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  2. Anti-infection
  3. HIV
  4. Peptide T TFA

Peptide T (TFA) 是源自HIV-1 gp120的V2區(qū)的八肽。 Peptide T是 CD4 受體的配體，可阻止 HIV 與CD4受體結合。

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Custom Peptide Synthesis

Peptide T TFA Chemical Structure

Peptide T TFA Chemical Structure

CAS No. : 1610056-01-3

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Peptide T TFA 的其他形式現(xiàn)貨產品:

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  • 生物活性

  • 實驗參考方法

  • 純度 & 產品資料

  • 參考文獻

生物活性

Peptide T (TFA) is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of HIV to the CD4 receptor.

IC50 & Target

HIV-1

 

體外研究
(In Vitro)

Peptide T acts to block viral entry as it inhibits in the MAGI cell assay and blocks infection in the luciferase reporter assay using HIV virions pseudotyped with ADA envelope. Peptide T selectively inhibits HIV replication using chemokine receptor CCR5 compared to CXC4[2]. Peptide T at 10-8 M induces IL-10 production by the human Th2 cell line and PBMC. Also peptide T at 10-9 M concentration significantly inhibits IFN-g production by PBMC[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內研究
(In Vivo)

Peptide T is administered subcutaneously at different doses and phases of the experimental autoimmune encephalomyelitis (EAE) disease, but Peptide T neither prevents nor ameliorates EAE[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

971.89

Formula

C37H56F3N9O18
CAS 號
Sequence

Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr
Sequence Shortening

ASTTTNYT
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產品資料
參考文獻
Cell Assay
[3]

Peripheral blood mononuclear cells are stimulated with PHA (5 mg/mL) along with various concentrations of peptide T (10-6-10-12 M) for 48 h at 37°C. Supernatants are collected and frozen until analysis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[4]

Rats[4]

Peptide T (125, 250, 500, 800 μg) is randomly given subcutaneously to Female Lewis rats aged 6-8 weeks in the hind foot flanks in a final volume of 0.2 mL. Control animals receive the same volume of saline alone[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻

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  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
Peptide T TFA
目錄號：
HY-P0272A
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