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GS-441524

GS-441524 是一種具有藥理活性的三磷酸核苷分子的分子前體，是貓傳染性腹膜炎病毒 feline infectious peritonitis virus (FIPV) 的有效抑制劑，其EC50值為0.78 μM。

GS-441524 Chemical Structure

GS-441524 Chemical Structure

CAS: 1191237-69-0

規(guī)格 價(jià)格 庫存 購買數(shù)量
5mg 794.43 現(xiàn)貨
25mg 1777.23 現(xiàn)貨
100mg 4668.39 現(xiàn)貨
1g 23669.52 現(xiàn)貨
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GS-441524相關(guān)產(chǎn)品

細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

細(xì)胞系 實(shí)驗(yàn)類型 給藥濃度 孵育時(shí)間 活性描述 文獻(xiàn)信息
HuH7 Function assay 10 uM 24 hrs Cmax in human HuH7 cells assessed as triphosphate concentration per million cells at 10 uM incubated for 24 hrs measured after washout by LC-MS analysis, Cmax=0.0000176μM 22446091
Vero Antiviral assay 24 hrs Antiviral activity against Parainfluenza 3 C 243 infected in african green monkey Vero cells assessed as inhibition of virus induced cytopathic effect after 24 hrs by MTS assay, EC50=1.71μM 22446091
Vero Antiviral assay 24 hrs Antiviral activity against SARS coronavirus Toronto-2 infected in african green monkey Vero cells assessed as inhibition of virus induced cytopathic effect after 24 hrs by MTS assay, EC50=2.24μM 22446091
HuH7 Antiviral assay 24 hrs Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH7 cells assessed as inhibition of virus induced cytopathic effect after 24 hrs by MTS assay, EC50=4.1μM 22446091
Vero E6 Antiviral assay 24 hrs Antiviral activity against Dengue virus type 2 New Guinea C infected in african green monkey Vero E6 cells assessed as inhibition of virus induced cytopathic effect after 24 hrs by MTS assay, EC50=9.46μM 22446091
HeLa Antiviral assay 24 hrs Antiviral activity against Yellow fever virus 17D infected in human HeLa cells assessed as inhibition of virus induced cytopathic effect after 24 hrs by MTS assay, EC50=11μM 22446091
MDCK Antiviral assay 24 hrs Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as inhibition of virus induced cytopathic effect after 24 hrs by MTS assay, EC50=27.9μM 22446091
Hep2 Antiviral assay 4 days Antiviral activity against Respiratory syncytial virus A2 infected in human Hep2 cells assessed as reduction of virus-induced cytopathic effect after 4 days by Cell-Titer Glo assay, EC50=0.53μM 28124907
HMVEC Antiviral assay 3 to 4 days Antiviral activity against GFP-fused Ebolavirus infected in TERT-immortalized HMVEC assessed as reduction in viral replication preincubated with cells followed by viral infection measured after 3 to 4 days by fluorescence assay, EC50=0.78μM 28124907
HuH7 Antiviral assay 3 days Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH7 cells preincubated with cells for 3 days followed by viral infection by luciferase assay, EC50=4.1μM 28124907
HuH7 Antiviral assay 3 days Antiviral activity against Ebolavirus infected in human HuH7 cells after 3 days by end point dilution assay, EC50=1.5μM 28792763
點(diǎn)擊查看更多細(xì)胞系數(shù)據(jù)

生物活性

產(chǎn)品描述 GS-441524 是一種具有藥理活性的三磷酸核苷分子的分子前體，是貓傳染性腹膜炎病毒 feline infectious peritonitis virus (FIPV) 的有效抑制劑，其EC50值為0.78 μM。
靶點(diǎn)
FIPV [1]
(Cell-free assay)
0.78 μM(EC50)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05996744 Terminated
COVID-19
Gilead Sciences
 December 26 2023 Phase 2|Phase 3
NCT05715528 Completed
COVID-19
Gilead Sciences
 February 8 2023 Phase 3
NCT05603143 Terminated
COVID-19
Gilead Sciences
 November 5 2022 Phase 3
NCT04582266 Completed
COVID-19
National Institute of Allergy and Infectious Diseases (NIAID)|Gilead Sciences
 March 31 2021 --
NCT04859244 Completed
COVID-19
Copycat Sciences LLC
 January 1 2021 Phase 1
NCT04539262 Completed
COVID-19
Gilead Sciences
 September 14 2020 Phase 1|Phase 2

化學(xué)信息&溶解度

分子量 291.26 分子式

C12H13N5O4
CAS號 1191237-69-0 SDF --
Smiles C1=C2C(=NC=NN2C(=C1)C3(C(C(C(O3)CO)O)O)C#N)N
儲存條件(自收到貨起) 3年 -20°C 粉狀

體外溶解度
批次：

DMSO : 58 mg/mL ( (199.13 mM) ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO)

Water : Insoluble

Ethanol : Insoluble

摩爾濃度計(jì)算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑

 動物體內(nèi)配方計(jì)算器

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量 濃度 體積 分子量

動物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過程中的損耗，建議多配一只動物的藥量）

mg/kg g μL 只

第二步：請輸入動物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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