC50=1.08104 μM SANGER
GT3TKB Growth inhibition assay Inhibition of human GT3TKB cell growth in a cell viability assay. IC50=8.67964 μM SANGER
GP5d Growth inhibition assay Inhibition of human GP5d cell growth in a cell viability assay. IC50=6.97394 μM SANGER
D-283MED Growth inhibition assay Inhibition of human D-283MED cell growth in a cell viability assay. IC50=18.0088 μM SANGER
GR-ST Growth inhibition assay Inhibition of human GR-ST cell growth in a cell viability assay. IC50=28.6696 μM SANGER
DB Growth inhibition assay Inhibition of human DB cell growth in a cell viability assay. IC50=7.61005 μM SANGER
HC-1 Growth inhibition assay Inhibition of human HC-1 cell growth in a cell viability assay. IC50=5.51839 μM SANGER
HAL-01 Growth inhibition assay Inhibition of human HAL-01 cell growth in a cell viability assay. IC50=8.5191 μM SANGER
HCC1187 Growth inhibition assay Inhibition of human HCC1187 cell growth in a cell viability assay. IC50=20.6734 μM SANGER
HCC1419 Growth inhibition assay Inhibition of human HCC1419 cell growth in a cell viability assay. IC50=0.36408 μM SANGER
HCC1395 Growth inhibition assay Inhibition of human HCC1395 cell growth in a cell viability assay. IC50=14.9338 μM SANGER
DEL Growth inhibition assay Inhibition of human DEL cell growth in a cell viability assay. IC50=10.3946 μM SANGER
DOHH-2 Growth inhibition assay Inhibition of human DOHH-2 cell growth in a cell viability assay. IC50=20.5463 μM SANGER
HCC1937 Growth inhibition assay Inhibition of human HCC1937 cell growth in a cell viability assay. IC50=12.7564 μM SANGER
HCC38 Growth inhibition assay Inhibition of human HCC38 cell growth in a cell viability assay. IC50=42.9618 μM SANGER
HCC1954 Growth inhibition assay Inhibition of human HCC1954 cell growth in a cell viability assay. IC50=11.0754 μM SANGER
HCC2218 Growth inhibition assay Inhibition of human HCC2218 cell growth in a cell viability assay. IC50=0.009869 μM SANGER
HCE-4 Growth inhibition assay Inhibition of human HCE-4 cell growth in a cell viability assay. IC50=9.21558 μM SANGER
HCE-T Growth inhibition assay Inhibition of human HCE-T cell growth in a cell viability assay. IC50=0.88428 μM SANGER
HL-60 Growth inhibition assay Inhibition of human HL-60 cell growth in a cell viability assay. IC50=4.86611 μM SANGER
HCT-116 Growth inhibition assay Inhibition of human HCT-116 cell growth in a cell viability assay. IC50=4.41007 μM SANGER
HEL Growth inhibition assay Inhibition of human HEL cell growth in a cell viability assay. IC50=7.71203 μM SANGER
HCT-15 Growth inhibition assay Inhibition of human HCT-15 cell growth in a cell viability assay. IC50=22.7441 μM SANGER
HLE Growth inhibition assay Inhibition of human HLE cell growth in a cell viability assay. IC50=0.35046 μM SANGER
HH Growth inhibition assay Inhibition of human HH cell growth in a cell viability assay. IC50=16.5162 μM SANGER
HD-MY-Z Growth inhibition assay Inhibition of human HD-MY-Z cell growth in a cell viability assay. IC50=48.786 μM SANGER
HO-1-N-1 Growth inhibition assay Inhibition of human HO-1-N-1 cell growth in a cell viability assay. IC50=0.27853 μM SANGER
HN Growth inhibition assay Inhibition of human HN cell growth in a cell viability assay. IC50=0.13077 μM SANGER
HDLM-2 Growth inhibition assay Inhibition of human HDLM-2 cell growth in a cell viability assay. IC50=0.00572 μM SANGER
EM-2 Growth inhibition assay Inhibition of human EM-2 cell growth in a cell viability assay. IC50=14.8576 μM SANGER
HOP-92 Growth inhibition assay Inhibition of human HOP-92 cell growth in a cell viability assay. IC50=26.1226 μM SANGER
HPAF-II Growth inhibition assay Inhibition of human HPAF-II cell growth in a cell viability assay. IC50=41.6709 μM SANGER
HSC-2 Growth inhibition assay Inhibition of human HSC-2 cell growth in a cell viability assay. IC50=0.16837 μM SANGER
ES1 Growth inhibition assay Inhibition of human ES1 cell growth in a cell viability assay. IC50=19.9213 μM SANGER
