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  2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. Durvalumab

Durvalumab  (Synonyms: 德瓦魯單抗; MEDI 4736)

目錄號(hào): HY-P9919 純度: 99.60%
COA 技術(shù)支持

Durvalumab (MEDI 4736) 是一種人源的抗 PD-L1 蛋白單克隆抗體。Durvalumab (MEDI 4736) 完全阻斷 PD-L1 與 PD-1 和 CD80 結(jié)合， IC50 分別為 0.1 和 0.04 nM。

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CAS No. : 1428935-60-7

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥1800
In-stock
5 mg ￥5400
In-stock
10 mg ￥8370
In-stock
50 mg   詢價(jià)  
100 mg   詢價(jià)  

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Customer Review

Other Forms of Durvalumab:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Durvalumab (MEDI 4736) is an human anti-PD-L1 monoclonal antibody[1]. Durvalumab (MEDI4736) completely blocks the binding of PD-L1 to both PD-1 and CD80, with IC50s of 0.1 and 0.04 nM, respectively[2].

同型

Human IgG1 kappa
推薦同型對(duì)照抗體
種屬

Human
IC50 & Target

IC50: 0.1 nM (PD-L1/PD-1), 0.04 nM (PD-L1/CD80)[2]
體外研究
(In Vitro)

Durvalumab (0.02-20 μg/mL，3 天) 克服 PD-L1 對(duì) T 細(xì)胞激活的抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Durvalumab (0.1-5 mg/kg，腹腔注射，每周兩次，三周) 在小鼠模型中通過 T 細(xì)胞抑制人類腫瘤生長(zhǎng)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD/SCID mice with HPAC tumor, following coimplantation of primary human T cells; NOD/SCID mice with A375 tumor, following coimplantation of primary human T cells[2]
Dosage: 5, 1, 0.1, and 0.01 mg/kg for NOD/SCID mice with HPAC tumor; 5, 1, and 0.1 mg/kg for NOD/SCID mice with A375 tumor
Administration: Administration i.p.; twice per week; for 3 weeks
Result: Significantly inhibited the tumor growth of both HPAC and A375 xenografts compared with an isotype-matched control antibody.
Clinical Trial
CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

中文名稱

度伐單抗；德瓦魯單抗； 度伐利尤單抗
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Flow cytometry analysis of PD-L1 overexpression CHO cells labelling PD-L1 with Durvalumab at 20 nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/1000 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
純度 & 產(chǎn)品資料

純度: 99.60%

參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Durvalumab
目錄號(hào)：
HY-P9919
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