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Ganciclovir

別名: RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine 中文名稱：更昔洛韋,丙氧鳥苷

Ganciclovir是一種抗病毒藥，作用于貓科動物1型皰疹病毒，無細(xì)胞試驗(yàn)中IC50為5.2 μM。

Ganciclovir Chemical Structure

Ganciclovir Chemical Structure

CAS: 82410-32-0

規(guī)格 價格 庫存 購買數(shù)量
10mM (1mL in DMSO) 732.15 現(xiàn)貨
50mg 565.06 現(xiàn)貨
250mg 2212.74 現(xiàn)貨
1g 5487.3 現(xiàn)貨
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Ganciclovir相關(guān)產(chǎn)品

細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

細(xì)胞系 實(shí)驗(yàn)類型 給藥濃度 孵育時間 活性描述 文獻(xiàn)信息
HFF Antiviral assay 5 uM Antiviral activity against HCMV Towne infected in human HFF cells assessed as reduction in viral DNA yields in the supernatant at 5 uM treated with compound following viral infection at MOI of 0.1 PFU/cell by US17 real time PCR analysis 32191456
HFF Antiviral assay 5 uM Antiviral activity against HCMV Towne infected in human HFF cells assessed as reduction in viral DNA replication at 5 uM treated with compound following viral infection at MOI of 0.1 PFU/cell by US17 real time PCR analysis 32191456
Vero Function assay 10 uM Inhibition of UL42 gene transcription in HSV-1 infected in African green monkey Vero cells at 10 uM by qRT-PCR analysis 31503476
HEL Antiviral assay 3 days Antiviral activity against Human herpesvirus 2 strain G infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 3 days by microscopic method, EC50=0.01μM. 30286952
HEL Antiviral assay 3 days Antiviral activity against Herpes simplex virus 1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 3 days by microscopic method, EC50=0.01μM. 30286952
HEL Antiviral assay 2 to 3 days Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as inhibition of plaque formation measured after 2 to 3 days post infection, EC50=0.019μM. 29550734
HEL Antiviral assay 4 days Antiviral activity against HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 4 days, EC50=0.02μM. 22459876
Vero Antiviral assay 72 hrs Antiviral activity against HSV-1 infected in African green monkey Vero cells assessed as inhibition of GFP expression after 72 hrs by GFP-based fluorescence microscopic analysis, EC50=0.025μM. 31503476
HEL Antiviral assay 2 to 3 days Antiviral activity against acyclovir-sensitive Herpes simplex virus 1 KOS infected in HEL cells assessed as protection from virus-induced cytopathogenicity after 2 to 3 days by MTT assay, EC50=0.03μM. 20034711
HEL Antiviral assay 2 to 3 days Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as protection from virus-induced cytopathogenicity after 2 to 3 days by MTT assay, EC50=0.03μM. 20034711
HEL Antiviral assay 2 to 3 days Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as protection from virus-induced cytopathogenicity after 2 to 3 days by MTT assay, EC50=0.03μM. 20034711
HEL Antiviral assay 4 days Antiviral activity against Herpes simplex virus 1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 4 days by microscopic analysis, EC50=0.03μM. 21696963
HEL Antiviral assay 4 days Antiviral activity against Herpes simplex virus-2 G infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 4 days by microscopic analysis, EC50=0.03μM. 21696963
HEL Antiviral assay 4 days Antiviral activity against HSV2 G infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 4 days, EC50=0.03μM. 22459876
HFF Antiviral assay 1 hr Antiviral activity against Human cytomegalovirus (strain AD169) infected in 1 hr pretreated human HFF cells assessed as reduction in viral-induced cytopathic effect by neutral red uptake assay, EC50=0.04μM. 21376429
Vero Antiviral assay 36 hrs Antiviral activity against HSV 1 infected in African green monkey Vero cells assessed as reduction in plaque formation incubated for 36 hrs by crystal violet staining based assay, EC50=0.04μM. 32191456
HEL Antiviral assay 2 to 3 days Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of plaque formation measured after 2 to 3 days post infection, EC50=0.045μM. 29550734
human Antiviral assay 7 days Antiviral activity against HSV2 G infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 7 days, EC50=0.05μM. 21128666
HEL Antiviral assay 2 to 3 days Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as inhibition of virus-induced cytopathic effect measured after 2 to 3 days post-infection, EC50=0.051μM. 29670705
HEL Antiviral assay 2 to 3 days Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect measured after 2 to 3 days post-infection, EC50=0.057μM. 29670705
HEL Antiviral assay 3 days Antiviral activity against Human herpesvirus 2 strain G infected human HEL cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay, EC50=0.07μM. ChEMBL
HELF Antiviral assay 7 days Antiviral activity against Herpes simplex virus 1 KOS infected in human HELF cells assessed as reduction in virus-induced cytopathogenicity incubated for 7 days by microscopic analysis, EC50=0.07μM. 31586832
HEL Antiviral assay 7 days Antiviral activity against HSV1 KOS infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 7 days, EC50=0.08μM. 21128666
HEL Antiviral assay 3 days Antiviral activity against Human herpesvirus 2 strain G infected HEL cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTT assay, EC50=0.08μM. ChEMBL
HEL Antiviral assay 3 days Antiviral activity against Human herpesvirus 1 strain KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTT assay, EC50=0.08μM. ChEMBL
HEL Antiviral assay 3 days Antiviral activity against Human herpesvirus 1 strain KOS infected human HEL cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay, EC50=0.09μM. ChEMBL
HFF Antiviral assay 10 days Antiviral activity against HCMV Towne infected in HFF cells incubated for 10 days by plaque reduction assay, IC50=0.14μM. 21812420
HEL Antiviral assay 3 days Antiviral activity against acyclovir-resistant TK-defecient Herpes simplex virus 1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 3 days by microscopic method, EC50=0.2μM. 30286952
HELF Antiviral assay 7 days Antiviral activity against Herpes simplex virus 2 G infected in human HELF cells assessed as reduction in virus-induced cytopathogenicity incubated for 7 days by microscopic analysis, EC50=0.3μM. 31586832
HS27 Antiviral assay 7 days Antiviral activity against human cytomegalovirus infected in human HS27 cells after 7 days by GFP-based fluorescent reduction assay, EC50=0.32μM. 20047911
Vero Antiviral assay 36 hrs Antiviral activity against HSV 2 infected in African green monkey Vero cells assessed as reduction in plaque formation incubated for 36 hrs by crystal violet staining based assay, EC50=0.58μM. 32191456
HEL Antiviral assay 5 days Antiviral activity against Varicella zoster virus OKA infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 5 days, EC50=0.59μM. 19339082
Vero Antiviral assay 36 to 48 hrs Antiviral activity against Herpes simplex virus 1 F infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs, EC50=0.7μM. 17438061
HFF Antiviral assay 8 to 10 days Antiviral activity against HCMV TB40 infected in human HFF cells assessed as reduction in plaque formation treated with compound following viral infection and incubated for 8 to 10 days by crystal violet staining based assay, EC50=0.72μM. 32191456
fibroblast cells Antiviral assay 1 hour Antiviral activity against human cytomegalovirus Ad169 (WT) plaque forming unit grown on Human foreskin fibroblast cells upon incubation for 1 hour at 37 degrees C with compound dissolved in DMSO, IC50=0.8μM. 16134946
fibroblast cells Antiviral assay 1 hour Antiviral activity against human cytomegalovirus Ad169 (V823A) plaque forming unit grown on Human foreskin fibroblast cells upon incubation for 1 hour at 37 degrees C with compound dissolved in DMSO, IC50=0.8μM. 16134946
HEL Antiviral assay 4 days Antiviral activity against acyclovir-resistant TK-deficient Herpes simplex virus-1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 4 days by microscopic analysis, EC50=0.8μM. 21696963
HELF Antiviral assay 7 days Antiviral activity against Herpes simplex virus 1 TK-KOS-ACV infected in human HELF cells assessed as reduction in virus-induced cytopathogenicity incubated for 7 days by microscopic analysis, EC50=0.8μM. 31586832
Vero Antiviral assay 3 days Antiviral activity against Herpes simplex virus 1 strain F VR-733 infected in African green monkey Vero cells after 3 days by MTT assay, EC50=0.9μM. 26460883
MEF Antiviral assay 3 days Antiviral activity against Mouse Cytomegalovirus Smith (ATCC VR-1399) infected in mouse MEF cells assessed as reduction in plaque formation measured after 3 days by crystal violet staining based assay, EC50=0.96μM. 32191456
HFF Antiviral assay 5 days Antiviral activity against HCMV infected HFF cells after 5 days by dot blot assay, IC50=1μM. 17329103
HEL Antiviral assay 5 days Antiviral activity against Varicella zoster virus YS infected in human HEL cells assessed as inhibition of virus induced cytopathicity after 5 days, EC50=1.1μM. 19339082
