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Prostaglandin E2 (PGE2)

別名: Dinoprostone 中文名稱：前列腺素E2

Prostaglandin E2 (PGE2, Dinoprostone) 在分娩中發(fā)揮重要作用（可軟化宮頸，引起子宮收縮），也刺激成骨細胞釋放能刺激破骨細胞吸收的因子。液體環(huán)境中長期保存易變色，建議以粉末形式保存，現(xiàn)配現(xiàn)用！

Prostaglandin E2 (PGE2) Chemical Structure

Prostaglandin E2 (PGE2) Chemical Structure

CAS: 363-24-6

規(guī)格 價格 庫存 購買數(shù)量
5mg 794.81 現(xiàn)貨
25mg 2375.79 現(xiàn)貨
100mg 6200.68 現(xiàn)貨
1g 16134.3 現(xiàn)貨
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Prostaglandin E2 (PGE2)相關產品

細胞實驗數(shù)據示例

細胞系 實驗類型 給藥濃度 孵育時間 活性描述 文獻信息
CHO Function assay 100 nM Activity at recombinant EP1 receptor (unknown origin) expressed in CHO cells co-expressing Gq protein at 100 nM by electrical cell substrate impedance sensing system 25701254
CHO Function assay 100 nM Activity at recombinant EP4 receptor (unknown origin) expressed in CHO cells co-expressing Gs protein at 100 nM by electrical cell substrate impedance sensing system 25701254
CHO Function assay 100 nM Activity at recombinant EP3 receptor (unknown origin) expressed in CHO cells co-expressing Gi protein at 100 nM by electrical cell substrate impedance sensing system 25701254
CHO Function assay 60 mins Displacement of [3H]-PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by liquid scintillation counting, Ki = 0.0031 μM. 22119471
CHO Function assay 60 mins Displacement of [3H]-PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by liquid scintillation counting, Ki = 0.005 μM. 22119471
CHO Function assay 20 mins Displacement of [3H]-PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting, Ki = 0.006 μM. 22119471
CHO Function assay 60 mins Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting, Ki = 0.022 μM. 22119471
CHO Function assay 60 mins Displacement of [3H]-PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting, Ki = 0.0031 μM. 22386979
CHO Function assay 60 mins Displacement of [3H]-PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting, Ki = 0.005 μM. 22386979
CHO Function assay 60 mins Displacement of [3H]-PGE2 from mouse EP1 receptor expressed in CHO cells after 60 mins by scintillation counting, Ki = 0.006 μM. 22386979
CHO Function assay 60 mins Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting, Ki = 0.022 μM. 22386979
CHEM1 Function assay 2 hrs Displacement of [3H]PGE2 from human recombinant prostanoid EP4 receptor in CHEM1 cells after 2 hrs, Ki = 0.00045 μM. 23403082
CHEM1 Function assay 2 hrs Displacement of [3H]PGE2 from human recombinant prostanoid EP4 receptor in CHEM1 cells after 2 hrs, IC50 = 0.0011 μM. 23403082
CHO Function assay 30 mins Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method, EC50 = 0.0019 μM. 26985320
CHO Function assay 30 mins Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method, EC50 = 0.0075 μM. 26985320
HEK293 Function assay 90 mins Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay, EC50 = 0.346 μM. 26985320
CHO Function assay 30 mins Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method, EC50 = 0.347 μM. 26985320
HEK293 Function assay 120 mins Displacement of [3H]PGE2 from human recombinant EP4 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method, IC50 = 0.00055 μM. 27876250
HEK293 Function assay 120 mins Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method, IC50 = 0.0026 μM. 27876250
S2 Function assay TP_TRANSPORTER: uptake in OAT4-expressing S2 cells, Km = 0.154 μM. 11907186
S2 Function assay TP_TRANSPORTER: uptake in OCT2-expressing S2 cells, Km = 0.0289 μM. 11907186
HeLa Function assay TP_TRANSPORTER: uptake in PGT-expressing HeLa cells, K1/2 = 0.1 μM. 8787677
HeLa Function assay TP_TRANSPORTER: uptake in PGT-expressing HeLa cells, Km = 0.094 μM. 7754369
S2 Function assay TP_TRANSPORTER: uptake in OAT3-expressing S2 cells, Km = 0.345 μM. 11907186
S2 Function assay TP_TRANSPORTER: uptake in OCT1-expressing S2 cells, Km = 0.657 μM. 11907186
S2 Function assay TP_TRANSPORTER: uptake in OAT2-expressing S2 cells, Km = 0.713 μM. 11907186
S2 Function assay TP_TRANSPORTER: uptake in OAT1-expressing S2 cells, Km = 0.97 μM. 11907186
HEK293 Function assay Inhibitory activity against human EP4 receptor expressed in HEK293 ebna cells, IC50 = 0.0007 μM. 12643927
HEK293 Function assay EP4 agonist potency utilizing a stable clone of pSV40-EP4 transfected into HEK293 cells expressing EP4 receptor, EC50 = 0.003 μM. 12643927
Sf9 Function assay TP_TRANSPORTER: uptake (vesicle) in membrane vesicles from MRP4-expressing Sf9 cells, Km = 3.4 μM. 12835412
HEK293 Function assay Displacement of [3H]PGE2 from human EP3 receptor expressed in HEK293 cells, Ki = 0.00033 μM. 17531488
HEK293 Function assay Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells, Ki = 0.00079 μM. 17531488
HEK293 Function assay Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells, Ki = 0.0049 μM. 17531488
HEK293 Function assay Displacement of [3H]PGE2 from human EP1 receptor expressed in HEK293 cells, Ki = 0.0091 μM. 17531488
HEK293 Function assay Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release, EC50 = 0.0002 μM. 19250823
HEK293 Function assay Agonist activity against rat EP4 receptor expressed in HEK293 cells assessed as stimulation of cAMP release, EC50 = 0.0007 μM. 19250823
HEK293 Function assay Inhibition of rat EP4 receptor expressed in HEK293 cells, IC50 = 0.0021 μM. 19250823
HEK293 Function assay Inhibition of rat EP2 receptor expressed in HEK293 cells, IC50 = 0.0052 μM. 19250823
CHO Function assay Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis, EC50 = 0.0025 μM. 26985320
CHO Function assay Agonist activity at human EP1 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis, EC50 = 0.0037 μM. 26985320
Chem1 Function assay Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysis, EC50 = 0.25 μM. 26985320
HEK293 Function assay Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells, IC50 = 0.0026 μM. 26988801
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生物活性

