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  2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Apoptosis
  3. Topoisomerase Androgen Receptor Estrogen Receptor/ERR Apoptosis
  4. Alternariol

Alternariol  (Synonyms: 交鏈孢酚)

目錄號: HY-N6714 純度: 99.67%
COA 產(chǎn)品使用指南

Alternariol 是一種由 Alternaria 產(chǎn)生的可口服霉菌毒素，能夠抑制拓撲異構(gòu)酶 I 和 II (topoisomerase I，topoisomerase II) 的活性，具有弱雌激素 (Estrogen Receptor/ERR) 及雄激素/抗雄激素 (Androgen Receptor) 效應。Alternariol 能誘導細胞凋亡，引發(fā)細胞周期停滯，抑制先天免疫反應，并展現(xiàn)抗腫瘤活性。Alternariol 具有遺傳毒性、誘變性和內(nèi)分泌干擾作用。

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Alternariol Chemical Structure

Alternariol Chemical Structure

CAS No. : 641-38-3

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥2700
In-stock
5 mg 現(xiàn)貨 詢價
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Customer Review

Other Forms of Alternariol:

查看 Topoisomerase 亞型特異性產(chǎn)品:

查看 Estrogen Receptor/ERR 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects[1][2][3][4][5].

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
A2780 IC50
> 10 μM
Compound: 12
Cytotoxicity against human A2780 cells by MTT assay
Cytotoxicity against human A2780 cells by MTT assay
[PMID: 27441892]
BGC-823 IC50
> 10 μM
Compound: 12
Cytotoxicity against human BGC823 cells by MTT assay
Cytotoxicity against human BGC823 cells by MTT assay
[PMID: 27441892]
HCT-116 IC50
> 10 μM
Compound: 12
Cytotoxicity against human HCT116 cells by MTT assay
Cytotoxicity against human HCT116 cells by MTT assay
[PMID: 27441892]
HepG2 IC50
> 10 μM
Compound: 12
Cytotoxicity against human HepG2 cells by MTT assay
Cytotoxicity against human HepG2 cells by MTT assay
[PMID: 27441892]
HT-29 IC50
> 20 μM
Compound: 17
Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay
[PMID: 28409637]
L5178Y EC50
1.7 μg/mL
Compound: 1
Cytotoxicity against mouse L5178Y cells by MTT assay
Cytotoxicity against mouse L5178Y cells by MTT assay
[PMID: 18494522]
MCF7 IC50
> 20 μM
Compound: 17
Cytotoxicity against human MCF7 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human MCF7 cells after 3 days by sulforhodamine B assay
[PMID: 28409637]
NCI-H1650 IC50
> 10 μM
Compound: 12
Cytotoxicity against human NCI-H1650 cells by MTT assay
Cytotoxicity against human NCI-H1650 cells by MTT assay
[PMID: 27441892]
RAW264.7 IC50
51.4 μM
Compound: 14
Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs by Griess reagent assay
Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs by Griess reagent assay
[PMID: 35007071]
體外研究
(In Vitro)

Alternariol (10 μM，24 h) 抑制人肺上皮細胞 (BEAS-2B) 和小鼠巨噬細胞 (RAW264.7) 的先天免疫反應[2]。
Alternariol (5-10 μM，24 h) 在 LPS (HY-D1056，10 μg) 誘導的 BEAS-2B 細胞炎癥中呈劑量依賴性降低[2]。
Alternariol (1-100 μM，24 h) 抑制 BEAS-2B 細胞增殖，誘導細胞周期阻滯[2]。
Alternariol (10 μM，24 h) 在 V79 細胞和小鼠淋巴瘤 L5178Y tk+/? 細胞 (MLC) 中誘導 HPRT 和 TK 突變[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR[2]

Cell Line: BEAS-2B, RAW264.7 (induced by LPS)
Concentration: 10 μM
Incubation Time: 24 h
Result: Reduced IL6, IL8, MCP-1/CCL2 levels, induced cytochrome P450 CYP1A1 gene expression, and partially prevented LPS-induced downregulation.

Cell Viability Assay[2]

Cell Line: BEAS-2B
Concentration: 1, 5, 10, 15, 20, 25, 30, 50, 100 μM
Incubation Time: 24 h
Result: Inhibited cell proliferation, but not cell death.
體內(nèi)研究
(In Vivo)

Alternariol (1-5 mg/kg，靜脈注射，每日一次，4 天) 對小鼠胚胎和嬰兒發(fā)育階段具有胚胎毒性和免疫毒性，誘導凋亡[4]。
Alternariol (50-200 mg/kg，口服，每天一次，24 周) 在 DMBA (HY-W011845) 誘導的乳腺癌小鼠中誘導細胞凋，和抑制細胞增殖，可以顯著抑制乳腺癌[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pregnant mice[4]
Dosage: 1, 3, 5 mg/kg; daily; 4 days
Administration: Intravenous injection (i.v.)
Result: Showed embryonic apoptosis at the blastocyst stage, fetal weight loss, triggering a significant increase in total oxidative stress content and expression of genes encoding antioxidant proteins, and reducing the expression of CXCL1, IL-1β and IL-8.
Animal Model: Mice induced by DMBA(HY-W011845)[5]
Dosage: 50, 100, 200 mg/kg; daily; 24 weeks
Administration: Oral
Result: Reduced proliferative lesions of breast tissue, restored normal histopathological characteristics of breast tissue, downregulated the expression of oncogenic markers such as PI3K and Akt, increased the expression of apoptosis markers such as p53, caspase-3 and Bax, reduced cell proliferation and increased cell apoptosis.
分子量

258.23

Formula

C14H10O5
CAS 號
性狀

固體

顏色

White to light brown

中文名稱

交鏈孢酚
結(jié)構(gòu)分類
初始來源

fungi of the genus Alternaria
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : ≥ 30 mg/mL (116.18 mM; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.8725 mL 19.3626 mL 38.7252 mL
5 mM 0.7745 mL 3.8725 mL 7.7450 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.67%

參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8725 mL 19.3626 mL 38.7252 mL 96.8129 mL
5 mM 0.7745 mL 3.8725 mL 7.7450 mL 19.3626 mL
10 mM 0.3873 mL 1.9363 mL 3.8725 mL 9.6813 mL
15 mM 0.2582 mL 1.2908 mL 2.5817 mL 6.4542 mL
20 mM 0.1936 mL 0.9681 mL 1.9363 mL 4.8406 mL
25 mM 0.1549 mL 0.7745 mL 1.5490 mL 3.8725 mL
30 mM 0.1291 mL 0.6454 mL 1.2908 mL 3.2271 mL
40 mM 0.0968 mL 0.4841 mL 0.9681 mL 2.4203 mL
50 mM 0.0775 mL 0.3873 mL 0.7745 mL 1.9363 mL
60 mM 0.0645 mL 0.3227 mL 0.6454 mL 1.6135 mL
80 mM 0.0484 mL 0.2420 mL 0.4841 mL 1.2102 mL
100 mM 0.0387 mL 0.1936 mL 0.3873 mL 0.9681 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Alternariol
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HY-N6714
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