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  2. Immunology/Inflammation
  3. NO Synthase
  4. Bryonolic acid

Bryonolic acid  (Synonyms: 瀉根醇酸)

目錄號: HY-N2965
產(chǎn)品使用指南

Bryonolic acid 是一種活性三萜化合物，具有免疫調(diào)節(jié)、抗炎，抗氧化和抗癌等活性。

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Bryonolic acid Chemical Structure

Bryonolic acid Chemical Structure

CAS No. : 24480-45-3

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥2400
1 - 2 周
5 mg ￥6000
1 - 2 周
10 mg   詢價  
50 mg   詢價  

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查看 NO Synthase 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Bryonolic acid is an active triterpenoid compound with immunomodulatory, anti-inflammatory, antioxidant and anticancer activities[1][2][3].

體外研究
(In Vitro)

Bryonolic acid exerts anti-allergic activity by inhibiting homologous passive cutaneous anaphylaxis and delayed hypersensitivity. Bryonolic acid reduces nitric oxide by suppressing inducible nitric oxide synthase expression, indicating anti-inflammatory activity[1].
In rat adrenal pheochromocytoma (PC12) cells, Bryonolic acid against N-methyl-D-aspartate (NMDA)-induced neurotoxicity, indicating it as a candidate neuroprotective agent for cerebral ischemic treatment[1].
Bryonolic acid (1-200 μM) inhibits acyl-coA: cholesterol acyl transferase (ACAT) activity in rat liver microsomes in a concentration-dependent manner, blocking the biosynthesis of the cholesterol fatty acid ester tumour promoter. Bryonolic acid inhibits ACAT in intact cancer cells with an IC50 of 12.6 μM[2].
Bryonolic acid inhibits both clonogenicity and invasiveness in MCF-7 MB-231, U87 and 3T3-EA cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Bryonolic acid (500 mg/kg; i.p.; once) potently induces HO-1 in a manner dependent on the Nrf2-Keap1 pathway[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type and Nrf2-/- mice[3]
Dosage: 500 mg/kg
Administration: i.p.; once
Result: Induced HO-1 in a manner dependent on the Nrf2-Keap1 pathway.
分子量

456.70

Formula

C30H48O3
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

瀉根醇酸
結(jié)構(gòu)分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Bryonolic acid
目錄號：
HY-N2965
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