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  2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Amino-PEG2-C2-acid

Amino-PEG2-C2-acid 

目錄號: HY-W040168 純度: ≥98.0%
COA 產(chǎn)品使用指南

Amino-PEG2-C2-acid 是一種可降解 (cleavable) 的 3 單元 PEG 類的 ADC linker，用于抗體偶聯(lián)活性分子 (ADC) 的合成。Amino-PEG2-C2-acid 也是一種基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。

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Amino-PEG2-C2-acid Chemical Structure

Amino-PEG2-C2-acid Chemical Structure

CAS No. : 791028-27-8

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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Amino-PEG2-C2-acid is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG2-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1] [1]

Cleavable Linker

 

PEGs

 

體外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

177.20

Formula

C7H15NO4
CAS 號
性狀

固體

顏色

White to off-white

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻

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  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Amino-PEG2-C2-acid
目錄號：
HY-W040168
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