CRFK Antiviral assay 3 days Antiviral activity against Feline herpesvirus infected in CRFK cells assessed as inhibition of virus-induced cytopathicity after 3 days, EC50=1.2μM. 23047229
HEL Antiviral assay 7days Antiviral activity against human cytomegalovirus Davis in HEL cells assessed as reduction of plaque formation after 7days, EC50=1.3μM. 17539622
HEL Antiviral assay 3 days Antiviral activity against HCMV Davis infected in HEL cells assessed as reduction of virus-induced cytopathogenicity after 3 days, EC50=1.3μM. 17961851
Vero Antiviral assay 3 days Antiviral activity against Herpes simplex virus 2 strain MS VR-540 infected in African green monkey Vero cells after 3 days by MTT assay, EC50=1.4μM. 26460883
MRC5 Antiviral assay 7 days Antiviral activity against human cytomegalovirus infected in human MRC5 cells after 7 days by GFP-based fluorescent reduction assay, EC50=1.65μM. 20047911
HEL Antiviral assay 4 days Antiviral activity against Cytomegalovirus AD-169 infected in HEL cells assessed as inhibition of virus plaque formation after 4 days, EC50=1.65μM. 22459876
HEL Antiviral assay 4 days Antiviral activity against Human cytomegalovirus Davis infected in HEL cells assessed as inhibition of virus plaque formation after 4 days, EC50=1.65μM. 22459876
HEL Antiviral assay 7 days Antiviral activity against HCMV AD169 infected in human HEL cells assessed inhibition of virus-induced cytopathicity after 7 days postinfection, EC50=2μM. 19226140
HFF Antiviral assay 8 days Antiviral activity against HCMV infected in human HFF cells assessed as reduction in cytopathic effect after 8 days by plaque reduction assay, IC50=2.1μM. 22607883
HFF Antiviral assay 8 to 10 days Antiviral activity against HCMV Towne infected in human HFF cells assessed as reduction in plaque formation treated with compound following viral infection and incubated for 8 to 10 days by crystal violet staining based assay, EC50=2.1μM. 32191456
Vero Antiviral assay 3 days Antiviral activity against Human cytomegalovirus Davis VR-807 infected in African green monkey Vero cells after 3 days by MTT assay, EC50=2.14μM. 26460883
HEL Antiviral assay 5 days Antiviral activity against TK+ VZV YS in HEL cells assessed as reduction of virus plaque formation after 5 days, EC50=2.3μM. 17622128
HELF Antiviral assay 7 days Antiviral activity against Cytomegalovirus Davis infected in human HELF cells assessed as reduction in virus-induced cytopathogenicity incubated for 7 days by Giemsa staining based microscopic analysis, EC50=2.3μM. 31586832
HEL299 Antiviral assay 7 days Antiviral activity against human cytomegalovirus infected in HEL299 cells after 7 days by GFP-based fluorescent reduction assay, EC50=2.39μM. 20047911
HEL Antiviral assay 7 days Antiviral activity against human cytomegalovirus Davis infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 7 days post infection, EC50=2.5μM. 19339082
HEL Antiviral assay 5 days Antiviral activity against thymidine kinase deficient Varicella zoster virus 07/1 infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 5 days, EC50=2.5μM. 19339082
HEL Antiviral assay 7 days Antiviral activity against CMV Davis in human HEL cells after 7 days, EC50=2.6μM. 17672445
hhTERT-BJ1 Antiviral assay 2 days Antiviral activity against Human cytomegalovirus Towne infected in human hhTERT-BJ1 cells assessed as inhibition of virus mediated DNA synthesis after 2 days, EC50=3μM. 18458124
HEL Antiviral assay 7 days Antiviral activity against acyclovir-resistant thymidine kinase deficient HSV1 KOS infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 7 days, EC50=3μM. 21128666
HFF Antiviral assay 10 days Antiviral activity against Human cytomegalovirus Towne infected in HFF cells assessed as reduction in plaque formation after 10 days, IC50=3μM. 21641218
HELF Antiviral assay 7 days Antiviral activity against Cytomegalovirus AD169 infected in human HELF cells assessed as reduction in virus-induced cytopathogenicity incubated for 7 days by Giemsa staining based microscopic analysis, EC50=3.15μM. 31586832
HEL Antiviral assay 6 to 7 days Antiviral activity against Human cytomegalovirus Davis infected in HEL cells assessed as inhibition of virus-induced cytopathic effect measured after 6 to 7 days post-infection, EC50=3.31μM. 29670705
HEL Antiviral assay 7 days Antiviral activity against HCMV Davis infected in human HEL cells assessed inhibition of virus-induced cytopathicity after 7 days postinfection, EC50=3.6μM. 19226140
HEL Antiviral assay 2 to 3 days Antiviral activity against thymidine kinase-deficient ACV-resistant Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of plaque formation measured after 2 to 3 days post infection, EC50=3.91μM. 29550734
CRFK Antiviral assay 4 days Antiviral activity against Feline herpesvirus infected in cat CRFK cells assessed as inhibition of virus-induced cytopathic effect after 4 days by colorimetric formazan-based MTS assay, EC50=4.1μM. 22459876
HEL Antiviral assay 7 days Antiviral activity against Human cytomegalovirus Davis expressed in HEL cells assessed as reduction in plaque formation incubated for 7 days by Giemsa stain based microscopy, EC50=4.72μM. 26291038
HEL Antiviral assay 7 days Antiviral activity against human cytomegalovirus AD169 in HEL cells assessed as reduction of plaque formation after 7 days, EC50=4.8μM. 17539622
HEL Antiviral assay 3 days Antiviral activity against HCMV AD169 infected in HEL cells assessed as reduction of virus-induced cytopathogenicity after 3 days, EC50=4.8μM. 17961851
HEL Antiviral assay 6 to 7 days Antiviral activity against Human cytomegalovirus Davis infected in HEL cells assessed as inhibition of plaque formation measured after 6 to 7 days post infection, EC50=4.83μM. 29550734
HFF Antiviral assay 5 to 7 days Antiviral activity against HCMV infected HFF cells after 5 to 7 days by viral yield assay, EC99.9=5μM. 17329103
HEL Antiviral assay 7 days Antiviral activity against HCMV AD169 in HEL cells assessed as reduction of virus plaque formation after 7 days, EC50=5.1μM. 17622128
HEL Antiviral assay 7 days Antiviral activity against HCMV AD169/Davis infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 7 days, EC50=5.2μM. 21128666
AKATA Antiviral assay 48 hrs Antiviral activity against EBV infected in human AKATA cells assessed as reduction in IgG-induced lytic virus replication measured at 48 hrs post-lytic induction by qRT-PCR analysis, EC50=5.2μM. 32191456
NIH 3T3 Antiviral assay 4 to 5 days Antiviral activity against Murine cytomegalovirus strain Smith infected in mouse NIH 3T3 cells after 4 to 5 days by plaque reduction assay, EC50=5.7μM. 18458124
RG2TK+ Cytotoxicity assay 72 hrs Cytotoxicity against HSV1-tk gene overexpressing RG2TK+ cells after 72 hrs by MTT assay, CC50=5.86μM. 18800764
HEL Antiviral assay 3 days Antiviral activity against acyclovir-resistant TK-deficient Hepres simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTT assay, EC50=6μM. ChEMBL
HEL Antiviral assay 7 days Antiviral activity against Human cytomegalovirus AD169 expressed in HEL cells assessed as reduction in plaque formation incubated for 7 days by Giemsa stain based microscopy, EC50=6.12μM. 26291038
HEL Antiviral assay 6 to 7 days Antiviral activity against Human cytomegalovirus AD169 infected in HEL cells assessed as inhibition of plaque formation measured after 6 to 7 days post infection, EC50=6.46μM. 29550734
HEL Antiviral assay 7 days Antiviral activity against CMV AD169 in human HEL cells after 7 days, EC50=6.5μM. 17672445
CRFK Antiviral assay 3 days Antiviral activity against Felid herpesvirus 1 infected cat CRFK cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay, EC50=7.3μM. ChEMBL
HEL Antiviral assay 6 to 7 days Antiviral activity against Human cytomegalovirus AD169 infected in HEL cells assessed as inhibition of virus-induced cytopathic effect measured after 6 to 7 days post-infection, EC50=7.41μM. 29670705
HEL Antiviral assay 7 days Antiviral activity against HCMV Davis in HEL cells assessed as reduction of virus plaque formation after 7 days, EC50=8.7μM. 17622128
Vero Antiviral assay 3 days Antiviral activity against Varicella-zoster virus Ellen VR-1367 infected in African green monkey Vero cells after 3 days by MTT assay, EC50=11.1μM. 26460883
HEL Antiviral assay 7 days Antiviral activity against human cytomegalovirus AD169 infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 7 days post infection, EC50=12.6μM. 19339082
Vero Antiviral assay 36 to 48 hrs Antiviral activity against Herpes B virus 24105 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs, EC50=14.5μM. 17438061
Vero Antiviral assay 36 to 48 hrs Antiviral activity against Herpes B virus E90-136 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs, EC50=19.2μM. 17438061
