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  2. Anti-infection
  3. Fungal
  4. Hecogenin

Hecogenin 是從劍麻 (Agave sisalana) 分離的類(lèi)固醇皂苷，是人 UDP-葡萄糖醛酸糖基轉(zhuǎn)移酶的選擇性抑制劑。Hecogenin 具有廣泛的藥理活性，包括抗炎，抗真菌和胃保護(hù)作用。

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Hecogenin Chemical Structure

Hecogenin Chemical Structure

CAS No. : 467-55-0

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規(guī)格 價(jià)格 是否有貨 數(shù)量
5 mg ￥171
In-stock
10 mg ￥246
In-stock
25 mg ￥433
In-stock
50 mg ￥621
In-stock
100 mg ￥915
In-stock
200 mg   詢價(jià)  
500 mg   詢價(jià)  

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Customer Review

Other Forms of Hecogenin:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects[1].

IC50 & Target

Human UDP-glucuronosyltransferases[1]
細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 40 μM
Compound: Hecogenin
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 33735799]
BT-474 IC50
38.2 μM
Compound: 1
Antiproliferative activity against human BT474 cells after 72 hrs by MTT assay
Antiproliferative activity against human BT474 cells after 72 hrs by MTT assay
[PMID: 29066046]
HT-29 IC50
> 40 μM
Compound: Hecogenin
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 33735799]
HUVEC IC50
> 100 μM
Compound: Hecogenin
Cytotoxicity against human HUVEC cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HUVEC cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 33735799]
MCF7 IC50
28.7 μM
Compound: Hecogenin
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 33735799]
MCF7 IC50
31 μM
Compound: 1
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 29066046]
MDA-MB-231 IC50
28.7 μM
Compound: 1
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 29066046]
MDA-MB-231 IC50
31.21 μM
Compound: Hecogenin
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 33735799]
MDA-MB-231 IC50
37.1 μM
Compound: 1
Antiinvasive activity against human MDA-MB-231 cells after 24 hrs by cell invasion assay
Antiinvasive activity against human MDA-MB-231 cells after 24 hrs by cell invasion assay
[PMID: 29066046]
MDA-MB-468 IC50
35.2 μM
Compound: 1
Antiproliferative activity against human MDA-MB-468 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-468 cells after 72 hrs by MTT assay
[PMID: 29066046]
SK-BR-3 IC50
33.3 μM
Compound: 1
Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT assay
Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT assay
[PMID: 29066046]
T47D IC50
36.6 μM
Compound: 1
Antiproliferative activity against human T47D cells after 72 hrs by MTT assay
Antiproliferative activity against human T47D cells after 72 hrs by MTT assay
[PMID: 29066046]
體內(nèi)研究
(In Vivo)

Hecogenin (3.1-90 mg/kg；口服給藥；15 小時(shí)；雄性瑞士小鼠) 在乙醇之前急性給藥，表現(xiàn)出強(qiáng)大的胃保護(hù)作用。Hecogenin 預(yù)處理使 GSH 水平正?；@著降低胃中的脂質(zhì)過(guò)氧化和亞硝酸鹽水平，正如乙醇誘導(dǎo)的胃損傷模型所評(píng)估的那樣。Hecogenin 還可以減少 MPO 釋放并顯著保護(hù)胃粘膜[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss mice (20-30 g) with ethanol[1]
Dosage: 3.1 mg/kg, 7.5 mg/kg, 15 mg/kg, 30 mg/kg, 60 mg/kg and 90 mg/kg
Administration: Oral administration; for 15 hours
Result: Normalized GSH levels and significantly reduced lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Decreased MPO release and significantly protected the gastric mucosa.
分子量

430.62

Formula

C27H42O4
CAS 號(hào)
性狀

固體

顏色

White to off-white

結(jié)構(gòu)分類(lèi)
初始來(lái)源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMF 中的溶解度 : 16.67 mg/mL (38.71 mM; 超聲助溶 (<60°C))

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.3222 mL 11.6112 mL 23.2223 mL
5 mM 0.4644 mL 2.3222 mL 4.6445 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.85%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 2.3222 mL 11.6112 mL 23.2223 mL 58.0558 mL
5 mM 0.4644 mL 2.3222 mL 4.6445 mL 11.6112 mL
10 mM 0.2322 mL 1.1611 mL 2.3222 mL 5.8056 mL
15 mM 0.1548 mL 0.7741 mL 1.5482 mL 3.8704 mL
20 mM 0.1161 mL 0.5806 mL 1.1611 mL 2.9028 mL
25 mM 0.0929 mL 0.4644 mL 0.9289 mL 2.3222 mL
30 mM 0.0774 mL 0.3870 mL 0.7741 mL 1.9352 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Hecogenin
目錄號(hào)：
HY-N1422
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