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  2. Apoptosis
  3. Apoptosis
  4. Beta-Zearalanol

Beta-Zearalanol  (Synonyms: β-玉米赤霉醇)

目錄號(hào): HY-N6740 純度: 99.83%
COA 產(chǎn)品使用指南 技術(shù)支持

Beta-Zearalanol 是由鐮刀菌屬 Fusarium 產(chǎn)生的一種霉菌毒素，可以在哺乳動(dòng)物生殖細(xì)胞中引起細(xì)胞凋亡 (apoptosis) 和氧化應(yīng)激反應(yīng)。 Beta-Zearalanol 是玉米赤霉烯酮（ZEA）的衍生物，可以與葡萄糖醛酸 (glucuronic acid) 結(jié)合。

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Beta-Zearalanol Chemical Structure

Beta-Zearalanol Chemical Structure

CAS No. : 42422-68-4

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥1760
In-stock
5 mg ￥1600
In-stock
10 mg ￥2600
In-stock
50 mg   詢(xún)價(jià)  
100 mg   詢(xún)價(jià)  

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Customer Review

Other Forms of Beta-Zearalanol:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells[1]. Beta-Zearalenol is the derivative of zearalenone (ZEA) which can conjugate with glucuronic acid[2].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF7 IC50
> 25 μM
Compound: 10
Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay
[PMID: 21513293]
MCF7 IC50
> 25 μM
Compound: 12
Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay
[PMID: 21513293]
NCI-H460 IC50
15.4 μM
Compound: 10
Cytotoxicity against human H460 cells after 72 hrs by MTS assay
Cytotoxicity against human H460 cells after 72 hrs by MTS assay
[PMID: 21513293]
NCI-H460 IC50
9.5 μM
Compound: 12
Cytotoxicity against human H460 cells after 72 hrs by MTS assay
Cytotoxicity against human H460 cells after 72 hrs by MTS assay
[PMID: 21513293]
SF-268 IC50
> 25 μM
Compound: 12
Cytotoxicity against human SF268 cells after 72 hrs by MTS assay
Cytotoxicity against human SF268 cells after 72 hrs by MTS assay
[PMID: 21513293]
SF-268 IC50
> 50 μM
Compound: 10
Cytotoxicity against human SF268 cells after 72 hrs by MTS assay
Cytotoxicity against human SF268 cells after 72 hrs by MTS assay
[PMID: 21513293]
Vero IC50
1.5 μM
Compound: 17
Antiviral activity against HSV1 F infected in african green monkey Vero cells assessed as reduction of virus-induced cytopathic effect by cellular replication assay
Antiviral activity against HSV1 F infected in african green monkey Vero cells assessed as reduction of virus-induced cytopathic effect by cellular replication assay
[PMID: 12828470]
Vero IC50
15 μM
Compound: 21
Antiviral activity against HSV1 F infected in african green monkey Vero cells assessed as reduction of virus-induced cytopathic effect by cellular replication assay
Antiviral activity against HSV1 F infected in african green monkey Vero cells assessed as reduction of virus-induced cytopathic effect by cellular replication assay
[PMID: 12828470]
Vero IC50
22.61 μM
Compound: 3
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by green fluorescent protein-based assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by green fluorescent protein-based assay
[PMID: 27311894]
體外研究
(In Vitro)

βeta-Zearalenol (0-200 μM；24 小時(shí)) 以劑量依賴(lài)性方式抑制 BGC 增殖，IC50 為 25 μM[1]。
βeta-Zearalenol (0-100 μM；72 hours) 在 HepG2 細(xì)胞中表現(xiàn)出高毒性，IC50 為 15.2 μM，與 與 β-ZOL+ZEN 或 β-ZOL+α-ZOL 有協(xié)同作用， IC50 值分別為 19.8 uM、16.8 uM[2]。
βeta-Zearalenol (0-10 μM；72 hours) 對(duì)所研究的所有三種細(xì)胞因子均具有最高的抑制作用：IL-8、IL-1β 和TNF-α 與 ZEA 或 α-Zearalenol 進(jìn)行比較[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: HepG2 cells
Concentration: 0-100 μM
Incubation Time: 72 hours
Result: Shown a dose-dependent reduction of viability of cells treated with Beta-Zearalanol.

Cell Proliferation Assay[1]

Cell Line: BGC cells
Concentration: 0 μM, 5 μM, 10 μM, 15 μM, 25 μM, 50 μM, 100 μM, and 200 μM
Incubation Time: 24?hours
Result: Inhibited cell proliferation in a dose-dependent manner.

RT-PCR[2]

Cell Line: HepG2 cells
Concentration: 1 μM, 5 μM, 10 μM
Incubation Time: 72 hours
Result: Had the higher cytotoxic effect in comparation with α-Zearalenol.
分子量

322.40

Formula

C18H26O5
CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱(chēng)

β-玉米赤霉醇
結(jié)構(gòu)分類(lèi)
初始來(lái)源

Fusarium species
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 100 mg/mL (310.17 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.1017 mL 15.5087 mL 31.0174 mL
5 mM 0.6203 mL 3.1017 mL 6.2035 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.83%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1017 mL 15.5087 mL 31.0174 mL 77.5434 mL
5 mM 0.6203 mL 3.1017 mL 6.2035 mL 15.5087 mL
10 mM 0.3102 mL 1.5509 mL 3.1017 mL 7.7543 mL
15 mM 0.2068 mL 1.0339 mL 2.0678 mL 5.1696 mL
20 mM 0.1551 mL 0.7754 mL 1.5509 mL 3.8772 mL
25 mM 0.1241 mL 0.6203 mL 1.2407 mL 3.1017 mL
30 mM 0.1034 mL 0.5170 mL 1.0339 mL 2.5848 mL
40 mM 0.0775 mL 0.3877 mL 0.7754 mL 1.9386 mL
50 mM 0.0620 mL 0.3102 mL 0.6203 mL 1.5509 mL
60 mM 0.0517 mL 0.2585 mL 0.5170 mL 1.2924 mL
80 mM 0.0388 mL 0.1939 mL 0.3877 mL 0.9693 mL
100 mM 0.0310 mL 0.1551 mL 0.3102 mL 0.7754 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Beta-Zearalanol
目錄號(hào)：
HY-N6740
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