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  1. Antibody-drug Conjugate/ADC Related PROTAC
  2. ADC Linker PROTAC Linkers
  3. N-Boc-4-hydroxy-L-proline methyl ester

N-Boc-4-hydroxy-L-proline methyl ester 

目錄號: HY-Y0755 純度: ≥98.0%
COA 產(chǎn)品使用指南

N-Boc-cis-4-hydroxy-L-proline methyl ester 是不可降解 (non-cleavable) 的 ADC linker,用于合成抗體偶聯(lián)活性分子 (ADCs)。N-Boc-cis-4-hydroxy-L-proline methyl ester 也是一個基于烷基鏈 (alkyl chain) 的 PROTAC linker,可用于合成 PROTAC。

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N-Boc-4-hydroxy-L-proline methyl ester Chemical Structure

N-Boc-4-hydroxy-L-proline methyl ester Chemical Structure

CAS No. : 102195-79-9

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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

N-Boc-cis-4-hydroxy-L-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2

IC50 & Target

Non-cleavable Linker

 

體外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

245.27

Formula

C11H19NO5

CAS 號
性狀

固體

顏色

White to off-white

運輸條件

Room temperature in continental US; may vary elsewhere.

儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻
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This equation is commonly abbreviated as: C1V1 = C2V2

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  • Do most proteins show cross-species activity?

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產(chǎn)品名稱:
N-Boc-4-hydroxy-L-proline methyl ester
目錄號:
HY-Y0755
需求量: