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  2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Autophagy
  3. Apoptosis Reactive Oxygen Species Autophagy
  4. Daucosterol

Daucosterol  (Synonyms: 胡蘿卜苷; Eleutheroside A; β-Sitosterol β-D-glucoside)

目錄號: HY-N0410 純度: 93.98%
COA 產(chǎn)品使用指南 技術(shù)支持

Daucosterol 是一種具有口服活性的天然甾醇化合物，具有抗炎、抗癌和免疫調(diào)節(jié)活性。Daucosterol 通過 ROS 依賴性方式誘導(dǎo)自噬來抑制癌細(xì)胞增殖。Daucosterol 還通過誘導(dǎo)細(xì)胞凋亡、抑制細(xì)胞遷移和侵襲以及靶向 caspase 信號通路來抑制結(jié)腸癌生長。

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Daucosterol Chemical Structure

Daucosterol Chemical Structure

CAS No. : 474-58-8

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規(guī)格 價格 是否有貨 數(shù)量
5 mg ￥850
In-stock
10 mg ￥1350
In-stock
25 mg ￥2650
In-stock
50 mg   詢價  
100 mg   詢價  

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Customer Review

Other Forms of Daucosterol:

    Daucosterol purchased from MCE. Usage Cited in: Eur J Pharmacol. 2019 Jul 15;855:112-123.  [Abstract]

    Western blot analysis of p53 expression and phosphorylation in DS treated A549 cells with the indicated concentrations after 72 h incubation. DS up-regulates p53 expression and phosphorylation which resulted in activation of downstream regulator p21.

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Daucosterol is an orally active natural sterol compound, which has anti-inflammatory, anticancer and immunomodulatory activities. Daucosterol inhibits cancer cell proliferation by inducing autophagy through ROS-dependent manner. Daucosterol also inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway[1][2][3].

    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    A2780 IC50
    > 10 μg/mL
    Compound: page 1629, R26C1
    Cytotoxicity against human A2780 cells after 96 hrs by MTT assay
    Cytotoxicity against human A2780 cells after 96 hrs by MTT assay
    		[PMID: 17125236]
    A549 IC50
    > 10 μg/mL
    Compound: page 1629, R26C1
    Cytotoxicity against human A549 cells after 96 hrs by MTT assay
    Cytotoxicity against human A549 cells after 96 hrs by MTT assay
    		[PMID: 17125236]
    A549 IC50
    > 20 μg/mL
    Compound: 10
    Cytotoxicity against human A549 cells by MTT assay
    Cytotoxicity against human A549 cells by MTT assay
    		[PMID: 22413887]
    A549 GI50
    35.5 μM
    Compound: 6
    Growth inhibition of human A549 cells by MTT assay
    Growth inhibition of human A549 cells by MTT assay
    		[PMID: 20153184]
    A549 ED50
    4.73 μg/mL
    Compound: beta-sitosterol-beta-D-glucopyranoside
    Cytotoxicity against human A549 cells after 7 days
    Cytotoxicity against human A549 cells after 7 days
    		[PMID: 1453182]
    Bel-7402 IC50
    > 10 μg/mL
    Compound: page 1629, R26C1
    Cytotoxicity against human Bel-7402 cells after 96 hrs by MTT assay
    Cytotoxicity against human Bel-7402 cells after 96 hrs by MTT assay
    		[PMID: 17125236]
    BGC-823 IC50
    > 10 μg/mL
    Compound: page 1629, R26C1
    Cytotoxicity against human BGC-823 cells after 96 hrs by MTT assay
    Cytotoxicity against human BGC-823 cells after 96 hrs by MTT assay
    		[PMID: 17125236]
    Ca9-22 IC50
    > 20 μg/mL
    Compound: 10
    Cytotoxicity against human Ca9-22 cells by MTT assay
    Cytotoxicity against human Ca9-22 cells by MTT assay
    		[PMID: 22413887]
    HCT-8 IC50
    > 10 μg/mL
    Compound: page 1629, R26C1
    Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay
    Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay
    		[PMID: 17125236]
    Hep 3B2 IC50
    > 20 μg/mL
    Compound: 10
    Cytotoxicity against human Hep3B cells by MTT assay
    Cytotoxicity against human Hep3B cells by MTT assay
    		[PMID: 22413887]
    HepG2 IC50
    > 20 μg/mL
    Compound: 10
    Cytotoxicity against human HepG2 cells by MTT assay
    Cytotoxicity against human HepG2 cells by MTT assay
    		[PMID: 22413887]
    HL-60 GI50
    50.8 μM
    Compound: 6
    Growth inhibition of human HL60 cells by MTT assay
    Growth inhibition of human HL60 cells by MTT assay
    		[PMID: 20153184]
    HT-1080 ED50
    > 100 μM
    Compound: 15
    Antiproliferative activity against human HT1080 cells by MTT assay
    Antiproliferative activity against human HT1080 cells by MTT assay
    		[PMID: 11277741]
    HT-29 ED50
    4.44 x 10-1 μg/mL
    Compound: beta-sitosterol-beta-D-glucopyranoside
    Cytotoxicity against human HT-29 cells after 7 days
    Cytotoxicity against human HT-29 cells after 7 days
    		[PMID: 1453182]
    HT-29 GI50
    46.8 μM
    Compound: 6
    Growth inhibition of human HT-29 cells by MTT assay
    Growth inhibition of human HT-29 cells by MTT assay
    		[PMID: 20153184]
    MCF7 IC50
    > 20 μg/mL
    Compound: 10
    Cytotoxicity against human MCF7 cells by MTT assay
    Cytotoxicity against human MCF7 cells by MTT assay
    		[PMID: 22413887]
    MCF7 ED50
    44.39 μg/mL
    Compound: beta-sitosterol-beta-D-glucopyranoside
    Cytotoxicity against human MCF7 cells after 7 days
    Cytotoxicity against human MCF7 cells after 7 days
    		[PMID: 1453182]
    MDA-MB-231 IC50
    > 20 μg/mL
    Compound: 10
    Cytotoxicity against human MDA-MB-231 cells by MTT assay
    Cytotoxicity against human MDA-MB-231 cells by MTT assay
    		[PMID: 22413887]
    NCI-H460 IC50
    > 50 μM
    Compound: 3
    Cytotoxicity against human NCI-H460 cells incubated for 24 hrs by MTT assay
    Cytotoxicity against human NCI-H460 cells incubated for 24 hrs by MTT assay
    		[PMID: 28606759]
    SK-OV-3 GI50
    29.8 μM
    Compound: 6
    Growth inhibition of human SKOV3 cells by MTT assay
    Growth inhibition of human SKOV3 cells by MTT assay
    		[PMID: 20153184]
    體外研究
    (In Vitro)

