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Ribavirin (ICN-1229)

別名: NSC-163039, RTCA, Tribavirin 中文名稱:利巴韋林

Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin)是一種抗病毒劑,用于治療重癥RSV感染,丙型肝炎病毒感染和其他病毒感染。

Ribavirin (ICN-1229) Chemical Structure

Ribavirin (ICN-1229) Chemical Structure

CAS: 36791-04-5

規(guī)格 價格 庫存 購買數(shù)量
10mM (1mL in DMSO) 738.91 現(xiàn)貨
100mg 574.27 現(xiàn)貨
1g 3030.3 現(xiàn)貨
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Ribavirin (ICN-1229)相關(guān)產(chǎn)品

細(xì)胞實驗數(shù)據(jù)示例

細(xì)胞系 實驗類型 給藥濃度 孵育時間 活性描述 文獻(xiàn)信息
human KB cells Function assay 1-1000 μg/ml 72 h Antiviral activity against Rhinovirus type 13 infected in human KB cells assessed as inhibition of virus-induced cytopathic effect at 1 to 1000 ug/ml after 72 hrs 211234
MDCK cells Function assay 3 days Antiviral activity against Influenza B virus (B/HK/5/72) infected in MDCK cells assessed as virus-induced cytopathic effect after 3 days by microscopic analysis, EC50=0.094 μM 23117173
mouse L1210 cells Function assay 20-60 mins Inhibition of IMPDH in mouse L1210 cells assessed as formation of [2,8-3H]hypoxanthine from [2,8-3H]IMP after 20 to 60 mins, IC50=1 μM 22555152
human CEM cells Function assay 20-60 mins Inhibition of IMPDH in human CEM cells assessed as formation of [2,8-3H]hypoxanthine from [2,8-3H]IMP after 20 to 60 mins, IC50=1 μM 22555152
MDCK cells Function assay 36 h Antiinfluenza activity against influenza A virus H1N1 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 36 hrs, IC50=1.9 μM 22341943
MDBK cells Function assay 2 days Antiviral activity against Bovine viral diarrhea virus 1-NADL ATCC VR534 infected in MDBK cells assessed as reduction of viral cytopathic effect after 2 days bt MTS assay, EC50=4.6 μM 22944333
african green monkey Vero cells Function assay 5 days Antiviral activity against RSV A2 infected in african green monkey Vero cells after 5 days by plaque reduction assay, EC50=7 μM 20359898
HEL cells Function assay 2-3 days Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as protection from virus-induced cytopathogenicity after 2 to 3 days by MTT assay, EC50=10 μM 20034711
HEK293 cells Function assay 24 h Inhibition of influenza A virus RNA-dependent RNA polymerase expressed in HEK293 cells after 24 hrs by dual luciferase reporter gene assay, EC50=15 μM 24313730
human BE(2)-C cells Function assay 18-20 h Antiviral activity against Western equine encephalomyelitis virus infected in human BE(2)-C cells assessed as inhibition of viral RNA replication after 18 to 20 hrs by luciferase reporter gene assay, IC50=16 μM 24151954
human MT4 cells Cytotoxic?assay 96 h Cytotoxicity against human MT4 cells after 96 hrs by MTT assay, CC50=31 μM 19482481
human HuH7 cells Cytotoxic?assay 3 days Cytotoxicity against human HuH7 cells infected with HCV1b after 3 days by MTS assay, CC50=32 μM 22100256
human KB cells Function assay 72 h Antiviral activity against Rhinovirus type 13 infected in human KB cells assessed as inhibition of virus-induced cytopathic effect after 72 hrs relative to control 722730
E6SM cell lines Function assay Effective concentration required to inhibit Herpes simplex virus-1(HSV-1) / thymine kinase deficient (TK-)B2006 / VMW1837 induced cytopathicity by 50% in E6SM cell lines, EC50=0.005 μM 11495586
BHK21 cell line Function assay Inhibition of West Nile virus VLP replicon in BHK21 cell line, EC50=1.1 μM 16539402
HeLa cell Function assay Effective concentration required to inhibit respiratory synaptial(RSV) virus-induced cytopathicity by 50% in HeLa cell lines, EC50=1.5 μM 11495586
human HuH7-J20 cells Function assay Antiviral activity against HCV JFH1 infected in human HuH7-J20 cells assessed as inhibition of viral life cycle by measuring secreted alkaline phosphatase level preincubated with cells for 1 hr followed by viral inoculation for 3 hrs measured at 72 hrs, EC50=30.4 μM 26428870
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生物活性