HSC-3 Growth inhibition assay Inhibition of human HSC-3 cell growth in a cell viability assay. IC50=0.21198 μM SANGER
HSC-4 Growth inhibition assay Inhibition of human HSC-4 cell growth in a cell viability assay. IC50=0.01748 μM SANGER
ES7 Growth inhibition assay Inhibition of human ES7 cell growth in a cell viability assay. IC50=19.6292 μM SANGER
HT-144 Growth inhibition assay Inhibition of human HT-144 cell growth in a cell viability assay. IC50=27.4032 μM SANGER
ESS-1 Growth inhibition assay Inhibition of human ESS-1 cell growth in a cell viability assay. IC50=18.5206 μM SANGER
HT-29 Growth inhibition assay Inhibition of human HT-29 cell growth in a cell viability assay. IC50=3.07309 μM SANGER
HT-3 Growth inhibition assay Inhibition of human HT-3 cell growth in a cell viability assay. IC50=1.28753 μM SANGER
HT55 Growth inhibition assay Inhibition of human HT55 cell growth in a cell viability assay. IC50=2.5738 μM SANGER
EW-16 Growth inhibition assay Inhibition of human EW-16 cell growth in a cell viability assay. IC50=27.2947 μM SANGER
HTC-C3 Growth inhibition assay Inhibition of human HTC-C3 cell growth in a cell viability assay. IC50=27.2561 μM SANGER
HT-1376 Growth inhibition assay Inhibition of human HT-1376 cell growth in a cell viability assay. IC50=1.01513 μM SANGER
EW-22 Growth inhibition assay Inhibition of human EW-22 cell growth in a cell viability assay. IC50=41.8697 μM SANGER
Hs-578-T Growth inhibition assay Inhibition of human Hs-578-T cell growth in a cell viability assay. IC50=45.0294 μM SANGER
G-361 Growth inhibition assay Inhibition of human G-361 cell growth in a cell viability assay. IC50=26.1027 μM SANGER
HuH-7 Growth inhibition assay Inhibition of human HuH-7 cell growth in a cell viability assay. IC50=28.4028 μM SANGER
HuO-3N1 Growth inhibition assay Inhibition of human HuO-3N1 cell growth in a cell viability assay. IC50=5.24043 μM SANGER
HuO9 Growth inhibition assay Inhibition of human HuO9 cell growth in a cell viability assay. IC50=11.8774 μM SANGER
G-402 Growth inhibition assay Inhibition of human G-402 cell growth in a cell viability assay. IC50=35.9867 μM SANGER
IGROV-1 Growth inhibition assay Inhibition of human IGROV-1 cell growth in a cell viability assay. IC50=0.25952 μM SANGER
HuP-T3 Growth inhibition assay Inhibition of human HuP-T3 cell growth in a cell viability assay. IC50=16.6576 μM SANGER
HuP-T4 Growth inhibition assay Inhibition of human HuP-T4 cell growth in a cell viability assay. IC50=0.6976 μM SANGER
GCT Growth inhibition assay Inhibition of human GCT cell growth in a cell viability assay. IC50=20.3026 μM SANGER
IST-MEL1 Growth inhibition assay Inhibition of human IST-MEL1 cell growth in a cell viability assay. IC50=11.456 μM SANGER
GI-1 Growth inhibition assay Inhibition of human GI-1 cell growth in a cell viability assay. IC50=22.7658 μM SANGER
IST-MES1 Growth inhibition assay Inhibition of human IST-MES1 cell growth in a cell viability assay. IC50=18.4428 μM SANGER
J82 Growth inhibition assay Inhibition of human J82 cell growth in a cell viability assay. IC50=15.057 μM SANGER
JAR Growth inhibition assay Inhibition of human JAR cell growth in a cell viability assay. IC50=19.299 μM SANGER
H-EMC-SS Growth inhibition assay Inhibition of human H-EMC-SS cell growth in a cell viability assay. IC50=32.9678 μM SANGER
JEG-3 Growth inhibition assay Inhibition of human JEG-3 cell growth in a cell viability assay. IC50=22.378 μM SANGER
JVM-2 Growth inhibition assay Inhibition of human JVM-2 cell growth in a cell viability assay. IC50=0.88299 μM SANGER
H9 Growth inhibition assay Inhibition of human H9 cell growth in a cell viability assay. IC50=0.07132 μM SANGER
KARPAS-299 Growth inhibition assay Inhibition of human KARPAS-299 cell growth in a cell viability assay. IC50=20.3422 μM SANGER
JVM-3 Growth inhibition assay Inhibition of human JVM-3 cell growth in a cell viability assay. IC50=7.89599 μM SANGER
