IWP-2

目錄號：S7085 Purity: 99.60%

IWP-2是一種Wnt信號和分泌抑制劑，無細(xì)胞試驗(yàn)中IC50為27 nM，選擇性阻斷Porcn介導(dǎo)的Wnt棕櫚?；?，一般不影響Wnt/β-catenin，且對Wnt刺激的細(xì)胞反應(yīng)沒有影響。IWP-2可特定低抑制 CK1δ。

IWP-2 Chemical Structure

CAS: 686770-61-6

規(guī)格	價格	庫存
10mg	806.41	現(xiàn)貨
50mg	2766.42	現(xiàn)貨
1g	24488.1	現(xiàn)貨
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產(chǎn)品質(zhì)控

批次：純度： 99.60%

99.60

常與IWP-2一起在實(shí)驗(yàn)中被使用的化合物

IWP-4

IWP-2和IWP-4是WNT抑制劑，通常用作人類心肌細(xì)胞(CM)分化的小分子。

Moon SH, et al. Int J Stem Cells. 2017 May 30;10(1):1-11.

LGK-974

IWP-2和LGK-974降低RWPE-1和PZ-HPV7敲低(KD)細(xì)胞中CD44的球體形成和轉(zhuǎn)錄活性。

Yun EJ, et al. Clin Cancer Res. 2016 Feb 1;22(3):670-9.

PRI-724

IWP-2和PRI-724誘導(dǎo)細(xì)胞凋亡，影響HNSCC細(xì)胞遷移，并強(qiáng)烈影響HNSCC細(xì)胞中β-catenin依賴性基因的表達(dá)。

Kleszcz R, et al. Cell Oncol (Dordr). 2019 Aug;42(4):505-520.

VPA (Valproic acid)

IWP-2促進(jìn)腸上皮細(xì)胞分化，Valproicacid抑制Lgr5+干細(xì)胞分化。

Yin X, et al. Nat Methods. 2014 Jan;11(1):106-12.

IWP-2相關(guān)產(chǎn)品

相關(guān)靶點(diǎn)	WNT β-catenin Wnt/β-catenin	點(diǎn)擊展開
相關(guān)產(chǎn)品	IWR-1-endo SKL2001 BML-284 (Wnt agonist 1) PRI-724 Salinomycin (from Streptomyces albus) FH535 PNU-74654 LF3 KYA1797K KY02111 iCRT3 Adavivint (SM04690) MSAB Isoquercitrin IQ-1 iCRT14 CCT251545 Isoxazole 9 (ISX-9) JW55 Methyl Vanillate M435-1279 WAY-262611 JW74	點(diǎn)擊展開
相關(guān)化合物庫	激酶抑制劑庫 FDA藥物庫干細(xì)胞小分子化合物庫 GPCR小分子化合物庫干細(xì)胞分化化合物庫	點(diǎn)擊展開

