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Cytoskeletal Signaling
HSP (HSP90) inhibitor
-
Autophagy activator
-
Mitophagy activator
-
Apoptosis related activator
Tanespimycin (17-AAG)
僅限科研使用
Tanespimycin (17-AAG)
別名: CP127374, NSC-330507, KOS 953 中文名稱：坦螺旋霉素
Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) 是一種有效的HSP90抑制劑，無細(xì)胞試驗(yàn)中IC50為5 nM，作用于來自腫瘤細(xì)胞的HSP90比作用于來自正常細(xì)胞HSP90結(jié)合親和力高100倍。Tanespimycin (17-AAG)可誘導(dǎo)細(xì)胞凋亡、壞死、自噬和線粒體自噬。Phase 3。
Tanespimycin (17-AAG) Chemical Structure
CAS: 75747-14-7
產(chǎn)品質(zhì)控
批次：
純度：
99.92%
99.92
Tanespimycin (17-AAG)相關(guān)產(chǎn)品
| 相關(guān)靶點(diǎn) | HSP40 HSP70 HSP90 HSP105 HSF1 | 點(diǎn)擊展開 |
|---|---|---|
| 相關(guān)產(chǎn)品 | Luminespib (NVP-AUY922) Elesclomol (STA-4783) Ganetespib (STA-9090) Alvespimycin (17-DMAG) HCl VER155008 BIIB021 Onalespib (AT13387) NVP-BEP800 KRIBB11 SNX-2112 HA15 Zelavespib (PU-H71) HSP990 (NVP-HSP990) NMS-E973 Apoptozole XL888 PF-04929113 (SNX-5422) KNK437 Teprenone TRC051384 VER-50589 Rocaglamide VER-49009 Pimitespib (TAS-116) JG98 DTHIB KW-2478 | 點(diǎn)擊展開 |
| 相關(guān)化合物庫 | 激酶抑制劑庫 血管生成相關(guān)化合物庫 TGF-beta/Smad信號(hào)通路庫 細(xì)胞骨架信號(hào)通路化合物庫 抗心血管疾病化合物庫 | 點(diǎn)擊展開 |
相關(guān)信號(hào)通路圖
細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例
| 細(xì)胞系 | 實(shí)驗(yàn)類型 | 給藥濃度 | 孵育時(shí)間 | 活性描述 | 文獻(xiàn)信息 |
|---|---|---|---|---|---|
| C2BBe1 | Growth Inhibition Assay | IC50=0.2219 μM | SANGER | ||
| TE-9 | Growth Inhibition Assay | IC50=0.21786 μM | SANGER | ||
| MFE-280 | Growth Inhibition Assay | IC50=0.21298 μM | SANGER | ||
| 769-P | Growth Inhibition Assay | IC50=0.2128 μM | SANGER | ||
| HPAF-II | Growth Inhibition Assay | IC50=0.21264 μM | SANGER | ||
| A172 | Growth Inhibition Assay | IC50=0.21022 μM | SANGER | ||
| AM-38 | Growth Inhibition Assay | IC50=0.20848 μM | SANGER | ||
| DoTc2-4510 | Growth Inhibition Assay | IC50=0.20769 μM | SANGER | ||
| S-117 | Growth Inhibition Assay | IC50=0.20564 μM | SANGER | ||
| U031 | Growth Inhibition Assay | IC50=0.20547 μM | SANGER | ||
| SBC-5 | Growth Inhibition Assay | IC50=0.20118 μM | SANGER | ||
| NCI-H1650 | Growth Inhibition Assay | IC50=0.20057 μM | SANGER | ||
| COLO-680N | Growth Inhibition Assay | IC50=0.19364 μM | SANGER | ||
| Capan-2 | Growth Inhibition Assay | IC50=0.19256 μM | SANGER | ||
| RVH-421 | Growth Inhibition Assay | IC50=0.19116 μM | SANGER | ||
| RD | Growth Inhibition Assay | IC50=0.19113 μM | SANGER | ||
| CAL-27 | Growth Inhibition Assay | IC50=0.19022 μM | SANGER | ||
| BCPAP | Growth Inhibition Assay | IC50=0.18872 μM | SANGER | ||
| JEG-3 | Growth Inhibition Assay | IC50=0.18705 μM | SANGER | ||
| NCI-H1395 | Growth Inhibition Assay | IC50=0.18682 μM | SANGER | ||
| DEL | Growth Inhibition Assay | IC50=0.1845 μM | SANGER | ||
| IGROV-1 | Growth Inhibition Assay | IC50=0.18443 μM | SANGER | ||
| KNS-81-FD | Growth Inhibition Assay | IC50=0.18394 μM | SANGER | ||
| LK-2 | Growth Inhibition Assay | IC50=0.18303 μM | SANGER | ||
| KYSE-520 | Growth Inhibition Assay | IC50=0.182 μM | SANGER | ||
| MDA-MB-157 | Growth Inhibition Assay | IC50=0.18082 μM | SANGER | ||
| SCC-4 | Growth Inhibition Assay | IC50=0.17777 μM | SANGER | ||
| KOSC-2 | Growth Inhibition Assay | IC50=0.17734 μM | SANGER | ||
| NCI-H650 | Growth Inhibition Assay | IC50=0.17682 μM | SANGER | ||
| MZ7-mel | Growth Inhibition Assay | IC50=0.17649 μM | SANGER | ||
| SK-OV-3 | Growth Inhibition Assay | IC50=0.17571 μM | SANGER | ||
| NCI-H2170 | Growth Inhibition Assay | IC50=0.17536 μM | SANGER | ||
| NCI-H2087 | Growth Inhibition Assay | IC50=0.17368 μM | SANGER | ||
| BB30-HNC | Growth Inhibition Assay | IC50=0.1733 μM | SANGER | ||
| COLO-824 | Growth Inhibition Assay | IC50=0.17294 μM | SANGER | ||
| U-2-OS | Growth Inhibition Assay | IC50=0.17173 μM | SANGER | ||
| HT-1376 | Growth Inhibition Assay | IC50=0.16936 μM | SANGER | ||
| SCC-9 | Growth Inhibition Assay | IC50=0.16716 μM | SANGER | ||
| OC-314 | Growth Inhibition Assay | IC50=0.1669 μM | SANGER | ||
| FTC-133 | Growth Inhibition Assay | IC50=0.1654 μM | SANGER | ||
| SW1088 | Growth Inhibition Assay | IC50=0.16413 μM | SANGER | ||
| NCI-H1299 | Growth Inhibition Assay | IC50=0.16285 μM | SANGER | ||
| HCC1937 | Growth Inhibition Assay | IC50=0.16275 μM | SANGER | ||
| CAL-62 | Growth Inhibition Assay | IC50=0.16169 μM | SANGER | ||
| BxPC-3 | Growth Inhibition Assay | IC50=0.15966 μM | SANGER | ||
| ETK-1 | Growth Inhibition Assay | IC50=0.159 μM | SANGER | ||
| 786-0 | Growth Inhibition Assay | IC50=0.15381 μM | SANGER | ||
| NCI-H1648 | Growth Inhibition Assay | IC50=0.15232 μM | SANGER | ||
| AsPC-1 | Growth Inhibition Assay | IC50=0.15225 μM | SANGER | ||
| 639-V | Growth Inhibition Assay | IC50=0.15013 μM | SANGER | ||
| Mewo | Growth Inhibition Assay | IC50=0.14889 μM | SANGER | ||
| NCI-H2347 | Growth Inhibition Assay | IC50=0.14839 μM | SANGER | ||
| SW1573 | Growth Inhibition Assay | IC50=0.14758 μM | SANGER | ||
| HCC1419 | Growth Inhibition Assay | IC50=0.14576 μM | SANGER | ||
| GI-1 | Growth Inhibition Assay | IC50=0.14558 μM | SANGER | ||
| NUGC-3 | Growth Inhibition Assay | IC50=0.14478 μM | SANGER | ||
| MPP-89 | Growth Inhibition Assay | IC50=0.14125 μM | SANGER | ||
| LC-2-ad | Growth Inhibition Assay | IC50=0.14121 μM | SANGER | ||
| GP5d | Growth Inhibition Assay | IC50=0.14104 μM | SANGER | ||
| RT-112 | Growth Inhibition Assay | IC50=0.14035 μM | SANGER | ||
| NCI-H2452 | Growth Inhibition Assay | IC50=0.13956 μM | SANGER | ||
| LB831-BLC | Growth Inhibition Assay | IC50=0.13883 μM | SANGER | ||
| SK-MEL-24 | Growth Inhibition Assay | IC50=0.1387 μM | SANGER | ||
