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  1. Apoptosis Autophagy
  2. Autophagy Apoptosis
  3. Sotetsuflavone

Sotetsuflavone 是一種黃酮類化合物,可以從 Cycas revolute 中分離出來。Sotetsuflavone 通過逆轉(zhuǎn) EMT 抑制 A549 細(xì)胞的遷移和侵襲,誘導(dǎo)細(xì)胞凋亡 (apoptosis) 和自噬 (autophagy)。Sotetsuflavone 抑制 A549 細(xì)胞中 HIF-1α、VEGF、血管抑制素、MMP-9 和 MMP-13 的表達(dá)。Sotetsuflavone 還可以保護(hù)小鼠免受克羅恩病 (CD) 樣結(jié)腸炎的侵害。Sotetsuflavone 可用于 NSCLC 研究。

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Sotetsuflavone Chemical Structure

Sotetsuflavone Chemical Structure

CAS No. : 2608-21-1

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1 mg ¥5500
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  • 生物活性

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生物活性

Sotetsuflavone is a flavonoid that can be isolated from Cycas revolute. Sotetsuflavone inhibits migration and invasion of A549 cells by reversing EMT, and induces cell apoptosis and autophagy. Sotetsuflavone inhibits HIF-1α, VEGF, angiostatin, MMP-9, and MMP-13 expression in A549 cells. Sotetsuflavone also protects mice against Crohn's disease (CD)-like colitis. Sotetsuflavone can be used for research of NSCLC[1][2].

分子量

552.48

Formula

C31H20O10

CAS 號
性狀

固體

顏色

Light brown to brown

中文名稱

蘇鐵雙黃酮

結(jié)構(gòu)分類
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

純度 & 產(chǎn)品資料
參考文獻(xiàn)
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產(chǎn)品名稱:
Sotetsuflavone
目錄號:
HY-N2199
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