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  2. Apoptosis Anti-infection
  3. Apoptosis Fungal Parasite
  4. Hypocrellin B

Hypocrellin B 是從真菌Hypocrella bambusae 和Shiraia bambusicola 中分離得到的一種色素，是一個凋亡誘導劑。Hypocrellin B 是一種光敏劑，可用于癌癥光動力研究。Hypocrellin B 還擁有抗菌和抗利什曼活性。

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Hypocrellin B Chemical Structure

Hypocrellin B Chemical Structure

CAS No. : 123940-54-5

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥798
In-stock
5 mg ￥1900
In-stock
10 mg ￥3200
In-stock
25 mg ￥5582
In-stock
50 mg 現(xiàn)貨 詢價
100 mg 現(xiàn)貨 詢價
200 mg   詢價  
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Customer Review

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial activities[1][2][3].

IC50 & Target

Leishmania

 

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
BGC-823 IC50
40 nM
Compound: 2
Cytotoxicity against human BGC823 cells assessed as cell death preincubated for 5 hrs in dark condition followed by irradiation with a 532 nm laser of 20 J/cm2 for 1000 seconds measured after 24 hrs by MTT assay
Cytotoxicity against human BGC823 cells assessed as cell death preincubated for 5 hrs in dark condition followed by irradiation with a 532 nm laser of 20 J/cm2 for 1000 seconds measured after 24 hrs by MTT assay
[PMID: 22352922]
體外研究
(In Vitro)

Hypocrellin B (2.5 μM, 4 h) 在對 HepG2 細胞 聲動力療法 (SDT) 24 h 后產(chǎn)生細胞毒性，并誘導早期凋亡[2]。
Hypocrellin B 對 白色念珠菌 和 杜氏利什曼原蟲 具有抗真菌和抗寄生蟲活性 (IC50: 5 和 12.7 μg/mL)[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Hypocrellin B (2 mg/kg，靜脈注射) 可抑制 A549 荷瘤小鼠的腫瘤生長，但抗癌效果低于負載 Hypocrellin B 的納米顆粒[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

528.51

Formula

C30H24O9
CAS 號
性狀

固體

顏色

Brown to black

結構分類
初始來源

Hypocrella bambusae, Shiraia bambusicola

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

*Hypocrellin B is usually formulated as a suspension.

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.61%

參考文獻
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Hypocrellin B
目錄號：
HY-N1453
需求量：