N-Acetylneuraminic acid

別名: Neu5Ac, NeuAc, Acido aceneuramico, Acide aceneuramique, Acidium aceneuramicum, Sialic acid 中文名稱：N-乙酰神經(jīng)氨酸

目錄號(hào)：S4792 Purity: 99.82%

N-Acetylneuraminic acid (Neu5Ac, NeuAc, Acido aceneuramico, Acide aceneuramique, Acidium aceneuramicum, Sialic acid, NANA) is the predominant sialic acid found in mammalian cells. Sialic acids are negatively charged monosaccharides attached to the end of sugar chains, giving rise to a wide variety of glycoproteins and glycolipids in biological fluids and cell membranes.

N-Acetylneuraminic acid Chemical Structure

CAS: 131-48-6

規(guī)格	價(jià)格	庫(kù)存
25mg	794.8	現(xiàn)貨
1g	7944.3	現(xiàn)貨
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產(chǎn)品質(zhì)控

批次： S479202 DMSO]62 mg/mL]false]Water]62 mg/mL]false]Ethanol]Insoluble]false 純度： 99.82%

99.82

N-Acetylneuraminic acid相關(guān)產(chǎn)品

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相關(guān)化合物庫(kù)	FDA藥物庫(kù) 天然產(chǎn)物庫(kù) 已知活性藥物庫(kù)-I 多樣性化合物母核庫(kù)	點(diǎn)擊展開

生物活性

產(chǎn)品描述	N-Acetylneuraminic acid (Neu5Ac, NeuAc, Acido aceneuramico, Acide aceneuramique, Acidium aceneuramicum, Sialic acid, NANA) is the predominant sialic acid found in mammalian cells. Sialic acids are negatively charged monosaccharides attached to the end of sugar chains, giving rise to a wide variety of glycoproteins and glycolipids in biological fluids and cell membranes.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
臨床試驗(yàn)信息 (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT03545568	Completed	N-Acetylneuraminic Acid Storage Disease	University of Lausanne\|University of Modena and Reggio Emilia	May 1 2018	Not Applicable
NCT02346461	Completed	GNE Myopathy	National Human Genome Research Institute (NHGRI)\|National Center for Advancing Translational Sciences (NCATS)\|National Institutes of Health Clinical Center (CC)	February 5 2015	Phase 2
NCT01236898	Completed	Nonaka Myopathy\|Hereditary Inclusion Body Myopathy	Tohoku University	November 2010	Phase 1

參考文獻(xiàn)
[1] Carlson SE, et al. J Nutr. 1986, 116(5):881-6. [2] Zhang Yida, et al. Food Nutr Res. 2015, 59.

參考文獻(xiàn)

[1] Carlson SE, et al. J Nutr. 1986, 116(5):881-6.
[2] Zhang Yida, et al. Food Nutr Res. 2015, 59.

化學(xué)信息&溶解度

分子量	309.27	分子式	C₁₁H₁₉NO₉
CAS號(hào)	131-48-6	SDF	Download N-Acetylneuraminic acid SDF
Smiles	CC(=O)NC1C(CC(OC1C(C(CO)O)O)(C(=O)O)O)O
儲(chǔ)存條件(自收到貨起)	3年-20°C粉狀	儲(chǔ)備液保存和期限建議分裝儲(chǔ)備液，避免反復(fù)凍融！	1年-80°C溶于溶劑
儲(chǔ)存條件(自收到貨起)	3年-20°C粉狀	儲(chǔ)備液保存和期限建議分裝儲(chǔ)備液，避免反復(fù)凍融！	1個(gè)月-20°C溶于溶劑

體外溶解度
批次：

DMSO : 62 mg/mL ( (200.47 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開封DMSO)

Water : 62 mg/mL (200.47 mM)

Ethanol : Insoluble

摩爾濃度計(jì)算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請(qǐng)按從左到右的順序依次添加，澄清后再加入下一溶劑

動(dòng)物體內(nèi)配方計(jì)算器

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量	濃度	體積	分子量
=	×	×

稀釋計(jì)算器分子量計(jì)算器

動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請(qǐng)輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過(guò)程中的損耗，建議多配一只動(dòng)物的藥量）

給藥劑量 mg/kg 動(dòng)物平均體重 g 每只動(dòng)物給藥體積 μL 動(dòng)物數(shù)量只

第二步：請(qǐng)輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請(qǐng)聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO + % + % Tween 80 + % ddH2O

%DMSO+ %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過(guò)該批次藥物DMSO溶解度，請(qǐng)先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH₂O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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