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Acyclovir (Aciclovir)

別名: Acycloguanosine, ACV, NSC 645011,BW 248U 中文名稱：阿昔洛韋

Acyclovir (Aciclovir)是一種合成的核苷類似物，有效作用于皰疹病毒。Acyclovir 可在Jurkat白血病細(xì)胞中誘導(dǎo)細(xì)胞周期紊亂和凋亡。

Acyclovir (Aciclovir) Chemical Structure

Acyclovir (Aciclovir) Chemical Structure

CAS: 59277-89-3

規(guī)格 價(jià)格 庫存 購買數(shù)量
10mM (1mL in DMSO) 1058.76 現(xiàn)貨
50mg 814.95 現(xiàn)貨
1g 5487.3 現(xiàn)貨
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Acyclovir (Aciclovir)相關(guān)產(chǎn)品

細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

細(xì)胞系 實(shí)驗(yàn)類型 給藥濃度 孵育時(shí)間 活性描述 文獻(xiàn)信息
african green monkey Vero cells Function assay 48 h Antiviral activity against HSV2 strain 333 infected in african green monkey Vero cells assessed as inhibition of cytopathic effect after 48 hrs by plaque reduction assay, EC50=1.87 μM 22704890
HEL cells Function assay 4 days Antiviral activity against HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 4 days, EC50=0.2 μM 22459876
African green monkey Vero 76 cells Cytotoxicity assay 48-96 h Cytotoxicity against African green monkey Vero 76 cells assessed as cell viability after 48 to 96 hrs by crystal violet staining, CC50=13 μM 26119992
BSC-1 cells Function assay Antiviral activity of the compound was evaluated against the Herpes simplex virus type-1 in BSC-1 cells, IC50=2.6 μM 2913300
P3HR-1 cells Function assay Effective concentration for the inhibition of Epstein-Barr virus EBV-DNA synthesis in human lymphoblastoid P3HR-1 cells, EC50=6.75 μM 12408726
HFF cells Function assay Concentration for HSV-1 plaque reduction (VPR) by 50% in HFF cells, EC50=1.1 μM 14584954
HFF cells Function assay Inhibitory concentration required to reduce HSV-1 induced cytopathogenic effect (CPE) by 50 % in HFF cells, EC50=2.22 μM 14584954
human embryonic lung cells Function assay Antiviral activity was measured as effective concentration required to reduce Varicella Zoster virus (OKA)-induced plaque formation in human embryonic lung cells, EC50=1.1 μM 11549457
HEL cells Function assay Compound was tested for anti-viral activity against HSV-1(G) in HEL cells, EC50=1.3 μM 14643328
HEL cell Function assay Effective concentration required to inhibit Tyrosine kinase (TK+) Varicella-Zoster virus-induced cytopathicity by 50% in OKA strain HEL cell lines, EC50=4.53 μM 11495586
HSV-2 MS Vero cells Function assay Inhibition of viral cytopathic effect in infected human foreskin fibroblast cell monolayers of HSV-2 MS Vero cells by 50%, EC50=6.2 μM 11585457
HSV-1 E-377 Vero cells Function assay Inhibition of plaque formation in monolayers of HSV-1 E-377 Vero cells by 50%, EC50=4.4 μM 11585457
HSV-1 KOS Vero cells Function assay Inhibition of plaque formation in monolayers of HSV-1 KOS Vero cells by 50%, EC50=2.2 μM 11585457
HeLa cell Function assay Ability to inhibit cytopathogenicity of herpes simplex type 1 virus (G) in HeLa cell culture, IC50=0.19 μM 11356110
HEp-2 cells Function assay Minimum inhibitory concentration causing 25% inhibition of cytopathic effect induced by Herpes simplex virus-1 (K979) in HEp-2 cells 2842506
HeLa cells Function assay Inhibition of HSV-1 DNA synthesis in virus-infected HeLa cells, IC50=1.9 μM 7752206
human HFF cells Function assay Inhibitory concentration of the drug against the cytopathic effect for E-377 strain of herpes simplex virus-1 (HSV-1) in human HFF cells, EC50=0.04 μM 8394933
human HFF cells Function assay Inhibitory concentration of the drug against the cytopathic effect for MS strain of herpes simplex virus-2 (HSV-2) in human HFF cells, EC50=0.09 μM 8394933
MRC-5 cells Function assay Antiviral activity in plaque reduction assay was determined against herpes simplex virus type 2 (HSV-2) in MRC-5 cells, IC50=2.5 μM 2153202
human lung fibroblasts (MRC-5) Function assay Compound was tested for antiviral activity against Herpes Simplex virus Type-1(18189) in human lung fibroblasts (MRC-5) 3040998
Raji cells Function assay Inhibitory concentration of the drug against the antigen production against P3HR-1 strain of epstein barr virus-2 (EBV) in Raji cells, EC50=2.9 μM 8394933
Vero cells Function assay Inhibitory activity against herpes simplex virus type 2 (HSV 2) strain 186 in Vero cells, IC50=1.7 μM 8576922
BSC-1 cells Function assay Effective concentration required to inhibit herpes simplex virus 1 in BSC-1 cells in ELISA, EC50=1.5 μM 15634003
HFF cells Function assay Effective concentration required to inhibit varicella zoster virus replication in HFF cells, EC50=1.6 μM 15634003
HFF cells Function assay Effective concentration required to inhibit herpes simplex virus 1 in HFF cells in cytopathic effect (CPE) assay, EC50=0.9 μM 15634003
Daudi cells Function assay Inhibition of EBV replication in Daudi cells by viral capsid antigen-ELISA, EC50=0.33 μM 17004726
WI-38 cell Function assay Anti viral activity against VZV(pplla strain) in WI-38 cell monolayers, ID50=4 μM 1316966
HEL cells Function assay Antiviral activity against HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect, EC50=0.14 μM 23099097
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生物活性

產(chǎn)品描述 Acyclovir (Aciclovir)是一種合成的核苷類似物，有效作用于皰疹病毒。Acyclovir 可在Jurkat白血病細(xì)胞中誘導(dǎo)細(xì)胞周期紊亂和凋亡。
靶點(diǎn)
HSV [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06228430 Not yet recruiting
Healthy Volunteer
International Bio service
 February 12 2024 Phase 1
NCT05589688 Not yet recruiting
Obesity
University Hospital Toulouse
 January 2024 Phase 1
NCT06058858 Not yet recruiting
Cytomegalovirus Infections|Acute Leukemia|B Cell Lymphoma
Assistance Publique - H?pitaux de Paris
 October 1 2023 --
NCT05468619 Recruiting
Herpes Simplex
National Institute of Allergy and Infectious Diseases (NIAID)
 September 23 2022 Phase 1

化學(xué)信息&溶解度

分子量 225.2 分子式

C8H11N5O3
CAS號(hào) 59277-89-3 SDF Download Acyclovir (Aciclovir) SDF
Smiles C1=NC2=C(N1COCCO)N=C(NC2=O)N
儲(chǔ)存條件(自收到貨起)

體外溶解度
批次：

DMSO : 45 mg/mL ( (199.82 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開封DMSO)

Water : Insoluble

Ethanol : Insoluble

摩爾濃度計(jì)算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請(qǐng)按從左到右的順序依次添加，澄清后再加入下一溶劑

 動(dòng)物體內(nèi)配方計(jì)算器

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量 濃度 體積 分子量

動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請(qǐng)輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過程中的損耗，建議多配一只動(dòng)物的藥量）

mg/kg g μL 只

第二步：請(qǐng)輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請(qǐng)聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請(qǐng)先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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