| VMRC-RCZ | Growth Inhibition Assay | IC50=0.13762 μM | SANGER | ||
| GAK | Growth Inhibition Assay | IC50=0.13567 μM | SANGER | ||
| BPH-1 | Growth Inhibition Assay | IC50=0.1341 μM | SANGER | ||
| PC-14 | Growth Inhibition Assay | IC50=0.13211 μM | SANGER | ||
| NCI-H292 | Growth Inhibition Assay | IC50=0.1311 μM | SANGER | ||
| HuP-T4 | Growth Inhibition Assay | IC50=0.12943 μM | SANGER | ||
| CAMA-1 | Growth Inhibition Assay | IC50=0.12924 μM | SANGER | ||
| A375 | Growth Inhibition Assay | IC50=0.12778 μM | SANGER | ||
| NCI-H1666 | Growth Inhibition Assay | IC50=0.12774 μM | SANGER | ||
| SAS | Growth Inhibition Assay | IC50=0.1269 μM | SANGER | ||
| EW-3 | Growth Inhibition Assay | IC50=0.12661 μM | SANGER | ||
| SNB75 | Growth Inhibition Assay | IC50=0.12169 μM | SANGER | ||
| NCI-H1437 | Growth Inhibition Assay | IC50=0.12157 μM | SANGER | ||
| SW1990 | Growth Inhibition Assay | IC50=0.12157 μM | SANGER | ||
| HMV-II | Growth Inhibition Assay | IC50=0.1202 μM | SANGER | ||
| COLO-829 | Growth Inhibition Assay | IC50=0.12005 μM | SANGER | ||
| RXF393 | Growth Inhibition Assay | IC50=0.11982 μM | SANGER | ||
| NCI-H28 | Growth Inhibition Assay | IC50=0.11817 μM | SANGER | ||
| BT-549 | Growth Inhibition Assay | IC50=0.11799 μM | SANGER | ||
| OMC-1 | Growth Inhibition Assay | IC50=0.11797 μM | SANGER | ||
| RKO | Growth Inhibition Assay | IC50=0.11764 μM | SANGER | ||
| KALS-1 | Growth Inhibition Assay | IC50=0.11393 μM | SANGER | ||
| SH-4 | Growth Inhibition Assay | IC50=0.11356 μM | SANGER | ||
| SK-MEL-28 | Growth Inhibition Assay | IC50=0.11321 μM | SANGER | ||
| TE-8 | Growth Inhibition Assay | IC50=0.11264 μM | SANGER | ||
| COLO-679 | Growth Inhibition Assay | IC50=0.11211 μM | SANGER | ||
| TGBC11TKB | Growth Inhibition Assay | IC50=0.10903 μM | SANGER | ||
| HD-MY-Z | Growth Inhibition Assay | IC50=0.10873 μM | SANGER | ||
| NKM-1 | Growth Inhibition Assay | IC50=0.10666 μM | SANGER | ||
| BB65-RCC | Growth Inhibition Assay | IC50=0.10554 μM | SANGER | ||
| MMAC-SF | Growth Inhibition Assay | IC50=0.10531 μM | SANGER | ||
| U251 | Growth Inhibition Assay | IC50=0.10525 μM | SANGER | ||
| SiHa | Growth Inhibition Assay | IC50=0.10486 μM | SANGER | ||
| G-401 | Growth Inhibition Assay | IC50=0.10353 μM | SANGER | ||
| U-87-MG | Growth Inhibition Assay | IC50=0.10307 μM | SANGER | ||
| NCI-H1581 | Growth Inhibition Assay | IC50=0.1029 μM | SANGER | ||
| PANC-03-27 | Growth Inhibition Assay | IC50=0.10286 μM | SANGER | ||
| A498 | Growth Inhibition Assay | IC50=0.1018 μM | SANGER | ||
| SN12C | Growth Inhibition Assay | IC50=0.10107 μM | SANGER | ||
| LB2241-RCC | Growth Inhibition Assay | IC50=0.10054 μM | SANGER | ||
| EFO-27 | Growth Inhibition Assay | IC50=0.09997 μM | SANGER | ||
| NCI-H2122 | Growth Inhibition Assay | IC50=0.09745 μM | SANGER | ||
| MCF7 | Growth Inhibition Assay | IC50=0.09677 μM | SANGER | ||
| NCI-H1792 | Growth Inhibition Assay | IC50=0.09618 μM | SANGER | ||
| 8-MG-BA | Growth Inhibition Assay | IC50=0.09472 μM | SANGER | ||
| D-247MG | Growth Inhibition Assay | IC50=0.09455 μM | SANGER | ||
| KYSE-180 | Growth Inhibition Assay | IC50=0.09262 μM | SANGER | ||
| TE-1 | Growth Inhibition Assay | IC50=0.09204 μM | SANGER | ||
| SK-MEL-2 | Growth Inhibition Assay | IC50=0.0906 μM | SANGER | ||
| M059J | Growth Inhibition Assay | IC50=0.09027 μM | SANGER | ||
| LCLC-97TM1 | Growth Inhibition Assay | IC50=0.08728 μM | SANGER | ||
| OVCAR-8 | Growth Inhibition Assay | IC50=0.08622 μM | SANGER | ||
| HT-1080 | Growth Inhibition Assay | IC50=0.08439 μM | SANGER | ||
| MKN45 | Growth Inhibition Assay | IC50=0.08219 μM | SANGER | ||
| A431 | Growth Inhibition Assay | IC50=0.0821 μM | SANGER | ||
| L-363 | Growth Inhibition Assay | IC50=0.08206 μM | SANGER | ||
| TGBC1TKB | Growth Inhibition Assay | IC50=0.08043 μM | SANGER | ||
| TE-11 | Growth Inhibition Assay | IC50=0.07996 μM | SANGER | ||
| BFTC-909 | Growth Inhibition Assay | IC50=0.07969 μM | SANGER | ||
| M14 | Growth Inhibition Assay | IC50=0.07913 μM | SANGER | ||
| CAL-39 | Growth Inhibition Assay | IC50=0.07766 μM | SANGER | ||
| HuO9 | Growth Inhibition Assay | IC50=0.07589 μM | SANGER | ||
| HCC2998 | Growth Inhibition Assay | IC50=0.07347 μM | SANGER | ||
| MEL-HO | Growth Inhibition Assay | IC50=0.07255 μM | SANGER | ||
| A2058 | Growth Inhibition Assay | IC50=0.07228 μM | SANGER | ||
| Hs-578-T | Growth Inhibition Assay | IC50=0.07208 μM | SANGER | ||
| HCC1806 | Growth Inhibition Assay | IC50=0.07131 μM | SANGER | ||
| SW620 | Growth Inhibition Assay | IC50=0.07026 μM | SANGER | ||
| 23132-87 | Growth Inhibition Assay | IC50=0.0695 μM | SANGER | ||
| HT-29 | Growth Inhibition Assay | IC50=0.06919 μM | SANGER | ||
| MV-4-11 | Growth Inhibition Assay | IC50=0.06803 μM | SANGER | ||
| GMS-10 | Growth Inhibition Assay | IC50=0.06699 μM | SANGER | ||
| SF539 | Growth Inhibition Assay | IC50=0.06681 μM | SANGER | ||
| SW684 | Growth Inhibition Assay | IC50=0.06591 μM | SANGER | ||
| HEC-1 | Growth Inhibition Assay | IC50=0.06588 μM | SANGER | ||
| MZ2-MEL | Growth Inhibition Assay | IC50=0.06553 μM | SANGER | ||
| SF295 | Growth Inhibition Assay | IC50=0.06452 μM | SANGER | ||
| KM12 | Growth Inhibition Assay | IC50=0.06348 μM | SANGER | ||
| NCI-H1755 | Growth Inhibition Assay | IC50=0.06341 μM | SANGER | ||
| LU-99A | Growth Inhibition Assay | IC50=0.06237 μM | SANGER | ||
| EPLC-272H | Growth Inhibition Assay | IC50=0.06205 μM | SANGER | ||
| TCCSUP | Growth Inhibition Assay | IC50=0.05964 μM | SANGER | ||
| GT3TKB | Growth Inhibition Assay | IC50=0.05942 μM | SANGER | ||
| LOXIMVI | Growth Inhibition Assay | IC50=0.05872 μM | SANGER | ||
| 5637 | Growth Inhibition Assay | IC50=0.0574 μM | SANGER | ||
| YH-13 | Growth Inhibition Assay | IC50=0.05722 μM | SANGER | ||
| NCI-H2030 | Growth Inhibition Assay | IC50=0.05414 μM | SANGER | ||
| LB1047-RCC | Growth Inhibition Assay | IC50=0.05296 μM | SANGER | ||
| HuO-3N1 | Growth Inhibition Assay | IC50=0.05237 μM | SANGER | ||
| KYSE-150 | Growth Inhibition Assay | IC50=0.05235 μM | SANGER | ||
| YKG-1 | Growth Inhibition Assay | IC50=0.05071 μM | SANGER | ||
| SW48 | Growth Inhibition Assay | IC50=0.05039 μM | SANGER | ||
| AN3-CA | Growth Inhibition Assay | IC50=0.05 μM | SANGER | ||
| SKG-IIIa | Growth Inhibition Assay | IC50=0.04986 μM | SANGER | ||
| COR-L88 | Growth Inhibition Assay | IC50=0.04912 μM | SANGER | ||
| DOK | Growth Inhibition Assay | IC50=0.04902 μM | SANGER | ||
| G-402 | Growth Inhibition Assay | IC50=0.04789 μM | SANGER | ||
| KYSE-410 | Growth Inhibition Assay | IC50=0.04772 μM | SANGER | ||
| KP-4 | Growth Inhibition Assay | IC50=0.04753 μM | SANGER | ||
| KYSE-510 | Growth Inhibition Assay | IC50=0.04649 μM | SANGER | ||
| PSN1 | Growth Inhibition Assay | IC50=0.04603 μM | SANGER | ||
| CaR-1 | Growth Inhibition Assay | IC50=0.04549 μM | SANGER | ||
| BT-474 | Growth Inhibition Assay | IC50=0.045 μM | SANGER | ||
| MEL-JUSO | Growth Inhibition Assay | IC50=0.04475 μM | SANGER | ||
| VA-ES-BJ | Growth Inhibition Assay | IC50=0.04447 μM | SANGER | ||
| H9 | Growth Inhibition Assay | IC50=0.04371 μM | SANGER | ||
| HN | Growth Inhibition Assay | IC50=0.04272 μM | SANGER | ||
| BB49-HNC | Growth Inhibition Assay | IC50=0.04243 μM | SANGER | ||
| Detroit562 | Growth Inhibition Assay | IC50=0.04239 μM | SANGER | ||
| SW780 | Growth Inhibition Assay | IC50=0.04203 μM | SANGER | ||
| ACN | Growth Inhibition Assay | IC50=0.04162 μM | SANGER | ||
| T98G | Growth Inhibition Assay | IC50=0.04103 μM | SANGER | ||
| HO-1-N-1 | Growth Inhibition Assay | IC50=0.04021 μM | SANGER | ||
| TYK-nu | Growth Inhibition Assay | IC50=0.03985 μM | SANGER | ||
| SW962 | Growth Inhibition Assay | IC50=0.03945 μM | SANGER | ||
| Becker | Growth Inhibition Assay | IC50=0.03885 μM | SANGER | ||
| DSH1 | Growth Inhibition Assay | IC50=0.03807 μM | SANGER | ||
| WM-115 | Growth Inhibition Assay | IC50=0.03762 μM | SANGER | ||
| VM-CUB-1 | Growth Inhibition Assay | IC50=0.03657 μM | SANGER | ||
| SK-MES-1 | Growth Inhibition Assay | IC50=0.03606 μM | SANGER | ||
| OVCAR-5 | Growth Inhibition Assay | IC50=0.0348 μM | SANGER | ||
| CP50-MEL-B | Growth Inhibition Assay | IC50=0.0345 μM | SANGER | ||
| GAMG | Growth Inhibition Assay | IC50=0.03435 μM | SANGER | ||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50=0.03354 μM | SANGER | ||
| D-336MG | Growth Inhibition Assay | IC50=0.03309 μM | SANGER | ||
| SK-UT-1 | Growth Inhibition Assay | IC50=0.03178 μM | SANGER | ||
| HT-144 | Growth Inhibition Assay | IC50=0.03093 μM | SANGER | ||
| H4 | Growth Inhibition Assay | IC50=0.0309 μM | SANGER | ||
| SK-LU-1 | Growth Inhibition Assay | IC50=0.03082 μM | SANGER | ||
| OE19 | Growth Inhibition Assay | IC50=0.03077 μM | SANGER | ||
| SW982 | Growth Inhibition Assay | IC50=0.02999 μM | SANGER | ||
| ME-180 | Growth Inhibition Assay | IC50=0.02891 μM | SANGER | ||
| D-263MG | Growth Inhibition Assay | IC50=0.02786 μM | SANGER | ||
| NCI-H23 | Growth Inhibition Assay | IC50=0.02665 μM | SANGER | ||
| CHP-212 | Growth Inhibition Assay | IC50=0.02628 μM | SANGER | ||
| NCI-N87 | Growth Inhibition Assay | IC50=0.02593 μM | SANGER | ||
| NCI-H720 | Growth Inhibition Assay | IC50=0.02546 μM | SANGER | ||
| A2780 | Growth Inhibition Assay | IC50=0.02531 μM | SANGER | ||
| HCC2218 | Growth Inhibition Assay | IC50=0.02494 μM | SANGER | ||
| CGTH-W-1 | Growth Inhibition Assay | IC50=0.02349 μM | SANGER | ||
| DU-4475 | Growth Inhibition Assay | IC50=0.02261 μM | SANGER | ||
| CHL-1 | Growth Inhibition Assay | IC50=0.02251 μM | SANGER | ||
| A204 | Growth Inhibition Assay | IC50=0.02249 μM | SANGER | ||
| NCI-H460 | Growth Inhibition Assay | IC50=0.01974 μM | SANGER | ||
| AGS | Growth Inhibition Assay | IC50=0.01938 μM | SANGER | ||
| TI-73 | Growth Inhibition Assay | IC50=0.01796 μM | SANGER | ||
| MDA-MB-361 | Growth Inhibition Assay | IC50=0.01495 μM | SANGER | ||
| CAL-51 | Growth Inhibition Assay | IC50=0.01405 μM | SANGER | ||
| KS-1 | Growth Inhibition Assay | IC50=0.01355 μM | SANGER | ||
| MIA-PaCa-2 | Growth Inhibition Assay | IC50=0.01009 μM | SANGER | ||
| HSC-3 | Growth Inhibition Assay | IC50=0.00929 μM | SANGER | ||
| RPMI-7951 | Growth Inhibition Assay | IC50=0.00717 μM | SANGER | ||
| HGC-27 | Growth Inhibition Assay | IC50=0.0051 μM | SANGER | ||
| LXF-289 | Growth Inhibition Assay | IC50=0.00419 μM | SANGER | ||
| D-566MG | Growth Inhibition Assay | IC50=0.0039 μM | SANGER | ||
| C32 | Growth Inhibition Assay | IC50=0.00304 μM | SANGER | ||
| FADU | Growth Inhibition Assay | IC50=0.00209 μM | SANGER | ||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=0.00207 μM | SANGER | ||
| IST-MEL1 | Growth Inhibition Assay | IC50=0.000407 μM | SANGER | ||
| A549 | Growth Inhibition Assay | IC50=0.000303 μM | SANGER | ||
| EoL-1-cell | Growth Inhibition Assay | IC50=0.22203 μM | SANGER | ||
| G-361 | Growth Inhibition Assay | IC50=0.22682 μM | SANGER | ||
| KYSE-270 | Growth Inhibition Assay | IC50=0.23084 μM | SANGER | ||
| TK10 | Growth Inhibition Assay | IC50=0.23117 μM | SANGER | ||
| ML-2 | Growth Inhibition Assay | IC50=0.23119 μM | SANGER | ||
| MHH-ES-1 | Growth Inhibition Assay | IC50=0.23681 μM | SANGER | ||