Vero Antiviral assay 36 to 48 hrs Antiviral activity against Herpes B virus 32425 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs, EC50=23.5μM. 17438061
HFF Antiviral assay 8 to 10 days Antiviral activity against GCV-resistant HCMV Towne infected in human HFF cells assessed as reduction in plaque formation treated with compound following viral infection and incubated for 8 to 10 days by crystal violet staining based assay, EC50=29.7μM. 32191456
bone marrow cells Cytotoxicity assay 15 days Cytotoxicity against human bone marrow cells assessed as inhibition of CFU-GM formation after 15 days, CC50=30μM. 17329103
HFF Antiviral assay 6 hrs Antiviral activity against pp28-luciferase expressing HCMV Towne infected in human HFF cells assessed as reduction in viral replication treated with compound immediately after viral infection at MOI of 1 PFU/cell followed by compound washout after 6 hrs a 32191456
HEL Antiviral assay Antiviral activity against HSV2 G infected in HEL cells assessed as inhibition of virus-induced cytopathic effect, EC50=0.013μM. 23099097
HEL Antiviral assay Antiviral activity against HSV-1 KOS infected in HEL cells assessed as inhibition of viral-induced cytopathogenicity, EC50=0.01μM. 23795238
HEL Antiviral assay Antiviral activity against HSV-2 G infected in HEL cells assessed as inhibition of viral-induced cytopathogenicity, EC50=0.01μM. 23795238
HEL Antiviral assay Antiviral activity against HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect, EC50=0.01μM. 21232828
HEL Antiviral assay Antiviral activity against HSV2 G in HEL cells assessed as reduction of virus-induced cytopathogenicity, MIC=0.0064μM. 17672445
OST TK- cells Cytotoxicity assay Cytotoxicity against human OST TK- cells expressing HSV1 TK, IC50=0.0019μM. 17181158
E6SM cell lines Function assay Effective concentration required to inhibit Herpes simplex virus-2 (HSV-2) induced cytopathicity by 50% in E6SM cell lines, EC50=1.2 nM 11495586
HEL Antiviral assay Antiviral activity against HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect, EC50=0.015μM. 23099097
OST TK- cells Cytotoxicity assay Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 2.5 uM 1-[6-(triphenylmethoxy)hexyl]thymine, IC50=0.018μM. 17181158
HEL Antiviral assay Antiviral activity against HSV1 KOS in HEL cells, EC50=0.019μM. 17181162
HEL Antiviral assay Antiviral activity against HSV1 KOS in human HEL cells assessed as protection against virus-induced cytopathicity, EC50=0.02μM. 19281225
HEL Antiviral assay Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as reduction of virus-induced cytopathogenicity, EC50=0.02μM. 26001344
HEL Antiviral assay Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathicity, EC50=0.02μM. 29880251
HEL Antiviral assay Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as inhibition of virus-induced cytopathicity, EC50=0.02μM. 29880251
HEL Antiviral assay Antiviral activity against Human herpesvirus 2 G infected in HEL cells assessed as protection against virus-induced cytopathicity, EC50=0.027μM. 21565516
HEL Antiviral assay Antiviral activity against HSV1 KOS infected in HEL cells by viral CPE assay, EC50=0.027μM. 22858222
HEL Antiviral assay Antiviral activity against HSV2 G infected in HEL cells by viral CPE assay, EC50=0.029μM. 22858222
HEL Antiviral assay Antiviral activity against Human herpesvirus 1 KOS infected in HEL cells assessed as protection against virus-induced cytopathicity, EC50=0.03μM. 21565516
HEL Antiviral assay Antiviral activity against Herpes simplex virus-2 G infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity, EC50=0.03μM. 23811093
HEL Antiviral assay Antiviral activity against Herpes simplex virus-1 KOS infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity, EC50=0.03μM. 23811093
HEL Antiviral assay Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as reduction of virus-induced cytopathogenicity, EC50=0.03μM. 26001344
HEL Antiviral assay Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as inhibition of virus plaque formation, EC50=0.03μM. 27639368
HELF Antiviral assay Antiviral activity against Human herpesvirus 1 KOS strain infected in HELF cells assessed as inhibition of virus-induced cytopathogenicity, EC50=0.03μM. 30098481
HELF Antiviral assay Antiviral activity against Human herpesvirus 2 G strain infected in HELF cells assessed as inhibition of virus-induced cytopathogenicity, EC50=0.03μM. 30098481
HEL Antiviral assay Antiviral activity against Herpes simplex virus 1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect, EC50=0.03μM. 28829913
HEL Antiviral assay Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as inhibition of virus-induced cytopathic effect, EC50=0.03μM. 28757102
HEL Antiviral assay Antiviral activity against HSV2 in HEL cells, EC50=0.032μM. 17181162
HEL Antiviral assay Antiviral activity against HSV1 KOS in HEL cells assessed as reduction of virus-induced cytopathogenicity, MIC=0.032μM. 17672445
HEL Antiviral assay Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as reduction in virus-induced cytopathogenicity, EC50=0.032μM. 27750154
OST TK- cells Cytotoxicity assay Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 5 uM 1-[6-(triphenylmethoxy)hexyl]thymine, IC50=0.033μM. 17181158
fibroblast cells Antiviral assay Antiviral activity against Human cytomegalovirus AD169 infected in human foreskin fibroblast cells assessed as inhibition of virus-induced cytopathic effect, EC50=0.04μM. 19397271
HEL Antiviral assay Antiviral activity against HSV2 G infected in HEL cells assessed as inhibition of virus-induced cytopathic effect, EC50=0.04μM. 21232828
HEL Antiviral assay Antiviral activity against Herpes simplex virus 2 G infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect, EC50=0.04μM. 28829913
HEL Antiviral assay Antiviral activity against wild type Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect, EC50=0.04μM. 28757102
OST TK- cells Cytotoxicity assay Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 10 uM 1-[6-(triphenylmethoxy)hexyl]thymine, IC50=0.041μM. 17181158
OST TK- cells Cytotoxicity assay Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 2.5 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine, IC50=0.05μM. 17181158
HEL Antiviral assay Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as reduction in virus-induced cytopathogenicity, EC50=0.055μM. 27750154
HEL Function assay Compound was tested for anti-viral activity against HSV-1(G) in HEL cells, EC50=0.06μM. 14643328
Hel Function assay Effective concentration required to inhibit herpes simplex virus type 1 Kos strain induced cytopathicity in Hel cells, EC50=0.06μM. 15658858
HEL Antiviral assay Antiviral activity against HSV1 KOS in HEL cells, EC50=0.06μM. 16392791
HEL Antiviral assay Antiviral activity against HSV2 G in HEL cells, EC50=0.06μM. 16392791
HEL Antiviral assay Antiviral activity against herpes simplex virus 1 KOS infected in HEL cells assessed as reduction in virus-induced cytopathogenicity by microscopic analysis, EC50=0.07μM. 30738653
OST TK- cells Cytotoxicity assay Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 5 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine, IC50=0.081μM. 17181158
HEL Antiviral assay Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus plaque formation, EC50=0.09μM. 27639368
E6SM Antiviral assay Antiviral activity against HSV1 KOS-induced cytopathogenicity in E6SM cells, MIC=0.096μM. 17092728
E6SM Antiviral assay Antiviral activity against HSV2 G-induced cytopathogenicity in E6SM cells, MIC=0.096μM. 17092728
HEL Antiviral assay Antiviral activity against thymidine kinase deficient acyclovir-resistant HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect, EC50=0.1μM. 21232828
HEL Antiviral assay Antiviral activity against thymidine kinase-deficient ACV-resistant Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect, EC50=0.1μM. 28757102
OST TK- cells Cytotoxicity assay Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 10 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine, IC50=0.11μM. 17181158
HFF Function assay Inhibition of HCMV AD169 replication in HFF cells by cytopathic effect assay, EC50=0.15μM. 17004726
MCA-TK Cytotoxicity assay Cytotoxicity against MCA-TK cells, IC50=0.15μM. 17960926
vero Antiviral assay Antiviral activity was determined in plaque reduction assay in vero cells against HSV-1 F strain, ID50=0.2μM. 3871860
Vero Antiviral assay In vitro antiviral activity was measured against HSV-1(F) in Vero cells, ID50=0.2μM. 3009811
Vero Antiviral assay Antiviral activity determined against herpes simplex type 1 (F strain) by plaque reduction in Vero cells, ID50=0.2μM. 3016263
HEL Antiviral assay Antiviral activity against HSV2 G in human HEL cells assessed as protection against virus-induced cytopathicity, EC50=0.2μM. 19281225
