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Kaempferol

別名: NSC 407289, Robigenin 中文名稱：山奈酚

Kaempferol是一種黃酮，是ERRα和ERRγ的反向激動(dòng)劑。抑制topoisomerase I催化的DNA再連接和fatty acid synthase的活性。

Kaempferol Chemical Structure

Kaempferol Chemical Structure

CAS: 520-18-3

規(guī)格 價(jià)格 庫(kù)存 購(gòu)買數(shù)量
50mg 647.01 現(xiàn)貨
200mg 1056.51 現(xiàn)貨
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Kaempferol相關(guān)產(chǎn)品

相關(guān)信號(hào)通路圖

Estrogen/progestogen Receptor Signaling Pathways

Estrogen/progestogen Receptor信號(hào)通路圖

細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

細(xì)胞系 實(shí)驗(yàn)類型 給藥濃度 孵育時(shí)間 活性描述 文獻(xiàn)信息
human U87 cells Cytotoxicity assay 5-40 μM 72 h Cytotoxicity against human U87 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay 22871217
human A549 cells Cytotoxicity assay 5-40 μM 72 h Cytotoxicity against human A549 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay 22871217
human MCF7 cells Cytotoxicity assay 5-40 μM 72 h Cytotoxicity against human MCF7 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay 22871217
MDA-MB-231 cells Cytotoxicity assay 5-40 μM 72 h Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay 22871217
human NCI-H2126 cells Cytotoxicity assay 5-40 μM 72 h Cytotoxicity against human NCI-H2126 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay 22871217
human SMMC7721 cells Cytotoxicity assay 5-40 μM 72 h Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay 22871217
human PANC1 cells Cytotoxicity assay 5-40 μM 72 h Cytotoxicity against human PANC1 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay 22871217
human BxPC3 cells Cytotoxicity assay 5-40 μM 72 h Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay 22871217
MDCK cells Function assay 50 μM Antiviral activity against influenza A virus H1N1 A/PR/8/34 infected in MDCK cells assessed as reduction in fluorescence positive cells at 50 uM immunofluorescence assay 19729316
human MV4-11 cells Cytotoxicity assay 72 h Cytotoxicity against human MV4-11 cells harboring FLT3 mutation after 72 hrs by tetrazolium based Ez CyTox cell viability assay, GI50=3.34 μM 23411073
HEK293 FS cells Function assay Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay, IC50=1.2 μM 20731357
human HeLa cells Function assay Inhibition of MRP1 transfected in human HeLa cells assessed as inhibition of [3H]LTC4 transport by rapid filtration assay, Ki=2.4 μM 19725578
MDCK cells Function assay Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining, IC50=4.7 μM 21354800
human MDA-kb2 cells Function assay Antagonist activity at androgen receptor in human MDA-kb2 cells assessed as inhibition of DHT-induced luciferase activity by luciferase reporter gene assay, IC50=9.7 μM 19592245
B16-4A5 cells Function assay Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells after 72 hrs, IC50=20 μM 19615910
human HL60 cells Cytotoxicity assay Cytotoxicity against human HL60 cells assessed as cell survival at 50 uM after 72 hrs by CCK8 assay 25074815
mouse 3T3L1 cells Function assay Inhibition of AMPK-mediated adipocyte differentiation in mouse 3T3L1 cells 20822902
mouse RAW264.7 cells Function assay Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as nitrite level at 1 to 100 uM after 24 hrs by Griess method 21353543
mouse L929 cells Function assay Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality treated with drug after 2 hrs of TNFalpha treatment 9287415
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生物活性

產(chǎn)品描述 Kaempferol是一種黃酮，是ERRα和ERRγ的反向激動(dòng)劑。抑制topoisomerase I催化的DNA再連接和fatty acid synthase的活性。
靶點(diǎn)
ERRα [1] ERRγ [1] Topo I [2] fatty acid synthase [3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05073523 Completed
Healthy
Chalmers University of Technology
 September 27 2021 Not Applicable

化學(xué)信息&溶解度

分子量 286.23 分子式

C15H10O6
CAS號(hào) 520-18-3 SDF Download Kaempferol SDF
儲(chǔ)存條件(自收到貨起)

體外溶解度
批次：

DMSO : 57 mg/mL ( (199.14 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開封DMSO)

Ethanol : 3 mg/mL (10.48 mM)

Water : Insoluble

摩爾濃度計(jì)算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請(qǐng)按從左到右的順序依次添加，澄清后再加入下一溶劑

 動(dòng)物體內(nèi)配方計(jì)算器

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量 濃度 體積 分子量

動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請(qǐng)輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過(guò)程中的損耗，建議多配一只動(dòng)物的藥量）

mg/kg g μL 只

第二步：請(qǐng)輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請(qǐng)聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過(guò)該批次藥物DMSO溶解度，請(qǐng)先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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