Juglone (Synonyms: 胡桃醌; 5-Hydroxy-1,4-naphthalenedione)

目錄號: HY-N6949 純度: 97.45%: FAQs
Data Sheet SDS COA 產品使用指南

摩爾計算器

Juglone (5-Hydroxy-1,4-naphthalenedione) 是可從胡桃 Juglans regia 中提取的一種黃色染料。Juglone 通過線粒體途徑誘導細胞凋亡。Juglone 具有抗菌、抗腫瘤活性。

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Juglone Chemical Structure

CAS No. : 481-39-0

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規(guī)格	價格	是否有貨
5 mg	￥440	In-stock
10 mg	￥621	In-stock
25 mg	￥1025	In-stock
50 mg	￥1435	In-stock
100 mg	￥2009	In-stock
200 mg		詢價
500 mg		詢價

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Customer Review

Other Forms of Juglone:

Juglone (Standard) 詢價

MCE 顧客使用本產品發(fā)表的 2 篇科研文獻

•Int J Biol Macromol. 2021 Apr 24.
•Journal of Traditional Chinese Medical Sciences. 31 July 2022.

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生物活性
純度 & 產品資料
參考文獻

生物活性

Juglone (5-hydroxy-1,4-naphthalenedione) is a yellow dye that can be extracted from Juglans regia. Juglone induces apoptosis through the mitochondrial pathway. Juglone has antibacterial and antitumor activity ^[1]^[2]^[3].

細胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A2780	IC₅₀	1.4 μM Compound: 14	Antiproliferative activity against human A2780 cells after 2 days by alamar-blue assay Antiproliferative activity against human A2780 cells after 2 days by alamar-blue assay	[PMID: 19028102]
A2780	GI₅₀	64 μM Compound: 6	Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay	[PMID: 20304655]
A549	IC₅₀	7 μM Compound: 1	Growth inhibition of human A549 cells by MTT assay Growth inhibition of human A549 cells by MTT assay	[PMID: 26706169]
B16-F10	IC₅₀	6 μM Compound: 1	Growth inhibition of mouse B16F10 cells by MTT assay Growth inhibition of mouse B16F10 cells by MTT assay	[PMID: 26706169]
BT-549	GI₅₀	> 100 μM Compound: 4	Antiproliferative activity against human BT-549 cells measured after 72 hrs by SRB assay Antiproliferative activity against human BT-549 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
CAL-51	GI₅₀	> 100 μM Compound: 4	Antiproliferative activity against human CAL-51 cells measured after 72 hrs by SRB assay Antiproliferative activity against human CAL-51 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
DU-145	IC₅₀	11.67 μM Compound: Juglone	Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay	[PMID: 23791367]
HBL-100	GI₅₀	66 μM Compound: 6	Growth inhibition of human HBL100 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HBL100 cells after 48 hrs by sulforhodamine B assay	[PMID: 20304655]
HCC1954	GI₅₀	6.44 μM Compound: 4	Antiproliferative activity against human HCC1954 cells measured after 72 hrs by SRB assay Antiproliferative activity against human HCC1954 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
HCT-116	GI₅₀	4.2 μM Compound: 4	Antiproliferative activity against human HCT-116 cells measured after 72 hrs by SRB assay Antiproliferative activity against human HCT-116 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
HEK293	EC₅₀	1.7 μM Compound: 5	Activation of human TRPA1 expressed in HEK293 cells assessed as increase in calcium level by fluo-4 dye based plate reader analysis Activation of human TRPA1 expressed in HEK293 cells assessed as increase in calcium level by fluo-4 dye based plate reader analysis	[PMID: 26905390]
HeLa	IC₅₀	65.46 μM Compound: 12	Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTS assay Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTS assay	[PMID: 24631733]
HeLa	IC₅₀	68.46 μM Compound: 12	Cytotoxicity against human HeLa cells assessed as cell viability after 24 hrs by MTS assay Cytotoxicity against human HeLa cells assessed as cell viability after 24 hrs by MTS assay	[PMID: 24631733]
HeLa	GI₅₀	89 μM Compound: 6	Growth inhibition of human HeLa cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HeLa cells after 48 hrs by sulforhodamine B assay	[PMID: 20304655]
HeLa	IC₅₀	93.7 μM Compound: 1a	Cytotoxicity against human HeLa cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell viability after 48 hrs by MTT assay	[PMID: 24953027]
Hs 683	IC₅₀	7 μM Compound: 1	Growth inhibition of human Hs683 cells by MTT assay Growth inhibition of human Hs683 cells by MTT assay	[PMID: 26706169]
HT-29	IC₅₀	> 100 μM Compound: 1a	Cytotoxicity against human HT-29 cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	[PMID: 24953027]
HT-29	IC₅₀	7.71 μM Compound: Juglone	Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTS assay Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTS assay	[PMID: 23791367]
K562	GI₅₀	> 100 μM Compound: 4	Antiproliferative activity against human K562 cells measured after 72 hrs by SRB assay Antiproliferative activity against human K562 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
LNCaP	IC₅₀	13.8 μM Compound: Juglone	Antiproliferative activity against human LNCAP cells after 24 hrs by MTT assay Antiproliferative activity against human LNCAP cells after 24 hrs by MTT assay	[PMID: 23643730]
MCF7	IC₅₀	13 μM Compound: 1	Growth inhibition of human MCF7 cells by MTT assay Growth inhibition of human MCF7 cells by MTT assay	[PMID: 26706169]
MCF7	IC₅₀	16.5 μM Compound: 1a	Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	[PMID: 24953027]
MCF7	GI₅₀	32.6 μM Compound: 4	Antiproliferative activity against human MCF7 cells measured after 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
MDA-MB-231	IC₅₀	7.15 μM Compound: Juglone	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTS assay Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTS assay	[PMID: 23791367]
MDA-MB-231	IC₅₀	75.76 μM Compound: 1a	Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	[PMID: 24953027]
MDA-MB-453	IC₅₀	27.52 μM Compound: 1a	Cytotoxicity against human MDA-MB-453 cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-453 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	[PMID: 24953027]
ME-180	IC₅₀	65.4 μM Compound: 1a	Cytotoxicity against human ME180 cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human ME180 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	[PMID: 24953027]
MOLM-13	GI₅₀	21.9 μM Compound: 4	Antiproliferative activity against human MOLM-13 cells measured after 72 hrs by SRB assay Antiproliferative activity against human MOLM-13 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
MV4-11	GI₅₀	0.06 μM Compound: 4	Antiproliferative activity against human MV4-11 cells measured after 72 hrs by SRB assay Antiproliferative activity against human MV4-11 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
PC-3	GI₅₀	4.77 μM Compound: Juglone	Antiproliferative activity against human PC3 cells after 96 hrs by MTT assay Antiproliferative activity against human PC3 cells after 96 hrs by MTT assay	[PMID: 30153964]
PC-3	GI₅₀	4.77 μM Compound: Juglone	Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay	[PMID: 28838831]
PC-3	IC₅₀	88.7 μM Compound: 1a	Cytotoxicity against human PC3 cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human PC3 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	[PMID: 24953027]
SK-MEL-28	IC₅₀	7 μM Compound: 1	Growth inhibition of human SK-MEL-28 cells by MTT assay Growth inhibition of human SK-MEL-28 cells by MTT assay	[PMID: 26706169]
SW1573	GI₅₀	50 μM Compound: 6	Growth inhibition of human SW1573 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SW1573 cells after 48 hrs by sulforhodamine B assay	[PMID: 20304655]
T47D	GI₅₀	77 μM Compound: 6	Growth inhibition of human T47D cells after 48 hrs by sulforhodamine B assay Growth inhibition of human T47D cells after 48 hrs by sulforhodamine B assay	[PMID: 20304655]
U-373MG ATCC	IC₅₀	17 μM Compound: 1	Growth inhibition of human U373 cells by MTT assay Growth inhibition of human U373 cells by MTT assay	[PMID: 26706169]
WiDr	GI₅₀	81 μM Compound: 6	Growth inhibition of human WiDr cells after 48 hrs by sulforhodamine B assay Growth inhibition of human WiDr cells after 48 hrs by sulforhodamine B assay	[PMID: 20304655]

體外研究
(In Vitro)

Juglone (0-500 μg/mL, 15 h) 對金黃色葡萄球菌表現出顯著的抗菌活性， MIC 值在 64-512 μg/mL范圍^[1]。
Juglone(5-20 μM, 24 h) 通過 ROS 的產生和 Bcl-2/Bax 比值的降低介導線粒體途徑誘導 SGC-7901 細胞凋亡^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay ^[2]

Cell Line:	SGC-7901
Concentration:	5, 10, 15, 20 μM
Incubation Time:	24 h
Result:	Inhibited cell growth in a dose-dependent manner.

Apoptosis Analysis ^[2]

Cell Line:	SGC-7901
Concentration:	5, 10, 15, 20 μM
Incubation Time:	24 h
Result:	Increased the number of early apoptotic cells.

Western Blot Analysis ^[2]

Cell Line:	SGC-7901
Concentration:	5, 10, 15, 20 μM
Incubation Time:	24 h
Result:	Decreased the expression of Bcl-2 and increased the Bax protein.