| BHY | Growth Inhibition Assay | IC50=0.23691 μM | SANGER | ||
| LS-513 | Growth Inhibition Assay | IC50=0.23961 μM | SANGER | ||
| COLO-678 | Growth Inhibition Assay | IC50=0.24044 μM | SANGER | ||
| NCI-H747 | Growth Inhibition Assay | IC50=0.24169 μM | SANGER | ||
| K5 | Growth Inhibition Assay | IC50=0.2438 μM | SANGER | ||
| OS-RC-2 | Growth Inhibition Assay | IC50=0.24509 μM | SANGER | ||
| KINGS-1 | Growth Inhibition Assay | IC50=0.24529 μM | SANGER | ||
| SCC-25 | Growth Inhibition Assay | IC50=0.24563 μM | SANGER | ||
| CAPAN-1 | Growth Inhibition Assay | IC50=0.24783 μM | SANGER | ||
| ESS-1 | Growth Inhibition Assay | IC50=0.24805 μM | SANGER | ||
| TE-6 | Growth Inhibition Assay | IC50=0.2575 μM | SANGER | ||
| LB2518-MEL | Growth Inhibition Assay | IC50=0.25777 μM | SANGER | ||
| COLO-800 | Growth Inhibition Assay | IC50=0.25812 μM | SANGER | ||
| LU-134-A | Growth Inhibition Assay | IC50=0.26136 μM | SANGER | ||
| NCI-H1155 | Growth Inhibition Assay | IC50=0.26162 μM | SANGER | ||
| MFM-223 | Growth Inhibition Assay | IC50=0.26363 μM | SANGER | ||
| HTC-C3 | Growth Inhibition Assay | IC50=0.26506 μM | SANGER | ||
| HCT-116 | Growth Inhibition Assay | IC50=0.26599 μM | SANGER | ||
| Ca-Ski | Growth Inhibition Assay | IC50=0.26678 μM | SANGER | ||
| SBC-1 | Growth Inhibition Assay | IC50=0.26742 μM | SANGER | ||
| NB69 | Growth Inhibition Assay | IC50=0.27087 μM | SANGER | ||
| J82 | Growth Inhibition Assay | IC50=0.27265 μM | SANGER | ||
| U-118-MG | Growth Inhibition Assay | IC50=0.27579 μM | SANGER | ||
| NCI-H1355 | Growth Inhibition Assay | IC50=0.28074 μM | SANGER | ||
| NCI-H1048 | Growth Inhibition Assay | IC50=0.28956 μM | SANGER | ||
| SW954 | Growth Inhibition Assay | IC50=0.29227 μM | SANGER | ||
| NMC-G1 | Growth Inhibition Assay | IC50=0.29277 μM | SANGER | ||
| SW1710 | Growth Inhibition Assay | IC50=0.29494 μM | SANGER | ||
| KY821 | Growth Inhibition Assay | IC50=0.29872 μM | SANGER | ||
| HCC38 | Growth Inhibition Assay | IC50=0.30078 μM | SANGER | ||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=0.3054 μM | SANGER | ||
| ES8 | Growth Inhibition Assay | IC50=0.30784 μM | SANGER | ||
| COLO-792 | Growth Inhibition Assay | IC50=0.31251 μM | SANGER | ||
| BFTC-905 | Growth Inhibition Assay | IC50=0.31521 μM | SANGER | ||
| ChaGo-K-1 | Growth Inhibition Assay | IC50=0.31715 μM | SANGER | ||
| Daoy | Growth Inhibition Assay | IC50=0.31723 μM | SANGER | ||
| SJSA-1 | Growth Inhibition Assay | IC50=0.31847 μM | SANGER | ||
| KNS-62 | Growth Inhibition Assay | IC50=0.32088 μM | SANGER | ||
| CAKI-1 | Growth Inhibition Assay | IC50=0.32111 μM | SANGER | ||
| UACC-62 | Growth Inhibition Assay | IC50=0.32227 μM | SANGER | ||
| HuCCT1 | Growth Inhibition Assay | IC50=0.32283 μM | SANGER | ||
| CTB-1 | Growth Inhibition Assay | IC50=0.32753 μM | SANGER | ||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=0.32836 μM | SANGER | ||
| T-24 | Growth Inhibition Assay | IC50=0.33159 μM | SANGER | ||
| KYSE-70 | Growth Inhibition Assay | IC50=0.33283 μM | SANGER | ||
| SW626 | Growth Inhibition Assay | IC50=0.33532 μM | SANGER | ||
| LB996-RCC | Growth Inhibition Assay | IC50=0.33619 μM | SANGER | ||
| DMS-273 | Growth Inhibition Assay | IC50=0.33916 μM | SANGER | ||
| SW1783 | Growth Inhibition Assay | IC50=0.33997 μM | SANGER | ||
| KU812 | Growth Inhibition Assay | IC50=0.34038 μM | SANGER | ||
| HSC-2 | Growth Inhibition Assay | IC50=0.34053 μM | SANGER | ||
| A3-KAW | Growth Inhibition Assay | IC50=0.34162 μM | SANGER | ||
| COLO-684 | Growth Inhibition Assay | IC50=0.34501 μM | SANGER | ||
| NCI-H2405 | Growth Inhibition Assay | IC50=0.34631 μM | SANGER | ||
| NCI-H2228 | Growth Inhibition Assay | IC50=0.35357 μM | SANGER | ||
| NB13 | Growth Inhibition Assay | IC50=0.36829 μM | SANGER | ||
| no-11 | Growth Inhibition Assay | IC50=0.3695 μM | SANGER | ||
| DK-MG | Growth Inhibition Assay | IC50=0.37188 μM | SANGER | ||
| NBsusSR | Growth Inhibition Assay | IC50=0.37285 μM | SANGER | ||
| KP-N-YS | Growth Inhibition Assay | IC50=0.37463 μM | SANGER | ||
| CFPAC-1 | Growth Inhibition Assay | IC50=0.37518 μM | SANGER | ||
| KARPAS-45 | Growth Inhibition Assay | IC50=0.37862 μM | SANGER | ||
| NCI-H1793 | Growth Inhibition Assay | IC50=0.3851 μM | SANGER | ||
| HCE-T | Growth Inhibition Assay | IC50=0.38603 μM | SANGER | ||
| NCI-H520 | Growth Inhibition Assay | IC50=0.38703 μM | SANGER | ||
| HCC2157 | Growth Inhibition Assay | IC50=0.38781 μM | SANGER | ||
| EW-18 | Growth Inhibition Assay | IC50=0.38941 μM | SANGER | ||
| RO82-W-1 | Growth Inhibition Assay | IC50=0.39699 μM | SANGER | ||
| HuP-T3 | Growth Inhibition Assay | IC50=0.40143 μM | SANGER | ||
| PANC-10-05 | Growth Inhibition Assay | IC50=0.4117 μM | SANGER | ||
| NCI-H1703 | Growth Inhibition Assay | IC50=0.41446 μM | SANGER | ||
| TE-10 | Growth Inhibition Assay | IC50=0.41447 μM | SANGER | ||
| HOS | Growth Inhibition Assay | IC50=0.41682 μM | SANGER | ||
| LN-405 | Growth Inhibition Assay | IC50=0.41687 μM | SANGER | ||
| A427 | Growth Inhibition Assay | IC50=0.41981 μM | SANGER | ||
| CAL-12T | Growth Inhibition Assay | IC50=0.4278 μM | SANGER | ||
| SW756 | Growth Inhibition Assay | IC50=0.44183 μM | SANGER | ||
| YAPC | Growth Inhibition Assay | IC50=0.4508 μM | SANGER | ||
| GOTO | Growth Inhibition Assay | IC50=0.4516 μM | SANGER | ||
| C3A | Growth Inhibition Assay | IC50=0.45437 μM | SANGER | ||
| UM-UC-3 | Growth Inhibition Assay | IC50=0.4547 μM | SANGER | ||
| NCI-H1573 | Growth Inhibition Assay | IC50=0.45569 μM | SANGER | ||
| LS-411N | Growth Inhibition Assay | IC50=0.46527 μM | SANGER | ||
