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  2. Stem Cell/Wnt
  3. PKG
  4. Vasonatrin Peptide (VNP)

Vasonatrin Peptide (VNP) 是心鈉素 (ANP) 和C型利鈉肽 (CNP) 的嵌合體。Vasonatrin Peptide 具有 CNP 的靜脈擴張作用、ANP 的利尿作用以及與 ANP 或 CNP 無關的獨特的動脈血管擴張作用。Vasonatrin Peptide 通過 cGMP-PKG 信號通路抑制內(nèi)質網(wǎng)應激對糖尿病心臟缺血再灌注損傷的保護作用。

在相同的摩爾濃度下，化合物鹽形式與游離形式有相同的生物活性，但鹽形式 Vasonatrin Peptide (VNP) (TFA) 通常具有更好的水溶性和穩(wěn)定性。

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Custom Peptide Synthesis

Vasonatrin Peptide (VNP) Chemical Structure

Vasonatrin Peptide (VNP) Chemical Structure

CAS No. : 141676-35-9

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Vasonatrin Peptide (VNP) 的其他形式現(xiàn)貨產(chǎn)品:

Customer Review

Other Forms of Vasonatrin Peptide (VNP):

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Vasonatrin Peptide (VNP) is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Vasonatrin peptide possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway[1][2][3].

IC50 & Target

Natriuretic peptide receptors[1]
體外研究
(In Vitro)

Vasonatrin Peptide (VNP) markedly enhances adiponectin mRNA expression, as well as protein secretion, however, suppresses IL-6 production in mature adipocytes. In addition, VNP significantly increases the intracellular levels of cGMP. The effects of VNP are mimicked by 8-br-cGMP, whereas inhibits by HS-142-1, or KT-5823[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Vasonatrin peptide (100 μg/kg; i.v. ; 10 min before reperfusion) attenuates myocardial ischemia-reperfusion injury in diabetic rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: High-fat diet-fed streptozotocin-induced diabetic Sprague-Dawley rats[3]
Dosage: 100 μg/kg
Administration: I.v. ; 10 min before reperfusion
Result: Significantly improved the instantaneous first derivation of left ventricle pressure (±LV dP/dtmax) and LV systolic pressure and reduced LV end-diastolic pressure, apoptosis index, caspase-3 activity, plasma creatine kinase (CK), and lactate dehydrogenase (LDH) activities. Inhibited endoplasmic reticulum (ER) stress by suppressing glucose-regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP).
分子量

2865.37

Formula

C123H198N36O36S3
CAS 號
Sequence

Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bridge: Cys6-Cys22)
Sequence Shortening

GLSKGCFGLKLDRIGSMSGLGCNSFRY (Disulfide bridge: Cys6-Cys22)
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
細胞實驗： 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
純度 & 產(chǎn)品資料
參考文獻

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Vasonatrin Peptide (VNP)
目錄號：
HY-P1556
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