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  2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. Neurokinin A

Neurokinin A  (Synonyms: 神經激肽A; Substance K; Neurokinin α; Neuromedin L; NKA)

目錄號: HY-P0197 純度: 99.68%
COA 產品使用指南 技術支持

Neurokinin A (Substance K) 是速激肽家族的一種肽類神經遞質，通過 NK-2 受體發(fā)揮作用。在人氣道和胃腸道組織中作為主要的介體。

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Custom Peptide Synthesis

Neurokinin A Chemical Structure

Neurokinin A Chemical Structure

CAS No. : 86933-74-6

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥1000
In-stock
5 mg ￥1500
In-stock
10 mg ￥2600
In-stock
50 mg   詢價  
100 mg   詢價  

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Customer Review

Other Forms of Neurokinin A:

MCE 顧客使用本產品發(fā)表的 2 篇科研文獻

查看 Neurokinin Receptor 亞型特異性產品:

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues[1].

IC50 & Target

NK-2 receptor[1]
細胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO EC50
53 nM
Compound: Neurokinin-A
Compound was evaluated for concentration-dependent and oscillatory increase in [Ca2+], caused by activation of hNK3 receptors in CHO cells
Compound was evaluated for concentration-dependent and oscillatory increase in [Ca2+], caused by activation of hNK3 receptors in CHO cells
[PMID: 9871763]
HEK293 EC50
0.55 nM
Compound: NKA
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry
[PMID: 19746979]
HEK293 EC50
64.8 nM
Compound: NKA
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay
[PMID: 19746979]
體外研究
(In Vitro)

Neurokinin A (substance K) is a peptide neurotransmitter of the tachykinin family with potential as a major mediator in human airway and gastrointestinal tissues. Neurokinin A acts via the NK-2 receptor believed to be localized on smooth muscle cells and pharmacologically coupled to a GTP-binding protein. Neurokinin A is a member of a family of peptide neurotransmitters known as tachykinins. These peptides are associated with the central and peripheral nervous systems and display a wide tissue distribution. Tachykinins share the COOH-terminal structure Phe-X-Gly-Leu-Met-NH. The best known members of this family are Substance P and Neurokinin A or Substance K[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1133.32

Formula

C50H80N14O14S
CAS 號
性狀

固體

顏色

White to off-white

Sequence

His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2
Sequence Shortening

HKTDSFVGLM-NH2
中文名稱

神經激肽 A
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據
細胞實驗： 

H2O 中的溶解度 : 100 mg/mL (88.24 mM; 超聲助溶)

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 0.8824 mL 4.4118 mL 8.8236 mL
5 mM 0.1765 mL 0.8824 mL 1.7647 mL
查看完整儲備液配制表

* 請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
該產品水溶性佳，請具體參考實測 水 / PBS / Saline 中的溶解度數(shù)據。
您所需的儲備液濃度超過該產品的實測溶解度，如有需要，請與 MCE 中國技術支持聯(lián)系。
純度 & 產品資料
參考文獻

完整儲備液配制表

* 請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8824 mL 4.4118 mL 8.8236 mL 22.0591 mL
5 mM 0.1765 mL 0.8824 mL 1.7647 mL 4.4118 mL
10 mM 0.0882 mL 0.4412 mL 0.8824 mL 2.2059 mL
15 mM 0.0588 mL 0.2941 mL 0.5882 mL 1.4706 mL
20 mM 0.0441 mL 0.2206 mL 0.4412 mL 1.1030 mL
25 mM 0.0353 mL 0.1765 mL 0.3529 mL 0.8824 mL
30 mM 0.0294 mL 0.1471 mL 0.2941 mL 0.7353 mL
40 mM 0.0221 mL 0.1103 mL 0.2206 mL 0.5515 mL
50 mM 0.0176 mL 0.0882 mL 0.1765 mL 0.4412 mL
60 mM 0.0147 mL 0.0735 mL 0.1471 mL 0.3677 mL
80 mM 0.0110 mL 0.0551 mL 0.1103 mL 0.2757 mL

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
Neurokinin A
目錄號：
HY-P0197
需求量：