Plumbagin (Synonyms: 白花丹素; 2-Methyljuglone)

目錄號: HY-N1497 純度: 99.39%: FAQs
Data Sheet SDS COA 產(chǎn)品使用指南

摩爾計算器

Plumbagin (2-Methyljuglone) 是從 Plumbago zeylanica 中得到的萘醌類物質，具有抗腫瘤、抗增殖活性。

MCE 的所有產(chǎn)品僅用作科學研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務

Plumbagin Chemical Structure

CAS No. : 481-42-5

1. 客戶無需承擔相應的運輸費用。

2. 同一機構（單位）同一產(chǎn)品試用裝僅限申領一次，同一機構（單位）一年內(nèi)

可免費申領三個不同產(chǎn)品的試用裝。

3. 試用裝只面向終端客戶。

規(guī)格	價格	是否有貨
10 mM * 1 mL in DMSO	￥1045	In-stock
50 mg	￥950	In-stock
100 mg	￥1500	In-stock
200 mg		詢價
500 mg		詢價

or 大包裝詢價

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Customer Review

Other Forms of Plumbagin:

Plumbagin (Standard) 詢價

MCE 顧客使用本產(chǎn)品發(fā)表的 2 篇科研文獻

•Int J Biol Macromol. 2021 Apr 24.
•Crit Rev Eukaryot Gene Expr. 2024 Oct 23.

Plumbagin 相關產(chǎn)品

•相關化合物庫:

•同靶點產(chǎn)品:

•同靶點蛋白產(chǎn)品:

生物活性
純度 & 產(chǎn)品資料
參考文獻

生物活性

Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica, exhibits anticancer and antiproliferative activities^[1].

細胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	12.4 μM Compound: 1; PL	Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 28558333]
A549	IC₅₀	3 μM Compound: 2	Growth inhibition of human A549 cells by MTT assay Growth inhibition of human A549 cells by MTT assay	[PMID: 26706169]
A549	IC₅₀	7.2 μM Compound: 2	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
A549	IC₅₀	8.9 μM Compound: PL ; 1	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 29772386]
ACHN	EC₅₀	3.7 μM Compound: 6	Cytotoxicity against human ACHN cells assessed as cell death after 20 to 24 hrs by XTT assay Cytotoxicity against human ACHN cells assessed as cell death after 20 to 24 hrs by XTT assay	[PMID: 22313254]
ACHN	EC₅₀	7.3 μM Compound: 6	Cytotoxicity against human ACHN cells assessed as cell death after 20 to 24 hrs by XTT assay in presence of 40 ng/ml TRAIL Cytotoxicity against human ACHN cells assessed as cell death after 20 to 24 hrs by XTT assay in presence of 40 ng/ml TRAIL	[PMID: 22313254]
B16-F10	IC₅₀	1 μM Compound: 2	Growth inhibition of mouse B16F10 cells by MTT assay Growth inhibition of mouse B16F10 cells by MTT assay	[PMID: 26706169]
BT-474	IC₅₀	0.8 μM Compound: 1, Plumbagin	Cytotoxicity against Her2-overexpressing human BT474 cells after 72 hrs by MTT assay Cytotoxicity against Her2-overexpressing human BT474 cells after 72 hrs by MTT assay	[PMID: 22512718]
BT-474	IC₅₀	1.8 μM Compound: 1, Plumbagin	Cytotoxicity against Her2-overexpressing human BT474 cells after 24 hrs by MTT assay Cytotoxicity against Her2-overexpressing human BT474 cells after 24 hrs by MTT assay	[PMID: 22512718]
DU-145	IC₅₀	5.23 μM Compound: Plumbagin	Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay	[PMID: 23791367]
HCT-116	IC₅₀	20 μM Compound: 1	Cytotoxicity against human HCT116 cells expressing p53 assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human HCT116 cells expressing p53 assessed as cell viability after 24 hrs by MTT assay	[PMID: 24828199]
HCT-116	IC₅₀	20 μM Compound: 1	Cytotoxicity against p53-deficient human HCT116 cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against p53-deficient human HCT116 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 24828199]
HCT-116	IC₅₀	9.8 μM Compound: PL ; 1	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 29772386]
HEK293	EC₅₀	0.46 μM Compound: 7	Activation of human TRPA1 expressed in HEK293 cells assessed as increase in calcium level by fluo-4 dye based plate reader analysis Activation of human TRPA1 expressed in HEK293 cells assessed as increase in calcium level by fluo-4 dye based plate reader analysis	[PMID: 26905390]
HeLa	IC₅₀	> 50 μM Compound: 18a	Inhibition of PCAF in human HeLa cells using [3H]-acetyl-CoA as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by liquid scintillation counting analysis Inhibition of PCAF in human HeLa cells using [3H]-acetyl-CoA as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by liquid scintillation counting analysis	[PMID: 31195169]
HeLa	IC₅₀	20 μM Compound: 18a	Inhibition of P300 in human HeLa cells using [3H]-acetyl-CoA as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by liquid scintillation counting analysis Inhibition of P300 in human HeLa cells using [3H]-acetyl-CoA as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by liquid scintillation counting analysis	[PMID: 31195169]
HeLa	IC₅₀	25.5 μM Compound: 1a	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 24913712]
HeLa	IC₅₀	59 μM Compound: 1b	Cytotoxicity against human HeLa cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell viability after 48 hrs by MTT assay	[PMID: 24953027]
HepG2	IC₅₀	10.66 μM Compound: 1; PL	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 28558333]
HepG2	IC₅₀	9.17 μM Compound: PL ; 1	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 29772386]
HK-2	IC₅₀	23.58 μM Compound: PL ; 1	Cytotoxicity against human HK2 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HK2 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 29772386]
HL-60	IC₅₀	1.1 μM Compound: 2	Cytotoxicity against human HL60 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human HL60 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
HL-60	IC₅₀	3.67 μM Compound: Plumbagin	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 30007564]
HL-60	IC₅₀	8.25 μM Compound: Plumbagin	Cytotoxicity against human HL60 cells after 24 hrs by MTT assay Cytotoxicity against human HL60 cells after 24 hrs by MTT assay	[PMID: 30007564]
Hs 683	IC₅₀	4 μM Compound: 2	Growth inhibition of human Hs683 cells by MTT assay Growth inhibition of human Hs683 cells by MTT assay	[PMID: 26706169]
HT-29	IC₅₀	26.2 μM Compound: 1b	Cytotoxicity against human HT-29 cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	[PMID: 24953027]
HT-29	IC₅₀	4.19 μM Compound: Plumbagin	Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTS assay Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTS assay	[PMID: 23791367]
Jurkat	IC₅₀	0.95 μM Compound: 2	Cytotoxicity against human Jurkat cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human Jurkat cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
LS174T	IC₅₀	9.9 μM Compound: 2	Cytotoxicity against human LS174T cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human LS174T cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
MCF7	IC₅₀	12.2 μM Compound: 1b	Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	[PMID: 24953027]
MCF7	IC₅₀	2.84 μM Compound: 13	Cytotoxicity against human MCF7 cells expressing HER2 assessed as reduction of cell viability after 48 hrs CellTiter-Glo assay Cytotoxicity against human MCF7 cells expressing HER2 assessed as reduction of cell viability after 48 hrs CellTiter-Glo assay	[PMID: 24355130]
MCF7	IC₅₀	3 μM Compound: 2	Growth inhibition of human MCF7 cells by MTT assay Growth inhibition of human MCF7 cells by MTT assay	[PMID: 26706169]
MCF7	IC₅₀	3.35 μM Compound: 13	Cytotoxicity against human MCF7 cells expressing pcDNA3 assessed as reduction of cell viability after 48 hrs CellTiter-Glo assay Cytotoxicity against human MCF7 cells expressing pcDNA3 assessed as reduction of cell viability after 48 hrs CellTiter-Glo assay	[PMID: 24355130]
MCF7	IC₅₀	3.5 μM Compound: Plumbagin	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay	[PMID: 36846377]
MCF7	IC₅₀	3.5 μM Compound: Plumbagin	Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 33234343]
MCF7	IC₅₀	3.5 μM Compound: Plumbagin	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 30810041]
MCF7	IC₅₀	4.1 μM Compound: 2	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
MCF7	IC₅₀	5.1 μM Compound: 13	Cytotoxicity against human MCF7 cells expressing HER2delta16 assessed as reduction of cell viability after 48 hrs CellTiter-Glo assay Cytotoxicity against human MCF7 cells expressing HER2delta16 assessed as reduction of cell viability after 48 hrs CellTiter-Glo assay	[PMID: 24355130]