| COR-L23 | Growth Inhibition Assay | IC50=0.46764 μM | SANGER | ||
| HCE-4 | Growth Inhibition Assay | IC50=0.47446 μM | SANGER | ||
| NCI-H2291 | Growth Inhibition Assay | IC50=0.47896 μM | SANGER | ||
| A101D | Growth Inhibition Assay | IC50=0.48053 μM | SANGER | ||
| HT-3 | Growth Inhibition Assay | IC50=0.48217 μM | SANGER | ||
| HOP-62 | Growth Inhibition Assay | IC50=0.49865 μM | SANGER | ||
| PC-3 | Growth Inhibition Assay | IC50=0.51507 μM | SANGER | ||
| CTV-1 | Growth Inhibition Assay | IC50=0.52669 μM | SANGER | ||
| PANC-08-13 | Growth Inhibition Assay | IC50=0.53177 μM | SANGER | ||
| CAL-120 | Growth Inhibition Assay | IC50=0.53399 μM | SANGER | ||
| UMC-11 | Growth Inhibition Assay | IC50=0.55234 μM | SANGER | ||
| MSTO-211H | Growth Inhibition Assay | IC50=0.55762 μM | SANGER | ||
| NCI-H2126 | Growth Inhibition Assay | IC50=0.56815 μM | SANGER | ||
| SNU-C2B | Growth Inhibition Assay | IC50=0.57977 μM | SANGER | ||
| DBTRG-05MG | Growth Inhibition Assay | IC50=0.58053 μM | SANGER | ||
| MKN1 | Growth Inhibition Assay | IC50=0.58783 μM | SANGER | ||
| ES3 | Growth Inhibition Assay | IC50=0.59124 μM | SANGER | ||
| OVCAR-3 | Growth Inhibition Assay | IC50=0.59341 μM | SANGER | ||
| ACHN | Growth Inhibition Assay | IC50=0.60569 μM | SANGER | ||
| SW872 | Growth Inhibition Assay | IC50=0.60763 μM | SANGER | ||
| CP66-MEL | Growth Inhibition Assay | IC50=0.60969 μM | SANGER | ||
| NCI-H661 | Growth Inhibition Assay | IC50=0.61104 μM | SANGER | ||
| UACC-893 | Growth Inhibition Assay | IC50=0.63681 μM | SANGER | ||
| JVM-3 | Growth Inhibition Assay | IC50=0.63804 μM | SANGER | ||
| SF268 | Growth Inhibition Assay | IC50=0.64349 μM | SANGER | ||
| OCI-AML2 | Growth Inhibition Assay | IC50=0.65397 μM | SANGER | ||
| RPMI-8226 | Growth Inhibition Assay | IC50=0.66323 μM | SANGER | ||
| MKN28 | Growth Inhibition Assay | IC50=0.66624 μM | SANGER | ||
| MDA-MB-453 | Growth Inhibition Assay | IC50=0.6718 μM | SANGER | ||
| BV-173 | Growth Inhibition Assay | IC50=0.68679 μM | SANGER | ||
| NCI-H358 | Growth Inhibition Assay | IC50=0.68726 μM | SANGER | ||
| NCI-H1651 | Growth Inhibition Assay | IC50=0.7 μM | SANGER | ||
| MDA-MB-415 | Growth Inhibition Assay | IC50=0.70829 μM | SANGER | ||
| 8305C | Growth Inhibition Assay | IC50=0.72498 μM | SANGER | ||
| EFM-19 | Growth Inhibition Assay | IC50=0.73671 μM | SANGER | ||
| RERF-LC-MS | Growth Inhibition Assay | IC50=0.74613 μM | SANGER | ||
| A388 | Growth Inhibition Assay | IC50=0.76467 μM | SANGER | ||
| GI-ME-N | Growth Inhibition Assay | IC50=0.77235 μM | SANGER | ||
| IGR-1 | Growth Inhibition Assay | IC50=0.79043 μM | SANGER | ||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=0.80004 μM | SANGER | ||
| SK-MEL-3 | Growth Inhibition Assay | IC50=0.81508 μM | SANGER | ||
| UACC-257 | Growth Inhibition Assay | IC50=0.82231 μM | SANGER | ||
| OE33 | Growth Inhibition Assay | IC50=0.85101 μM | SANGER | ||
| QIMR-WIL | Growth Inhibition Assay | IC50=0.85141 μM | SANGER | ||
| NCI-H2009 | Growth Inhibition Assay | IC50=0.85311 μM | SANGER | ||
| NCI-H522 | Growth Inhibition Assay | IC50=0.87783 μM | SANGER | ||
| Saos-2 | Growth Inhibition Assay | IC50=0.87871 μM | SANGER | ||
| NB17 | Growth Inhibition Assay | IC50=0.88025 μM | SANGER | ||
| D-392MG | Growth Inhibition Assay | IC50=0.89356 μM | SANGER | ||
| SHP-77 | Growth Inhibition Assay | IC50=0.90485 μM | SANGER | ||
| SK-MEL-30 | Growth Inhibition Assay | IC50=0.91185 μM | SANGER | ||
| GCIY | Growth Inhibition Assay | IC50=0.91843 μM | SANGER | ||
| HCC70 | Growth Inhibition Assay | IC50=0.92059 μM | SANGER | ||
| LU-65 | Growth Inhibition Assay | IC50=0.92591 μM | SANGER | ||
| NCI-H1563 | Growth Inhibition Assay | IC50=0.94865 μM | SANGER | ||
| KURAMOCHI | Growth Inhibition Assay | IC50=0.95192 μM | SANGER | ||
| PA-1 | Growth Inhibition Assay | IC50=0.95424 μM | SANGER | ||
| NOS-1 | Growth Inhibition Assay | IC50=0.97489 μM | SANGER | ||
| NCI-H69 | Growth Inhibition Assay | IC50=0.97634 μM | SANGER | ||
| KYSE-450 | Growth Inhibition Assay | IC50=0.98626 μM | SANGER | ||
| 8505C | Growth Inhibition Assay | IC50=0.99982 μM | SANGER | ||
| TGBC24TKB | Growth Inhibition Assay | IC50=1.00084 μM | SANGER | ||
| PFSK-1 | Growth Inhibition Assay | IC50=1.01428 μM | SANGER | ||
| EKVX | Growth Inhibition Assay | IC50=1.03121 μM | SANGER | ||
| RCM-1 | Growth Inhibition Assay | IC50=1.05507 μM | SANGER | ||
| SW900 | Growth Inhibition Assay | IC50=1.0783 μM | SANGER | ||
| D-542MG | Growth Inhibition Assay | IC50=1.07855 μM | SANGER | ||
| SK-PN-DW | Growth Inhibition Assay | IC50=1.10056 μM | SANGER | ||
| NCI-H727 | Growth Inhibition Assay | IC50=1.10154 μM | SANGER | ||
| SW837 | Growth Inhibition Assay | IC50=1.10954 μM | SANGER | ||
| BT-20 | Growth Inhibition Assay | IC50=1.11204 μM | SANGER | ||
| RH-18 | Growth Inhibition Assay | IC50=1.13103 μM | SANGER | ||
| TE-12 | Growth Inhibition Assay | IC50=1.13333 μM | SANGER | ||
| NB10 | Growth Inhibition Assay | IC50=1.13344 μM | SANGER | ||
| AU565 | Growth Inhibition Assay | IC50=1.15973 μM | SANGER | ||
| OAW-42 | Growth Inhibition Assay | IC50=1.18306 μM | SANGER | ||
| DJM-1 | Growth Inhibition Assay | IC50=1.19881 μM | SANGER | ||
| HH | Growth Inhibition Assay | IC50=1.23831 μM | SANGER | ||
| LAMA-84 | Growth Inhibition Assay | IC50=1.27394 μM | SANGER | ||
| KNS-42 | Growth Inhibition Assay | IC50=1.30296 μM | SANGER | ||
| NCI-H2052 | Growth Inhibition Assay | IC50=1.30507 μM | SANGER | ||
| MLMA | Growth Inhibition Assay | IC50=1.32407 μM | SANGER | ||
| NB12 | Growth Inhibition Assay | IC50=1.35636 μM | SANGER | ||
