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  2. Immunology/Inflammation Apoptosis
  3. Interleukin Related Apoptosis
  4. Benralizumab

Benralizumab  (Synonyms: 貝那利珠單抗; MEDI-563; BIW-8405)

目錄號(hào): HY-P9923 純度: 99.1%
COA 技術(shù)支持

Benralizumab (MEDI-563) 是一種白介素 5 受體 α (IL-5Rα) 定向的溶細(xì)胞單克隆抗體，通過增強(qiáng)抗體依賴性細(xì)胞介導(dǎo)的細(xì)胞毒性誘導(dǎo)嗜酸性粒細(xì)胞直接，快速和幾乎完全耗盡。Benralizumab 可用于嚴(yán)重的嗜酸性哮喘。

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CAS No. : 1044511-01-4

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規(guī)格 價(jià)格 是否有貨
1 mg ￥4800
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Benralizumab 的其他形式現(xiàn)貨產(chǎn)品:

Customer Review

Other Forms of Benralizumab:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Benralizumab (MEDI-563) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma[1].

同型

Human IgG1 kappa
推薦同型對(duì)照抗體
種屬

Humanized
IC50 & Target[1]

IL-5Rα

 

體外研究
(In Vitro)

Benralizumab (MEDI-563) binds to recombinant human and cynomolgus monkey IL-5Rα extracellular domains with a dissociation constant of 11 and 42 pM, respectively[2].
Benralizumab (1 pM-100 nM, 48 h) inhibits IL-5–induced proliferation of CTLL-2 cells transfected with recombinant human IL-5Rαβ with an IC50 of 0.3 nM[2].
Benralizumab binds only to the constructs containing human IL-5Rα D1[2].
Benralizumab mediates ADCC (antibody-dependent cell-mediated cytotoxicity) of human eosinophils and basophils with EC50s of 0.9 pM and 0.5 pM, respectively, and mediates eosinophil apoptosis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: CTLL-2 human IL-5Rαβ cells
Concentration: 1 pM-100 nM
Incubation Time: 48 h
Result: Inhibited cell proliferation with an IC50 of 0.3 nM.
體內(nèi)研究
(In Vivo)

Benralizumab (MEDI-563) (0-30 mg/kg; i.v.; once every 3 weeks for 12 weeks) reduces peripheral blood and bone marrow eosinophil[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female and male cynomolgus monkeys[2]
Dosage: 0.1, 1, 10, and 30 mg/kg
Administration: Intravenous injection, once every 3 weeks for 12 weeks
Result: Blood eosinophil counts decreased close to the limit of detection after the first administration at all dose levels and remained undetectable. Eosinophil precursors in the bone marrow were reduced 80% or greater in all doses 3 days after the last administration (terminal necropsy) and remained undetectable until 18 days after the last dose in the 30 mg/kg group. The profound effect observed in the bone marrow was specific for the eosinophil lineage.
Clinical Trial
CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

中文名稱

貝那利珠單抗
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
純度 & 產(chǎn)品資料

純度: ≥99.1%

參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Benralizumab
目錄號(hào)：
HY-P9923
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