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  2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Apoptosis
  3. P-glycoprotein Reactive Oxygen Species Apoptosis
  4. (20S)-Protopanaxadiol

(20S)-Protopanaxadiol  (Synonyms: 20 (S)-原人參二醇; 20-Epiprotopanaxadiol; 20(S)-APPD)

目錄號: HY-N0797 純度: 99.85%
COA 產(chǎn)品使用指南 技術(shù)支持

20S-protopanaxadiol (aPPD) 是人參皂甙的代謝產(chǎn)物，抑制 Akt 活性并誘導多種腫瘤細胞凋亡。

MCE 的所有產(chǎn)品僅用作科學研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務

(20S)-Protopanaxadiol Chemical Structure

(20S)-Protopanaxadiol Chemical Structure

CAS No. : 30636-90-9

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2.  同一機構(gòu)（單位）同一產(chǎn)品試用裝僅限申領(lǐng)一次，同一機構(gòu)（單位）一年內(nèi)

     可免費申領(lǐng)三個不同產(chǎn)品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥446
In-stock
5 mg ￥440
In-stock
10 mg ￥679
In-stock
25 mg ￥1424
In-stock
50 mg ￥2278
In-stock
100 mg ￥3484
In-stock
200 mg   詢價  
500 mg   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of (20S)-Protopanaxadiol:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

20S-protopanaxadiol (aPPD) is a metabolite of ginseng saponins, inhibits Akt activity and induces apoptosis in various tumor cells[1].

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
99.89 μM
Compound: PPD
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 22342101]
A549 IC50
99.89 μM
Compound: PPD
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 21216145]
COLO 205 IC50
49.16 μM
Compound: PPD
Cytotoxicity against human COLO205 cells after 72 hrs by MTT assay
Cytotoxicity against human COLO205 cells after 72 hrs by MTT assay
[PMID: 21216145]
DU-145 IC50
60.41 μM
Compound: PPD
Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
[PMID: 21216145]
Hep 3B2 IC50
14.69 μM
Compound: PPD
Cytotoxicity against human Hep3B cells after 72 hrs by MTT assay
Cytotoxicity against human Hep3B cells after 72 hrs by MTT assay
[PMID: 22342101]
HepG2 IC50
39.42 μM
Compound: PPD
Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
[PMID: 21216145]
HepG2 IC50
45.67 μM
Compound: 3
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 26420067]
HL-60 IC50
15.53 μM
Compound: 3
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
[PMID: 26420067]
HL-60 IC50
27.06 μM
Compound: PPD
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
[PMID: 21216145]
HUVEC EC50
2.16 μg/mL
Compound: 1
Antiproliferative activity against HUVEC cells after 72 hrs
Antiproliferative activity against HUVEC cells after 72 hrs
[PMID: 18271556]
LLC-PK1 IC50
36.7 μM
Compound: PPD
Cytotoxicity against pig LLC-PK1 cells after 4 hrs by MTT assay
Cytotoxicity against pig LLC-PK1 cells after 4 hrs by MTT assay
[PMID: 25453798]
MCF7 IC50
6.62 μM
Compound: PPD
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 21216145]
MDA-MB-231 IC50
5.9 μM
Compound: PPD
Antiproliferative activity against human MDA-MB-231 cells after 4 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 4 hrs by MTT assay
[PMID: 25453798]
SF-188 IC50
24 μM
Compound: 1
Cytotoxicity against human SF188 cells after 24 hrs
Cytotoxicity against human SF188 cells after 24 hrs
[PMID: 17261067]
U-87MG ATCC IC50
36.74 μM
Compound: PPD
Cytotoxicity against human U87 cells after 72 hrs by MTT assay
Cytotoxicity against human U87 cells after 72 hrs by MTT assay
[PMID: 22342101]
U-87MG ATCC IC50
38 μM
Compound: 1
Cytotoxicity against human U87MG cells after 24 hrs
Cytotoxicity against human U87MG cells after 24 hrs
[PMID: 17261067]
體外研究
(In Vitro)

20S-protopanaxadiol treatment upregulates the flotillin-1 level in the rafts of N2a cells to 142.91±10.71% of the control. 20S-protopanaxadiol can have an opposite effect on raft resident protein flotillin-1, depending on the cell type[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

460.73

Formula

C30H52O3
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

20 (S)-原人參二醇
結(jié)構(gòu)分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 50 mg/mL (108.52 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.1705 mL 10.8523 mL 21.7047 mL
5 mM 0.4341 mL 2.1705 mL 4.3409 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物實驗：

請根據(jù)您的 實驗動物和給藥方式 選擇適當?shù)娜芙夥桨浮?

以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
——為保證實驗結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當天使用；
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

  • 方案 一

    請依序添加每種溶劑： 10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (5.43 mM); 澄清溶液

    此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液，此方案實驗周期在半個月以上的動物實驗酌情使用。

    以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 900 μL玉米油中，混合均勻。

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
請輸入您的動物體內(nèi)配方組成：
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
如果您的動物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。
方案所需 助溶劑 包括：DMSO， ，均可在 MCE 網(wǎng)站選購。 ，Tween 80，均可在 MCE 網(wǎng)站選購。
計算結(jié)果
工作液所需濃度 : mg/mL
儲備液配制方法 : mg 藥物溶于 μL  DMSO（母液濃度為 mg/mL）。
您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，以下方案僅供參考，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
動物實驗體內(nèi)工作液的配制方法 : 取 μL DMSO 儲備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。
連續(xù)給藥周期超過半月以上，請謹慎選擇該方案。
請確保第一步儲備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱 （超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。
純度 & 產(chǎn)品資料

純度: 99.85%

參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1705 mL 10.8523 mL 21.7047 mL 54.2617 mL
5 mM 0.4341 mL 2.1705 mL 4.3409 mL 10.8523 mL
10 mM 0.2170 mL 1.0852 mL 2.1705 mL 5.4262 mL
15 mM 0.1447 mL 0.7235 mL 1.4470 mL 3.6174 mL
20 mM 0.1085 mL 0.5426 mL 1.0852 mL 2.7131 mL
25 mM 0.0868 mL 0.4341 mL 0.8682 mL 2.1705 mL
30 mM 0.0723 mL 0.3617 mL 0.7235 mL 1.8087 mL
40 mM 0.0543 mL 0.2713 mL 0.5426 mL 1.3565 mL
50 mM 0.0434 mL 0.2170 mL 0.4341 mL 1.0852 mL
60 mM 0.0362 mL 0.1809 mL 0.3617 mL 0.9044 mL
80 mM 0.0271 mL 0.1357 mL 0.2713 mL 0.6783 mL
100 mM 0.0217 mL 0.1085 mL 0.2170 mL 0.5426 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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(20S)-Protopanaxadiol
目錄號：
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