| NCI-H1838 | Growth Inhibition Assay | IC50=1.36306 μM | SANGER | ||
| NCI-H526 | Growth Inhibition Assay | IC50=1.37853 μM | SANGER | ||
| LS-123 | Growth Inhibition Assay | IC50=1.39094 μM | SANGER | ||
| HDLM-2 | Growth Inhibition Assay | IC50=1.39271 μM | SANGER | ||
| MC-IXC | Growth Inhibition Assay | IC50=1.42371 μM | SANGER | ||
| HCT-15 | Growth Inhibition Assay | IC50=1.43068 μM | SANGER | ||
| NCI-H596 | Growth Inhibition Assay | IC50=1.45061 μM | SANGER | ||
| ZR-75-30 | Growth Inhibition Assay | IC50=1.47082 μM | SANGER | ||
| A704 | Growth Inhibition Assay | IC50=1.66563 μM | SANGER | ||
| OVCAR-4 | Growth Inhibition Assay | IC50=1.69607 μM | SANGER | ||
| SW1417 | Growth Inhibition Assay | IC50=1.72849 μM | SANGER | ||
| CAS-1 | Growth Inhibition Assay | IC50=1.73936 μM | SANGER | ||
| IST-SL1 | Growth Inhibition Assay | IC50=1.79759 μM | SANGER | ||
| A253 | Growth Inhibition Assay | IC50=1.82239 μM | SANGER | ||
| EW-16 | Growth Inhibition Assay | IC50=1.82875 μM | SANGER | ||
| SK-NEP-1 | Growth Inhibition Assay | IC50=1.86988 μM | SANGER | ||
| NCI-H226 | Growth Inhibition Assay | IC50=1.89359 μM | SANGER | ||
| HOP-92 | Growth Inhibition Assay | IC50=1.96099 μM | SANGER | ||
| NCI-H441 | Growth Inhibition Assay | IC50=2.02337 μM | SANGER | ||
| LU-139 | Growth Inhibition Assay | IC50=2.03114 μM | SANGER | ||
| SJRH30 | Growth Inhibition Assay | IC50=2.04253 μM | SANGER | ||
| MG-63 | Growth Inhibition Assay | IC50=2.14111 μM | SANGER | ||
| NH-12 | Growth Inhibition Assay | IC50=2.15006 μM | SANGER | ||
| NB7 | Growth Inhibition Assay | IC50=2.19673 μM | SANGER | ||
| LB771-HNC | Growth Inhibition Assay | IC50=2.20595 μM | SANGER | ||
| HCC1569 | Growth Inhibition Assay | IC50=2.24583 μM | SANGER | ||
| D-283MED | Growth Inhibition Assay | IC50=2.24782 μM | SANGER | ||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=2.25351 μM | SANGER | ||
| ATN-1 | Growth Inhibition Assay | IC50=2.33082 μM | SANGER | ||
| HCC1954 | Growth Inhibition Assay | IC50=2.34408 μM | SANGER | ||
| SCC-15 | Growth Inhibition Assay | IC50=2.39312 μM | SANGER | ||
| COLO-668 | Growth Inhibition Assay | IC50=2.432 μM | SANGER | ||
| LB373-MEL-D | Growth Inhibition Assay | IC50=2.54677 μM | SANGER | ||
| no-10 | Growth Inhibition Assay | IC50=2.54947 μM | SANGER | ||
| HT-1197 | Growth Inhibition Assay | IC50=2.63188 μM | SANGER | ||
| DU-145 | Growth Inhibition Assay | IC50=2.79162 μM | SANGER | ||
| SK-N-AS | Growth Inhibition Assay | IC50=2.84692 μM | SANGER | ||
| MOLT-4 | Growth Inhibition Assay | IC50=2.85322 μM | SANGER | ||
| EW-22 | Growth Inhibition Assay | IC50=2.92841 μM | SANGER | ||
| DB | Growth Inhibition Assay | IC50=2.97759 μM | SANGER | ||
| HL-60 | Growth Inhibition Assay | IC50=3.04376 μM | SANGER | ||
| SK-N-DZ | Growth Inhibition Assay | IC50=3.05075 μM | SANGER | ||
| NY | Growth Inhibition Assay | IC50=3.08542 μM | SANGER | ||
| T47D | Growth Inhibition Assay | IC50=3.10558 μM | SANGER | ||
| NCI-H2029 | Growth Inhibition Assay | IC50=3.22477 μM | SANGER | ||
| KARPAS-299 | Growth Inhibition Assay | IC50=3.26027 μM | SANGER | ||
| KM-H2 | Growth Inhibition Assay | IC50=3.3068 μM | SANGER | ||
| CHP-134 | Growth Inhibition Assay | IC50=3.4739 μM | SANGER | ||
| 22RV1 | Growth Inhibition Assay | IC50=3.49168 μM | SANGER | ||
| NB5 | Growth Inhibition Assay | IC50=3.50689 μM | SANGER | ||
| CW-2 | Growth Inhibition Assay | IC50=3.55314 μM | SANGER | ||
| EFO-21 | Growth Inhibition Assay | IC50=3.5694 μM | SANGER | ||
| HuH-7 | Growth Inhibition Assay | IC50=3.58414 μM | SANGER | ||
| ALL-PO | Growth Inhibition Assay | IC50=3.62335 μM | SANGER | ||
| EM-2 | Growth Inhibition Assay | IC50=3.69011 μM | SANGER | ||
| KLE | Growth Inhibition Assay | IC50=3.73029 μM | SANGER | ||
| NEC8 | Growth Inhibition Assay | IC50=3.91808 μM | SANGER | ||
| KP-N-YN | Growth Inhibition Assay | IC50=3.93476 μM | SANGER | ||
| SK-MEL-1 | Growth Inhibition Assay | IC50=4.03518 μM | SANGER | ||
| CAL-54 | Growth Inhibition Assay | IC50=4.0591 μM | SANGER | ||
| MS-1 | Growth Inhibition Assay | IC50=4.16155 μM | SANGER | ||
| NCI-H209 | Growth Inhibition Assay | IC50=4.29999 μM | SANGER | ||
| NOMO-1 | Growth Inhibition Assay | IC50=4.32131 μM | SANGER | ||
| RPMI-2650 | Growth Inhibition Assay | IC50=4.36327 μM | SANGER | ||
| NCI-H810 | Growth Inhibition Assay | IC50=4.39736 μM | SANGER | ||
| Ca9-22 | Growth Inhibition Assay | IC50=4.45691 μM | SANGER | ||
| ES4 | Growth Inhibition Assay | IC50=4.47095 μM | SANGER | ||
| ES6 | Growth Inhibition Assay | IC50=4.49657 μM | SANGER | ||
| DMS-114 | Growth Inhibition Assay | IC50=4.54691 μM | SANGER | ||
| ONS-76 | Growth Inhibition Assay | IC50=4.5795 μM | SANGER | ||
| K-562 | Growth Inhibition Assay | IC50=4.73814 μM | SANGER | ||
| MHH-NB-11 | Growth Inhibition Assay | IC50=4.75461 μM | SANGER | ||
| Calu-3 | Growth Inhibition Assay | IC50=4.78548 μM | SANGER | ||
| HT55 | Growth Inhibition Assay | IC50=4.84545 μM | SANGER | ||
| SK-N-FI | Growth Inhibition Assay | IC50=4.85009 μM | SANGER | ||
| ES1 | Growth Inhibition Assay | IC50=4.86057 μM | SANGER | ||
| SF126 | Growth Inhibition Assay | IC50=4.93184 μM | SANGER | ||
| ES5 | Growth Inhibition Assay | IC50=5.12427 μM | SANGER | ||
| LoVo | Growth Inhibition Assay | IC50=5.15871 μM | SANGER | ||
| SNU-387 | Growth Inhibition Assay | IC50=5.32339 μM | SANGER | ||
| C8166 | Growth Inhibition Assay | IC50=5.36339 μM | SANGER | ||
| LS-1034 | Growth Inhibition Assay | IC50=5.42307 μM | SANGER | ||
| GR-ST | Growth Inhibition Assay | IC50=5.52201 μM | SANGER | ||
| NCI-H1092 | Growth Inhibition Assay | IC50=5.72843 μM | SANGER | ||
