Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC₅₀=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9 and caspase-3.

Angelicin (30-50 μM; 48 h) 在 SH-SY5Y 細胞中誘導細胞凋亡，引起 Bcl-2、Bcl-xL 和 Mcl-1 蛋白表達的下調(diào)，并激活 caspase-9 和 caspase-3 的裂解，導致細胞凋亡^[1]。
Angelicin (28.95 μM; 48 h) 在 MHV-68 感染的 BHK21 細胞中抑制病毒復制，引起病毒蛋白 ORF45 和 ORF65 的表達下降，并減少病毒基因組復制和 RTA mRNA 的表達^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Angelicin (1、5、10 mg/kg；腹腔注射；給藥1次，于 LPS 誘導前 1 小時給藥) 在 LPS 誘導的小鼠急性肺損傷模型中具有抗炎作用，通過抑制 MAPK 和 NF-κB 通路減少炎癥細胞浸潤和細胞因子產(chǎn)生^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

186.16

C₁₁H₆O₃

523-50-2

固體

White to off-white

異補骨脂素；異香檸檬烯；異佛手柑內(nèi)酯；異補骨酯素；當歸素

Room temperature in continental US; may vary elsewhere.

• [1]. Rahman MA, et al. Angelicin induces apoptosis through intrinsic caspase-dependent pathway in human SH-SY5Y neuroblastoma cells. Mol Cell Biochem. 2012 Oct;369(1-2):95-104.  [Content Brief]

  [2]. Cho HJ, et al. Antiviral activity of angelicin against gammaherpesviruses. Antiviral Res. 2013 Oct;100(1):75-83.  [Content Brief]

  [3]. Liu F, et al. Angelicin regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. J Surg Res. 2013 Nov;185(1):300-9.  [Content Brief]