Melanotan I (Synonyms: 美拉諾坦 I; MT-I; [Nle4,D-Phe7]-α-MSH)

目錄號: HY-N2466 純度: 99.75%: FAQs
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Melanotan I 是一種有效非選擇性黑素皮質(zhì)激素受體 (MCR) 激動劑。Melanotan I 是一種合成的 α- 黑素細胞刺激激素 (α-MSH) 的類似物，刺激黑色素生成。Melanotan I 可以通過模仿 α-MSH 對黑素細胞的黑素皮質(zhì)素 1 型受體 (MC1R) 的作用來誘導皮膚曬黑。Melanotan I 可以用于陽光誘發(fā)皮膚癌、黑色素瘤、炎癥和男性勃起功能障礙等研究。

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Custom Peptide Synthesis

Melanotan I Chemical Structure

CAS No. : 75921-69-6

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Other Forms of Melanotan I:

Melanotan I acetate 詢價

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻

•Theranostics. 2020 Aug 13;10(24):11110-11126. [Abstract]

Melanotan I 相關(guān)產(chǎn)品

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MC1R MC3R MC2R MC4R MC5R

生物活性
純度 & 產(chǎn)品資料
參考文獻

生物活性

Melanotan I is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I can be used for the research of sun-induced skin cancer, melanoma, inflammation and male erectile dysfunction^[1]^[2]^[3]^[4].

