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  2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel Protein Tyrosine Kinase/RTK
  3. Endogenous Metabolite iGluR VEGFR
  4. Glycine

Glycine (甘氨酸) 是中樞神經(jīng)系統(tǒng)的一種抑制性神經(jīng)遞質(zhì)，同時也是 glutamate 的一種聯(lián)合激動劑，有促進(jìn)谷氨酸能 NMDA (N-methyl-D-aspartic acid ) 受體興奮的潛能。Glycine 具有口服活性。Glycine 可用于細(xì)胞保護(hù)、癌癥、神經(jīng)系統(tǒng)疾病和血管生成等方面的研究。

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Glycine Chemical Structure

Glycine Chemical Structure

CAS No. : 56-40-6

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in Water ￥500
In-stock
500 mg ￥400
In-stock
1 g ￥500
In-stock
5 g   詢價  
10 g   詢價  

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Customer Review

Other Forms of Glycine:

查看 iGluR 亞型特異性產(chǎn)品:

查看 VEGFR 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis[1][2][3][4][5][6].

IC50 & Target

NMDA Receptor

 

Human Endogenous Metabolite

 

Microbial Metabolite

 

NINJ1

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
106 μM
Compound: 750
Substrate uptake and inhibition of the Glycine Transporter-1 (GlyT1, SLC6A9) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC6A9 cells
Substrate uptake and inhibition of the Glycine Transporter-1 (GlyT1, SLC6A9) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC6A9 cells
10.5281/zenodo.7361399
HEK293 EC50
128 μM
Compound: 750
Substrate uptake by the Glycine Transporter-2 (GlyT2, SLC6A5) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC6A5 cells
Substrate uptake by the Glycine Transporter-2 (GlyT2, SLC6A5) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC6A5 cells
10.5281/zenodo.7360571
HEK293 EC50
94 μM
Compound: glycine
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay
[PMID: 17722904]
KB 3-1 IC50
> 50 mM
Compound: glycine
Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay
[PMID: 21657271]
KB-V1 IC50
> 50 mM
Compound: glycine
Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay
Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay
[PMID: 21657271]
體外研究
(In Vitro)

Glycine (0-1 mM, 0-48 h) 具有抗腫瘤和抗血管生成的作用。它能下調(diào)腫瘤細(xì)胞 HCT-116，HT-29 和 CC-531 中VEGF 的產(chǎn)生，又能通過 GlyR 抑制內(nèi)皮細(xì)胞 HUVEC 生長，并間接抑制 HUVEC 遷移和毛細(xì)血管形成[3]。
Glycine (5 mM, 50 mM, 10 min) 可以防止 NINJ1 在質(zhì)膜內(nèi)聚集，抑制NINJ1 依賴性質(zhì)膜破裂導(dǎo)致的細(xì)胞死亡，從而發(fā)揮細(xì)胞保護(hù)作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay [3]

Cell Line: HUVEC cells
Concentration: 0, 0.01, 0.1, or 1 mM
Incubation Time: 0-48 h
Result: Reduced VEGF or conditioned medium-stimulated HUVEC migration and angiogenesis but had no direct effect on HUVEC migration.
體內(nèi)研究
(In Vivo)

Glycine (single 40-800 mg/kg, i.p.) 可劑量依賴性地預(yù)防東莨菪堿 Scopolamine (HY-N0296) 引起的成年大鼠社會認(rèn)知障礙[2]。
Glycine (每天注射 500 或 1000 mg/kg，連續(xù)注射 14 天, i.p.) 可以通過抑制 ROS 的產(chǎn)生顯著減輕鉛暴露小鼠的腎損傷[5]。
Glycine (單次口服 1 or 2 g/kg, p.o.) 會增加大鼠前額皮質(zhì)的細(xì)胞外血清素，但不會增加多巴胺[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: renal injury in mice exposed to Pb, adult male BALB/c mice (25–30 g)[5]
Dosage: 500 and 1000 mg/kg/day for 14 days
Administration: i.p.
Result: Significantly reduces elevated serum BUN and creatinine levels due to lead exposure.
Significantly reduced ROS elevation in renal tissue due to lead exposure.
Mitigated renal histopathological alterations in mice exposed to lead, included tubular dilation, protein cast, vacuolization, and inflammation.
Clinical Trial
分子量

75.07

Formula

C2H5NO2
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

甘氨酸；氨基乙酸；膠糖
結(jié)構(gòu)分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細(xì)胞實驗： 

H2O 中的溶解度 : 25 mg/mL (333.02 mM; 超聲助溶)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

Methanol 中的溶解度 : < 1 mg/mL (insoluble)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 13.3209 mL 66.6045 mL 133.2090 mL
5 mM 2.6642 mL 13.3209 mL 26.6418 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用，-20°C儲存時，請在1年內(nèi)使用。

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳，請具體參考實測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用，-20°C儲存時，請在1年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 13.3209 mL 66.6045 mL 133.2090 mL 333.0225 mL
5 mM 2.6642 mL 13.3209 mL 26.6418 mL 66.6045 mL
10 mM 1.3321 mL 6.6605 mL 13.3209 mL 33.3023 mL
15 mM 0.8881 mL 4.4403 mL 8.8806 mL 22.2015 mL
20 mM 0.6660 mL 3.3302 mL 6.6605 mL 16.6511 mL
25 mM 0.5328 mL 2.6642 mL 5.3284 mL 13.3209 mL
30 mM 0.4440 mL 2.2202 mL 4.4403 mL 11.1008 mL
40 mM 0.3330 mL 1.6651 mL 3.3302 mL 8.3256 mL
50 mM 0.2664 mL 1.3321 mL 2.6642 mL 6.6605 mL
60 mM 0.2220 mL 1.1101 mL 2.2202 mL 5.5504 mL
80 mM 0.1665 mL 0.8326 mL 1.6651 mL 4.1628 mL
100 mM 0.1332 mL 0.6660 mL 1.3321 mL 3.3302 mL

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Glycine
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