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  2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Anti-infection
  3. P-glycoprotein Cytochrome P450 Bacterial Endogenous Metabolite
  4. Roquefortine C

Roquefortine C  (Synonyms: 異煙棒曲霉素 C)

目錄號: HY-N6748 純度: 98.42%
COA 產品使用指南 技術支持

Roquefortine C 是一種從羅氏青霉分離的真菌環(huán)肽，可激活 P-gp 并抑制 P450-3A和其他血紅蛋白。Roquefortine C 對革蘭氏陽性細菌具有抑菌活性。

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Roquefortine C Chemical Structure

Roquefortine C Chemical Structure

CAS No. : 58735-64-1

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規(guī)格 價格 是否有貨 數(shù)量
500 μg ￥3609
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MCE 顧客使用本產品發(fā)表的 1 篇科研文獻

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

Roquefortine C, a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits P450-3A and other haemoproteins. Roquefortine C has bacteriostatic activities against Gram-positive bacteria[1].

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
BT-474 IC50
29.6 μM
Compound: 2; Roq C
Antiproliferative activity against human BT-474 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human BT-474 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 26692349]
MCF7 IC50
21.7 μM
Compound: 2; Roq C
Antiproliferative activity against human MCF7 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 26692349]
MDA-MB-231 IC50
23.5 μM
Compound: 2; Roq C
Antiproliferative activity against human MDA-MB-231 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 26692349]
MDA-MB-468 IC50
28.6 μM
Compound: 2; Roq C
Antiproliferative activity against human MDA-MB-468 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-468 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 26692349]
SK-BR-3 IC50
23.4 μM
Compound: 2; Roq C
Antiproliferative activity against human SK-BR-3 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human SK-BR-3 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 26692349]
分子量

389.45

Formula

C22H23N5O2
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

異煙棒曲霉素 C
結構分類
初始來源

Penicillium roqueforti
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 10 mg/mL (25.68 mM; 超聲加熱助溶; 吸濕的 DMSO 對產品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 2.5677 mL 12.8386 mL 25.6772 mL
5 mM 0.5135 mL 2.5677 mL 5.1354 mL
查看完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產品資料

純度: 98.42%

參考文獻

完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5677 mL 12.8386 mL 25.6772 mL 64.1931 mL
5 mM 0.5135 mL 2.5677 mL 5.1354 mL 12.8386 mL
10 mM 0.2568 mL 1.2839 mL 2.5677 mL 6.4193 mL
15 mM 0.1712 mL 0.8559 mL 1.7118 mL 4.2795 mL
20 mM 0.1284 mL 0.6419 mL 1.2839 mL 3.2097 mL
25 mM 0.1027 mL 0.5135 mL 1.0271 mL 2.5677 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
Roquefortine C
目錄號：
HY-N6748
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