IC₅₀ & Target

MC1R

細胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
CHO	IC₅₀	1.5 x 10^-10 M Compound: NDP-alpha-MSH	Displacement of [125I]NDP-a-MSH from human recombinant MC4 receptor expressed in CHO cells measured after 120 mins by scintillation counting method Displacement of [125I]NDP-a-MSH from human recombinant MC4 receptor expressed in CHO cells measured after 120 mins by scintillation counting method	[PMID: 27876250]
HEK293	EC₅₀	0.01 nM Compound: NDP-MSH	Agonist activity at mouse melanocortin receptor 1 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay Agonist activity at mouse melanocortin receptor 1 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	[PMID: 31845801]
HEK293	EC₅₀	0.012 nM Compound: NDP-MSH	Agonist activity at mouse melanocortin receptor 1 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP AlphaScreen assay Agonist activity at mouse melanocortin receptor 1 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP AlphaScreen assay	[PMID: 32184956]
HEK293	EC₅₀	0.018 nM Compound: NDP-MSH	Agonist activity at mouse melanocortin 1 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay Agonist activity at mouse melanocortin 1 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	[PMID: 21306168]
HEK293	EC₅₀	0.023 nM Compound: NDP-MSH	Agonist activity at mouse MC1R expressed in HEK293 cells by beta-galactosidase assay Agonist activity at mouse MC1R expressed in HEK293 cells by beta-galactosidase assay	[PMID: 15615519]
HEK293	EC₅₀	0.03 nM Compound: NDP-MSH	Agonist activity at mouse MC1R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay Agonist activity at mouse MC1R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	[PMID: 26959173]
HEK293	EC₅₀	0.03 nM Compound: NDP-MSH	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	[PMID: 21306168]
HEK293	EC₅₀	0.05 nM Compound: NDP-MSH	Agonist activity at mouse MC1 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay Agonist activity at mouse MC1 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	[PMID: 23432160]
HEK293	EC₅₀	0.051 nM Compound: NDP-MSH	Full agonist activity at mouse MC1R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay Full agonist activity at mouse MC1R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	[PMID: 30741545]
HEK293	EC₅₀	0.062 nM Compound: NDP-MSH	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	[PMID: 15615519]
HEK293	EC₅₀	0.07 nM Compound: NDP-MSH	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	[PMID: 31845801]
HEK293	EC₅₀	0.07 nM Compound: NDP-MSH	Agonist activity at human MC1R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay Agonist activity at human MC1R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	[PMID: 29578343]
HEK293	EC₅₀	0.085 nM Compound: NDP-MSH	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	[PMID: 15615519]
HEK293	EC₅₀	0.088 nM Compound: NDP-MSH	Agonist activity at mouse melanocortin-1 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs Agonist activity at mouse melanocortin-1 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	[PMID: 24517312]
HEK293	EC₅₀	0.088 nM Compound: NDP-MSH	Agonist activity at mouse MC1R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay Agonist activity at mouse MC1R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	[PMID: 18800761]
HEK293	EC₅₀	0.092 nM Compound: NDP-MSH	Activity at mouse MC1R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay Activity at mouse MC1R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	[PMID: 25347033]
HEK293	EC₅₀	0.12 nM Compound: NDP-MSH	Agonist activity at mouse melanocortin-4 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs Agonist activity at mouse melanocortin-4 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	[PMID: 24517312]
HEK293	EC₅₀	0.12 nM Compound: NDP-MSH	Agonist activity at mouse MC4R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay Agonist activity at mouse MC4R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	[PMID: 18800761]
HEK293	EC₅₀	0.13 nM Compound: NDP-MSH	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	[PMID: 31845801]
HEK293	EC₅₀	0.13 nM Compound: NDP-MSH	Agonist activity at human MC4R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay Agonist activity at human MC4R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	[PMID: 29578343]
HEK293	EC₅₀	0.13 nM Compound: NDP-MSH	Agonist activity at mouse MC4R expressed in HEK293 cells by beta-galactosidase assay Agonist activity at mouse MC4R expressed in HEK293 cells by beta-galactosidase assay	[PMID: 15615519]
HEK293	EC₅₀	0.14 nM Compound: NDP-MSH	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	[PMID: 21306168]
HEK293	EC₅₀	0.19 nM Compound: NDP-MSH	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	[PMID: 32184956]
HEK293	EC₅₀	0.2 nM Compound: NDP-MSH	Agonist activity at mouse melanocortin 4 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay Agonist activity at mouse melanocortin 4 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	[PMID: 21306168]
HEK293	EC₅₀	0.2 nM Compound: NDP-MSH	Agonist activity at mouse MC4 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay Agonist activity at mouse MC4 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	[PMID: 23432160]
HEK293	EC₅₀	0.2 nM Compound: NDP-MSH	Activity at mouse MC4R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay Activity at mouse MC4R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	[PMID: 25347033]
HEK293	EC₅₀	0.23 nM Compound: NDP-MSH	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	[PMID: 23432160]
HEK293	EC₅₀	0.24 nM Compound: NDP-MSH	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	[PMID: 26959173]
HEK293	EC₅₀	0.26 nM Compound: NDP-MSH	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	[PMID: 24517312]
HEK293	EC₅₀	0.26 nM Compound: NDP-MSH	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	[PMID: 18800761]
HEK293	EC₅₀	0.279 nM Compound: NDP-MSH	Agonist activity at mouse MC4R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay Agonist activity at mouse MC4R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	[PMID: 30741545]
HEK293	EC₅₀	0.28 nM Compound: NDP-MSH	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	[PMID: 23432160]
HEK293	IC₅₀	0.29 nM Compound: NDP-MSH	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 1 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 1 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	[PMID: 31845801]
HEK293	EC₅₀	0.3 nM Compound: NDP-MSH	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	[PMID: 32184956]
HEK293	EC₅₀	0.3 nM Compound: NDP-MSH	Agonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay Agonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	[PMID: 29578343]
HEK293	IC₅₀	0.31 nM Compound: NDP-MSH	Displacement of 125I-NDP-MSH from mouse MC1R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis Displacement of 125I-NDP-MSH from mouse MC1R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	[PMID: 26959173]
HEK293	EC₅₀	0.31 nM Compound: NDP-MSH	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	[PMID: 26959173]
HEK293	EC₅₀	0.33 nM Compound: NDP-MSH	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	[PMID: 24517312]
HEK293	EC₅₀	0.33 nM Compound: NDP-MSH	Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	[PMID: 18800761]
HEK293	EC₅₀	0.4 nM Compound: NDP-MSH	Agonist activity at EYFP-fused human MC4R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay Agonist activity at EYFP-fused human MC4R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	[PMID: 28972753]
HEK293	EC₅₀	0.4 nM Compound: NDP-MSH	Agonist activity at human MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay Agonist activity at human MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	[PMID: 29578343]
HEK293	EC₅₀	0.414 nM Compound: NDP-MSH	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	[PMID: 30741545]
HEK293	EC₅₀	0.46 nM Compound: NDP-MSH	Agonist activity at mouse MC4R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay Agonist activity at mouse MC4R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	[PMID: 26959173]
HEK293	EC₅₀	0.51 nM Compound: NDP-alpha-MSH	Agonist activity at the mutant MC4R F184A expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R F184A expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	EC₅₀	0.81 nM Compound: NDP-MSH	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	[PMID: 25347033]
HEK293	EC₅₀	0.9 nM Compound: NDP-MSH	Agonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay Agonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	[PMID: 31845801]
HEK293	EC₅₀	1 nM Compound: NDP-alpha-MSH	Agonist activity at the mutant MC4R Y287F expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R Y287F expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	IC₅₀	1.09 nM Compound: NDP-MSH	Displacement of 125I-NDP-MSH from mouse MC4R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis Displacement of 125I-NDP-MSH from mouse MC4R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	[PMID: 26959173]
HEK293	EC₅₀	1.1 nM Compound: NDP-MSH	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	[PMID: 28972753]
HEK293	EC₅₀	1.1 nM Compound: NDP-MSH	Agonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay Agonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	[PMID: 32184956]
HEK293	EC₅₀	1.1 nM Compound: NDP-alpha-MSH	Agonist activity at the mutant MC4R F184L expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R F184L expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	EC₅₀	1.1 nM Compound: NDP-alpha-MSH	Agonist activity at the mutant MC4R I129A expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R I129A expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	EC₅₀	1.2 nM Compound: NDP-alpha-MSH	Agonist activity at the human wild type MC4R expressed in HEK293 cells by cAMP accumulation Agonist activity at the human wild type MC4R expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	IC₅₀	1.3 nM Compound: NDP-MSH	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 4 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 4 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	[PMID: 31845801]
HEK293	EC₅₀	1.4 nM Compound: NDP-alpha-MSH	Agonist activity at the mutant MC4R I125A expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R I125A expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	EC₅₀	1.5 nM Compound: NDP-alpha-MSH	Agonist activity at the mutant MC4R Y268F expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R Y268F expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	EC₅₀	1.98 nM Compound: NDP-MSH	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	[PMID: 30741545]
HEK293	IC₅₀	10 nM Compound: NDP-MSH	Displacement of [125I]-NDP-MSH from human melanocortin receptor 4 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method Displacement of [125I]-NDP-MSH from human melanocortin receptor 4 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	[PMID: 31845801]
HEK293	IC₅₀	140 nM Compound: NDP-MSH	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	[PMID: 31845801]
HEK293	EC₅₀	2 nM Compound: NDP-alpha-MSH	Agonist activity at the mutant MC4R Y268A expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R Y268A expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	IC₅₀	4.18 nM Compound: NDP-MSH	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	[PMID: 26959173]
HEK293	EC₅₀	5.1 nM Compound: NDP-alpha-MSH	Agonist activity at the mutant MC4R I291A expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R I291A expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	EC₅₀	6.4 nM Compound: NDP-MSH	Agonist activity at EYFP-fused human MC4R expressed in HEK293 cells assessed as increase in cAMP accumulation after 30 mins by luminescent enzymatic complementation based assay Agonist activity at EYFP-fused human MC4R expressed in HEK293 cells assessed as increase in cAMP accumulation after 30 mins by luminescent enzymatic complementation based assay	[PMID: 28972753]
HEK293	EC₅₀	6.8 nM Compound: NDP-MSH	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	[PMID: 28972753]
HEK293	IC₅₀	8.2 nM Compound: NDP-MSH	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	[PMID: 31845801]
HEK293	EC₅₀	9 nM Compound: NDP-alpha-MSH	Agonist activity at the mutant MC4R Y287A expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R Y287A expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]