fibroblast cells Function assay Inhibition of viral cytopathic effect in infected human foreskin fibroblast cell in monolayers of HSV-2 AD Vero cells by 50%, EC50=0.23μM. 11585457
HEL Antiviral assay Antiviral activity against Cytomegalovirus AD169 infected in HEL cells, EC50=0.25μM. 27128178
vero Antiviral assay In vitro antiviral and anticellular activity was evaluated against herpes simplex virus HSV-1 (F strain) in vero cells tissue culture, ID50=0.3μM. 2993615
HEL Antiviral assay Antiviral activity against Cytomegalovirus Davis infected in human HEL cells assessed as reduction in virus plaque formation, EC50=0.38μM. 23911856
HEL Antiviral assay Antiviral activity against Cytomegalovirus Davis 07/1 infected in HEL cells, EC50=0.4μM. 27128178
HEL Antiviral assay Antiviral activity against herpes simplex virus 2 G infected in HEL cells assessed as reduction in virus-induced cytopathogenicity by microscopic analysis, EC50=0.4μM. 30738653
HEL Antiviral assay Antiviral activity against HSV1 KOS in HEL cells, EC50=0.48μM. 17181162
HFF Function assay Inhibitory concentration of the drug against the cytopathic effect for AD169 strain of epstein barr virus-2 (HCMV) in human HFF cells, EC50=0.5μM. 8394933
HEL Function assay Inhibition of human CMV DNA synthesis in CMV-infected HEL cells, IC50=0.5μM. 7752205
HEL Antiviral assay Antiviral activity against thymidine kinase-deficient acyclovir-resistant Herpes simplex virus 1 KOS infected in HEL cells assessed as reduction of virus-induced cytopathogenicity, EC50=0.5μM. 26001344
HELF Antiviral assay Antiviral activity against thymidine kinase-deficient acyclovir-resistant Human herpesvirus 1 KOS strain infected in HELF cells assessed as inhibition of virus-induced cytopathogenicity, EC50=0.5μM. 30098481
HEL Antiviral assay Antiviral activity against wild type HCMV Davis infected in HEL cells assessed as inhibition of virus-induced cytopathicity, EC50=0.66μM. 19226140
HEL Antiviral assay Antiviral activity against acyclovir-resistant HCMV AD169 clone 1 infected in HEL cells assessed as inhibition of virus-induced cytopathicity, EC50=0.69μM. 19226140
HEL Antiviral assay Antiviral activity against wild type HCMV AD169 infected in HEL cells assessed as inhibition of virus-induced cytopathicity, EC50=0.7μM. 19226140
E6SM Antiviral assay Antiviral activity against HSV1 TK- KOS ACV-induced cytopathogenicity in E6SM cells, MIC=0.8μM. 17092728
HEL Antiviral assay Antiviral activity against acyclovir-resistant thymidine kinase deficient Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathicity, EC50=0.8μM. 29880251
HEL Antiviral assay Antiviral activity against thymidine kinase deficient and aciclovir resistant herpes simplex virus 1 KOS infected in HEL cells assessed as reduction in virus-induced cytopathogenicity by microscopic analysis, EC50=0.8μM. 30738653
HEL Antiviral assay Antiviral activity against Herpes simplex virus-2 G infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity, EC50=0.9μM. 23911856
CRFK Antiviral assay Antiviral activity against Feline Herpes virus infected in cat CRFK cells assessed as inhibition of virus-induced cytopathic effect by MTS assay, EC50=0.9μM. 23911856
MRC5 Antiviral assay Antiviral activity against HCMV in MRC5 cells by plaque reduction assay, IC50=0.91μM. 17239594
HEL Antiviral assay Antiviral activity against ACV-resistant TK-deficient HSV-1 KOS infected in HEL cells assessed as inhibition of viral-induced cytopathogenicity, EC50=1μM. 23795238
HFF Antiviral assay Antiviral activity against Cytomegalovirus CMV T2211 infected in HFF cells by SEAP reporter gene assay, EC50=1.1μM. 17709468
CRFK Antiviral assay Antiviral activity against Feline herpesvirus infected in CRFK cells by viral CPE assay, EC50=1.15μM. 22858222
HEL Antiviral assay Antiviral activity against HPMPA-resistant HCMV AD169 clone 2 mutant infected in HEL cells assessed as inhibition of virus-induced cytopathicity, EC50=1.2μM. 19226140
fibroblast cells Antiviral assay Antiviral activity against Human cytomegalovirus Towne infected in human foreskin fibroblast cells by plaque reduction assay, EC50=1.2μM. 19397271
HFF Function assay Inhibitory concentration required against human cytomegalovirus (HCMV) wild type expressed in HFF cells was determined by plaque reduction assay, IC50=1.2μM. 15509176
HFF Function assay Inhibitory concentration required against human cytomegalovirus (HCMV) D10 strain (UL89 mutant gene) expressed in HFF cells was determined by plaque reduction assay, IC50=1.2μM. 15509176
HFF Function assay Inhibitory concentration required against human cytomegalovirus (HCMV) r56 strain (UL56 mutant gene) expressed in HFF cells was determined by plaque reduction assay, IC50=1.2μM. 15509176
FRCK Antiviral assay Antiviral activity against Feline herpesvirus in feline FRCK cells assessed as inhibition of virus-induced cytopathicity, EC50=1.2μM. 19281225
vero Antiviral assay In vitro antiviral and anticellular activity was evaluated against herpes simplex virus HSV-2 (G strain) in vero cells, ID50=1.3μM. 2993615
fibroblast cells Antiviral assay Antiviral activity against human cytomegalovirus (Davis strain) grown on human foreskin fibroblast cells determined by reduction in plaque formation upon incubation at 37 degrees C with the compound dissolved in DMSO, IC50=1.3μM. 16134946
HFF Antiviral assay Antiviral activity against Human CMV T2211 in HFF cells by SEAP assay, IC50=1.3μM. 17043128
HFF Antiviral assay Antiviral activity against HCMV Davis in HFF cells by plaque reduction assay, IC50=1.3μM. 17434304
HFF Antiviral assay Antiviral activity against Human cytomegalovirus infected in HFF cells by plaque reduction assay, IC50=1.3μM. 20167488
HFF Function assay Inhibition of HCMV DNA polymerase infected in HFF cells, IC50=1.3μM. 20403696
MRC5 Function assay Inhibitory concentration against Davis strain of HCMV in MRC5 cells, IC50=1.4μM. 11454465
HFF Antiviral assay Antiviral activity against Human CMV T2241 in HFF cells by SEAP assay, IC50=1.4μM. 17043128
HFF Antiviral assay Antiviral activity against Human CMV T2233 in HFF cells by SEAP assay, IC50=1.4μM. 17043128
MRC5 Function assay Inhibitory concentration against Towne strain of HCMV in MRC5 cells, IC50=1.5μM. 11454465
CCL81 Antiviral assay Antiviral activity against HSV1 in CCL81 cells, EC50=1.5μM. 17188402
CCL81 Antiviral assay Antiviral activity against HSV2 in CCL81 cells, EC50=1.5μM. 17188402
MRC5 Function assay Inhibitory concentration against 2599R strain of HCMV in MRC5 cells, IC50=1.6μM. 11454465
Vero Antiviral assay In vitro antiviral activity was measured against HSV-2(G) in Vero cells, ID50=1.6μM. 3009811
HFF Function assay In vitro reduction in yield of Towne strain of HCMV in HFF (human fibroblast) cells, IC90=1.6μM. 9057865
HFF Function assay Inhibitory concentration against human cytomegalovirus replication in HFF cells was determined by yield reduction assay, IC90=1.6μM. 9438017
HFF Function assay Compound was tested for antiviral activity against Towne strain of HCMV in a yield reduction assay using HFF cells, IC90=1.6μM. 10882374
HFF Function assay Compound was tested for antiviral activity against human cytomegalovirus (HCMV) by yield reduction assay using HFF cells, IC90=1.6μM. 10882375
HFF Antiviral assay Antiviral activity against towne strain HCMV was determined by yield reduction assay in duplicate wells using HFF cells, IC90=1.6μM. 10882370
HFF Antiviral assay Antiviral activity against HCMV was determined by yield reduction assay using HFF cells, IC90=1.6μM. 10882372
HFF Function assay Inhibition of HCMV towne replication in HFF cells by plaque reduction assay, EC50=1.8μM. 17004726
HFF Antiviral assay Antiviral activity against Human CMV AD169 in HFF cells by PRA, IC50=1.9μM. 17043128
HFF Function assay Inhibition of HCMV Towne replication in HFF cells by plaque reduction assay, EC50=2.1μM. 15615545
HEL Antiviral assay Antiviral activity against Human cytomegalovirus Davis infected in HEL cells assessed as inhibition of virus plaque formation, EC50=2.1μM. 27639368
HFF Function assay Inhibition of HCMV AD169 replication in HFF cells by CPE inhibition assay, EC50=2.2μM. 15615545
HEL Antiviral assay Antiviral activity against Human cytomegalovirus Davis infected in HEL cells assessed as inhibition of virus-induced cytopathicity, EC50=2.29μM. 29880251
HFF Function assay Inhibitory concentration required against human cytomegalovirus (HCMV) C4 strain (UL56 + UL89 mutant gene) expressed in HFF cells was determined by plaque reduction assay, IC50=2.5μM. 15509176
HFF Antiviral assay Antiviral activity against Human cytomegalovirus Towne infected in HFF cells by plaque reduction assay, EC50=2.5μM. 18082410
HFF Function assay Inhibitory concentration against human cytomegalovirus replication in HFF cells was determined by cytopathic effect inhibition assay, IC50=2.6μM. 9438017