| 647-V | Growth Inhibition Assay | IC50=5.74706 μM | SANGER | ||
| EW-13 | Growth Inhibition Assay | IC50=5.76627 μM | SANGER | ||
| KGN | Growth Inhibition Assay | IC50=6.09921 μM | SANGER | ||
| D-423MG | Growth Inhibition Assay | IC50=6.40284 μM | SANGER | ||
| ECC10 | Growth Inhibition Assay | IC50=7.10101 μM | SANGER | ||
| TE-5 | Growth Inhibition Assay | IC50=7.41298 μM | SANGER | ||
| P12-ICHIKAWA | Growth Inhibition Assay | IC50=7.45523 μM | SANGER | ||
| NCI-H82 | Growth Inhibition Assay | IC50=7.45701 μM | SANGER | ||
| NCI-H1993 | Growth Inhibition Assay | IC50=7.83063 μM | SANGER | ||
| RH-1 | Growth Inhibition Assay | IC50=7.85244 μM | SANGER | ||
| SW948 | Growth Inhibition Assay | IC50=7.96049 μM | SANGER | ||
| CAL-33 | Growth Inhibition Assay | IC50=7.99938 μM | SANGER | ||
| U-266 | Growth Inhibition Assay | IC50=8.15777 μM | SANGER | ||
| CAL-72 | Growth Inhibition Assay | IC50=8.2032 μM | SANGER | ||
| SNU-423 | Growth Inhibition Assay | IC50=9.36666 μM | SANGER | ||
| KG-1 | Growth Inhibition Assay | IC50=9.58456 μM | SANGER | ||
| HCC1395 | Growth Inhibition Assay | IC50=9.92352 μM | SANGER | ||
| BE-13 | Growth Inhibition Assay | IC50=10.8892 μM | SANGER | ||
| MKN7 | Growth Inhibition Assay | IC50=10.9765 μM | SANGER | ||
| 697 | Growth Inhibition Assay | IC50=11.1472 μM | SANGER | ||
| LU-135 | Growth Inhibition Assay | IC50=11.2307 μM | SANGER | ||
| ES7 | Growth Inhibition Assay | IC50=11.3313 μM | SANGER | ||
| SK-HEP-1 | Growth Inhibition Assay | IC50=11.7646 μM | SANGER | ||
| BEN | Growth Inhibition Assay | IC50=11.851 μM | SANGER | ||
| NCI-H1770 | Growth Inhibition Assay | IC50=12.126 μM | SANGER | ||
| SW13 | Growth Inhibition Assay | IC50=12.1541 μM | SANGER | ||
| MZ1-PC | Growth Inhibition Assay | IC50=12.5452 μM | SANGER | ||
| Mo-T | Growth Inhibition Assay | IC50=12.7421 μM | SANGER | ||
| HLE | Growth Inhibition Assay | IC50=12.8215 μM | SANGER | ||
| RCC10RGB | Growth Inhibition Assay | IC50=13.671 μM | SANGER | ||
| COLO-320-HSR | Growth Inhibition Assay | IC50=13.7381 μM | SANGER | ||
| BHT-101 | Growth Inhibition Assay | IC50=13.8345 μM | SANGER | ||
| OCUB-M | Growth Inhibition Assay | IC50=14.1602 μM | SANGER | ||
| MEG-01 | Growth Inhibition Assay | IC50=14.3708 μM | SANGER | ||
| RS4-11 | Growth Inhibition Assay | IC50=14.742 μM | SANGER | ||
| MN-60 | Growth Inhibition Assay | IC50=14.7894 μM | SANGER | ||
| NCI-H1304 | Growth Inhibition Assay | IC50=15.0425 μM | SANGER | ||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=15.0581 μM | SANGER | ||
| NCI-H2342 | Growth Inhibition Assay | IC50=15.2044 μM | SANGER | ||
| LAN-6 | Growth Inhibition Assay | IC50=15.4414 μM | SANGER | ||
| JVM-2 | Growth Inhibition Assay | IC50=15.5748 μM | SANGER | ||
| P30-OHK | Growth Inhibition Assay | IC50=16.0614 μM | SANGER | ||
| C-33-A | Growth Inhibition Assay | IC50=16.6214 μM | SANGER | ||
| RPMI-8866 | Growth Inhibition Assay | IC50=16.8496 μM | SANGER | ||
| NCI-H630 | Growth Inhibition Assay | IC50=16.8537 μM | SANGER | ||
| KYSE-140 | Growth Inhibition Assay | IC50=17.2028 μM | SANGER | ||
| T84 | Growth Inhibition Assay | IC50=18.8695 μM | SANGER | ||
| KU-19-19 | Growth Inhibition Assay | IC50=18.9608 μM | SANGER | ||
| BALL-1 | Growth Inhibition Assay | IC50=19.3399 μM | SANGER | ||
| Calu-6 | Growth Inhibition Assay | IC50=19.492 μM | SANGER | ||
| EGI-1 | Growth Inhibition Assay | IC50=19.598 μM | SANGER | ||
| MFH-ino | Growth Inhibition Assay | IC50=19.7454 μM | SANGER | ||
| GB-1 | Growth Inhibition Assay | IC50=20.3535 μM | SANGER | ||
| NCI-H1693 | Growth Inhibition Assay | IC50=20.6505 μM | SANGER | ||
| SW1116 | Growth Inhibition Assay | IC50=20.9362 μM | SANGER | ||
| H-EMC-SS | Growth Inhibition Assay | IC50=22.045 μM | SANGER | ||
| D-502MG | Growth Inhibition Assay | IC50=22.8261 μM | SANGER | ||
| IA-LM | Growth Inhibition Assay | IC50=23.2493 μM | SANGER | ||
| SW1463 | Growth Inhibition Assay | IC50=23.79 μM | SANGER | ||
| JAR | Growth Inhibition Assay | IC50=24.3293 μM | SANGER | ||
| HT | Growth Inhibition Assay | IC50=24.4753 μM | SANGER | ||
| LCLC-103H | Growth Inhibition Assay | IC50=24.8449 μM | SANGER | ||
| SNU-449 | Growth Inhibition Assay | IC50=24.8741 μM | SANGER | ||
| KE-37 | Growth Inhibition Assay | IC50=25.0928 μM | SANGER | ||
| NCI-H1623 | Growth Inhibition Assay | IC50=27.1303 μM | SANGER | ||
| MOLT-13 | Growth Inhibition Assay | IC50=27.3516 μM | SANGER | ||
| COLO-741 | Growth Inhibition Assay | IC50=31.3333 μM | SANGER | ||
| NB6 | Growth Inhibition Assay | IC50=32.2876 μM | SANGER | ||
| MOLT-16 | Growth Inhibition Assay | IC50=33.0055 μM | SANGER | ||
| IST-MES1 | Growth Inhibition Assay | IC50=34.0541 μM | SANGER | ||
| A4-Fuk | Growth Inhibition Assay | IC50=35.066 μM | SANGER | ||
| CAL-85-1 | Growth Inhibition Assay | IC50=35.2817 μM | SANGER | ||
| CCRF-CEM | Growth Inhibition Assay | IC50=37.1536 μM | SANGER | ||
| HAL-01 | Growth Inhibition Assay | IC50=38.4889 μM | SANGER | ||
| HEL | Growth Inhibition Assay | IC50=43.3409 μM | SANGER | ||
| EW-1 | Growth Inhibition Assay | IC50=43.4768 μM | SANGER | ||
| MDA-MB-231 | Growth Inhibition Assay | IC50=45.1199 μM | SANGER | ||
| ABC-1 | Growth Inhibition Assay | IC50=46.8538 μM | SANGER | ||
| NCI-H446 | Growth Inhibition Assay | IC50=48.5058 μM | SANGER | ||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=49.6007 μM | SANGER | ||
| DOHH-2 | Growth Inhibition Assay | IC50=49.6656 μM | SANGER | ||
| GCT | Growth Inhibition Assay | IC50=49.6976 μM | SANGER | ||
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生物活性