體外研究
(In Vitro)

Melanotan I (1 μM, 72 h) 不會改變或輕微抑制腫瘤集落的形成，在體外抑制黑色素瘤細胞增殖^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

體內(nèi)研究
(In Vivo)

Melanotan I (2 mg/kg/dayfor 12 weeks, s.c.) 在嚙齒類動物體內(nèi)實驗中無急性毒性作用^[2]。
Melanotan I (2/10 mg/kg, s.c.) 不會增加 SCID (免疫缺陷) 小鼠中人類黑色素瘤的腫瘤發(fā)生率，也不會導致腫瘤惡性轉(zhuǎn)化，沒有表現(xiàn)出促癌作用^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	rats^[2]
Dosage:	0.6 mg/kg/day for 30 days
Administration:	s.c.
Result:	Well tolerated with no change in lethality, no effect on weight gain, no serum chemistry changes, except for a slight increase (30 %) in lactic dehydrogenase levels.

分子量

1646.85

Formula

C₇₈H₁₁₁N₂₁O₁₉

CAS 號

75921-69-6

性狀

固體

顏色

White to off-white

Sequence

Ac-Ser-Tyr-Ser-{Nle}-Glu-His-{d-Phe}-Arg-Trp-Gly-Lys-Pro-Val-NH2

Sequence Shortening

Ac-SYS-{Nle}-EH-{d-Phe}-RWGKPV-NH2

中文名稱

美拉諾坦 I

運輸條件

Room temperature in continental US; may vary elsewhere.