HEL Antiviral assay Antiviral activity against foscarnet-resistant HCMV AD169 clone C infected in HEL cells assessed as inhibition of virus-induced cytopathicity, EC50=2.6μM. 19226140
HFF Antiviral assay Antiviral activity against Cytomegalovirus CMV T2417 with pol A809V mutant infected in HFF cells by SEAP reporter gene assay, EC50=2.6μM. 17709468
CRFK Antiviral assay Antiviral activity against Feline herpesvirus infected in cat CRFK cells assessed as protection from virus-induced cytopathogenicity by MTT assay, EC50=2.6μM. 20034711
HFF Antiviral assay Antiviral activity against Cytomegalovirus CMV T2542 with pol T813S mutant infected in HFF cells by SEAP reporter gene assay, EC50=2.7μM. 17709468
HEL Antiviral assay Antiviral activity against HCMV Davis in HEL cells assessed as reduction of virus plaque formation, EC50=2.75μM. 17518459
HEL Antiviral assay Antiviral activity against Human cytomegalovirus Davis infected in HEL cells assessed as inhibition of virus-induced cytopathic effect, EC50=2.96μM. 28757102
BSC-1 Antiviral assay Antiviral activity of the compound was evaluated against the Herpes simplex virus type-1 in BSC-1 cells, IC50=3μM. 2913300
MRC5 Function assay Inhibitory concentration against AD169 strain of HCMV in MRC5 cells, IC50=3μM. 11454465
HFF Antiviral assay Antiviral activity against HCMV Towne in HFF cells by plaque reduction assay, IC50=3μM. 17161946
HEL Antiviral assay Antiviral activity against Cytomegalovirus AD-169 infected in human HEL cells assessed as reduction in virus plaque formation, EC50=3.1μM. 23911856
HEL Antiviral assay Antiviral activity against Human cytomegalovirus AD169 infected in HEL cells assessed as inhibition of virus plaque formation, EC50=3.1μM. 27639368
HFF Antiviral assay Antiviral activity against ganciclovir-sensitive HCMV1 isolate replication in HFF cells by plaque reduction assay, IC50=3.22μM. 19010684
HFF Function assay Compound was tested for antiviral activity against wild-type AD169 strain of HCMV in yield reduction assay using HFF cells, IC90=3.3μM. 10882374
MEF Function assay Inhibitory concentration against murine cytomegalovirus replication in MEF cells was determined by plaque reduction assay, IC50=3.4μM. 9438017
BSC-1 Antiviral assay Antiviral activity against HSV-1 (herpes simplex virus), determined by ELISA in quadruplicate wells using BSC-1 cells, IC50=3.5μM. 10882370
BSC-1 Function assay ELISA assay was performed using BSC-1 cells to determine activity against HSV-1, IC50=3.5μM. 10882372
BSC-1 Antiviral assay In vitro antiviral activity against HSV-1 virus in BSC-1 (monkey kidney) cells, IC50=3.5μM. 9057865
HEL Antiviral assay Antiviral activity against PMEDAP-resistant HCMV AD169 clone 4 infected in HEL cells assessed as inhibition of virus-induced cytopathicity, EC50=3.5μM. 19226140
HFF Antiviral assay Antiviral activity against Cytomegalovirus CMV T2420 with pol G841A mutant infected in HFF cells by SEAP reporter gene assay, EC50=3.5μM. 17709468
BSC-1 Function assay Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay, IC50=3.5μM. 15509174
BSC-1 Function assay Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay, IC50=3.5μM. 15509175
BSC-1 Function assay Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay, IC50=3.5μM. 15509176
HFF Function assay Compound was tested for antiviral activity against 2916 AD169 strain of HCMV in yield reduction assay using HFF cells, IC90=3.6μM. 10882374
HFF Antiviral assay Antiviral activity against Cytomegalovirus CMV T2258 with UL97 C592G mutant infected in HFF cells by SEAP reporter gene assay, EC50=3.9μM. 17709468
MRC-5 Antiherpesvirus assay In vitro antiherpesvirus activity against MRC-5 cells infected with HCMV (AD-169 strain), IC50=4μM. 1323678
HEL Antiviral assay Antiviral activity against cidofovir HCMV AD169 clone 5 infected in human HEL cells assessed as inhibition of virus-induced cytopathicity, EC50=4μM. 19226140
HEL Antiviral assay Antiviral activity against thymidine kinase deficient and acyclovir-resistant HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect, EC50=4μM. 23099097
HEL Antiviral assay Antiviral activity against TK-negative Herpes simplex virus 1 KOS infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity, EC50=4μM. 23811093
HEL Antiviral assay Antiviral activity against thymidine kinase-deficient acyclovir-resistant Herpes simplex virus 1 KOS infected in HEL cells assessed as reduction in virus-induced cytopathogenicity, EC50=4μM. 27750154
HEL Antiviral assay Antiviral activity against Human cytomegalovirus Davis infected in HEL cells assessed as reduction in viral cytopathic effect, EC50=4.05μM. 29407990
HFF Function assay Compound was tested for antiviral activity against C-4 Towne strain of HCMV in yield reduction assay using HFF cells, IC50=4.1μM. 10882374
HFF Antiviral assay Antiviral activity against Human CMV T2291 in HFF cells by PRA, IC50=4.1μM. 17043128
CRFK Antiviral assay Antiviral activity against feline herpesvirus infected in cat CRFK cells assessed as reduction of virus-induced cytopathogenicity by MTS assay, EC50=4.1μM. 23811093
HEL Antiviral assay Antiviral activity against ganciclovir-resistant HCMV AD169 clone 4 infected in HEL cells assessed as inhibition of virus-induced cytopathicity, EC50=4.3μM. 19226140
HEL Antiviral assay Antiviral activity against ACV-resistant thymidine kinase deficient Herpes simplex virus 1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect, EC50=4.3μM. 28829913
HFF Function assay Compound was tested for antiviral activity against wild-type Towne strain of HCMV in yield reduction assay using HFF cells, IC50=4.5μM. 10882374
MRC5 Antiviral assay Antiviral activity against Human CMV Towne in MRC5 cells by PRA, IC50=4.9μM. 17043128
MRC5 Antiviral assay In vitro antiviral activity was measured against HCMV(AD-169) in MRC5 cells, ID50=5μM. 3009811
H-1 Function assay Effective concentration required to inhibit Epstein-barr virus replication in H-1 cells in DNA hybridization assay, EC50=5μM. 15634003
H1 Function assay Inhibition of EBV replication in H1 cells by DNA hybridization assay, EC50=5μM. 17004726
H1 Function assay Inhibition of EBV replication in H1 cells by DNA hybridization assay, EC50=5μM. 15615545
CEM Cytotoxicity assay Cytotoxicity against CEM cells, CC50=5μM. 15615545
MRC5 Antiviral assay Antiviral activity against Human CMV T2296 in MRC5 cells by PRA, IC50=5.4μM. 17043128
fibroblast cells Antiviral assay Antiviral activity against Murine cytomegalovirus infected in mouse embryonic fibroblast cells by plaque reduction assay, EC50=5.5μM. 19397271
HFF Antiviral assay Antiviral activity against Human CMV T2293 in HFF cells by SEAP assay, IC50=5.6μM. 17043128
HEL Antiviral assay Antiviral activity against Human cytomegalovirus AD169 infected in HEL cells assessed as reduction in viral cytopathic effect, EC50=5.63μM. 29407990
MRC-5 Function assay Concentration required to reduce viral plaque formation by Human Cytomegalovirus (HCMV) (strain AD-169) in MRC-5 cells, IC50=5.9μM. 10966740
HEL Antiviral assay Antiviral activity against HCMV Davis infected in HEL cells by viral CPE assay, EC50=5.9μM. 22858222
HEL Antiviral assay Antiviral activity against Cytomegalovirus Davis infected in human HEL cells assessed as reduction of plaque formation, EC50=5.98μM. 23811093
HCMV AD 169 Antiviral assay In vitro antiviral and anticellular activity was evaluated against human cytomegalovirus (HCMV AD 169) in (HCMV AD 169) cells, ID50=6μM. 2993615
HEL Antiviral assay Antiviral activity against Human cytomegalovirus AD169 infected in HEL cells assessed as protection against virus-induced cytopathicity, EC50=6μM. 21565516
HFF Antiviral assay Antiviral activity against Cytomegalovirus CMV T2784 with pol A809V UL97 C592G double mutant infected in HFF cells by SEAP reporter gene assay, EC50=6.1μM. 17709468
MRC-5 Function assay Inhibitory concentration for anti-HCMV activity against AD-169 strain in MRC-5 cells, IC50=6.3μM. 9836613
HEL Antiviral assay Antiviral activity against HCMV AD169 in HEL cells assessed as reduction of virus plaque formation, EC50=6.3μM. 17518459
HEL Antiviral assay Antiviral activity against Cytomegalovirus AD-169 infected in HEL cells assessed as reduction of virus-induced cytopathogenicity, EC50=6.3μM. 26001344
HEL Antiviral assay Antiviral activity against Cytomegalovirus Davis infected in HEL cells assessed as reduction in virus plaque formation, EC50=6.5μM. 27750154
HELF Antiviral assay Antiviral activity against Human cytomegalovirus Davis strain infected in HELF cells assessed as inhibition of virus-induced cytopathogenicity, EC50=6.52μM. 30098481
HEL Antiviral assay Antiviral activity against Human cytomegalovirus Davis infected in HEL cells assessed as protection against virus-induced cytopathicity, EC50=6.54μM. 21565516
HFF Antiviral assay Antiviral activity against Cytomegalovirus CMV T2798 with pol T813S UL97 C592G double mutant infected in HFF cells by SEAP reporter gene assay, EC50=6.6μM. 17709468