產品描述 Prostaglandin E2 (PGE2, Dinoprostone) 在分娩中發(fā)揮重要作用（可軟化宮頸，引起子宮收縮），也刺激成骨細胞釋放能刺激破骨細胞吸收的因子。液體環(huán)境中長期保存易變色，建議以粉末形式保存，現(xiàn)配現(xiàn)用！
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06129604 Recruiting
Colorectal Carcinoma (CRC)|Endometrial Carcinoma (EC)
University of Oklahoma
 April 3 2024 Phase 2
NCT06307678 Completed
Periapical; Infection
Ataturk University
 July 7 2023 Not Applicable
NCT06190132 Completed
Uremic Pruritus in Hemodialysis Patients
Ain Shams University
 April 1 2023 Not Applicable

化學信息&溶解度

分子量 352.47 分子式

C20H32O5
CAS號 363-24-6 SDF Download Prostaglandin E2 (PGE2) SDF
Smiles CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
儲存條件(自收到貨起) 此產品性質不穩(wěn)定，需現(xiàn)配現(xiàn)用!建議您購買分裝規(guī)格，或者在收到貨后進行分裝。

體外溶解度
批次：

DMSO : 70 mg/mL ( (198.59 mM) ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO)

Ethanol : 70 mg/mL (198.59 mM)

Water : 2.5 mg/mL (7.09 mM)

摩爾濃度計算器

體內溶解度
批次：

現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑

 動物體內配方計算器

實驗計算

摩爾濃度計算器

質量 濃度 體積 分子量

動物體內配方計算器（澄清溶液）

第一步：請輸入基本實驗信息（考慮到實驗過程中的損耗，建議多配一只動物的藥量）

mg/kg g μL 只

第二步：請輸入動物體內配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；

體內配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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