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  2. 天然產(chǎn)物
  3. 疾病研究領(lǐng)域 植物 萜類
  4. 苦木科 癌癥 二萜
  5. 鴉膽子 止痢鴉膽子
  6. Bruceantin

Bruceantin  (Synonyms: 鴉膽亭; (-)-Bruceantin; NCI165563; NSC165563)

目錄號: HY-N0840 純度: 99.67%
COA 產(chǎn)品使用指南 技術(shù)支持

Bruceantin(NSC165563)可從鴉膽子中提取，對B16黑色素瘤，結(jié)腸癌38，L1210和白血病P388有抑制性。

MCE 的所有產(chǎn)品僅用作科學研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)

Bruceantin Chemical Structure

Bruceantin Chemical Structure

CAS No. : 41451-75-6

1.  客戶無需承擔相應(yīng)的運輸費用。

2.  同一機構(gòu)（單位）同一產(chǎn)品試用裝僅限申領(lǐng)一次，同一機構(gòu)（單位）一年內(nèi)

     可免費申領(lǐng)三個不同產(chǎn)品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥4224
In-stock
1 mg ￥1400
In-stock
5 mg ￥3500
In-stock
10 mg ￥5000
In-stock
50 mg   詢價  
100 mg   詢價  

* Please select Quantity before adding items.

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Bruceantin(NSC165563) is first isolated from Brucea javanica, a tree used in Ethiopia for the treatment of cancer, and activity was observed against B16 melanoma, colon 38, and L1210 and P388 leukemia in mice. IC50 value: Target: anticancer Cell differentiation was induced and c-MYC was down-regulated, suggesting a mechanistic correlation between c-MYC down-regulation and induction of cell differentiation or cell death. Treatment of HL-60 and RPMI 8226 cell lines induced apoptosis, and this involved the caspase and mitochondrial pathways. Moreover, an in vivo study using RPMI 8226 human-SCID xenografts demonstrated that bruceantin induced regression in early as well as advanced tumors, and these significant antitumor responses were facilitated in the absence of overt toxicity.

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
BV-173 IC50
< 15 ng/mL
Compound: Bruceantin
Cytotoxicity against human BV173 cells by trypan blue exclusion method
Cytotoxicity against human BV173 cells by trypan blue exclusion method
[PMID: 14987068]
Daudi IC50
< 15 ng/mL
Compound: Bruceantin
Cytotoxicity against human Daudi cells by trypan blue exclusion method
Cytotoxicity against human Daudi cells by trypan blue exclusion method
[PMID: 14987068]
HeLa IC50
0.051 μM
Compound: 7
Inhibition of protein synthesis in human HeLa cells assessed as [35S]methionine incorporation into protein treated for 45 mins before [35S]methionine addition by Whatman paper analysis
Inhibition of protein synthesis in human HeLa cells assessed as [35S]methionine incorporation into protein treated for 45 mins before [35S]methionine addition by Whatman paper analysis
[PMID: 19199792]
HL-60 EC50
0.02 μM
Compound: 2
Induction of cell differentiation in human HL60 cells assessed as superoxide anion production after 4 days by NBT reduction assay
Induction of cell differentiation in human HL60 cells assessed as superoxide anion production after 4 days by NBT reduction assay
[PMID: 11754601]
HL-60 IC50
0.04 μM
Compound: 2
Cytotoxicity against human HL60 cells assessed as loss of membrane integrity after 4 days by trypan blue exclusion assay
Cytotoxicity against human HL60 cells assessed as loss of membrane integrity after 4 days by trypan blue exclusion assay
[PMID: 11754601]
HL-60 IC50
0.04 μM
Compound: 2
Antiproliferative activity against human HL60 cells assessed as inhibition of [3H]thymidine incorporation after 4 days by liquid scintillation counter
Antiproliferative activity against human HL60 cells assessed as inhibition of [3H]thymidine incorporation after 4 days by liquid scintillation counter
[PMID: 11754601]
HL-60 IC50
12.2 nM
Compound: Bruceantin
Induction of apoptosis in human HL60 cells after 24 hrs by DAPI staining
Induction of apoptosis in human HL60 cells after 24 hrs by DAPI staining
[PMID: 14987068]
HL-60 IC50
20 ng/mL
Compound: Bruceantin
Cytotoxicity against human HL60 cells by trypan blue exclusion method
Cytotoxicity against human HL60 cells by trypan blue exclusion method
[PMID: 14987068]
Kasumi 1 IC50
20 ng/mL
Compound: Bruceantin
Cytotoxicity against human Kasumi-1 cells by trypan blue exclusion method
Cytotoxicity against human Kasumi-1 cells by trypan blue exclusion method
[PMID: 14987068]
LNCaP ED50
11 nM
Compound: 6
Cytotoxicity against hormone-dependent human LNCAP cells after 2 days by sulforhodamine B assay
Cytotoxicity against hormone-dependent human LNCAP cells after 2 days by sulforhodamine B assay
[PMID: 19026551]
Lu1 ED50
12 nM
Compound: 6
Cytotoxicity against human Lu1 cells after 2 days by sulforhodamine B assay
Cytotoxicity against human Lu1 cells after 2 days by sulforhodamine B assay
[PMID: 19026551]
MCF7 ED50
0.27 nM
Compound: 6
Cytotoxicity against human MCF7 cells after 2 days by sulforhodamine B assay in presence of 43 uM (-)-hydnocarpin
Cytotoxicity against human MCF7 cells after 2 days by sulforhodamine B assay in presence of 43 uM (-)-hydnocarpin
[PMID: 19026551]
MCF7 ED50
2 nM
Compound: 6
Cytotoxicity against human MCF7 cells after 2 days by sulforhodamine B assay
Cytotoxicity against human MCF7 cells after 2 days by sulforhodamine B assay
[PMID: 19026551]
NB-4 IC50
< 15 ng/mL
Compound: Bruceantin
Cytotoxicity against human NB4 cells by trypan blue exclusion method
Cytotoxicity against human NB4 cells by trypan blue exclusion method
[PMID: 14987068]
NCI-H929 IC50
115 nM
Compound: Bruceantin
Induction of apoptosis in human NCI-H929 cells after 24 hrs by DAPI staining
Induction of apoptosis in human NCI-H929 cells after 24 hrs by DAPI staining
[PMID: 14987068]
REH IC50
20 ng/mL
Compound: Bruceantin
Cytotoxicity against human REH cells by trypan blue exclusion method
Cytotoxicity against human REH cells by trypan blue exclusion method
[PMID: 14987068]
RPMI-8226 IC50
12.8 nM
Compound: Bruceantin
Induction of apoptosis in human RPMI8226 cells after 24 hrs by DAPI staining
Induction of apoptosis in human RPMI8226 cells after 24 hrs by DAPI staining
[PMID: 14987068]
RS4-11 IC50
< 15 ng/mL
Compound: Bruceantin
Cytotoxicity against human RS4:11 cells by trypan blue exclusion method
Cytotoxicity against human RS4:11 cells by trypan blue exclusion method
[PMID: 14987068]
SU-DHL-6 IC50
< 15 ng/mL
Compound: Bruceantin
Cytotoxicity against human DHL6 cells by trypan blue exclusion method
Cytotoxicity against human DHL6 cells by trypan blue exclusion method
[PMID: 14987068]
U-266 IC50
49 nM
Compound: Bruceantin
Induction of apoptosis in human U266 cells after 24 hrs by DAPI staining
Induction of apoptosis in human U266 cells after 24 hrs by DAPI staining
[PMID: 14987068]
U-937 IC50
< 15 ng/mL
Compound: Bruceantin
Cytotoxicity against human U937 cells by trypan blue exclusion method
Cytotoxicity against human U937 cells by trypan blue exclusion method
[PMID: 14987068]
分子量