KALS-1 Growth inhibition assay Inhibition of human KALS-1 cell growth in a cell viability assay. IC50=23.1414 μM SANGER
HCC1569 Growth inhibition assay Inhibition of human HCC1569 cell growth in a cell viability assay. IC50=2.58297 μM SANGER
KARPAS-45 Growth inhibition assay Inhibition of human KARPAS-45 cell growth in a cell viability assay. IC50=0.01671 μM SANGER
KE-37 Growth inhibition assay Inhibition of human KE-37 cell growth in a cell viability assay. IC50=25.7315 μM SANGER
KASUMI-1 Growth inhibition assay Inhibition of human KASUMI-1 cell growth in a cell viability assay. IC50=0.00911 μM SANGER
KGN Growth inhibition assay Inhibition of human KGN cell growth in a cell viability assay. IC50=32.633 μM SANGER
KLE Growth inhibition assay Inhibition of human KLE cell growth in a cell viability assay. IC50=4.40819 μM SANGER
HCC1806 Growth inhibition assay Inhibition of human HCC1806 cell growth in a cell viability assay. IC50=0.69666 μM SANGER
KM-H2 Growth inhibition assay Inhibition of human KM-H2 cell growth in a cell viability assay. IC50=34.1779 μM SANGER
KM12 Growth inhibition assay Inhibition of human KM12 cell growth in a cell viability assay. IC50=22.356 μM SANGER
HCC2998 Growth inhibition assay Inhibition of human HCC2998 cell growth in a cell viability assay. IC50=5.52615 μM SANGER
KNS-42 Growth inhibition assay Inhibition of human KNS-42 cell growth in a cell viability assay. IC50=35.5826 μM SANGER
KMOE-2 Growth inhibition assay Inhibition of human KMOE-2 cell growth in a cell viability assay. IC50=19.2242 μM SANGER
HCC70 Growth inhibition assay Inhibition of human HCC70 cell growth in a cell viability assay. IC50=0.57661 μM SANGER
HEC-1 Growth inhibition assay Inhibition of human HEC-1 cell growth in a cell viability assay. IC50=3.5895 μM SANGER
KP-4 Growth inhibition assay Inhibition of human KP-4 cell growth in a cell viability assay. IC50=42.8832 μM SANGER
KNS-81-FD Growth inhibition assay Inhibition of human KNS-81-FD cell growth in a cell viability assay. IC50=19.5468 μM SANGER
HGC-27 Growth inhibition assay Inhibition of human HGC-27 cell growth in a cell viability assay. IC50=31.5873 μM SANGER
KP-N-YN Growth inhibition assay Inhibition of human KP-N-YN cell growth in a cell viability assay. IC50=37.6195 μM SANGER
KP-N-YS Growth inhibition assay Inhibition of human KP-N-YS cell growth in a cell viability assay. IC50=40.6768 μM SANGER
KU-19-19 Growth inhibition assay Inhibition of human KU-19-19 cell growth in a cell viability assay. IC50=0.77464 μM SANGER
HOP-62 Growth inhibition assay Inhibition of human HOP-62 cell growth in a cell viability assay. IC50=11.6764 μM SANGER
HOS Growth inhibition assay Inhibition of human HOS cell growth in a cell viability assay. IC50=39.6273 μM SANGER
KURAMOCHI Growth inhibition assay Inhibition of human KURAMOCHI cell growth in a cell viability assay. IC50=7.94811 μM SANGER
KY821 Growth inhibition assay Inhibition of human KY821 cell growth in a cell viability assay. IC50=0.0206 μM SANGER
KYSE-270 Growth inhibition assay Inhibition of human KYSE-270 cell growth in a cell viability assay. IC50=2.02732 μM SANGER
KYSE-140 Growth inhibition assay Inhibition of human KYSE-140 cell growth in a cell viability assay. IC50=0.0833 μM SANGER
KYSE-150 Growth inhibition assay Inhibition of human KYSE-150 cell growth in a cell viability assay. IC50=42.1782 μM SANGER
KYSE-450 Growth inhibition assay Inhibition of human KYSE-450 cell growth in a cell viability assay. IC50=0.05978 μM SANGER
HT Growth inhibition assay Inhibition of human HT cell growth in a cell viability assay. IC50=40.6639 μM SANGER
KYSE-180 Growth inhibition assay Inhibition of human KYSE-180 cell growth in a cell viability assay. IC50=0.39089 μM SANGER
HT-1197 Growth inhibition assay Inhibition of human HT-1197 cell growth in a cell viability assay. IC50=4.52669 μM SANGER