體內研究
(In Vivo)

Juglone (0.25 或 1 mg/kg, 口服, 70 天) 通過抑制高脂飲食大鼠 TLR4/NF-kB 信號通路預防代謝性內毒素血癥誘導的肝炎和神經炎癥^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	High-fat diet rats model^[3]
Dosage:	0.25 or 1 mg/kg
Administration:	p.o. for 70 days
Result:	Regulated the expression of s TNF-α, IL-1β and IL-6. Inhibited the TLR4 expression and NF-kappa activity.

分子量

174.16

Formula

C₁₀H₆O₃

CAS 號

481-39-0

性狀

固體

顏色

Brown to orange

中文名稱

5-羥基對萘醌

結構分類

初始來源

運輸條件

Room temperature in continental US; may vary elsewhere.

儲存方式

4°C, protect from light

*該產品在溶液狀態(tài)不穩(wěn)定，建議您現用現配，即刻使用。

溶解性數據

細胞實驗：

Ethanol 中的溶解度 : 10 mg/mL (57.42 mM; 超聲助溶; DMSO can inactivate Juglone's activity)

配制儲備液

濃度溶劑體積質量	1 mg	5 mg	10 mg

1 mM	5.7418 mL	28.7092 mL	57.4185 mL
5 mM	1.1484 mL	5.7418 mL	11.4837 mL
10 mM	0.5742 mL	2.8709 mL	5.7418 mL

查看完整儲備液配制表

* 請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液；該產品在溶液狀態(tài)不穩(wěn)定，建議您現用現配，即刻使用。

摩爾計算器
稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

濃度 _(start)

體積 _(start)

濃度 _(final)

體積 _(final)

動物溶解方案計算器

請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

每只動物的給藥體積

μL

動物數量

只

由于實驗過程有損耗，建議您多配一只動物的量

計算結果

工作液所需濃度 : mg/mL

純度 & 產品資料

純度: 99.68%

選擇批次：

Data Sheet (622 KB) SDS (480 KB)

COA (294 KB) HNMR (127 KB) RP-HPLC (204 KB)

產品使用指南 (1538 KB)

參考文獻

[1]. Zmantar T, et al. Use of juglone as antibacterial and potential efflux pump inhibitors in Staphylococcus aureus isolated from the oral cavity. Microb Pathog. 2016 Dec;101:44-49. [Content Brief]

[2]. Ji YB, et al. Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway. Exp Toxicol Pathol. 2011 Jan;63(1-2):69-78. [Content Brief]

[3]. Peng X, et al. Juglone prevents metabolic endotoxemia-induced hepatitis and neuroinflammation via suppressing TLR4/NF-κB signaling pathway in high-fat diet rats. Biochem Biophys Res Commun. 2015 Jul 3;462(3):245-50. [Content Brief]

Juglone 相關分類

完整儲備液配制表

* 請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液；該產品在溶液狀態(tài)不穩(wěn)定，建議您現用現配，即刻使用。

可選溶劑	濃度溶劑體積質量	1 mg	5 mg	10 mg	25 mg

Ethanol	1 mM	5.7418 mL	28.7092 mL	57.4185 mL	143.5462 mL
	5 mM	1.1484 mL	5.7418 mL	11.4837 mL	28.7092 mL
	10 mM	0.5742 mL	2.8709 mL	5.7418 mL	14.3546 mL
	15 mM	0.3828 mL	1.9139 mL	3.8279 mL	9.5697 mL
	20 mM	0.2871 mL	1.4355 mL	2.8709 mL	7.1773 mL
	25 mM	0.2297 mL	1.1484 mL	2.2967 mL	5.7418 mL
	30 mM	0.1914 mL	0.9570 mL	1.9139 mL	4.7849 mL
	40 mM	0.1435 mL	0.7177 mL	1.4355 mL	3.5887 mL
	50 mM	0.1148 mL	0.5742 mL	1.1484 mL	2.8709 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Juglone481-39-05-Hydroxy-1,4-naphthalenedione5-羥基對萘醌BacterialNF-κBToll-like Receptor (TLR)ApoptosisNuclear factor-κBNuclear factor-kappaBYellowPigmentblackwalnutantimicrobialInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只為有資質的科研機構、醫(yī)藥企業(yè)基于科學研究或藥證申報的用途提供醫(yī)藥研發(fā)服務，不為任何個人或者非科研性質的、非用于藥證申報使用等其他用途提供服務。

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Juglone (Synonyms: 胡桃醌; 5-Hydroxy-1,4-naphthalenedione)

Customer Review

Other Forms of Juglone:

MCE 顧客使用本產品發(fā)表的 2 篇科研文獻