HEL Antiviral assay Antiviral activity against Human cytomegalovirus AD169 infected in HEL cells assessed as inhibition of virus-induced cytopathic effect, EC50=6.79μM. 28757102
HEL Function assay Inhibition against DNA of uninfected HEL cells by incorporation of [3H]TdR, IC50=7μM. 7752205
HFF Antiviral assay Antiviral activity against Human CMV T2291 in HFF cells by SEAP assay, IC50=7.1μM. 17043128
HEL Antiviral assay Antiviral activity against Human cytomegalovirus Davis infected in HEL cells assessed as reduction in virus-induced cytopathicity, EC50=7.1μM. 22578783
HEL Antiviral assay Antiviral activity against Cytomegalovirus Davis infected in HEL cells assessed as reduction of virus-induced cytopathogenicity, EC50=7.1μM. 26001344
HEL Antiviral assay Antiviral activity against human cytomegalovirus Davis infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect, EC50=7.3μM. 28829913
HFF Antiviral assay In vitro antiviral activity against HCMV (Towne strain) in HFF (human fibroblast) cells, IC50=7.4μM. 9057865
HFF Function assay Inhibitory concentration against human cytomegalovirus replication in HFF cells was determined by plaque reduction assay, IC50=7.4μM. 9438017
HFF Function assay Compound was tested for antiviral activity against Towne strain of HCMV in a plaque reduction assay using HFF cells, IC50=7.4μM. 10882374
HFF Function assay Compound was tested for antiviral activity against human cytomegalovirus (HCMV) by plaque reduction assay using HFF cells, IC50=7.4μM. 10882375
HFF Antiviral assay Antiviral activity against towne strain HCMV was determined by plaque reduction assay in duplicate wells using HFF cells, IC50=7.4μM. 10882370
HFF Antiviral assay Antiviral activity against HCMV was determined by plaque reduction assay using HFF cells, IC50=7.4μM. 10882372
HFF Function assay Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay, IC50=7.4μM. 15509174
HFF Function assay Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay, IC50=7.4μM. 15509175
HFF Function assay Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay, IC50=7.4μM. 15509176
HEL Antiviral assay Antiviral activity against human cytomegalovirus AD-169 infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect, EC50=7.4μM. 28829913
HEL Antiviral assay Antiviral activity against Human cytomegalovirus AD169 infected in HEL cells assessed as reduction in virus-induced cytopathicity, EC50=7.5μM. 22578783
HFF Antiviral assay Antiviral activity was determined by the HCMV plaque assay using HFF cells, IC50=7.7μM. 9057866
HEL Antiviral assay Antiviral activity against human cytomegalovirus Davis infected in HEL cells assessed as reduction in viral plaque formation, EC50=7.8μM. 26443550
HEL Antiviral assay Antiviral activity against Cytomegalovirus AD-169 infected in human HEL cells assessed as reduction of plaque formation, EC50=7.87μM. 23811093
CRFK Antiviral assay Antiviral activity against Feline herpesvirus infected in CRFK cells assessed as protection against virus-induced cytopathicity, EC50=8.1μM. 21565516
HEL Antiviral assay Antiviral activity against human Cytomegalovirus AD169 infected in HEL cells assessed as inhibition of virus-induced cytopathicity after, EC50=8.2μM. 23911854
HFF Function assay In vitro inhibition of human cytomegalovirus in HFF cells by plaque reduction assay, IC50=8.4μM. ChEMBL
HFF Antiviral assay Antiviral activity against Cytomegalovirus CMV 2817 with pol G841A UL97 C592G double mutant infected in HFF cells by SEAP reporter gene assay, EC50=8.4μM. 17709468
HEL Antiviral assay Antiviral activity against Human cytomegalovirus AD169 infected in HEL cells assessed as inhibition of virus-induced cytopathic effect, EC50=8.7μM. 28682067
HEL Antiviral assay Antiviral activity against thymidine kinase deficient and acyclovir resistant HSV1 KOS in human HEL cells assessed as protection against virus-induced cytopathicity, EC50=9μM. 19281225
HEL Antiviral assay Antiviral activity against HCMV AD169 infected in HEL cells by viral CPE assay, EC50=9.1μM. 22858222
MRC-5 Function assay Inhibitory activity of compound against human cytomegalovirus (HCMV) in MRC-5 cells, EC50=9.4μM. 12723951
Vero Antiviral assay In vitro antiviral activity was measured against HSV-1 (F delta 305) in Vero cells, ID50=10μM. 3009811
HFF Antiviral assay Antiviral activity against Human CMV T2293 in HFF cells by PRA, IC50=10μM. 17043128
HEL Antiviral assay Antiviral activity against Human cytomegalovirus AD169 infected in HEL cells assessed as inhibition of virus-induced cytopathicity, EC50=11.43μM. 29880251
HELF Antiviral assay Antiviral activity against Human cytomegalovirus AD169 strain infected in HELF cells assessed as inhibition of virus-induced cytopathogenicity, EC50=11.75μM. 30098481
HFF Antiviral assay Antiviral activity against Human CMV T2311 in HFF cells by PRA, IC50=12.4μM. 17043128
HEL Antiviral assay Antiviral activity against human cytomegalovirus AD169 infected in HEL cells assessed as reduction in viral plaque formation, EC50=13.9μM. 26443550
HEL Antiviral assay Antiviral activity against thymidine kinase negative and ACV resistant HSV1 KOS infected in HEL cells by viral CPE assay, EC50=14.7μM. 22858222
HEL Antiviral assay Antiviral activity against Cytomegalovirus AD169 infected in HEL cells assessed as reduction in virus plaque formation, EC50=14.9μM. 27750154
HEL Antiviral assay Antiviral activity against acyclovir-resistant Human herpesvirus 1 KOS infected in HEL cells assessed as protection against virus-induced cytopathicity, EC50=15.7μM. 21565516
HFF Antiviral assay Antiviral activity against ganciclovir-resistant HCMV3 isolate replication in HFF cells by plaque reduction assay, IC50=16.4μM. 19010684
HEL Antiviral assay Antiviral activity against HCMV Davis strain infected in HEL cells assessed as inhibition of virus-induced cytopathic effect, EC50=16.5μM. 28682067
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate E2490 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate MR9 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate MR4 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate MR5 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate MR6 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate MR2 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate A1 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate A2 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate A3 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate MR11 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate A5 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate MC1 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate MP1 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against HSV2 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate MR3 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate MR8 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate MR10 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate MR1 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate A4 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate MR7 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate MC2 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate MJ1 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate MJ2 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate MJ3 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against Macacine herpesvirus 1 isolate A6 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
Vero Antiviral assay Antiviral activity against HSV1 infected in african green monkey Vero cells by plaque reduction assay, EC50=19.3μM. 19858259
bone marrow cells Cytotoxicity assay Cytotoxicity against human bone marrow cells assessed as inhibition of colony forming unit of granulocyte/macrophage, IC50=30μM. 16814545
MRC5 Antiviral assay Antiviral activity against Human CMV T2287 in MRC5 cells by PRA, IC50=30.1μM. 17043128
HFF Antiviral assay Antiviral activity against Human CMV T2311 in HFF cells by SEAP assay, IC50=30.2μM. 17043128
neural precursor cells Function assay Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay 17417631
SJ-GBM2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells 29435139
A673 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells 29435139
SK-N-MC qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells 29435139
BT-37 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells 29435139
Saos-2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells 29435139
BT-12 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells 29435139
OHS-50 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells 29435139
MG 63 (6-TG R) qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells 29435139
Rh41 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells 29435139
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生物活性