KYSE-520 Growth inhibition assay Inhibition of human KYSE-520 cell growth in a cell viability assay. IC50=5.20839 μM SANGER
KYSE-70 Growth inhibition assay Inhibition of human KYSE-70 cell growth in a cell viability assay. IC50=30.5114 μM SANGER
HUTU-80 Growth inhibition assay Inhibition of human HUTU-80 cell growth in a cell viability assay. IC50=41.0569 μM SANGER
L-363 Growth inhibition assay Inhibition of human L-363 cell growth in a cell viability assay. IC50=16.4577 μM SANGER
L-428 Growth inhibition assay Inhibition of human L-428 cell growth in a cell viability assay. IC50=24.5791 μM SANGER
LAMA-84 Growth inhibition assay Inhibition of human LAMA-84 cell growth in a cell viability assay. IC50=4.1702 μM SANGER
HuCCT1 Growth inhibition assay Inhibition of human HuCCT1 cell growth in a cell viability assay. IC50=10.6034 μM SANGER
LB1047-RCC Growth inhibition assay Inhibition of human LB1047-RCC cell growth in a cell viability assay. IC50=2.74888 μM SANGER
IGR-1 Growth inhibition assay Inhibition of human IGR-1 cell growth in a cell viability assay. IC50=28.8874 μM SANGER
LB2518-MEL Growth inhibition assay Inhibition of human LB2518-MEL cell growth in a cell viability assay. IC50=49.8723 μM SANGER
LB373-MEL-D Growth inhibition assay Inhibition of human LB373-MEL-D cell growth in a cell viability assay. IC50=7.76771 μM SANGER
LB771-HNC Growth inhibition assay Inhibition of human LB771-HNC cell growth in a cell viability assay. IC50=35.1658 μM SANGER
IST-SL1 Growth inhibition assay Inhibition of human IST-SL1 cell growth in a cell viability assay. IC50=26.6591 μM SANGER
LCLC-103H Growth inhibition assay Inhibition of human LCLC-103H cell growth in a cell viability assay. IC50=36.7803 μM SANGER
LC-2-ad Growth inhibition assay Inhibition of human LC-2-ad cell growth in a cell viability assay. IC50=21.2729 μM SANGER
LCLC-97TM1 Growth inhibition assay Inhibition of human LCLC-97TM1 cell growth in a cell viability assay. IC50=4.53686 μM SANGER
LN-405 Growth inhibition assay Inhibition of human LN-405 cell growth in a cell viability assay. IC50=22.5913 μM SANGER
LK-2 Growth inhibition assay Inhibition of human LK-2 cell growth in a cell viability assay. IC50=13.7639 μM SANGER
J-RT3-T3-5 Growth inhibition assay Inhibition of human J-RT3-T3-5 cell growth in a cell viability assay. IC50=6.869 μM SANGER
LS-1034 Growth inhibition assay Inhibition of human LS-1034 cell growth in a cell viability assay. IC50=6.20706 μM SANGER
LS-123 Growth inhibition assay Inhibition of human LS-123 cell growth in a cell viability assay. IC50=3.74284 μM SANGER
K5 Growth inhibition assay Inhibition of human K5 cell growth in a cell viability assay. IC50=1.58357 μM SANGER
LS-411N Growth inhibition assay Inhibition of human LS-411N cell growth in a cell viability assay. IC50=5.79441 μM SANGER
LU-134-A Growth inhibition assay Inhibition of human LU-134-A cell growth in a cell viability assay. IC50=21.1026 μM SANGER
KG-1 Growth inhibition assay Inhibition of human KG-1 cell growth in a cell viability assay. IC50=24.1928 μM SANGER
KINGS-1 Growth inhibition assay Inhibition of human KINGS-1 cell growth in a cell viability assay. IC50=5.60944 μM SANGER
LU-65 Growth inhibition assay Inhibition of human LU-65 cell growth in a cell viability assay. IC50=0.12633 μM SANGER
LU-139 Growth inhibition assay Inhibition of human LU-139 cell growth in a cell viability assay. IC50=0.3051 μM SANGER
LU-99A Growth inhibition assay Inhibition of human LU-99A cell growth in a cell viability assay. IC50=37.5731 μM SANGER
LXF-289 Growth inhibition assay Inhibition of human LXF-289 cell growth in a cell viability assay. IC50=2.63565 μM SANGER
M14 Growth inhibition assay Inhibition of human M14 cell growth in a cell viability assay. IC50=44.1332 μM SANGER
KNS-62 Growth inhibition assay Inhibition of human KNS-62 cell growth in a cell viability assay. IC50=3.94731 μM SANGER
LoVo Growth inhibition assay Inhibition of human LoVo cell growth in a cell viability assay. IC50=2.10797 μM SANGER
