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  2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. PAR-4 Agonist Peptide, amide

PAR-4 Agonist Peptide, amide  (Synonyms: PAR-4-AP; AY-NH2)

目錄號(hào): HY-P1309 純度: 99.87%
COA 產(chǎn)品使用指南 技術(shù)支持

PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) 是一種蛋白酶激活受體-4 (PAR-4) 激動(dòng)劑，對(duì) PAR-1 或 PAR-2 都沒(méi)有作用，且其作用會(huì)被 PAR-4 拮抗劑阻斷。

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Custom Peptide Synthesis

PAR-4 Agonist Peptide, amide Chemical Structure

PAR-4 Agonist Peptide, amide Chemical Structure

CAS No. : 352017-71-1

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3.  試用裝只面向終端客戶(hù)。

規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥600
In-stock
5 mg ￥1800
In-stock
10 mg ￥3000
In-stock
50 mg   詢(xún)價(jià)  
100 mg   詢(xún)價(jià)  

* Please select Quantity before adding items.

Customer Review

Other Forms of PAR-4 Agonist Peptide, amide:

MCE 顧客使用本產(chǎn)品發(fā)表的 2 篇科研文獻(xiàn)

查看 Protease Activated Receptor (PAR) 亞型特異性產(chǎn)品:

  • 生物活性

  • 實(shí)驗(yàn)參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.

IC50 & Target

PAR-4[1]
體內(nèi)研究
(In Vivo)

Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001). PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

680.79

Formula

C34H48N8O7
CAS 號(hào)
性狀

固體

顏色

White to off-white

Sequence Shortening

AYPGKF-NH2
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 100 mg/mL (146.89 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 1.4689 mL 7.3444 mL 14.6888 mL
5 mM 0.2938 mL 1.4689 mL 2.9378 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻(xiàn)
Animal Administration
[1]

Mice[1]
SCID mice Male SCID mice and their BALB/cBy controls are operated as C57BL/6J mice, and on the 4th postoperative day mice receive intracolonically (IC) infusion of 100 μg PAR-4-AP or vehicle. Visceral pain measurements started 1 h following the end of infusion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4689 mL 7.3444 mL 14.6888 mL 36.7220 mL
5 mM 0.2938 mL 1.4689 mL 2.9378 mL 7.3444 mL
10 mM 0.1469 mL 0.7344 mL 1.4689 mL 3.6722 mL
15 mM 0.0979 mL 0.4896 mL 0.9793 mL 2.4481 mL
20 mM 0.0734 mL 0.3672 mL 0.7344 mL 1.8361 mL
25 mM 0.0588 mL 0.2938 mL 0.5876 mL 1.4689 mL
30 mM 0.0490 mL 0.2448 mL 0.4896 mL 1.2241 mL
40 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.9181 mL
50 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.7344 mL
60 mM 0.0245 mL 0.1224 mL 0.2448 mL 0.6120 mL
80 mM 0.0184 mL 0.0918 mL 0.1836 mL 0.4590 mL
100 mM 0.0147 mL 0.0734 mL 0.1469 mL 0.3672 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱(chēng)：
PAR-4 Agonist Peptide, amide
目錄號(hào)：
HY-P1309
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