產(chǎn)品描述 Ganciclovir是一種抗病毒藥，作用于貓科動物1型皰疹病毒，無細(xì)胞試驗(yàn)中IC50為5.2 μM。
體外研究(In Vitro)
體外研究活性 Ganciclovir由3種主要細(xì)胞酶代謝成三磷酸形式：（1）誘導(dǎo)的巨細(xì)胞病毒感染的細(xì)胞的脫氧鳥苷激酶; （2）鳥苷酸激酶;和（3）磷酸甘油酸激酶。[1] 在與HSV-TK表達(dá)細(xì)胞共同培養(yǎng)的大部分旁觀者細(xì)胞中， Ganciclovir足以誘導(dǎo)細(xì)胞死亡。[2] Ganciclovir顯著減少轉(zhuǎn)化的細(xì)胞中DNA合成，而Ganciclovir對在非轉(zhuǎn)化細(xì)胞的DNA合成的影響不大。Ganciclovir表現(xiàn)出濃度依賴性降低成熟的DNA中的伸長率。[3] 在HSVtk所轉(zhuǎn)導(dǎo)的B16F10黑色素瘤細(xì)胞中，Ganciclovir誘導(dǎo)細(xì)胞周期阻滯，而不是直接的化學(xué)效應(yīng)。[4]Ganciclovir輕度抑制DNA合成。Ganciclovir處理的細(xì)胞積聚在早S期并保持直到細(xì)胞死亡，這表明Ganciclovir摻入DNA模板中對細(xì)胞毒性很重要。[5]Ganciclovir誘導(dǎo)的凋亡是由于藥物插入DNA導(dǎo)致復(fù)制依賴性的DNA雙鏈斷裂的形成，并在稍后的階段產(chǎn)生S和G2 / M期阻滯。Ganciclovir激起的DNA不穩(wěn)定性可能是Bcl-2的水平和caspase-9/-3活化水平降低的原因。[6]
細(xì)胞實(shí)驗(yàn) 細(xì)胞系 BV-2 cells?
濃度 --
孵育時間 24 h
方法