KOSC-2 Growth inhibition assay Inhibition of human KOSC-2 cell growth in a cell viability assay. IC50=3.83451 μM SANGER
MC-IXC Growth inhibition assay Inhibition of human MC-IXC cell growth in a cell viability assay. IC50=11.6728 μM SANGER
MC116 Growth inhibition assay Inhibition of human MC116 cell growth in a cell viability assay. IC50=3.95489 μM SANGER
MDA-MB-175-VII Growth inhibition assay Inhibition of human MDA-MB-175-VII cell growth in a cell viability assay. IC50=0.03416 μM SANGER
MCF7 Growth inhibition assay Inhibition of human MCF7 cell growth in a cell viability assay. IC50=16.4723 μM SANGER
MDA-MB-361 Growth inhibition assay Inhibition of human MDA-MB-361 cell growth in a cell viability assay. IC50=0.72662 μM SANGER
KS-1 Growth inhibition assay Inhibition of human KS-1 cell growth in a cell viability assay. IC50=4.50889 μM SANGER
MDA-MB-157 Growth inhibition assay Inhibition of human MDA-MB-157 cell growth in a cell viability assay. IC50=2.21828 μM SANGER
MDA-MB-453 Growth inhibition assay Inhibition of human MDA-MB-453 cell growth in a cell viability assay. IC50=11.9515 μM SANGER
KU812 Growth inhibition assay Inhibition of human KU812 cell growth in a cell viability assay. IC50=0.15456 μM SANGER
ME-180 Growth inhibition assay Inhibition of human ME-180 cell growth in a cell viability assay. IC50=1.61096 μM SANGER
MEG-01 Growth inhibition assay Inhibition of human MEG-01 cell growth in a cell viability assay. IC50=4.99403 μM SANGER
KYSE-410 Growth inhibition assay Inhibition of human KYSE-410 cell growth in a cell viability assay. IC50=1.65672 μM SANGER
MEL-HO Growth inhibition assay Inhibition of human MEL-HO cell growth in a cell viability assay. IC50=30.1423 μM SANGER
MFE-280 Growth inhibition assay Inhibition of human MFE-280 cell growth in a cell viability assay. IC50=16.0488 μM SANGER
MFH-ino Growth inhibition assay Inhibition of human MFH-ino cell growth in a cell viability assay. IC50=37.3371 μM SANGER
KYSE-510 Growth inhibition assay Inhibition of human KYSE-510 cell growth in a cell viability assay. IC50=19.8748 μM SANGER
MFM-223 Growth inhibition assay Inhibition of human MFM-223 cell growth in a cell viability assay. IC50=16.3965 μM SANGER
MG-63 Growth inhibition assay Inhibition of human MG-63 cell growth in a cell viability assay. IC50=5.48762 μM SANGER
MHH-NB-11 Growth inhibition assay Inhibition of human MHH-NB-11 cell growth in a cell viability assay. IC50=16.0839 μM SANGER
LAN-6 Growth inhibition assay Inhibition of human LAN-6 cell growth in a cell viability assay. IC50=40.0112 μM SANGER
MKN1 Growth inhibition assay Inhibition of human MKN1 cell growth in a cell viability assay. IC50=3.47108 μM SANGER
MIA-PaCa-2 Growth inhibition assay Inhibition of human MIA-PaCa-2 cell growth in a cell viability assay. IC50=28.7959 μM SANGER
MKN28 Growth inhibition assay Inhibition of human MKN28 cell growth in a cell viability assay. IC50=32.7838 μM SANGER
ML-2 Growth inhibition assay Inhibition of human ML-2 cell growth in a cell viability assay. IC50=0.24802 μM SANGER
MKN45 Growth inhibition assay Inhibition of human MKN45 cell growth in a cell viability assay. IC50=21.1551 μM SANGER
MMAC-SF Growth inhibition assay Inhibition of human MMAC-SF cell growth in a cell viability assay. IC50=19.2607 μM SANGER
MKN7 Growth inhibition assay Inhibition of human MKN7 cell growth in a cell viability assay. IC50=2.35335 μM SANGER
LB2241-RCC Growth inhibition assay Inhibition of human LB2241-RCC cell growth in a cell viability assay. IC50=0.10884 μM SANGER
LB831-BLC Growth inhibition assay Inhibition of human LB831-BLC cell growth in a cell viability assay. IC50=38.6039 μM SANGER
MOLT-13 Growth inhibition assay Inhibition of human MOLT-13 cell growth in a cell viability assay. IC50=0.23975 μM SANGER
MSTO-211H Growth inhibition assay Inhibition of human MSTO-211H cell growth in a cell viability assay. IC50=45.9482 μM SANGER
