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  2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. Ciglitazone

Ciglitazone  (Synonyms: 環(huán)格列酮; ADD-3878; U-63287)

目錄號: HY-W011220 純度: 98.89%
COA 產(chǎn)品使用指南 技術(shù)支持

Ciglitazone 是一種有效的選擇性 PPARγ 激動劑 (EC50=3 μM)。Ciglitazone 抑制 th17 細(xì)胞的增殖和分化。Ciglitazone 是一種口服降糖劑，在肥胖高血糖動物模型中具有活性。Ciglitazone 誘導(dǎo)負(fù)鼠腎上皮細(xì)胞凋亡 (apoptosis)，同時激活 p38 MAPK 和凋亡誘導(dǎo)因子 (AIF) 的核轉(zhuǎn)位。

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Ciglitazone Chemical Structure

Ciglitazone Chemical Structure

CAS No. : 74772-77-3

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規(guī)格 價格 是否有貨 數(shù)量
5 mg ￥880
In-stock
10 mg ￥1364
In-stock
50 mg   詢價  
100 mg   詢價  

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MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

查看 PPAR 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Ciglitazone is a potent and selective PPARγ agonist (EC50=3 μM). Ciglitazone inhibits proliferation and differentiation of th17 cells. Ciglitazone is a hypoglycemic agent orally active in the obese-hyperglycemic animal models. Ciglitazone induces apoptosis accompanied by activation of p38 MAPK and nuclear translocation of apoptosis inducing factor (AIF) in opossum kidney (OK) renal epithelial cells[1][2][3][4].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 EC50
10 μM
Compound: Ciglitazone
Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis
Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis
[PMID: 20966043]
HepG2 EC50
14.1 μM
Compound: Ciglitazone
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
[PMID: 20966043]
LNCaP IC50
60 μM
Compound: 1, Ciglitazone
Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay in presence of 10% FBS
Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay in presence of 10% FBS
[PMID: 22468970]
LNCaP IC50
78 μM
Compound: 1, Ciglitazone
Inhibition of glucose transporter in human LNCAP cells assessed as blocking of [3H]-2-DG uptake after 30 mins by scintillation counting
Inhibition of glucose transporter in human LNCAP cells assessed as blocking of [3H]-2-DG uptake after 30 mins by scintillation counting
[PMID: 22468970]
NIH3T3 EC50
14.9 μM
Compound: ciglitazone
Agonist activity at human PPARgamma expressed in mouse NIH/3T3 cells assessed as receptor activation after 16 hrs by luciferase based reporter gene assay
Agonist activity at human PPARgamma expressed in mouse NIH/3T3 cells assessed as receptor activation after 16 hrs by luciferase based reporter gene assay
[PMID: 11975517]
PC-12 IC50
20 μM
Compound: Ciglitazone
Concentration required for 50% inhibition of cell proliferation in PC12 cells using sulforhodamine B assay
Concentration required for 50% inhibition of cell proliferation in PC12 cells using sulforhodamine B assay
[PMID: 15109648]
體外研究
(In Vitro)

Ciglitazone (0-20 μM；24 hours) 通過 PPAR 非依賴性機(jī)制誘導(dǎo)細(xì)胞凋亡。Ciglitazone 引起 ROS 的產(chǎn)生和細(xì)胞內(nèi) Ca2+ 的增加[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

在 C57BL/6J-ob/ob 小鼠中，Ciglitazone (100 mg/kg/天；2 天) 引起血糖急劇下降。在用 100 mg/kg/天 Ciglitazone[3] 處理 41-44 天的 ob/ob 小鼠中觀察到胰島 β 細(xì)胞再造粒和胰腺胰島素含量增加。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

333.45

Formula

C18H23NO3S
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

環(huán)格列酮；酪里達(dá)唑
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細(xì)胞實驗： 

DMSO 中的溶解度 : 100 mg/mL (299.89 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.9989 mL 14.9946 mL 29.9892 mL
5 mM 0.5998 mL 2.9989 mL 5.9978 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 98.89%

參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9989 mL 14.9946 mL 29.9892 mL 74.9731 mL
5 mM 0.5998 mL 2.9989 mL 5.9978 mL 14.9946 mL
10 mM 0.2999 mL 1.4995 mL 2.9989 mL 7.4973 mL
15 mM 0.1999 mL 0.9996 mL 1.9993 mL 4.9982 mL
20 mM 0.1499 mL 0.7497 mL 1.4995 mL 3.7487 mL
25 mM 0.1200 mL 0.5998 mL 1.1996 mL 2.9989 mL
30 mM 0.1000 mL 0.4998 mL 0.9996 mL 2.4991 mL
40 mM 0.0750 mL 0.3749 mL 0.7497 mL 1.8743 mL
50 mM 0.0600 mL 0.2999 mL 0.5998 mL 1.4995 mL
60 mM 0.0500 mL 0.2499 mL 0.4998 mL 1.2496 mL
80 mM 0.0375 mL 0.1874 mL 0.3749 mL 0.9372 mL
100 mM 0.0300 mL 0.1499 mL 0.2999 mL 0.7497 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Ciglitazone
目錄號：
HY-W011220
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