產(chǎn)品描述 Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin)是一種抗病毒劑,用于治療重癥RSV感染,丙型肝炎病毒感染和其他病毒感染。
體外研究(In Vitro)
體外研究活性 Ribavirin顯著降低了亞基因組復(fù)制子轉(zhuǎn)染細(xì)胞的復(fù)制系統(tǒng)的效率,盡管Ribavirin對HCV復(fù)制的水平幾乎沒有影響。Ribavirin增加丙型肝炎病毒的突變頻率,NS5A編碼區(qū)的突變率最高。Ribavirin增強(qiáng)TH1,同時抑制T2細(xì)胞因子產(chǎn)生刺激的T細(xì)胞。[1] Ribavirin顯示了抗病毒活性,抗多種RNA病毒,并結(jié)合使用α-干擾素來治療丙型肝炎病毒感染。Ribavirin減少感染的脊髓灰質(zhì)炎病毒的產(chǎn)生,少到細(xì)胞培養(yǎng)物的0.00001%。 [2] Ribavirin的抗病毒活性是通過病毒的遺傳物質(zhì)的致死突變直接作用。[3] Ribavirin在生理濃度(高達(dá)500毫克/毫升)顯著降低病毒引起的巨噬細(xì)胞的活化。Ribavirin抑制Th2細(xì)胞產(chǎn)生IL-4,而這并不會抹殺Th1細(xì)胞產(chǎn)生IFN-γ。[4] Ribavirin在體外表現(xiàn)出對DNA和RNA病毒廣泛的抗病毒活性。Ribavirin是一種細(xì)胞生長抑制劑,導(dǎo)致DNA,RNA和蛋白質(zhì)合成的的減少。Ribavirin能誘導(dǎo)輔助性T細(xì)胞表型從從2型轉(zhuǎn)變?yōu)?型。 [5]
實驗圖片 檢測方法 檢測指標(biāo) 實驗圖片 PMID
Western blot p53 / p-p53 / p21 / Mdm2 EZH2 / p-ERK / ERK / p-eIF4E / eIF4E / p21 Cyclin D1 p-AKT / AKT / pBP1 / BP1 22962590
Growth inhibition assay Cell number 21415224
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05940545 Recruiting
CCHF
Liverpool School of Tropical Medicine
July 12 2023 Phase 1|Phase 2
NCT04283513 Not yet recruiting
Hemorrhagic Fever
U.S. Army Medical Research and Development Command
October 31 2022 Phase 2
NCT04335123 Completed
COVID-19
University of Kansas Medical Center
April 4 2020 Phase 1
NCT04285034 Completed
Lassa Fever
University of Oxford
November 26 2019 --
NCT03889106 Terminated
Lassa Fever
University of Oxford|National Institute for Health Research United Kingdom|Kenema Government Hospital|London School of Hygiene and Tropical Medicine|Public Health England
March 1 2019 --
NCT03585725 Terminated
Follicular Lymphoma|Mantle Cell Lymphoma
Weill Medical College of Cornell University|Memorial Sloan Kettering Cancer Center
September 26 2018 Early Phase 1

化學(xué)信息&溶解度

分子量 244.20864 分子式

C8H12N4O5

CAS號 36791-04-5 SDF Download Ribavirin (ICN-1229) SDF
Smiles C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N
儲存條件(自收到貨起)

體外溶解度
批次:

DMSO : 49 mg/mL ( (200.64 mM) ;DMSO吸濕會降低化合物溶解度,請使用新開封DMSO)

Water : 49 mg/mL (200.64 mM)

Ethanol : Insoluble

摩爾濃度計算器

體內(nèi)溶解度
批次:

現(xiàn)配現(xiàn)用,請按從左到右的順序依次添加,澄清后再加入下一溶劑

動物體內(nèi)配方計算器
澄清溶液
5% DMSO 95% Corn oil
0.306mg/ml (1.25mM) 以1 mL工作液為例,取50μL 6.12mg/ml的澄清DMSO儲備液加到950μL玉米油中,混合均勻。工作液請現(xiàn)配現(xiàn)用!
澄清溶液
5%DMSO 40% 5% 50%ddH2O
2.45mg/ml (10.03mM) 以 1 mL 工作液為例,取50μL49mg/ml的澄清DMSO儲備液加到400μLPEG300中,混合均勻使其澄清;向上述體系中加入50μLTween80,混合均勻使其澄清;然后繼續(xù)加入500μLddH2O定容至1mL。工作液請現(xiàn)配現(xiàn)用!

實驗計算

摩爾濃度計算器

質(zhì)量 濃度 體積 分子量

動物體內(nèi)配方計算器(澄清溶液)

第一步:請輸入基本實驗信息(考慮到實驗過程中的損耗,建議多配一只動物的藥量)

mg/kg g μL

第二步:請輸入動物體內(nèi)配方組成(配方適用于不溶于水的藥物;不同批次藥物配方比例不同,請聯(lián)系Selleck為您提供正確的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結(jié)果:

工作液濃度: mg/ml;

DMSO母液配制方法: mg 藥物溶于μL DMSO溶液(母液濃度mg/mL,:如該濃度超過該批次藥物DMSO溶解度,請先聯(lián)系Selleck);

體內(nèi)配方配制方法:μL DMSO母液,加入μL PEG300,混勻澄清后加入μL Tween 80,混勻澄清后加入μL ddH2O,混勻澄清。

體內(nèi)配方配制方法:μL DMSO母液,加入μL Corn oil,混勻澄清。

注意:1. 首先保證母液是澄清的;
2.一定要按照順序依次將溶劑加入,進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液,可采用渦旋、超聲或水浴加熱等物理方法助溶。

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