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  2. Immunology/Inflammation
  3. NO Synthase
  4. Kuwanon A

Kuwanon A是從桑樹 (Morus alba L.) 的根皮中分離的的黃酮衍生物，抑制一氧化氮產(chǎn)生的IC50值為10.5 μM。

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Kuwanon A Chemical Structure

Kuwanon A Chemical Structure

CAS No. : 62949-77-3

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2 mg ￥950
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5 mg ￥1800
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10 mg ￥2790
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MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

查看 NO Synthase 亞型特異性產(chǎn)品:

  • 生物活性

  • 實(shí)驗(yàn)參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.); inhibits nitric oxide production with an IC50 of 10.5 μM.

IC50 & Target

IC50: 10.5 μM (nitric oxide)[1]
細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
5.3 μM
Compound: 4
Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay
Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay
[PMID: 21511472]
體外研究
(In Vitro)

Kuwanon A 顯示出對(duì) 3T3-L1 脂肪細(xì)胞分化的顯著抑制活性，TG 抑制值為 47.1%。Kuwanon A 在 RAW264.7 細(xì)胞中也顯示出顯著的一氧化氮 (NO) 生成抑制作用，IC50 值為 10.5 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

420.45

Formula

C25H24O6
CAS 號(hào)
性狀

固體

顏色

Light yellow to yellow

中文名稱

桑皮酮A；桑酮A；桑黃酮A
結(jié)構(gòu)分類
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

純度 & 產(chǎn)品資料
參考文獻(xiàn)
Cell Assay
[1]

RAW264.7 cells are treated with Kuwanon A (3, 10, 20, 30, 100 μM). Cell viability is measured using the MTT assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻(xiàn)

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  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Kuwanon A
目錄號(hào)：
HY-N2300
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