MCF7	IC₅₀	5.5 μM Compound: 1	Antiproliferative activity against ER-positive human MCF7 cells after 24 hrs by MTT assay Antiproliferative activity against ER-positive human MCF7 cells after 24 hrs by MTT assay	[PMID: 22483392]
MCF7/PTX	IC₅₀	3.5 μM Compound: Plumbagin	Cytotoxicity against paclitaxel-resistant human MCF7/PTX cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against paclitaxel-resistant human MCF7/PTX cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 30810041]
MDA-MB-231	IC₅₀	14.23 μM Compound: 1; PL	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 28558333]
MDA-MB-231	IC₅₀	21.24 μM Compound: Plumbagin	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTS assay Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTS assay	[PMID: 23791367]
MDA-MB-231	IC₅₀	3.5 μM Compound: 1	Antiproliferative activity against ER-negative human MDA-MB-231 cells after 24 hrs by MTT assay Antiproliferative activity against ER-negative human MDA-MB-231 cells after 24 hrs by MTT assay	[PMID: 22483392]
MDA-MB-231	IC₅₀	4.4 μM Compound: Plumbagin	Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay	[PMID: 33234343]
MDA-MB-231	IC₅₀	51.12 μM Compound: 1b	Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	[PMID: 24953027]
MDA-MB-231	IC₅₀	6.5 μM Compound: PL ; 1	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 29772386]
MDA-MB-453	IC₅₀	34.56 μM Compound: 1b	Cytotoxicity against human MDA-MB-453 cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-453 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	[PMID: 24953027]
MDA-MB-468	IC₅₀	2.5 μM Compound: 1	Antiproliferative activity against ER-negative human MDA-MB-468 cells after 48 hrs by MTT assay Antiproliferative activity against ER-negative human MDA-MB-468 cells after 48 hrs by MTT assay	[PMID: 22483392]
ME-180	IC₅₀	43.4 μM Compound: 1b	Cytotoxicity against human ME180 cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human ME180 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	[PMID: 24953027]
MONO-MAC-6	IC₅₀	2.6 μM Compound: 2	Cytotoxicity against human MONO-MAC-6 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human MONO-MAC-6 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
PBMC	EC₅₀	0.8 μM Compound: 1	Cytotoxicity against human PBMC cells assessed as viable fractions using annexin V-FITC/propidium iodide staining by flow cytometry Cytotoxicity against human PBMC cells assessed as viable fractions using annexin V-FITC/propidium iodide staining by flow cytometry	[PMID: 22019229]
PBMC	IC₅₀	2.7 μM Compound: 2	Cytotoxicity against human PBMC cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human PBMC cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
PC-3	IC₅₀	17.19 μM Compound: 1b	Cytotoxicity against human PC3 cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human PC3 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	[PMID: 24953027]
SAS	IC₅₀	3 μM Compound: 1a	Cytotoxicity against human SAS cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human SAS cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 24913712]
Sf21	IC₅₀	2 μM Compound: 99	Inhibition of recombinant full length p300 (unknown origin) expressed in baculovirus infected insect Sf21 cells using [3H]acetyl-CoA as substrate Inhibition of recombinant full length p300 (unknown origin) expressed in baculovirus infected insect Sf21 cells using [3H]acetyl-CoA as substrate	10.1039/C1MD00199J
Sf9	IC₅₀	> 100 μM Compound: 4, ZINC-58187	Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assay Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assay	[PMID: 20580552]
SK-BR-3	IC₅₀	1.8 μM Compound: 1, Plumbagin	Cytotoxicity against Her2-overexpressing human SKBR3 cells after 72 hrs by MTT assay Cytotoxicity against Her2-overexpressing human SKBR3 cells after 72 hrs by MTT assay	[PMID: 22512718]
SK-BR-3	IC₅₀	3.2 μM Compound: 1, Plumbagin	Cytotoxicity against Her2-overexpressing human SKBR3 cells after 24 hrs by MTT assay Cytotoxicity against Her2-overexpressing human SKBR3 cells after 24 hrs by MTT assay	[PMID: 22512718]
SK-MEL-28	IC₅₀	5 μM Compound: 2	Growth inhibition of human SK-MEL-28 cells by MTT assay Growth inhibition of human SK-MEL-28 cells by MTT assay	[PMID: 26706169]
SMMC-7721	IC₅₀	2.43 μM Compound: 10	Antitumor activity against human SMMC-7721 cells measured after 24 hrs Antitumor activity against human SMMC-7721 cells measured after 24 hrs	[PMID: 34669417]
SMMC-7721	IC₅₀	36.05 μM Compound: 10	Antitumor activity against human SMMC-7721 cells measured after 6 hrs Antitumor activity against human SMMC-7721 cells measured after 6 hrs	[PMID: 34669417]
SMMC-7721	IC₅₀	5.41 μM Compound: 10	Antitumor activity against human SMMC-7721 cells measured after 12 hrs Antitumor activity against human SMMC-7721 cells measured after 12 hrs	[PMID: 34669417]
SW480	IC₅₀	12 μM Compound: 1	Cytotoxicity against human SW480 cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human SW480 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 24828199]
SW480	IC₅₀	7.3 μM Compound: 1	Cytotoxicity against human SW480 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human SW480 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 24828199]
SW-620	IC₅₀	7.4 μM Compound: 1	Cytotoxicity against human SW620 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human SW620 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 24828199]
SW-620	IC₅₀	7.7 μM Compound: 1	Cytotoxicity against human SW620 cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human SW620 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 24828199]
SW982	IC₅₀	3.6 μM Compound: 2	Cytotoxicity against human SW982 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human SW982 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
THP-1	IC₅₀	1.1 μM Compound: 2	Cytotoxicity against human THP1 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human THP1 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
U-373MG ATCC	IC₅₀	5 μM Compound: 2	Growth inhibition of human U373 cells by MTT assay Growth inhibition of human U373 cells by MTT assay	[PMID: 26706169]
U-937	IC₅₀	2.4 μM Compound: 2	Cytotoxicity against human U937 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human U937 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
WI-38	IC₅₀	26.71 μM Compound: Plumbagin	Cytotoxicity against human WI38 cells after 48 hrs by MTT assay Cytotoxicity against human WI38 cells after 48 hrs by MTT assay	[PMID: 30007564]
WRL68	IC₅₀	15.36 μM Compound: PL ; 1	Cytotoxicity against human WRL68 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human WRL68 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 29772386]