MOLT-16 Growth inhibition assay Inhibition of human MOLT-16 cell growth in a cell viability assay. IC50=17.8935 μM SANGER
MOLT-4 Growth inhibition assay Inhibition of human MOLT-4 cell growth in a cell viability assay. IC50=7.02135 μM SANGER
MZ1-PC Growth inhibition assay Inhibition of human MZ1-PC cell growth in a cell viability assay. IC50=30.393 μM SANGER
MZ2-MEL Growth inhibition assay Inhibition of human MZ2-MEL cell growth in a cell viability assay. IC50=16.8403 μM SANGER
MPP-89 Growth inhibition assay Inhibition of human MPP-89 cell growth in a cell viability assay. IC50=22.8661 μM SANGER
MZ7-mel Growth inhibition assay Inhibition of human MZ7-mel cell growth in a cell viability assay. IC50=34.6487 μM SANGER
LNCaP-Clone-FGC Growth inhibition assay Inhibition of human LNCaP-Clone-FGC cell growth in a cell viability assay. IC50=15.4248 μM SANGER
Mewo Growth inhibition assay Inhibition of human Mewo cell growth in a cell viability assay. IC50=34.1349 μM SANGER
LOXIMVI Growth inhibition assay Inhibition of human LOXIMVI cell growth in a cell viability assay. IC50=5.63873 μM SANGER
NB12 Growth inhibition assay Inhibition of human NB12 cell growth in a cell viability assay. IC50=25.2947 μM SANGER
NB10 Growth inhibition assay Inhibition of human NB10 cell growth in a cell viability assay. IC50=22.2371 μM SANGER
NB13 Growth inhibition assay Inhibition of human NB13 cell growth in a cell viability assay. IC50=42.6217 μM SANGER
NB5 Growth inhibition assay Inhibition of human NB5 cell growth in a cell viability assay. IC50=1.41317 μM SANGER
NB14 Growth inhibition assay Inhibition of human NB14 cell growth in a cell viability assay. IC50=6.43836 μM SANGER
LS-513 Growth inhibition assay Inhibition of human LS-513 cell growth in a cell viability assay. IC50=4.31217 μM SANGER
NB17 Growth inhibition assay Inhibition of human NB17 cell growth in a cell viability assay. IC50=31.5185 μM SANGER
NB69 Growth inhibition assay Inhibition of human NB69 cell growth in a cell viability assay. IC50=1.02945 μM SANGER
NCI-H1048 Growth inhibition assay Inhibition of human NCI-H1048 cell growth in a cell viability assay. IC50=2.49158 μM SANGER
NBsusSR Growth inhibition assay Inhibition of human NBsusSR cell growth in a cell viability assay. IC50=3.18254 μM SANGER
LU-135 Growth inhibition assay Inhibition of human LU-135 cell growth in a cell viability assay. IC50=33.8829 μM SANGER
NCI-H1092 Growth inhibition assay Inhibition of human NCI-H1092 cell growth in a cell viability assay. IC50=16.8316 μM SANGER
NCI-H1155 Growth inhibition assay Inhibition of human NCI-H1155 cell growth in a cell viability assay. IC50=19.7238 μM SANGER
NCI-H1304 Growth inhibition assay Inhibition of human NCI-H1304 cell growth in a cell viability assay. IC50=26.9108 μM SANGER
NCI-H1395 Growth inhibition assay Inhibition of human NCI-H1395 cell growth in a cell viability assay. IC50=20.6697 μM SANGER
NCI-H1437 Growth inhibition assay Inhibition of human NCI-H1437 cell growth in a cell viability assay. IC50=18.1641 μM SANGER
MDA-MB-231 Growth inhibition assay Inhibition of human MDA-MB-231 cell growth in a cell viability assay. IC50=28.2795 μM SANGER
MDA-MB-415 Growth inhibition assay Inhibition of human MDA-MB-415 cell growth in a cell viability assay. IC50=23.9498 μM SANGER
MHH-ES-1 Growth inhibition assay Inhibition of human MHH-ES-1 cell growth in a cell viability assay. IC50=27.4447 μM SANGER
MHH-PREB-1 Growth inhibition assay Inhibition of human MHH-PREB-1 cell growth in a cell viability assay. IC50=10.1999 μM SANGER
MLMA Growth inhibition assay Inhibition of human MLMA cell growth in a cell viability assay. IC50=22.747 μM SANGER
MN-60 Growth inhibition assay Inhibition of human MN-60 cell growth in a cell viability assay. IC50=7.28089 μM SANGER
MS-1 Growth inhibition assay Inhibition of human MS-1 cell growth in a cell viability assay. IC50=30.8889 μM SANGER