    Daucosterol (0.01-100 μM, 48 h) 以劑量依賴性方式抑制 MCF-7、AGS、MGC803 和 BGC823 細(xì)胞的增殖，IC50 分別為 19.96 μM、3.13 μM、24.19 μM 和 16.95 μM[1]。
    Daucosterol (50 μM, 24 h) 顯著增加 MCF-7 和 BGC823 細(xì)胞中 ROS 的產(chǎn)生[1]。
    Daucosterol (0-80 μM, 48 h) 抑制 PC3 和 LNCap 細(xì)胞增殖并促進(jìn)細(xì)胞凋亡[2]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Western Blot Analysis[2]

    Cell Line: PC3 and LNCap cells
    Concentration: 0-80 μM
    Incubation Time: 48 h
    Result: Increased the expressions of cleaved caspase 3, cleaved caspase 9, Bax protein, LC3II/LC3I ration and Beclin 1.
    Decreased the the expressions of Bax protein and p62.
    體內(nèi)研究
    (In Vivo)

    Daucosterol (0.5-2.5 mg/kg, 口服, 每天一次, 持續(xù) 7 天) 顯著抑制接種 H22 肝癌細(xì)胞的 ICR 小鼠的 H22 腫瘤生長[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    576.85

    Formula

    C35H60O6
    CAS 號
    性狀

    固體

    顏色

    White to off-white

    中文名稱

    胡蘿卜苷；西托糖苷；胡蘿卜甙
    結(jié)構(gòu)分類
    初始來源
    運輸條件

    Room temperature in continental US; may vary elsewhere.
    儲存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    溶解性數(shù)據(jù)
    細(xì)胞實驗： 

    DMSO 中的溶解度 : 3.33 mg/mL (5.77 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

    配制儲備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 1.7336 mL 8.6678 mL 17.3355 mL
    5 mM 0.3467 mL 1.7336 mL 3.4671 mL
    查看完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

    • 摩爾計算器

    • 稀釋計算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動物溶解方案計算器
    請輸入動物實驗的基本信息：

    給藥劑量

    mg/kg

    動物的平均體重

    g

    每只動物的給藥體積

    μL

    動物數(shù)量

    只
    由于實驗過程有損耗，建議您多配一只動物的量
    計算結(jié)果
    工作液所需濃度 : mg/mL
    純度 & 產(chǎn)品資料
    參考文獻(xiàn)

    完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.7336 mL 8.6678 mL 17.3355 mL 43.3388 mL
    5 mM 0.3467 mL 1.7336 mL 3.4671 mL 8.6678 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    產(chǎn)品名稱：
    Daucosterol
    目錄號：
    HY-N0410
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