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Atorvastatin

中文名稱：阿托伐他汀

Atorvastatin 是一種降脂劑。 它是 hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase 的競(jìng)爭(zhēng)性抑制劑，它可通過甲羥戊酸途徑生物合成膽固醇的速率決定酶并激活自噬。

Atorvastatin Chemical Structure

Atorvastatin Chemical Structure

CAS: 134523-00-5

規(guī)格 價(jià)格 庫存 購買數(shù)量
10mM (1mL in DMSO) 810.81 現(xiàn)貨
25mg 795.31 現(xiàn)貨
100mg 1613.43 現(xiàn)貨
1g 7125.48 現(xiàn)貨
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Atorvastatin相關(guān)產(chǎn)品

相關(guān)信號(hào)通路圖

HMG-CoA Reductase Signaling Pathways

HMG-CoA Reductase信號(hào)通路圖

細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

細(xì)胞系 實(shí)驗(yàn)類型 給藥濃度 孵育時(shí)間 活性描述 文獻(xiàn)信息
hepatocytes Function assay 0.1 to 10 uM up to 90 mins Drug metabolism in Sprague-Dawley rat hepatocytes assessed per 10'6 cells at 0.1 to 10 uM up to 90 mins by media-loss method, Km=0.43μM 22593038
hepatocytes Function assay 0.1 to 10 uM up to 90 mins Drug metabolism in Sprague-Dawley rat hepatocytes assessed per 10'6 cells at 0.1 to 10 uM up to 90 mins by conventional assay, Km=1.3μM 22593038
Hep3G Function assay 25 uM 48 hrs Inhibition of HMG CoA reductase in human Hep3G cells assessed as increase in LDL receptor expression at 25 uM incubated for 48 hrs by immunofluorescence method 31005367
C2C12 Function assay 1 uM Induction of cell differentiation in mouse C2C12 cells assessed as myosin heavy chain expression at 1 uM 20081855
HepG2 Function assay 1 uM Upregulation of LDL receptor expression in human HepG2 cells at 1 uM in presence of ARH-specific siRNA 20356098
HepG2 Function assay 10 uM Induction of SREBP2 maturation in human HepG2 cells at 10 uM after overnight incubation by immunoblot analysis 26784936
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50=8.7μM 23570542
HS68 Cytotoxicity assay 72 hrs Cytotoxicity against human HS68 cells after 72 hrs by MTT assay, IC50=22.7μM 23570542
MEF Cytotoxicity assay 72 hrs Cytotoxicity against mouse MEF cells after 72 hrs by MTT assay, IC50=30.7μM 23570542
human red blood cells Antiplasmodial assay 48 hrs Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human red blood cells after 48 hrs by SYBR test, IC50=10.3μM 26988303
HEK293 Function assay TP_TRANSPORTER: uptake in OATP1B1-expressing HEK293 cells, Km=12.4μM 15970799
L6 Function assay Inhibition of cholesterol synthesis in rat L6 cells assessed as incorporation of [14C]acetate into cholesterol, IC50=0.078μM 18412317
HEK293 Function assay Activity at human liver OATP1B3 expressed in HEK293 Flp-In cells, Km=0.73μM 22541068
HEK293 Function assay Activity at human liver OATP1B1 expressed in HEK293 Flp-In cells, Km=0.77μM 22541068
HEK293 Function assay Activity at human liver OATP2B1 expressed in HEK293 Flp-In cells, Km=2.84μM 22541068
HEK293 Function assay Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells using estradiol-17beta-glucuronide substrate, IC50=0.6μM 22587986
HEK293 Function assay Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells using pitavastatin substrate, IC50=0.8μM 22587986
HEK293 Function assay Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells using estrone-3-sulfate substrate, IC50=1.6μM 22587986
A549 Function assay Reductase Activity Assay: The HMGR activity was performed using HMG-CoA reductase assay kit from Sigma-Aldrich with the human recombinant protein or 100 μg total cell lysates from A549 cells. Lovastatin was used as a positive control, and SAHA as a negati, IC50=0.0116μM ChEMBL
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生物活性

產(chǎn)品描述 Atorvastatin 是一種降脂劑。 它是 hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase 的競(jìng)爭(zhēng)性抑制劑，它可通過甲羥戊酸途徑生物合成膽固醇的速率決定酶并激活自噬。

化學(xué)信息&溶解度

分子量 558.64 分子式

C33H35FN2O5
CAS號(hào) 134523-00-5 SDF --
Smiles CC(C)C1=C(C(=C(N1CCC(CC(CC(=O)O)O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4
儲(chǔ)存條件(自收到貨起) 3年 -20°C 粉狀

體外溶解度
批次：

DMSO : 100 mg/mL ( (179.0 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開封DMSO)

Ethanol : 17 mg/mL (30.43 mM)

Water : Insoluble

摩爾濃度計(jì)算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請(qǐng)按從左到右的順序依次添加，澄清后再加入下一溶劑

 動(dòng)物體內(nèi)配方計(jì)算器

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量 濃度 體積 分子量

動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請(qǐng)輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過程中的損耗，建議多配一只動(dòng)物的藥量）

mg/kg g μL 只

第二步：請(qǐng)輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請(qǐng)聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請(qǐng)先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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