體外研究
(In Vitro)

Plumbagin (0、5、10 和 15 μM) 以劑量依賴的方式誘導前列腺癌細胞系的凋亡，例如 DU145、CWR22rv1 和 LNCaP^[1]。
(5，20 μM) 顯著抑制 PC3、DU145、CWR22rv1 細胞的侵襲^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:	DU145, CWR22rv1, LNCaP and RWPE-1 cells
Concentration:	0, 5, 10, and 15 μM
Incubation Time:	24 hours
Result:	Dose-dependently induced apoptosis of DU145, CWR22rv1 and LNCaP, but showed no effect on RWPE-1 cells at up to 20 μM.

體內(nèi)研究
(In Vivo)

Plumbagin (2 mg/kg，ip，每周 5 天，持續(xù) 11 周) 抑制雄性無胸腺裸鼠腫瘤的生長^[1]。
Plumbagin (2 mg/kg，ip，每周 5 天，持續(xù) 11 周) 在小鼠中抑制 PKCε 的表達，抑制 JAK-2 和 Stat3 磷酸化，并激活 Stat3、PCNA、VEGF 和 MMP-9^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male athymic nude mice bearing DU145 cells^[1]
Dosage:	2 mg/kg
Administration:	I.P. after 3 days post cell implantation, five days a week.
Result:	Delayed tumor growth by 3 weeks, and reduced tumor weight and volume in mice.

分子量

188.18

Formula

C₁₁H₈O₃

CAS 號

481-42-5

性狀

固體

顏色

Light yellow to orange

中文名稱

白花丹素；白花丹醌

結構分類

初始來源

運輸條件

Room temperature in continental US; may vary elsewhere.

儲存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性數(shù)據(jù)

細胞實驗：

DMSO 中的溶解度 : ≥ 150 mg/mL (797.11 mM; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲備液

濃度溶劑體積質量	1 mg	5 mg	10 mg

1 mM	5.3141 mL	26.5703 mL	53.1406 mL
5 mM	1.0628 mL	5.3141 mL	10.6281 mL
10 mM	0.5314 mL	2.6570 mL	5.3141 mL

查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

摩爾計算器
稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

濃度 _(start)

體積 _(start)

濃度 _(final)

體積 _(final)

動物實驗：

請根據(jù)您的實驗動物和給藥方式選擇適當?shù)娜芙夥桨浮?

