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Napabucasin (BBI608)

別名: BBI608

目錄號(hào)：S7977 Purity: 99.72%

Napabucasin (BBI608) 是一種口服具有活性的Stat3和癌細(xì)胞多能性抑制劑。

Napabucasin (BBI608) Chemical Structure

Napabucasin (BBI608) Chemical Structure

CAS: 83280-65-3

規(guī)格	價(jià)格	庫(kù)存	購(gòu)買數(shù)量
10mM (1mL in DMSO)	958.23	現(xiàn)貨
5mg	957.38	現(xiàn)貨
25mg	3261.41	現(xiàn)貨
100mg	8169.42	現(xiàn)貨
1g	30876.3	現(xiàn)貨
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產(chǎn)品質(zhì)控

批次：純度： 99.72%

99.72

Napabucasin (BBI608)相關(guān)產(chǎn)品

相關(guān)靶點(diǎn)	STAT1 STAT3 STAT5 STAT6	點(diǎn)擊展開
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相關(guān)化合物庫(kù)	激酶抑制劑庫(kù) FDA藥物庫(kù) 天然產(chǎn)物庫(kù) 酪氨酸激酶抑制劑分子庫(kù) JAK-STAT信號(hào)通路庫(kù)	點(diǎn)擊展開

相關(guān)信號(hào)通路圖

STAT信號(hào)通路圖

細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

細(xì)胞系	實(shí)驗(yàn)類型	給藥濃度	孵育時(shí)間	活性描述	文獻(xiàn)信息
MDA-MB-231	Function assay	100 uM	1 hr	Binding affinity to STAT3 in human MDA-MB-231 cells at 100 uM treated for 1 hr followed by thermolysin addition measured after 30 mins by DARTS-Western blot analysis	30003778
MDA-MB-231	Function assay	5 umol/L	24 hrs	Induction of superoxide generation in human MDA-MB-231 cells at 5 umol/L measured after 24 hrs by DHE staining based flow cytometry	30003778
MDA-MB-231	Function assay	5 umol/L	24 hrs	Induction of superoxide generation in human MDA-MB-231 cells at 5 umol/L measured after 24 hrs in presence of NQO1 inhibitor dicoumarol by DHE staining based flow cytometry	30003778
human HaCaT cells	Function assay		48 h	Antihyperproliferative activity against human HaCaT cells after 48 hrs by phase contrast microscopy, IC50=0.5 μM	22845014
human DU145 cells	Function assay		72 h	Anticancer activity against human DU145 cells after 72 hrs by XTT assay, IC50=0.02304 μM	18829316
MDA-MB-231	Cytotoxicity assay		72 hrs	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 0.34 μM.	28558333
HepG2	Cytotoxicity assay		72 hrs	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 0.66 μM.	28558333
A549	Cytotoxicity assay		72 hrs	Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 0.74 μM.	28558333
K562	Antiproliferative assay		48 hrs	Antiproliferative activity against human K562 cells measured after 48 hrs by MTT assay, IC50 = 1 μM.	30003778
MDA-MB-231	Function assay		4 hrs	Inhibition of STAT3 phosphorylation at Y705 in human MDA-MB-231 cells assessed as reduction in ratio of phosphorylated STAT3 to total STAT3 level after 4 hrs by HTRF assay, EC50 = 1.9 μM.	30003778
MDA-MB-231	Function assay		4 hrs	Inhibition of STAT3 phosphorylation at Y705 in human MDA-MB-231 cells after 4 hrs by HTRF assay, EC50 = 2 μM.	30003778
MDA-MB-231	Antiproliferative assay		48 hrs	Antiproliferative activity against human MDA-MB-231 cells measured after 48 hrs by MTT assay, IC50 = 2.1 μM.	30003778
HepG2	Antiproliferative assay		48 hrs	Antiproliferative activity against human HepG2 cells after 48 hrs by CCK-8 assay, IC50 = 10.2 μM.	29604543
L02	Antiproliferative assay		48 hrs	Antiproliferative activity against human L02 cells after 48 hrs by CCK-8 assay, IC50 = 18.7 μM.	29604543
human HaCaT cells	Proliferation assay			Antiproliferative activity against human HaCaT cells, IC50=0.5 μM	10479319
KB cells	Cytotoxicity assay			Effective cytotoxic dose against KB cells was evaluated, ED50=4.2 μM	9873618
點(diǎn)擊查看更多細(xì)胞系數(shù)據(jù)

生物活性

產(chǎn)品描述

Napabucasin (BBI608) 是一種口服具有活性的Stat3和癌細(xì)胞多能性抑制劑。

靶點(diǎn)

Stat3 ^[1]

體外研究(In Vitro)
體外研究活性	Napabucasin下調(diào)Stat3驅(qū)動(dòng)的干細(xì)胞基因表達(dá)和癌癥干細(xì)胞性能，并有效抑制高度多功能性癌細(xì)胞的自我更新，IC50范圍為0.291~1.19 μM，而對(duì)正常干細(xì)胞沒有抑制作用。^[1]
細(xì)胞實(shí)驗(yàn)	細(xì)胞系	腫瘤干細(xì)胞 U87-MG，U118，COLO205，DLD1，SW480，HCT116，F(xiàn)aDu，ACHN，SNU-475，Huh7，HepG2，H1975，A549，H460，CAOV-3，SW-626，PaCa2
	濃度	~2 μM
	孵育時(shí)間	72小時(shí)
	方法	對(duì)于各種癌癥干細(xì)胞，將球體解離，并在癌癥干細(xì)胞培養(yǎng)條件下接種到鍍層96孔板。培養(yǎng)72小時(shí)后，孔中加入指示劑量的化合物。加入72小時(shí)或24小時(shí)后，將CellTiter-Glo 2.0加入每個(gè)孔，熒光根據(jù)制造商的描述測(cè)量。IC50值使用GraphPad Prism軟件通過(guò)將四參數(shù)劑量響應(yīng)曲線擬合到標(biāo)準(zhǔn)數(shù)據(jù)計(jì)算。大部分細(xì)胞以5,000細(xì)胞/孔接種到96孔板。接種24小時(shí)后，細(xì)胞用指示濃度的化合物處理。存活率在72小時(shí)根據(jù)如上所述測(cè)定。
實(shí)驗(yàn)圖片	檢測(cè)方法	檢測(cè)指標(biāo)	實(shí)驗(yàn)圖片	PMID
	Western blot	CDK4 / Cyclin D1 STAT3 / β-catenin / c-Myc 感谢您访问我们的网站，您可能还对以下资源感兴趣：成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天排五开奖号码,天空彩票与你同行香港小说,任九奖金预测,2020香港马会开奖结果国产精品欧美亚洲韩国日本,爱搞视频网站,免费观看一级毛片,麻豆片免费观看在线看狠狠干天天爽,国产精品天天看天天爽,99色播,十三以下岁女子毛片国产精品2022不卡在线观看,久久久久青草线蕉亚洲麻豆,91蜜桃国产成人精品区,亚洲精品乱码久久久久久蜜桃图片欧美综合图区亚洲综合图区69,国产日韩久久久精品影院首页,另类综合视频,国产精品福利久久久久澳门,h视频在线观看免费网站,69黄在线看片免费视频,精品久久伊人