MV-4-11 Growth inhibition assay Inhibition of human MV-4-11 cell growth in a cell viability assay. IC50=3.87994 μM SANGER
Mo-T Growth inhibition assay Inhibition of human Mo-T cell growth in a cell viability assay. IC50=18.8204 μM SANGER
NB7 Growth inhibition assay Inhibition of human NB7 cell growth in a cell viability assay. IC50=2.29676 μM SANGER
NCI-H1299 Growth inhibition assay Inhibition of human NCI-H1299 cell growth in a cell viability assay. IC50=6.63171 μM SANGER
NCI-H1355 Growth inhibition assay Inhibition of human NCI-H1355 cell growth in a cell viability assay. IC50=34.3889 μM SANGER
NCI-H1792 Growth inhibition assay Inhibition of human NCI-H1792 cell growth in a cell viability assay. IC50=50.2744 μM SANGER
NCI-H2347 Growth inhibition assay Inhibition of human NCI-H2347 cell growth in a cell viability assay. IC50=58.3648 μM SANGER
NCI-H2452 Growth inhibition assay Inhibition of human NCI-H2452 cell growth in a cell viability assay. IC50=56.5819 μM SANGER
PSN1 Growth inhibition assay Inhibition of human PSN1 cell growth in a cell viability assay. IC50=50.9394 μM SANGER
RH-1 Growth inhibition assay Inhibition of human RH-1 cell growth in a cell viability assay. IC50=66.3277 μM SANGER
SK-LMS-1 Growth inhibition assay Inhibition of human SK-LMS-1 cell growth in a cell viability assay. IC50=51.9815 μM SANGER
SK-MEL-30 Growth inhibition assay Inhibition of human SK-MEL-30 cell growth in a cell viability assay. IC50=133.481 μM SANGER
SNB75 Growth inhibition assay Inhibition of human SNB75 cell growth in a cell viability assay. IC50=50.414 μM SANGER
SNU-423 Growth inhibition assay Inhibition of human SNU-423 cell growth in a cell viability assay. IC50=70.6017 μM SANGER
SW1088 Growth inhibition assay Inhibition of human SW1088 cell growth in a cell viability assay. IC50=50.0201 μM SANGER
SW1783 Growth inhibition assay Inhibition of human SW1783 cell growth in a cell viability assay. IC50=52.4982 μM SANGER
SBC-5 Growth inhibition assay Inhibition of human SBC-5 cell growth in a cell viability assay. IC50=51.1085 μM SANGER
A375 Growth inhibition assay Inhibition of human A375 cell growth in a cell viability assay. IC50=53.6768 μM SANGER
AM-38 Growth inhibition assay Inhibition of human AM-38 cell growth in a cell viability assay. IC50=52.9492 μM SANGER
YH-13 Growth inhibition assay Inhibition of human YH-13 cell growth in a cell viability assay. IC50=60.0468 μM SANGER
TYK-nu Growth inhibition assay Inhibition of human TYK-nu cell growth in a cell viability assay. IC50=76.6063 μM SANGER
COLO-668 Growth inhibition assay Inhibition of human COLO-668 cell growth in a cell viability assay. IC50=60.5077 μM SANGER
ES6 Growth inhibition assay Inhibition of human ES6 cell growth in a cell viability assay. IC50=57.7541 μM SANGER
D-247MG Growth inhibition assay Inhibition of human D-247MG cell growth in a cell viability assay. IC50=59.5888 μM SANGER
H4 Growth inhibition assay Inhibition of human H4 cell growth in a cell viability assay. IC50=60.5614 μM SANGER
HMV-II Growth inhibition assay Inhibition of human HMV-II cell growth in a cell viability assay. IC50=157.194 μM SANGER
HT-1080 Growth inhibition assay Inhibition of human HT-1080 cell growth in a cell viability assay. IC50=62.203 μM SANGER
IA-LM Growth inhibition assay Inhibition of human IA-LM cell growth in a cell viability assay. IC50=54.091 μM SANGER
K-562 Growth inhibition assay Inhibition of human K-562 cell growth in a cell viability assay. IC50=50.5633 μM SANGER
MEL-JUSO Growth inhibition assay Inhibition of human MEL-JUSO cell growth in a cell viability assay. IC50=56.1737 μM SANGER
M059J Growth inhibition assay Inhibition of human M059J cell growth in a cell viability assay. IC50=51.0252 μM SANGER
NB6 Growth inhibition assay Inhibition of human NB6 cell growth in a cell viability assay. IC50=71.0797 μM SANGER
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生物活性

