β,β-Dimethylacrylshikonin (Synonyms: Isoarnebin I)

目錄號: HY-N5112B 純度: 99.30%: FAQs
Data Sheet SDS COA 產(chǎn)品使用指南

摩爾計算器

β,β-Dimethylacrylshikonin (Isoarnebin I) 是從紫草中提取得到的一種萘醌衍生物，通過PI3K通路誘導(dǎo) eNOS、VEGF 和 HIF-1α 的表達(dá)，促進(jìn)血管生成。β,β-Dimethylacrylshikonin 具有抗腫瘤活性。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)

β,β-Dimethylacrylshikonin Chemical Structure

CAS No. : 24502-79-2

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Other Forms of β,β-Dimethylacrylshikonin:

β,β-Dimethylacrylalkannin In-stock

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

•Phytomedicine. 2023 Mar 15;114:154769. [Abstract]

β,β-Dimethylacrylshikonin 相關(guān)產(chǎn)品

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HIF-1α HIF

生物活性
純度 & 產(chǎn)品資料
參考文獻(xiàn)

生物活性

β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative isolated from Lithospermum erythrorhizon Sieb. et Zucc. , promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway.β,β-Dimethylacrylshikonin has anti-tumor activity^[1].

細(xì)胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
B16-F0	IC₅₀	1.2 μM Compound: DMAS	Cytotoxicity against mouse B16F0 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against mouse B16F0 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 31961147]
B16-F0	IC₅₀	1.2 μM Compound: DMAS	Cytotoxicity against mouse B16F0 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against mouse B16F0 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31961147]
CCRF-CEM	IC₅₀	1.9 μM Compound: 3	Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay	[PMID: 22530779]
HCT-116	IC₅₀	20 μM Compound: 3	Cytotoxicity against human HCT116 cells after 72 hrs by XTT assay Cytotoxicity against human HCT116 cells after 72 hrs by XTT assay	[PMID: 22530779]
MDA-MB-231	IC₅₀	23.2 μM Compound: 3	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by XTT assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by XTT assay	[PMID: 22530779]
MRC5	IC₅₀	2.4 μM Compound: 3	Cytotoxicity against human MRC5 cells after 72 hrs by XTT assay Cytotoxicity against human MRC5 cells after 72 hrs by XTT assay	[PMID: 22530779]
MRC5	IC₅₀	9.5 μM Compound: DMAS	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 24 hrs by EZ4U reagent based spectrophotometric method Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 24 hrs by EZ4U reagent based spectrophotometric method	[PMID: 31961147]
MUGMel1	IC₅₀	1 μM Compound: DMAS	Cytotoxicity against human MUGMel1 cells assessed as reduction in cell viability after 72 hrs by EZ4U reagent based spectrophotometric method Cytotoxicity against human MUGMel1 cells assessed as reduction in cell viability after 72 hrs by EZ4U reagent based spectrophotometric method	[PMID: 31961147]
MUGMel1	IC₅₀	1.1 μM Compound: DMAS	Cytotoxicity against human MUGMel1 cells assessed as reduction in cell viability after 48 hrs by EZ4U reagent based spectrophotometric method Cytotoxicity against human MUGMel1 cells assessed as reduction in cell viability after 48 hrs by EZ4U reagent based spectrophotometric method	[PMID: 31961147]
MUGMel1	IC₅₀	1.9 μM Compound: DMAS	Cytotoxicity against human MUGMel1 cells assessed as reduction in cell viability after 24 hrs by EZ4U reagent based spectrophotometric method Cytotoxicity against human MUGMel1 cells assessed as reduction in cell viability after 24 hrs by EZ4U reagent based spectrophotometric method	[PMID: 31961147]
MUGMel2	IC₅₀	1.7 μM Compound: DMAS	Cytotoxicity against human MUGMel2 cells harboring NRAS pQ61K mutant assessed as reduction in cell viability after 72 hrs by EZ4U reagent based spectrophotometric method Cytotoxicity against human MUGMel2 cells harboring NRAS pQ61K mutant assessed as reduction in cell viability after 72 hrs by EZ4U reagent based spectrophotometric method	[PMID: 31961147]
MUGMel2	IC₅₀	2.3 μM Compound: DMAS	Cytotoxicity against human MUGMel2 cells harboring NRAS pQ61K mutant assessed as reduction in cell viability after 48 hrs by EZ4U reagent based spectrophotometric method Cytotoxicity against human MUGMel2 cells harboring NRAS pQ61K mutant assessed as reduction in cell viability after 48 hrs by EZ4U reagent based spectrophotometric method	[PMID: 31961147]
MUGMel2	IC₅₀	5.1 μM Compound: DMAS	Cytotoxicity against human MUGMel2 cells harboring NRAS pQ61K mutant assessed as reduction in cell viability after 24 hrs by EZ4U reagent based spectrophotometric method Cytotoxicity against human MUGMel2 cells harboring NRAS pQ61K mutant assessed as reduction in cell viability after 24 hrs by EZ4U reagent based spectrophotometric method	[PMID: 31961147]
