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  2. 天然產物
  3. 疾病研究領域 植物 苯丙素類
  4. 木蘭科 炎癥/免疫 木脂素
  5. 辛夷
  6. Epimagnolin B

Epimagnolin B  (Synonyms: 表木蘭脂素 B)

目錄號: HY-N6261
產品使用指南 技術支持

Epimagnolin B 是從木蘭中分離得到的一種具有抗炎活性的雙環(huán)氧木質素。Epimagnolin B 抑制 LPS 激活的小膠質細胞中 NO 的產生。Epimagnolin B 具有抗過敏作用。

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Epimagnolin B Chemical Structure

Epimagnolin B Chemical Structure

CAS No. : 1134188-26-3

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  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

Epimagnolin B is a bisepoxylignan isolated from Magnolia fargesii, with anti-inflammatory activity and antiallergic effects. Epimagnolin B inhibits NO production in LPS-activated microglia. Epimagnolin B exhibited antiallergic effects[1][2].

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
BV-2 IC50
10.9 μM
Compound: 4
Inhibition of NO production in LPS-stimulated mouse BV2 cells assessed as nitrite accumulation after 20 hrs by Griess reagent method
Inhibition of NO production in LPS-stimulated mouse BV2 cells assessed as nitrite accumulation after 20 hrs by Griess reagent method
[PMID: 19110419]
體外研究
(In Vitro)

Epimagnolin B exhibits antiallergic effects without affecting the viability of BMMCs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

416.46

Formula

C23H28O7
CAS 號
中文名稱

表木蘭脂素 B
結構分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產品資料
參考文獻

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  • 稀釋計算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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