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  2. GPCR/G Protein
  3. Hydroxycarboxylic Acid Receptor (HCAR)
  4. 3-Chloro-5-hydroxybenzoic acid

3-Chloro-5-hydroxybenzoic acid  (Synonyms: 3-氯-5-羥基苯甲酸)

目錄號: HY-W016868 純度: 99.54%
COA 產(chǎn)品使用指南 技術(shù)支持

3-Chloro-5-hydroxybenzoic acid 是一種有效的、具有口服活性的，選擇性乳酸受體 GPR81 激動劑，對人 GPR81 的 EC50 為 16 μM。3-Chloro-5-hydroxybenzoic acid 在肥胖小鼠模型中顯示出良好的體內(nèi)脂肪分解作用。

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3-Chloro-5-hydroxybenzoic acid Chemical Structure

3-Chloro-5-hydroxybenzoic acid Chemical Structure

CAS No. : 53984-36-4

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥440
In-stock
25 mg ￥400
In-stock
50 mg ￥560
In-stock
100 mg ￥720
In-stock
200 mg   詢價  
500 mg   詢價  

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

3-Chloro-5-hydroxybenzoic acid is a potent, orally active and selective lactate receptor GPR81 agonist, with an EC50 of 16 μM for human GPR81. 3-Chloro-5-hydroxybenzoic acid exhibits favorable in vivo effects on lipolysis in a mouse model of obesity[1].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
COS-7 EC50
> 1000 μM
Compound: 2
Agonist activity at human recombinant GPR109a transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assay
Agonist activity at human recombinant GPR109a transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assay
[PMID: 24900524]
COS-7 EC50
16 μM
Compound: 2
Agonist activity at human recombinant GPR81 transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assay
Agonist activity at human recombinant GPR81 transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assay
[PMID: 24900524]
體外研究
(In Vitro)

3-Chloro-5-hydroxybenzoic acid shows potency against human (EC50=16 μM), monkey (EC50=17 μM), dog (EC50=67 μM), rat (EC50=7 μM), mouse (EC50=22 μM), and hamster GPR81 (EC50=27 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

3-Chloro-5-hydroxybenzoic acid (30, 100, and 300 mg/kg; PO in overnight fasted C57Bl6/J mice fed high fat chow for 10 weeks) shows significant reductions in free fatty acids at all doses tested, resulting in a minimum efficacious dose of 30 mg/kg[1].
Pharmacokinetic Parameters of 3-Chloro-5-hydroxybenzoic acid in Mice[1].

dose (mg/kg) tmax (h) AUCinf (h ng/mL) Cmax (ng/mL) Cmax (μM) t1/2 (h)
30 0.5 9356 11689.50 67.2 1.47
100 0.5 51312 55252.80 341.9 1.10

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl6/J mice (DIO mice)[1]
Dosage: 30, 100, and 300 mg/kg
Administration: PO in overnight fasted C57Bl6/J mice fed high fat chow for 10 weeks
Result: Significant reductions in nonesterified free fatty acid cholesterol (NEFAc) at all doses tested.
分子量

172.57

Formula

C7H5ClO3
CAS 號
性狀

固體

顏色

White to light brown

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 100 mg/mL (579.49 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 5.7949 mL 28.9743 mL 57.9485 mL
5 mM 1.1590 mL 5.7949 mL 11.5897 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請?jiān)?個月內(nèi)使用，-20°C儲存時，請?jiān)?個月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計(jì)算器
請輸入動物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.54%

參考文獻(xiàn)

3-Chloro-5-hydroxybenzoic acid 相關(guān)分類

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請?jiān)?個月內(nèi)使用，-20°C儲存時，請?jiān)?個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.7949 mL 28.9743 mL 57.9485 mL 144.8713 mL
5 mM 1.1590 mL 5.7949 mL 11.5897 mL 28.9743 mL
10 mM 0.5795 mL 2.8974 mL 5.7949 mL 14.4871 mL
15 mM 0.3863 mL 1.9316 mL 3.8632 mL 9.6581 mL
20 mM 0.2897 mL 1.4487 mL 2.8974 mL 7.2436 mL
25 mM 0.2318 mL 1.1590 mL 2.3179 mL 5.7949 mL
30 mM 0.1932 mL 0.9658 mL 1.9316 mL 4.8290 mL
40 mM 0.1449 mL 0.7244 mL 1.4487 mL 3.6218 mL
50 mM 0.1159 mL 0.5795 mL 1.1590 mL 2.8974 mL
60 mM 0.0966 mL 0.4829 mL 0.9658 mL 2.4145 mL
80 mM 0.0724 mL 0.3622 mL 0.7244 mL 1.8109 mL
100 mM 0.0579 mL 0.2897 mL 0.5795 mL 1.4487 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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3-Chloro-5-hydroxybenzoic acid
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