MUGMel2	IC₅₀	7.2 μM Compound: 1-76	Antitumor activity against human MUG-Mel2 cells assessed as reduction in cell viability incubated for 72 hrs by XTT assay Antitumor activity against human MUG-Mel2 cells assessed as reduction in cell viability incubated for 72 hrs by XTT assay	[PMID: 35367708]
SBcl2	IC₅₀	1.1 μM Compound: 1-76	Antitumor activity against human SBcl2 cells assessed as reduction in cell viability incubated for 72 hrs by XTT assay Antitumor activity against human SBcl2 cells assessed as reduction in cell viability incubated for 72 hrs by XTT assay	[PMID: 35367708]
SBcl2	IC₅₀	1.1 μM Compound: 3	Cytotoxicity against human SBcl2 cells after 72 hrs by XTT assay Cytotoxicity against human SBcl2 cells after 72 hrs by XTT assay	[PMID: 22530779]
SBcl2	IC₅₀	1.1 μM Compound: DMAS	Cytotoxicity against human SBcl2 cells harboring NRAS Q61I mutant assessed as reduction in cell viability after 48 hrs by EZ4U reagent based spectrophotometric method Cytotoxicity against human SBcl2 cells harboring NRAS Q61I mutant assessed as reduction in cell viability after 48 hrs by EZ4U reagent based spectrophotometric method	[PMID: 31961147]
SBcl2	IC₅₀	1.2 μM Compound: DMAS	Cytotoxicity against human SBcl2 cells harboring NRAS Q61I mutant assessed as reduction in cell viability after 72 hrs by EZ4U reagent based spectrophotometric method Cytotoxicity against human SBcl2 cells harboring NRAS Q61I mutant assessed as reduction in cell viability after 72 hrs by EZ4U reagent based spectrophotometric method	[PMID: 31961147]
SBcl2	IC₅₀	1.9 μM Compound: DMAS	Cytotoxicity against human SBcl2 cells harboring NRAS Q61I mutant assessed as reduction in cell viability after 24 hrs by EZ4U reagent based spectrophotometric method Cytotoxicity against human SBcl2 cells harboring NRAS Q61I mutant assessed as reduction in cell viability after 24 hrs by EZ4U reagent based spectrophotometric method	[PMID: 31961147]
U-251	IC₅₀	30.8 μM Compound: 3	Cytotoxicity against human U251 cells after 72 hrs by XTT assay Cytotoxicity against human U251 cells after 72 hrs by XTT assay	[PMID: 22530779]
WM164	IC₅₀	2.4 μM Compound: DMAS	Cytotoxicity against human WM164 cells harboring BRAF V600E mutant assessed as reduction in cell viability after 72 hrs by EZ4U reagent based spectrophotometric method Cytotoxicity against human WM164 cells harboring BRAF V600E mutant assessed as reduction in cell viability after 72 hrs by EZ4U reagent based spectrophotometric method	[PMID: 31961147]
WM164	IC₅₀	3 μM Compound: DMAS	Cytotoxicity against human WM164 cells harboring BRAF V600E mutant assessed as reduction in cell viability after 48 hrs by EZ4U reagent based spectrophotometric method Cytotoxicity against human WM164 cells harboring BRAF V600E mutant assessed as reduction in cell viability after 48 hrs by EZ4U reagent based spectrophotometric method	[PMID: 31961147]
WM164	IC₅₀	3.8 μM Compound: DMAS	Cytotoxicity against human WM164 cells harboring BRAF V600E mutant assessed as reduction in cell viability after 24 hrs by EZ4U reagent based spectrophotometric method Cytotoxicity against human WM164 cells harboring BRAF V600E mutant assessed as reduction in cell viability after 24 hrs by EZ4U reagent based spectrophotometric method	[PMID: 31961147]
WM164	IC₅₀	8.3 μM Compound: 1-76	Antitumor activity against human WM164 cells assessed as reduction in cell viability incubated for 72 hrs by XTT assay Antitumor activity against human WM164 cells assessed as reduction in cell viability incubated for 72 hrs by XTT assay	[PMID: 35367708]
WM164	IC₅₀	8.3 μM Compound: 3	Cytotoxicity against human WM164 cells after 72 hrs by XTT assay Cytotoxicity against human WM164 cells after 72 hrs by XTT assay	[PMID: 22530779]
WM793	IC₅₀	0.7 μM Compound: DMAS	Cytotoxicity against human WM793 cells harboring BRAF V600E mutant assessed as reduction in cell viability after 72 hrs by EZ4U reagent based spectrophotometric method Cytotoxicity against human WM793 cells harboring BRAF V600E mutant assessed as reduction in cell viability after 72 hrs by EZ4U reagent based spectrophotometric method	[PMID: 31961147]
WM793	IC₅₀	0.8 μM Compound: DMAS	Cytotoxicity against human WM793 cells harboring BRAF V600E mutant assessed as reduction in cell viability after 48 hrs by EZ4U reagent based spectrophotometric method Cytotoxicity against human WM793 cells harboring BRAF V600E mutant assessed as reduction in cell viability after 48 hrs by EZ4U reagent based spectrophotometric method	[PMID: 31961147]
WM793	IC₅₀	1.2 μM Compound: DMAS	Cytotoxicity against human WM793 cells harboring BRAF V600E mutant assessed as reduction in cell viability after 24 hrs by EZ4U reagent based spectrophotometric method Cytotoxicity against human WM793 cells harboring BRAF V600E mutant assessed as reduction in cell viability after 24 hrs by EZ4U reagent based spectrophotometric method	[PMID: 31961147]

