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  2. Others Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Apoptosis
  3. Fluorescent Dye Reactive Oxygen Species TNF Receptor Interleukin Related SOD
  4. Fluorene

Fluorene 是一種具有口服活性的多環(huán)芳烴 (PAH)，是其他芴類化合物的前體。Fluorene 及其衍生物可作為芴的染料前體。Fluorene 可在 A549 細(xì)胞中通過(guò)增加 ROS 和 SOD 生成、加劇脂質(zhì)過(guò)氧化、調(diào)節(jié)抗氧化酶活性變化以及上調(diào)促炎因子 TNF-α 和 IL-6 的表達(dá)，來(lái)誘導(dǎo)氧化應(yīng)激和炎癥反應(yīng)。在體內(nèi)，F(xiàn)luorene 表現(xiàn)出抗焦慮活性。Fluorene 有望用于炎癥和神經(jīng)疾病的研究。

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Fluorene Chemical Structure

Fluorene Chemical Structure

CAS No. : 86-73-7

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10 mM * 1 mL in DMSO ￥110
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500 mg ￥100
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1 g ￥150
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Other Forms of Fluorene:

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders[1][2][3].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
MDA-MB-231 IC50
> 50 μM
Compound: Fluorene
Cytotoxicity against triple-negative human MDA-MB-231 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
Cytotoxicity against triple-negative human MDA-MB-231 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
[PMID: 32726747]
體外研究
(In Vitro)

Fluorene (200-800 μM，24-48 小時(shí)) 在 A549 細(xì)胞中誘導(dǎo)氧化應(yīng)激和炎癥反應(yīng)，表現(xiàn)為 ROS 生成增加、脂質(zhì)過(guò)氧化加劇、抗氧化酶活性變化以及促炎因子 TNF-α 和 IL-6 表達(dá)上調(diào)[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: A549 human lung epithelial cells (lung injury)
Concentration: 200, 400, 600, 800 μM
Incubation Time: 24 hours, 48 hours
Result: Upregulated TNF-α and IL-6 mRNA and protein expression levels. Additionally, SP-A expression increased in Fluorene-treated groups (400 and 600 μM) but decreased in the PAH mixture-treated group (600 μM).

Cell Viability Assay[1]

Cell Line: A549 human lung epithelial cells (lung injury)
Concentration: 200, 400, 600, 800 μM
Incubation Time: 24 hours, 48 hours
Result: Induced ROS generation in A549 cells, increased MDA content, and enhanced SOD and CAT activity.
體內(nèi)研究
(In Vivo)

Fluorene (100 mg/kg，口服或腹腔注射，每日一次，持續(xù) 60 天) 會(huì)抑制 Wistar 大鼠體重增長(zhǎng)并增加其肝臟相對(duì)重量，其中腹腔注射途徑導(dǎo)致血液和大腦中 Fluorene 及其代謝物水平更高[3]。
Fluorene (1, 10 mg/kg/day, 口服或腹腔注射，每日一次，持續(xù) 60 天) 會(huì)降低 Wistar 大鼠焦慮水平，但未影響運(yùn)動(dòng)能力或?qū)W習(xí)能力[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fluorene oral or intraperitoneal (i.p.) administration-induced body weight and organ changes in Wistar rats[1]
Dosage: 1, 10, 100 mg/kg
Administration: Oral gavage (p.o.) or intraperitoneal injection (i.p.), once daily for 60 days
Result: Exhibited significantly reduced weight gain after 28 days and increased relative liver weight (The 100 mg/kg group). Additionally, higher concentrations of Fluorene and its hydroxylated metabolites were detected in the blood and brain of i.p.-treated rats compared to p.o.-treated ones.
Reduced anxiety levels in rats (1, 10 mg/kg), while the high dose (100 mg/kg) showed no significant changes. No effects on locomotor activity or learning ability were observed.
分子量

166.22

Formula

C13H10
CAS 號(hào)
性狀

固體

顏色

Off-white to light brown

中文名稱

芴
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

RT, protect from light

In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 62.5 mg/mL (376.00 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 6.0160 mL 30.0801 mL 60.1601 mL
5 mM 1.2032 mL 6.0160 mL 12.0320 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.35%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.0160 mL 30.0801 mL 60.1601 mL 150.4004 mL
5 mM 1.2032 mL 6.0160 mL 12.0320 mL 30.0801 mL
10 mM 0.6016 mL 3.0080 mL 6.0160 mL 15.0400 mL
15 mM 0.4011 mL 2.0053 mL 4.0107 mL 10.0267 mL
20 mM 0.3008 mL 1.5040 mL 3.0080 mL 7.5200 mL
25 mM 0.2406 mL 1.2032 mL 2.4064 mL 6.0160 mL
30 mM 0.2005 mL 1.0027 mL 2.0053 mL 5.0133 mL
40 mM 0.1504 mL 0.7520 mL 1.5040 mL 3.7600 mL
50 mM 0.1203 mL 0.6016 mL 1.2032 mL 3.0080 mL
60 mM 0.1003 mL 0.5013 mL 1.0027 mL 2.5067 mL
80 mM 0.0752 mL 0.3760 mL 0.7520 mL 1.8800 mL
100 mM 0.0602 mL 0.3008 mL 0.6016 mL 1.5040 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Fluorene
目錄號(hào)：
HY-W026772
需求量：