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  2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. Hemokinin 1 (mouse)

Hemokinin 1 (mouse) 是一種選擇性的神經(jīng)激肽-1 受體 (neurokinin 1 receptor) 激動劑，對人 NK1 受體和 NK2 受體的 Ki 分別為 0.175?nM 和 560?nM。

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Hemokinin 1 (mouse) Chemical Structure

Hemokinin 1 (mouse) Chemical Structure

CAS No. : 208041-90-1

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥700
In-stock
5 mg ￥1700
In-stock
10 mg ￥2700
In-stock
50 mg   詢價  
100 mg   詢價  

* Please select Quantity before adding items.

Customer Review

查看 Neurokinin Receptor 亞型特異性產(chǎn)品:

  • 生物活性

  • 實驗參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with Ki of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.

IC50 & Target

Ki: 0.175?nM (Human NK1 receptor), 560?nM (Human NK2 receptor)[1]
體外研究
(In Vitro)

Hemokinin 1 (mouse) (1?nM-3?μM) produces concentration-dependent contraction of RUB averaging 66±3% (n=6) of the maximal contraction produced by KCl (80?mM). Hemokinin 1 (mouse) (10?nM-10?μM) induces a quickly-developing contractile responses of GPI, as does the tachykinin NK3 receptor selective agonist senktide or neurokinin B (NKB). Hemokinin 1 (mouse) induces full agonist responses but with a 500 fold lower potency as compared to NKB[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Hemokinin 1 (mouse) (0.01-100?nmol/kg i.v., n=10) induces a dose-related hypotension that is maximal at the dose of 10?nmol/kg. For systolic blood pressure (SBP), the ED50 value is 0.2?nmol/kg (0.1-0.4?nmol/kg) for Hemokinin 1 (mouse). For diastolic blood pressure (DBP), the ED50 value is 0.1?nmol/kg (0.07-0.2?nmol/kg) for Hemokinin 1 (mouse). Hemokinin 1 (mouse) (0.1-100?nmol/kg, i.v.) induces a dose-related salivary secretion in atropine-pretreated rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1413.65

Formula

C61H100N22O15S
CAS 號
性狀

固體

顏色

White to off-white

Sequence Shortening

RSRTRQFYGLM-NH2
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Stored under nitrogen, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

溶解性數(shù)據(jù)
細(xì)胞實驗： 

DMSO 中的溶解度 : 100 mg/mL (70.74 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 0.7074 mL 3.5369 mL 7.0739 mL
5 mM 0.1415 mL 0.7074 mL 1.4148 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻(xiàn)
Animal Administration
[1]

Male albino Wistar Rats weighing 400-450?g are used throughout the study. On the day of the experiment, rats are anaesthetized with urethane (1.2?g/kg, s.c.). Following tracheotomy and placement of a tracheal cannula (PE 205), the left jugular vein is cannulated (PE50) for SP or Hemokinin 1 (mouse) administrations. The body temperature is maintained constant (36.5±0.5°C) by a thermoregulated heating lamp. About 1?h elapsed between the animal set-up and the start of the experiments, thereafter each animal receive atropine (1.4?μmol/kg i.v. as bolus followed by infusion of 1.4?μM in a volume of 300?μL/h) and 10?min later the vehicle (saline) and increasing doses (0.5 log units) of SP or Hemokinin 1 (mouse) (0.01, 0.03, 0.1, 0.3, 1, 3, 10, 30, and 100?nmol/kg); the first five doses are administered at 20?min intervals, whereas 30?min elapsed between each of the last four doses. Atropine pretreatment is performed in order to minimize the influence of cholinergic secretory reflexes in response to the placement of the cotton swab in the rat's oral cavity for the measurement of salivary secretion induced by SP or Hemokinin 1 (mouse).

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7074 mL 3.5369 mL 7.0739 mL 17.6847 mL
5 mM 0.1415 mL 0.7074 mL 1.4148 mL 3.5369 mL
10 mM 0.0707 mL 0.3537 mL 0.7074 mL 1.7685 mL
15 mM 0.0472 mL 0.2358 mL 0.4716 mL 1.1790 mL
20 mM 0.0354 mL 0.1768 mL 0.3537 mL 0.8842 mL
25 mM 0.0283 mL 0.1415 mL 0.2830 mL 0.7074 mL
30 mM 0.0236 mL 0.1179 mL 0.2358 mL 0.5895 mL
40 mM 0.0177 mL 0.0884 mL 0.1768 mL 0.4421 mL
50 mM 0.0141 mL 0.0707 mL 0.1415 mL 0.3537 mL
60 mM 0.0118 mL 0.0589 mL 0.1179 mL 0.2947 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Hemokinin 1 (mouse)
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HY-P1030
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