| 產(chǎn)品描述 | Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) 是一種有效的HSP90抑制劑，無細(xì)胞試驗(yàn)中IC50為5 nM，作用于來自腫瘤細(xì)胞的HSP90比作用于來自正常細(xì)胞HSP90結(jié)合親和力高100倍。Tanespimycin (17-AAG)可誘導(dǎo)細(xì)胞凋亡、壞死、自噬和線粒體自噬。Phase 3。 | ||
|---|---|---|---|
| 特性 | 17-AAG對(duì)正常細(xì)胞的毒性很小。 | ||
| 靶點(diǎn) |
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| 體外研究(In Vitro) | ||||
| 體外研究活性 | 17-AAG是格爾德霉素類似物, 但是與過量表達(dá)HER-2的癌細(xì)胞 (BT474, N87, SKOV3 和SKBR3)或BT474乳腺細(xì)胞衍生的Hsp90親和力高100多倍，IC50為5-6 nM, 而作用于正常人類原代細(xì)胞時(shí)，IC50為400-943 nM, 因?yàn)槟[瘤Hsp90 處于多伴復(fù)合體狀態(tài)，具有高ATP酶活性，而正常細(xì)胞Hsp90 處于潛在未結(jié)合狀態(tài), 且直接與那些細(xì)胞中17-AAG毒性相關(guān)。[1]17-AAG 引起HER2, HER3, Akt，突變和野生型雄激素受體(AR)降解，導(dǎo)致前列腺細(xì)胞如LNCaP, LAPC-4, DU-145,和PC-3中RB依賴的 G1 期生長(zhǎng)停頓，IC50為25-45 nM。[2]除了誘導(dǎo)改變野生型BCR-ABL的Ba/F3細(xì)胞凋亡, IC50為5.2 μM, 17-AAG還通過誘導(dǎo)野生型和突變型 BCR-ABL蛋白降解，而誘導(dǎo)改變T315I和 E255K BCR-ABL突變型細(xì)胞生長(zhǎng)，IC50分別為2.3 μM 和 1.0 μM。[3] |
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| 激酶實(shí)驗(yàn) | Hsp90結(jié)合實(shí)驗(yàn) | |||
| 純化的Hsp90蛋白或過量表達(dá)HER-2的癌細(xì)胞(BT474, N87, SKOV3 和 SKBR3) 裂解物或BT474乳腺癌細(xì)胞溶于溶解buffer(20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) ，與不同濃度17-AAG在4oC下溫育30分鐘，然后和生物素-GM鏈接的BioMag鏈霉親和素磁珠在4oC下溫育1小時(shí)。試管放置于磁架上,除去未結(jié)合的上清液。在溶解buffer中清洗三次磁珠，然后在SDS–PAGE 樣本緩沖液中在95oC下加熱5分鐘。在SDS蛋白凝膠上進(jìn)行樣本分析,使用特點(diǎn)抗體進(jìn)行Western Blotting。使用Bio-rad Fluor-S 多重圖像測(cè)量Western Blot條帶，計(jì)算抑制Hsp90與生物素-GM結(jié)合的百分?jǐn)?shù)。測(cè)定IC50。 | ||||
| 細(xì)胞實(shí)驗(yàn) | 細(xì)胞系 | BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, 和 PBMC | ||
| 濃度 | 溶于DMSO, 終濃度為10 μM 左右 | |||
| 孵育時(shí)間 | 5天 | |||
| 方法 | 細(xì)胞按每孔2000個(gè)接種在96孔板上，終培養(yǎng)體積為100 μL，培養(yǎng)24小時(shí)， 然后加入濃度不斷增高的17-AAG，溫育5天。使用 Celltiter 96 AQueous 非放射性細(xì)胞增殖檢測(cè)試劑盒測(cè)定存活細(xì)胞數(shù)。測(cè)定IC50。 |
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| 實(shí)驗(yàn)圖片 | 檢測(cè)方法 | 檢測(cè)指標(biāo) | 實(shí)驗(yàn)圖片 | PMID |
| Western blot | α-Synuclein / HSP90 / HSP70 / HSP32 / αB-Crystallin EGFR / PDGFR / AKT / MAPK / c-RAS pAKT / pMAPK / pRb Cleaved PARP / Survivin LATS1 / p-LATS1 / YAP / CTGF |
|
20090920 | |
| Immunofluorescence | STAT3 YAP / TAZ β-catenin / E-cadherin |
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27279418 | |
| Growth inhibition assay | Cell viability |
|
18682579 | |
| 體內(nèi)研究(In Vivo) | ||
| 體內(nèi)研究活性 | 17-AAG作用于攜帶3T3-src, B16或CT26移植瘤裸鼠，與Hsp90結(jié)合具有高親和力，IC50為8-35 nM，而作用于正常組織時(shí)，IC50為200-600 nM。[1] 17-AAG按50 mg/kg左右劑量處理，引起AR, HER2, HER3, 和 Akt表達(dá)明顯降低，降低達(dá)50%以上，這種作用存在劑量依賴性，結(jié)果導(dǎo)致雄激素依賴型 (CWR22)和非依賴型(CWR22R 和CWRSA6) 前列腺移植瘤生長(zhǎng)受抑制，抑制率分別為67%, 80%和 68%。[2] |
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| 動(dòng)物實(shí)驗(yàn) | Animal Models | 皮下注射雄激素依賴性CWR22移植瘤的雄性 nu/nu 無胸腺小鼠， 皮下注射雄激素非依賴性的CWR22R和CWRSA6移植瘤的雌性nu/nu 無胸腺小鼠。 |
| Dosages | 50 mg/kg 左右 | |
| Administration | 腹膜注射 | |
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT00103272 | Terminated | Adult Acute Basophilic Leukemia|Adult Acute Eosinophilic Leukemia|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Waldenstr?m Macroglobulinemia |
National Cancer Institute (NCI) |
April 2005 | Phase 1 |
| NCT00098488 | Terminated | B-cell Chronic Lymphocytic Leukemia|Prolymphocytic Leukemia|Refractory Chronic Lymphocytic Leukemia |
National Cancer Institute (NCI) |
April 2005 | Phase 1 |
| NCT00118248 | Completed | Recurrent Thyroid Cancer|Stage IV Follicular Thyroid Cancer|Stage IV Papillary Thyroid Cancer|Thyroid Gland Medullary Carcinoma |
National Cancer Institute (NCI) |
December 2004 | Phase 2 |
| NCT00098423 | Completed | Accelerated Phase Chronic Myelogenous Leukemia|Adult Acute Basophilic Leukemia|Adult Acute Eosinophilic Leukemia|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Blastic Phase Chronic Myelogenous Leukemia|Chronic Myelomonocytic Leukemia|de Novo Myelodysplastic Syndromes|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Refractory Anemia With Excess Blasts in Transformation|Relapsing Chronic Myelogenous Leukemia|Secondary Acute Myeloid Leukemia|Secondary Myelodysplastic Syndromes |
National Cancer Institute (NCI) |
November 2004 | Phase 1 |
化學(xué)信息&溶解度
| 分子量 | 585.69 | 分子式 | C31H43N3O8 |
| CAS號(hào) | 75747-14-7 | SDF | Download Tanespimycin (17-AAG) SDF |
| Smiles | CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC | ||
| 儲(chǔ)存條件(自收到貨起) | |||
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體外溶解度 |
DMSO : 100 mg/mL ( (170.73 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開封DMSO) Ethanol : 33 mg/mL (56.34 mM) Water : Insoluble |
摩爾濃度計(jì)算器 |
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體內(nèi)溶解度 現(xiàn)配現(xiàn)用，請(qǐng)按從左到右的順序依次添加，澄清后再加入下一溶劑 |
動(dòng)物體內(nèi)配方計(jì)算器 | ||||
實(shí)驗(yàn)計(jì)算
摩爾濃度計(jì)算器
動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）
第一步：請(qǐng)輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過程中的損耗，建議多配一只動(dòng)物的藥量）
mg/kg
g
μL
只
第二步：請(qǐng)輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請(qǐng)聯(lián)系Selleck為您提供正確的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
計(jì)算結(jié)果：
工作液濃度： mg/ml；
DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請(qǐng)先聯(lián)系Selleck）；
體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。
體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。
注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。
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常見問題及建議解決方法
問題 1:
What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?
回答：
17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html
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