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  2. Immunology/Inflammation
  3. Interleukin Related
  4. Tocilizumab

Tocilizumab  (Synonyms: 托珠單抗; Anti-Human IL6R, Humanized Antibody)

目錄號: HY-P9917 純度: 98.00%
COA 技術(shù)支持

Tocilizumab (Anti-Human IL6R, Humanized Antibody) 是一種抗人白細胞介素-6 受體 (IL-6R) 的中和抗體，可阻止 IL-6 與 IL-6R 的結(jié)合，從而抑制經(jīng)典和反式信號。Tocilizumab 可用于類風(fēng)濕性關(guān)節(jié)炎的相關(guān)研究。Tocilizumab 在重癥 COVID-19 病毒方面的研究效果顯著。

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CAS No. : 375823-41-9

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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis[1]. Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease)[4].

同型

Human IgG1 kappa
推薦同型對照抗體
種屬

Humanized
IC50 & Target[1][2]

IL-6

 

體外研究
(In Vitro)

Tocilizumab (抗人 IL6R，人源化抗體) (1-100 ng/mL；24 小時、48 小時) 以劑量依賴性方式抑制細胞增殖 (生長速率)，HACM 的生長速率幾乎完全降低 100 ng/mL tocilizumab[2]。
Tocilizumab (抗人 IL6R，人源化抗體) (0.001-10，000 μg/mL；2 天) 抑制 Ba/F3-gp130-IL-6R 細胞用 hIL-6 刺激增殖，IC50 為 13.5 ng/mL[1]。
Tocilizumab (抗人 IL6R，人源化抗體) (1 μM；6 小時) 在體外降低 STAT3 的磷酸化，與體內(nèi) SAS 細胞一致[3]。
Tocilizumab (抗人 IL6R，人源化抗體) (1-5 μM；24 小時) 用無血清培養(yǎng)基顯著降低SAS細胞中VEGF mRNA的表達[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Human-derived HARA-B cells
Concentration: 1 ng/mL, 10 ng/mL, and 100 ng/mL
Incubation Time: 24 hours, 48 hours
Result: Inhibited the IL-6R expressed on human-derived HARA-B cells.

Cell Cytotoxicity Assay[1]

Cell Line: Ba/F3-gp130-IL-6R cells
Concentration: 0.001–10000 μg/ml
Incubation Time: 2 days
Result: Inhibited Ba/F3-gp130-IL-6R cell proliferation.

Western Blot Analysis[3]

Cell Line: SAS cells
Concentration: 1 μM
Incubation Time: 6 hours
Result: Reduced the phosphorylation of STAT3.

RT-PCR[3]

Cell Line: SAS cells
Concentration: 1-5 μM
Incubation Time: 24 hours
Result: Reduced VEGF mRNA expression.
體內(nèi)研究
(In Vivo)

Tocilizumab (抗人 IL6R，人源化抗體) (靜脈注射；1.0 mg/100 μL；每周兩次，三周) 減少注射了 tocilizumab 的小鼠大腦中每個轉(zhuǎn)移灶的體積[2]。
Tocilizumab (抗人 IL6R，人源化抗體) (腹膜內(nèi)注射；100 μg/mL，每 48 小時一次；20 天) 抑制 OSCC 進展并抑制腫瘤血管生成[3]。
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MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A brain metastasis model of lung tumor cells by inoculating HARA-B cells in nude mice[2]
Dosage: 1.0 mg/100 μL
Administration: Intravenous injection; 1.0 mg/100 μL; twice a week, three weeks
Result: Led the volume of each metastatic focus significantly smaller.
Animal Model: SCID mice with SAS cells[3]
Dosage: 100 μg/mL
Administration: Intraperitoneal injection;100 μg/mL; every 48 hours; 20days
Result: Suppressed the growth of advanced tumors.
Clinical Trial
CAS 號
性狀

液體

顏色

Colorless to light yellow

中文名稱

托珠單抗
運輸條件

Shipping with dry ice.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Flow cytometry analysis of IL-6R expression U937 cells labelling IL-6R with Tocilizumab at 10nM (Red), 20ng/mL of FcγRI (CD64), FcγRII (CD32), and FcγRIII (CD16) were added to block the binding of Fc of antibody to cells respectively. Goat anti human IgG Fc(Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
純度 & 產(chǎn)品資料

純度: 99.67%

參考文獻

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Tocilizumab
目錄號：
HY-P9917
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