細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

細(xì)胞系	實(shí)驗(yàn)類型	孵育時間	活性描述	文獻(xiàn)信息
mouse L cells	Function assay	24 h	Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay, EC50=30 nM	23477365
HEK293T	Function assay	22 hrs	Inhibition of porcupine in HEK293T cells transfected with Wnt3A-expressing vector assessed as suppression of Wnt/beta-catenin signaling after 22 hrs by Super-top flash reporter gene assay, IC50 = 0.157 μM.	29630366
MIAPaCa2	Antiproliferative assay	48 hrs	Antiproliferative activity against human MIAPaCa2 cells after 48 hrs by MTT assay, EC50 = 1.9 μM.	29630366
SW620	Antiproliferative assay	48 hrs	Antiproliferative activity against human SW620 cells after 48 hrs by MTT assay, EC50 = 1.9 μM.	29630366
Capan1	Antiproliferative assay	48 hrs	Antiproliferative activity against human Capan1 cells after 48 hrs by MTT assay, EC50 = 2.05 μM.	29630366
PANC1	Antiproliferative assay	48 hrs	Antiproliferative activity against human PANC1 cells after 48 hrs by MTT assay, EC50 = 2.33 μM.	29630366
HEK293	Antiproliferative assay	48 hrs	Antiproliferative activity against human HEK293 cells after 48 hrs by MTT assay, EC50 = 2.76 μM.	29630366
Panc89	Antiproliferative assay	48 hrs	Antiproliferative activity against human Panc89 cells after 48 hrs by MTT assay, EC50 = 3.86 μM.	29630366
HT-29	Antiproliferative assay	48 hrs	Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay, EC50 = 4.67 μM.	29630366
A818-6	Antiproliferative assay	48 hrs	Antiproliferative activity against human A818-6 cells after 48 hrs by MTT assay, EC50 = 8.96 μM.	29630366
A673	qHTS assay		qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells	29435139
DAOY	qHTS assay		qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells	29435139
Saos-2	qHTS assay		qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells	29435139
BT-12	qHTS assay		qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells	29435139
OHS-50	qHTS assay		qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells	29435139
BT-12	qHTS assay		qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-12 cells	29435139
DAOY	qHTS assay		qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for DAOY cells	29435139
Rh41	qHTS assay		qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells	29435139
A673	qHTS assay		qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for A673 cells)	29435139
MG 63 (6-TG R)	qHTS assay		qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for MG 63 (6-TG R) cells	29435139
fibroblast cells	qHTS assay		qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for control Hh wild type fibroblast cells	29435139
Rh41	qHTS assay		qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh41 cells	29435139
SJ-GBM2	qHTS assay		qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells	29435139
SK-N-MC	qHTS assay		qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells	29435139
LAN-5	qHTS assay		qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells	29435139
SK-N-MC	qHTS assay		qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-MC cells	29435139
TC32	qHTS assay		qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for TC32 cells	29435139
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生物活性

產(chǎn)品描述

IWP-2是一種Wnt信號和分泌抑制劑，無細(xì)胞試驗(yàn)中IC50為27 nM，選擇性阻斷Porcn介導(dǎo)的Wnt棕櫚酰化，一般不影響Wnt/β-catenin，且對Wnt刺激的細(xì)胞反應(yīng)沒有影響。IWP-2可特定低抑制 CK1δ。

靶點(diǎn)

Wnt ^[1] (Cell-free assay)	^M82FCK1δ ^[3] (Cell-free assay)
27 nM	40 nM

體外研究(In Vitro)
體外研究活性	IWP-2在再生醫(yī)學(xué)和抗癌方面都非常有效。IWP-2使Porcn失活, Porcn是一種與O-?；D(zhuǎn)移酶(MBOAT)結(jié)合的膜,且選擇性抑制Wnt棕櫚酰化。IWP-2抑制Lrp6受體和Dvl2發(fā)生Wnt依賴性的磷酸化，也抑制β-catenin累積。^[1]
實(shí)驗(yàn)圖片	檢測方法	檢測指標(biāo)	實(shí)驗(yàn)圖片	PMID
實(shí)驗(yàn)圖片	Western blot	Wnt5-a/b / β-catenin / Axin2 c-myc / Cyclin D1 / Survivin 感谢您访问我们的网站，您可能还对以下资源感兴趣：成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天国产精品欧美亚洲韩国日本,爱搞视频网站,免费观看一级毛片,麻豆片免费观看在线看狠狠干天天爽,国产精品天天看天天爽,99色播,十三以下岁女子毛片国产精品2022不卡在线观看,久久久久青草线蕉亚洲麻豆,91蜜桃国产成人精品区,亚洲精品乱码久久久久久蜜桃图片欧美综合图区亚洲综合图区69,国产日韩久久久精品影院首页,另类综合视频,国产精品福利久久久久澳门,h视频在线观看免费网站,69黄在线看片免费视频,精品久久伊人

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