548.58

Formula

C28H36O11
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

鴉膽亭；鴉膽停；鴉膽丁
結(jié)構(gòu)分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 100 mg/mL (182.29 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 1.8229 mL 9.1144 mL 18.2289 mL
5 mM 0.3646 mL 1.8229 mL 3.6458 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物實驗：

請根據(jù)您的 實驗動物和給藥方式 選擇適當?shù)娜芙夥桨浮?

以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
——為保證實驗結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當天使用；
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

  • 方案 一

    請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.56 mM); 澄清溶液

    此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

    以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

    生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
  • 方案 二

    請依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (4.56 mM); 澄清溶液

    此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

    以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液 中，混合均勻。

    2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。

掃碼獲得
動物溶解方案

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
請輸入您的動物體內(nèi)配方組成：
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
如果您的動物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。
方案所需 助溶劑 包括：DMSO， PEG300/PEG400，Tween 80，均可在 MCE 網(wǎng)站選購。
純度 & 產(chǎn)品資料

純度: 99.94%

參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8229 mL 9.1144 mL 18.2289 mL 45.5722 mL
5 mM 0.3646 mL 1.8229 mL 3.6458 mL 9.1144 mL
10 mM 0.1823 mL 0.9114 mL 1.8229 mL 4.5572 mL
15 mM 0.1215 mL 0.6076 mL 1.2153 mL 3.0381 mL
20 mM 0.0911 mL 0.4557 mL 0.9114 mL 2.2786 mL
25 mM 0.0729 mL 0.3646 mL 0.7292 mL 1.8229 mL
30 mM 0.0608 mL 0.3038 mL 0.6076 mL 1.5191 mL
40 mM 0.0456 mL 0.2279 mL 0.4557 mL 1.1393 mL
50 mM 0.0365 mL 0.1823 mL 0.3646 mL 0.9114 mL
60 mM 0.0304 mL 0.1519 mL 0.3038 mL 0.7595 mL
80 mM 0.0228 mL 0.1139 mL 0.2279 mL 0.5697 mL
100 mM 0.0182 mL 0.0911 mL 0.1823 mL 0.4557 mL

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產(chǎn)品名稱：
Bruceantin
目錄號：
HY-N0840
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