分子量

370.40

Formula

C₂₁H₂₂O₆

CAS 號

24502-79-2

性狀

固體

顏色

Brown to reddish brown

結(jié)構(gòu)分類

初始來源

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)

細(xì)胞實驗：

DMSO 中的溶解度 : 12.5 mg/mL (33.75 mM; 超聲助溶 (<60°C); 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	2.6998 mL	13.4989 mL	26.9978 mL
5 mM	0.5400 mL	2.6998 mL	5.3996 mL
10 mM	0.2700 mL	1.3499 mL	2.6998 mL

查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

摩爾計算器
稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

濃度 _(start)

體積 _(start)

濃度 _(final)

體積 _(final)

動物實驗：

請根據(jù)您的實驗動物和給藥方式選擇適當(dāng)?shù)娜芙夥桨浮?

以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
——為保證實驗結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

方案一

請依序添加每種溶劑： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (5.62 mM); 澄清溶液

此方案可獲得 ≥ 2.08 mg/mL（飽和度未知）的澄清溶液，此方案實驗周期在半個月以上的動物實驗酌情使用。
以 1 mL 工作液為例，取 100 μL 20.8 mg/mL 的澄清 DMSO 儲備液加到 900 μL玉米油中，混合均勻。

動物溶解方案計算器

請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

每只動物的給藥體積

μL

動物數(shù)量

只

由于實驗過程有損耗，建議您多配一只動物的量

請輸入您的動物體內(nèi)配方組成：

DMSO +

Tween-80 +

Saline

如果您的動物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。

方案所需 助溶劑 包括：DMSO，，均可在 MCE 網(wǎng)站選購。，Tween 80，均可在 MCE 網(wǎng)站選購。

計算結(jié)果

工作液所需濃度 : mg/mL

儲備液配制方法 : mg 藥物溶于 μL DMSO（母液濃度為 mg/mL）。

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，以下方案僅供參考，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。

動物實驗體內(nèi)工作液的配制方法 : 取 μL DMSO 儲備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。

連續(xù)給藥周期超過半月以上，請謹(jǐn)慎選擇該方案。

請確保第一步儲備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱（超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。

純度 & 產(chǎn)品資料

純度: 99.30%

選擇批次：

Data Sheet (623 KB) SDS (762 KB)

COA (199 KB) LCMS (88 KB)

產(chǎn)品使用指南 (1538 KB)

參考文獻(xiàn)

[1]. Zeng Z, et al. Arnebin-1 promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. Int J Mol Med. 2015 Sep;36(3):685-97. [Content Brief]

[2]. Sidhu GS, et al. Arnebin-1 accelerates normal and hydrocortisone-induced impaired wound healing. J Invest Dermatol. 1999 Nov;113(5):773-81. [Content Brief]

β,β-Dimethylacrylshikonin 相關(guān)分類

完整儲備液配制表

可選溶劑	濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6998 mL	13.4989 mL	26.9978 mL	67.4946 mL
	5 mM	0.5400 mL	2.6998 mL	5.3996 mL	13.4989 mL
	10 mM	0.2700 mL	1.3499 mL	2.6998 mL	6.7495 mL
	15 mM	0.1800 mL	0.8999 mL	1.7999 mL	4.4996 mL
	20 mM	0.1350 mL	0.6749 mL	1.3499 mL	3.3747 mL
	25 mM	0.1080 mL	0.5400 mL	1.0799 mL	2.6998 mL
	30 mM	0.0900 mL	0.4500 mL	0.8999 mL	2.2498 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β,β-Dimethylacrylshikonin24502-79-2Isoarnebin IHIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHInhibitorinhibitorinhibit

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β,β-Dimethylacrylshikonin (Synonyms: Isoarnebin I)

Customer Review

Other Forms of β,β-Dimethylacrylshikonin:

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)