儲存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據(jù)

細胞實驗：

H₂O 中的溶解度 : ≥ 50 mg/mL (30.36 mM)

* "≥" means soluble, but saturation unknown.

配制儲備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	0.6072 mL	3.0361 mL	6.0722 mL
5 mM	0.1214 mL	0.6072 mL	1.2144 mL
10 mM	0.0607 mL	0.3036 mL	0.6072 mL

查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

摩爾計算器
稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

濃度 _(start)

體積 _(start)

濃度 _(final)

體積 _(final)

動物實驗：

以下溶解方案，請直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

方案一

請依序添加每種溶劑： PBS
Solubility: 100 mg/mL (60.72 mM); 澄清溶液; 超聲助溶

動物溶解方案計算器

請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

每只動物的給藥體積

μL

動物數(shù)量

只

由于實驗過程有損耗，建議您多配一只動物的量

計算結(jié)果

工作液所需濃度 : mg/mL

該產(chǎn)品水溶性佳，請具體參考實測水 / PBS / Saline 中的溶解度數(shù)據(jù)。

您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。

純度 & 產(chǎn)品資料

純度: 99.75%

選擇批次：

Data Sheet (637 KB) SDS (393 KB)

COA (195 KB) LCMS (88 KB)

產(chǎn)品使用指南 (1538 KB)

參考文獻

[1]. Langan EA, et al. Melanotropic peptides: more than just 'Barbie drugs' and 'sun-tan jabs'? Br J Dermatol. 2010 Sep;163(3):451-5. [Content Brief]

[2]. Mahiques-Santos L. Melanotan [Melanotan]. Actas Dermosifiliogr. 2012 May;103(4):257-9. Spanish. [Content Brief]

[3]. Hadley ME, et al. Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization. Peptides. 2006 Apr;27(4):921-30. [Content Brief]

[4]. Hadley ME, et al. Discovery and development of novel melanogenic drugs. Melanotan-I and -II. Pharm Biotechnol. 1998;11:575-95. [Content Brief]

Melanotan I 相關(guān)分類

完整儲備液配制表

可選溶劑	濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.6072 mL	3.0361 mL	6.0722 mL	15.1805 mL
	5 mM	0.1214 mL	0.6072 mL	1.2144 mL	3.0361 mL
	10 mM	0.0607 mL	0.3036 mL	0.6072 mL	1.5180 mL
	15 mM	0.0405 mL	0.2024 mL	0.4048 mL	1.0120 mL
	20 mM	0.0304 mL	0.1518 mL	0.3036 mL	0.7590 mL
	25 mM	0.0243 mL	0.1214 mL	0.2429 mL	0.6072 mL
	30 mM	0.0202 mL	0.1012 mL	0.2024 mL	0.5060 mL

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Melanotan I75921-69-6MT-I [Nle4,D-Phe7]-α-MSH美拉諾坦 IMelanocortin ReceptorMC Receptorsub cutaneous injectionhuman melanocytesmelanotropic peptideMelanotanskin cancersα-MSHMC1Rmelanocortin receptorInhibitorinhibitorinhibit

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Melanotan I (Synonyms: 美拉諾坦 I; MT-I; [Nle4,D-Phe7]-α-MSH)

Customer Review

Other Forms of Melanotan I:

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻

Melanotan I 相關(guān)產(chǎn)品

•相關(guān)化合物庫:

•同靶點產(chǎn)品:

•同靶點蛋白產(chǎn)品:

查看 Melanocortin Receptor 亞型特異性產(chǎn)品:

生物活性

純度 & 產(chǎn)品資料

參考文獻

摩爾計算器

稀釋計算器

Melanotan I 相關(guān)分類

完整儲備液配制表

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Melanotan I (Synonyms: 美拉諾坦 I; MT-I; [Nle4,D-Phe7]-α-MSH)

Customer Review

Other Forms of Melanotan I:

Melanotan I 相關(guān)抗體

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻

Melanotan I 相關(guān)產(chǎn)品

•相關(guān)化合物庫:

•同靶點產(chǎn)品:

•同靶點蛋白產(chǎn)品:

查看 Melanocortin Receptor 亞型特異性產(chǎn)品:

生物活性

純度 & 產(chǎn)品資料

參考文獻

Melanotan I 相關(guān)抗體:

摩爾計算器

稀釋計算器

Melanotan I 相關(guān)分類

完整儲備液配制表

Keywords:

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