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  2. Membrane Transporter/Ion Channel Neuronal Signaling Apoptosis
  3. Potassium Channel Sodium Channel Na+/K+ ATPase Calcium Channel Apoptosis
  4. Annonacin

Annonacin 是一種乙酰原素，它通過抑制線粒體復(fù)合物的途徑而具有毒性。Annonacin 在 R406W+/+ 小鼠中增加 tau 蛋白的磷酸化。Annonacin 可充當(dāng)鈉/鉀和肌漿網(wǎng) (SERCA)ATPase 泵的抑制劑。Annonacin 對卵巢癌、宮頸癌、乳腺癌、膀胱癌和皮膚癌等多種癌細(xì)胞系均有顯著殺傷作用。Annonacin 通過 Bax 和 caspase-3 相關(guān)途徑誘導(dǎo)細(xì)胞凋亡。

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Annonacin Chemical Structure

Annonacin Chemical Structure

CAS No. : 111035-65-5

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1 mg ￥2900
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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W+/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and sarcoplasmic reticulum (SERCA) ATPase pumps. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways[1][2][3][4].

體外研究
(In Vitro)

Annonacin (1-10 μg/mL; 0-72 小時) 可以誘導(dǎo)多種癌細(xì)胞系死亡，可使癌細(xì)胞阻滯在 G1 期[2]。
Annonacin (10 μg/mL; 0-24 小時) 可誘導(dǎo) T24 細(xì)胞的凋亡，增強(qiáng)促凋亡相關(guān)基因的表達(dá)[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: T24 cells
Concentration: 1 μg/mL
Incubation Time: 0, 24, 48 and 72 h
Result: Significantly reduced cell viability. Compared with untreated controls, only 56.0%, 34.2% and 35.3% of T24 cells were alive at 24, 48 and 72 hours, respectively.

Western Blot Analysis[2]

Cell Line: T24 cells
Concentration: 10 μg/mL
Incubation Time: 1, 4, 8, 12 and 24 h
Result: Increased the levels of Bax and Bad.
Inhibited the levels of procaspase-3.
體內(nèi)研究
(In Vivo)

Annonacin (0-9 mg/kg; 皮下滲透泵; 3 天) 可在 R406W+/+ 小鼠中增加 tau 蛋白的磷酸化[3]。
Annonacin (85 nM/100 μL; 局部外用; 一周兩次; 22 周) 在皮膚腫瘤小鼠模型中具有抗癌作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: R406W+/+ transgenic mice[3]
Dosage: 0, 6 and 9 mg/kg/day
Administration: Subcutaneous osmotic pump; 3 days
Result: Increased the number of neurons with phosphorylated tau in the somatodendritic compartment in several brain areas.
Increased the levels of phosphorylated tau protein.
Increased in total tau protein without increase in tau mRNA, but reduced proteasomal proteolytic activity.
Increased the levels of different tau kinases.
Significantly increased the ratio of p25/p35.
Animal Model: DMBA (HY-W011845)/TPA treated female ICR mice aged 6-7 weeks old[4]
Dosage: 85 nM/100 uL
Administration: Topical application; Twice a week for 22 weeks
Result: Significantly increased the tumor latency period and reduced the tumor incidence, tumor burden and tumor volume, respectively.
Suppressed tumorigenesis manifested by significant reduction of hyperkeratosis, dermal papillae and number of keratin pearls on skin tissues.
Showed no toxicity to the liver and kidneys.
分子量

596.88

Formula

C35H64O7
CAS 號
性狀

固體

顏色

White to off-white

結(jié)構(gòu)分類
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : ≥ 20 mg/mL (33.51 mM; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 1.6754 mL 8.3769 mL 16.7538 mL
5 mM 0.3351 mL 1.6754 mL 3.3508 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時，請?jiān)?個月內(nèi)使用，-20°C儲存時，請?jiān)?個月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
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體積
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分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

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體積 (start)

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動物溶解方案計(jì)算器
請輸入動物實(shí)驗(yàn)的基本信息：

給藥劑量

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動物數(shù)量

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由于實(shí)驗(yàn)過程有損耗，建議您多配一只動物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: ≥97.0%

參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時，請?jiān)?個月內(nèi)使用，-20°C儲存時，請?jiān)?個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6754 mL 8.3769 mL 16.7538 mL 41.8845 mL
5 mM 0.3351 mL 1.6754 mL 3.3508 mL 8.3769 mL
10 mM 0.1675 mL 0.8377 mL 1.6754 mL 4.1884 mL
15 mM 0.1117 mL 0.5585 mL 1.1169 mL 2.7923 mL
20 mM 0.0838 mL 0.4188 mL 0.8377 mL 2.0942 mL
25 mM 0.0670 mL 0.3351 mL 0.6702 mL 1.6754 mL
30 mM 0.0558 mL 0.2792 mL 0.5585 mL 1.3961 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Annonacin
目錄號：
HY-N2877
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