產(chǎn)品描述 Afatinib Dimaleate不可逆地抑制 EGFR/HER2，包括 EGFR(wt)，EGFR(L858R)，EGFR(L858R/T790M) 和 HER2，IC50 分別為0.5 nM，0.4 nM，10 nM 和 14 nM；活性比對Gefitinib抵抗型L858R-T790M EGFR突變體高100倍。Afatinib (BIBW2992) Dimaleate 可誘導(dǎo)自噬。
靶點
EGFR (L858R) [1]
(Cell-free assay)		 EGFR (wt) [1]
(Cell-free assay)		 EGFR (L858R/T790M) [1]
(Cell-free assay)		 HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 10 nM 14 nM
體外研究(In Vitro)
體外研究活性 在表達野生型(H1666)或L858R/T790M (NCI-H1975) EGFR的肺癌細胞系中，Afatinib比erlotinib、ge?tinib和lapatinib能夠更有效的抑制細胞生長。Afatinib同樣對表達HER2 776insV (NCI-H1781) 或EGFR E746_A750del (HCC827)的NSCLC細胞系有效，但對表達野生型EGFR 和HER2的A549細胞無效。[1] Afatinib可增強topotecan和mitoxantrone對SP細胞的細胞毒性，并增強topotecan和mitoxantrone對SP細胞的誘導(dǎo)凋亡作用。[1]
激酶實驗 體外激酶實驗
EGFR激酶：每100 μL酶反應(yīng)體系含10 μl 溶于50% Me2SO的抑制劑，20 μL底物溶液（200Mm HEPES pH 7.4，50 mM乙酸鎂，2.5 mg/mL聚（EY），5μg/mlbio-pEY）和20 μL酶。加入50μl 100 μM ATP（溶于10 mM MgCl2）開始酶促反應(yīng)，室溫下反應(yīng)30分鐘，加入50 μl終止液終止反應(yīng)（250 mM EDTA溶于20 mM pH 7.4 HEPES）。吸取100 μL到鏈霉親和素包被微孔中，室溫溫育60 min后，用200 μL/孔洗滌液（50 mM Tris，0.05% 吐溫20）洗滌。每孔加入100 μL 250 ng/mL HRPO標記的anti-PY抗體（Py20H Anti-Ptyr:HRP）。反應(yīng)60 min后，用200 μL洗滌液洗滌三次。加入100 μL TMB過氧化物酶溶液（A:B= 1:1）。反應(yīng)10分鐘后終止反應(yīng)，ELISA檢測器測定OD450 nm處吸光值。HER2-IC 酶：酶活性在50%Me2SO中，不同濃度的抑制劑存在或不存在下測定。每100μL酶反應(yīng)體系和EGFR激酶檢測體系類似，再加入1000 μM Na3VO4。在10mM醋酸鎂中加入50 μL 500 μM ATP溶液開始酶促反應(yīng)。酶需經(jīng)過稀釋，以含130 mM NaCl、0.05% Triton X-100、1 mM DTT和10% 甘油的20 mM pH 7.4 的HEPES稀釋。室溫反應(yīng)30 min，加入50 μL終止液終止。Src激酶的測定：每100μL反應(yīng)包含10 μL 含抑制劑的50% Me2SO，20 μL酶，20 μL 以1000 μM Na3VO4配置的底物。加入50 μL 1000 μM ATP溶液開始酶促反應(yīng)。BIRK激酶測定：250 mM pH 7.4 Tris-HCl、10 mM DTT、2.5 mg/mL poly(EY)、5 mg/mL bio-pEY作為底物溶劑，加入由8 mM MnCl2和20 mM 醋酸鎂配置的2 mM ATP開始酶促反應(yīng)。VEGF2和HGFR 激酶實驗：室溫反應(yīng)20 min，加入10 μL 5%磷酸終止。用96孔過濾收集板收集沉淀到GF/B過濾器中，經(jīng)洗滌后，50℃干燥1 h，密封和結(jié)合放射性由閃爍計數(shù)用TopCount?或Microbeta b counter?檢測放射性強度。
細胞實驗 細胞系 SP和NSP細胞系
濃度 1 μM
孵育時間 48 h
方法 采用MTT法測定細胞毒性。IC50值為導(dǎo)致50%細胞死亡的藥物濃度。用Bliss法擬合劑量應(yīng)答曲線和計算IC50值。
實驗圖片 檢測方法 檢測指標 實驗圖片 PMID
Growth inhibition assay Cell apoptosis Cell viability 25537503
Western blot CIP2A / p-AKT / AKT / PARP p-EGFR / p-IGF1R / p-ERK / p-AKT 25537503
Immunofluorescence p65 vacuoles 26317651
體內(nèi)研究(In Vivo)
體內(nèi)研究活性 在MDA-MB-453移植瘤模型中，Afatinib（20 mg/kg，口服給藥）可顯著誘導(dǎo)腫瘤衰退，累積治療/對照腫瘤體積比（T/C比）為2%，并下調(diào)EGFR和AKT磷酸化水平。[1] 在A7、A431、FaDu、UT-SCC-14和UT-SCC-15移植瘤模型中，Afatinib（30 mg/kg，口服給藥）可顯著延長腫瘤生長時間。[3] 在HER2擴增移植瘤模型中，Afatinib（30 mg/kg，口服給藥）可顯著抑制腫瘤生長，并顯著延長生存期。[4] 在HER2陽性胃癌NCI-N87移植瘤模型中，Afatinib（25 mg/kg）口服給藥4天可顯著減小腫瘤體積，給藥21天幾乎完全治愈腫瘤。[5]
動物實驗 Animal Models 負荷ARK2移植瘤的SCID小鼠
Dosages 25 mg/kg
Administration 口服給藥
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06302621 Recruiting
Advanced Solid Tumor|Unresectable Solid Tumor|Metastatic Solid Tumor|Cholangiocarcinoma
Massachusetts General Hospital|Boehringer Ingelheim|Incyte Corporation
 July 1 2024 Phase 1
NCT05298176 Recruiting
Non-Small Cell Lung Cancer
Amsterdam UMC location VUmc
 January 4 2022 Phase 2
NCT04795245 Completed
Non-squamous Non-Small Cell Lung Cancer
Boehringer Ingelheim
 August 26 2021 --
NCT04497584 Recruiting
Advanced Squamous Non Small Cell Lung Cancer
University of Texas Southwestern Medical Center
 August 4 2021 Phase 2
NCT04413201 Active not recruiting
Non-squamous NSCLC
Michael Hopp|Boehringer Ingelheim|Johannes Gutenberg University Mainz
 September 11 2020 Phase 4

化學(xué)信息&溶解度

分子量 717.18 分子式

C24H25ClFN5O3.2C4H4O4
CAS號 850140-73-7 SDF Download Afatinib Dimaleate SDF
Smiles CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
儲存條件(自收到貨起)

體外溶解度
批次：

DMSO : 100 mg/mL ( (139.43 mM) ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO)

Water : Insoluble

Ethanol : Insoluble

摩爾濃度計算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑

 動物體內(nèi)配方計算器

實驗計算

摩爾濃度計算器

質(zhì)量 濃度 體積 分子量

動物體內(nèi)配方計算器（澄清溶液）

第一步：請輸入基本實驗信息（考慮到實驗過程中的損耗，建議多配一只動物的藥量）

mg/kg g μL 只

第二步：請輸入動物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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