以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
——為保證實驗結果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當天使用；
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

方案一

請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (11.05 mM); 澄清溶液

此方案可獲得 ≥ 2.08 mg/mL（飽和度未知）的澄清溶液。
以 1 mL 工作液為例，取 100 μL 20.8 mg/mL 的澄清 DMSO 儲備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水定容至 1 mL。
生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
方案二

請依序添加每種溶劑： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (11.05 mM); 澄清溶液

此方案可獲得 ≥ 2.08 mg/mL（飽和度未知）的澄清溶液，此方案實驗周期在半個月以上的動物實驗酌情使用。
以 1 mL 工作液為例，取 100 μL 20.8 mg/mL 的澄清 DMSO 儲備液加到 900 μL玉米油中，混合均勻。

動物溶解方案計算器

請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

每只動物的給藥體積

μL

動物數(shù)量

只

由于實驗過程有損耗，建議您多配一只動物的量

請輸入您的動物體內(nèi)配方組成：

DMSO +

Tween-80 +

Saline

如果您的動物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。

方案所需 助溶劑 包括：DMSO，，均可在 MCE 網(wǎng)站選購。，Tween 80，均可在 MCE 網(wǎng)站選購。

計算結果

工作液所需濃度 : mg/mL

儲備液配制方法 : mg 藥物溶于 μL DMSO（母液濃度為 mg/mL）。

您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，以下方案僅供參考，如有需要，請與 MCE 中國技術支持聯(lián)系。

動物實驗體內(nèi)工作液的配制方法 : 取 μL DMSO 儲備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。

連續(xù)給藥周期超過半月以上，請謹慎選擇該方案。

請確保第一步儲備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱（超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。

純度 & 產(chǎn)品資料

純度: 99.39%

選擇批次：

Data Sheet (639 KB) SDS (480 KB)

COA (291 KB) LCMS (91 KB)

產(chǎn)品使用指南 (1538 KB)

參考文獻

[1]. Aziz MH, et al. Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer. Cancer Res. 2008 Nov 1;68(21):9024-32. [Content Brief]

Plumbagin 相關分類

完整儲備液配制表

可選溶劑	濃度溶劑體積質量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.3141 mL	26.5703 mL	53.1406 mL	132.8515 mL
	5 mM	1.0628 mL	5.3141 mL	10.6281 mL	26.5703 mL
	10 mM	0.5314 mL	2.6570 mL	5.3141 mL	13.2852 mL
	15 mM	0.3543 mL	1.7714 mL	3.5427 mL	8.8568 mL
	20 mM	0.2657 mL	1.3285 mL	2.6570 mL	6.6426 mL
	25 mM	0.2126 mL	1.0628 mL	2.1256 mL	5.3141 mL
	30 mM	0.1771 mL	0.8857 mL	1.7714 mL	4.4284 mL
	40 mM	0.1329 mL	0.6643 mL	1.3285 mL	3.3213 mL
	50 mM	0.1063 mL	0.5314 mL	1.0628 mL	2.6570 mL
	60 mM	0.0886 mL	0.4428 mL	0.8857 mL	2.2142 mL
	80 mM	0.0664 mL	0.3321 mL	0.6643 mL	1.6606 mL
	100 mM	0.0531 mL	0.2657 mL	0.5314 mL	1.3285 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Plumbagin481-42-52-Methyljuglone白花丹素白花丹醌OthersInhibitorinhibitorinhibit

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Plumbagin (Synonyms: 白花丹素; 2-Methyljuglone)

Customer Review

Other Forms of Plumbagin:

MCE 顧客使用本產(chǎn)品發(fā)表的 2 篇科研文獻

Plumbagin 相關產(chǎn)品

•相關化合物庫:

•同靶點產(chǎn)品:

•同靶點蛋白產(chǎn)品:

生物活性

純度 & 產(chǎn)品資料

參考文獻

摩爾計算器

稀釋計算器

Plumbagin 相關分類

完整儲備液配制表

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成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Plumbagin (Synonyms: 白花丹素; 2-Methyljuglone)

Customer Review

Other Forms of Plumbagin:

Plumbagin 相關抗體

MCE 顧客使用本產(chǎn)品發(fā)表的 2 篇科研文獻

Plumbagin 相關產(chǎn)品

•相關化合物庫:

•同靶點產(chǎn)品:

•同靶點蛋白產(chǎn)品:

生物活性

純度 & 產(chǎn)品資料

參考文獻

Plumbagin 相關抗體:

摩爾計算器

稀釋計算器

Plumbagin 相關分類

完整儲備液配制表

Keywords:

您最近查看的產(chǎn)品:

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