將總量為2 × 10<sup>4</sup>的BV-2細(xì)胞接種于96孔板，置于含10%FBS的DMEM中培養(yǎng)12小時、然后血清饑餓12小時，加入不同濃度的GCV進(jìn)行處理，處理24小時。在處理期間的最后8小時，將1 µCi/孔的[3H]thymidine通過脈沖加入到培養(yǎng)基中。最后通過β plate scintillation counter檢測摻入的放射性。
實(shí)驗(yàn)圖片 檢測方法 檢測指標(biāo) 實(shí)驗(yàn)圖片 PMID
Growth inhibition assay Cell viability 29845211
體內(nèi)研究(In Vivo)
體內(nèi)研究活性 抗病毒藥物ganciclovir (GCV)在實(shí)驗(yàn)性自身免疫性腦脊髓炎模型中抑制小神經(jīng)膠質(zhì)的增殖。GCV減輕神經(jīng)炎癥，而且并不顯著抑制外周免疫反應(yīng)[7]。
動物實(shí)驗(yàn) Animal Models C57BL/6小鼠
Dosages 100 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06407232 Not yet recruiting
Cytomegalovirus Infections|Kidney Transplant Infection|Pancreas Transplant
University of Wisconsin Madison|Merck Sharp & Dohme LLC
 May 2024 Phase 3
NCT06057194 Not yet recruiting
Infections Cytomegalovirus
Maimónides Biomedical Research Institute of Córdoba|MERCK SHARP & DOHME DE ESPA?A S.A.
 October 2023 Phase 2
NCT04706507 Recruiting
Acute Respiratory Failure
Fred Hutchinson Cancer Center|National Heart Lung and Blood Institute (NHLBI)
 June 29 2021 Phase 3
NCT04478474 Completed
Cytomegalovirus Infections
New York Medical College|Merck Sharp & Dohme LLC
 September 15 2020 --
NCT03698435 Unknown status
Cytomegalovirus Infections
University Medical Center Groningen
 May 25 2018 --

化學(xué)信息&溶解度

分子量 255.23 分子式

C9H13N5O4
CAS號 82410-32-0 SDF Download Ganciclovir SDF
Smiles C1=NC2=C(N1COC(CO)CO)N=C(NC2=O)N
儲存條件(自收到貨起)

體外溶解度
批次：

DMSO : 50 mg/mL ( (195.9 mM) ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO)

Water : Insoluble

Ethanol : Insoluble

摩爾濃度計(jì)算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑

 動物體內(nèi)配方計(jì)算器

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量 濃度 體積 分子量

動物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過程中的損耗，建議多配一只動物的藥量）

mg/kg g μL 只

第二步：請輸入動物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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